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| Number | Title | Issue Date |
| 7737159 | Antibacterial compounds Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compou... | 06/15/2010 |
| 7718633 | Prodrugs of HIV protease inhibitors A compound of the formula is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions for inhibiting HIV protease activity and treating HIV infection are also disclosed. ... | 05/18/2010 |
| 7632946 | Naphthyridine-based antibacterial compositions Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the comp... | 12/15/2009 |
| 7547678 | Method for treating a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate The present invention is directed to a method for inducing UGT1A1 isoform expression for treatment of a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate comprising the step of administering to a subject an effectiv... | 06/16/2009 |
| 7538105 | Anti-infective agents Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediate... | 05/26/2009 |
| 7517876 | Anti-infective agents Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermedia... | 04/14/2009 |
| 7320961 | Method for treating a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate The present invention is directed to a method for inducing UGT1A1 isoform expression for treatment of a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate comprising the step of administering to a subject an effectiv... | 01/22/2008 |
| 6933311 | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X1, X2, X3... | 08/23/2005 |
| 6872734 | Use of tiagabine for treatment of diabetic neuropathy and migraine (R)-N-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid and salts thereof are effective GABA uptake inhibitory compounds and exert pharmacological effects on pain associated with diabetic neuropathy and migraine. ... | 03/29/2005 |
| 6831193 | Trisubstituted-N-[(1S)-1,2,3,4-Tetrahydro-1-naphthalenyl]benzamides which inhibit P2X3 and P2X2/3 containing receptors Compounds of formula (I) are novel P2X3 and P2X2/P2X3 antagonists which are useful in treating pain, urinary incontinence and bladder overactivity. ... | 12/14/2004 |
| 6809105 | Diazabicyclic central nervous system active agents Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals. ... | 10/26/2004 |
| 6740527 | Methods and reagents for cyanide-free determination of hemoglobin and leukocytes in whole blood Cyanide-free reagents for the determination of hemoglobin and leukocytes present in a blood sample comprise an aqueous solutions of at least one quaternary ammonium salt, preferably selected from the group of alkyltrimethylammonium salts, alkyldimethylbenzylammonium... | 05/25/2004 |
| 6525113 | Process for producing cross-linked polyallylamine hydrochloride The present invention relates to a process for preparing a cross-linked pollyallylamine hydrochloride. The process involves mixing polyallylamine hydrochloride, water, a hydroxide or alkoxide, and a water-miscible organic solvent or co-solvents, to a reac... | 02/25/2003 |
| 6503935 | Imidazoles and related compounds as agonists Compounds having formula I: ##STR1## are useful in treating diseases prevented by or ameliorated with agonists. Also disclosed are agonist compositions and a method of activating 댑 adrenoceptors ... | 01/07/2003 |
| 6495576 | Aminal diones as potassium channel openers Compounds of formula (I) ##STR1## may be useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal... | 12/17/2002 |
| 6376488 | Benzoxazine -1 adrenergic compounds The present invention relates to compounds having formula I ##STR1## and to pharmaceutically acceptable salts thereof. Compounds of formula I inhibit 댑 adrenoreceptors and may be useful for treating benign prostatic hyperplasia (also cal... | 04/23/2002 |
| 6323231 | Use of adrenoceptor agonists with and antagonism for the treatment of stress urinary incontinence The following disclosure relates to a method of treating incontinence with a compound having a specific adrenoceptor profile.... | 11/27/2001 |
| 6307047 | Prostaglandin endoperoxide H synthase biosynthesis inhibitors The present invention describes pyridazinone compounds of formula I ##STR1## which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, a... | 10/23/2001 |
| 6265417 | Potassium channel openers Compounds having the formula ##STR1## are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.... | 07/24/2001 |
| 6191140 | Pyrano, piperidino, and thiopyrano compounds and methods of use The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.... | 02/20/2001 |
| 6166019 | Piperazinyl pyrimidine dione compounds selective for adrenoceptors Compounds of Formula I and II and their pharmaceutically acceptable, salts, esters and prodrugs thereof are selective alpha-1D adrenoceptor anatagonists and may be useful for treating disease states.... | 12/26/2000 |
| 6153614 | Piperazinyl pyrimidine dione compounds selective for adrenoceptors Compounds of Formula I ##STR1## and II and their pharmaceutically acceptable, salts, esters and prodrugs thereof are selective alpha-1D adrenoceptor anatagonists and may be useful for treating disease states, such as benign prostatic hyperplasia, ... | 11/28/2000 |
| 6124474 | Synthesis of chiral 2-azetidinemethanol compounds A process for preparing chiral isomers of N-protected 2-azetidinemethanol compounds, particularly N-(phenylmethyl)-2-azetidinemethanol and N-BOC-2-azetidinemethanol, and especially the (R)-isomers thereof, as well as O-substituted derivatives thereof.... | 09/26/2000 |
| 6103911 | Process for reduction of (2R)-4-oxoazetidinone-2-carboxylic acid The present invention relates to a process for the reduction of an azetidinone-carboxylic acid to an azetidine-alcohol.... | 08/15/2000 |
| 6046207 | Benzopyranopyrrole and benzopyranopyridine -1 adrenergic compounds The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are -1 adrenergic antagonists and are useful in the treatment of BPH; also ... | 04/04/2000 |
| 6001849 | Furopyridine, thienopyridine pyrrolopyridine useful in controlling chemical synaptic transmission Novel heterocyclic ether compounds having the formula: ##STR1## wherein A, m, R, X, Y1, Y2 and Y3 are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-e... | 12/14/1999 |
| 5998669 | Process for production of 2-amino-1,3-propanediol The present invention relates to a process of making 2-amino-1,3-propanediol by reacting 1,3-dihyrdroxyacetone dimer with an amine compound.... | 12/07/1999 |
| 5912162 | Dipteran-active compound and Bacillus thuringiensis strain The invention relates to a novel substance with activity against insect pests of the order Diptera. The invention further relates to the substance which acts together with a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal p... | 06/15/1999 |
| 5905134 | Process for the preparation of polyanhydrides Polymers can be prepared in solution by continuously distilling solvent from a solution of diacid prepolymers.... | 05/18/1999 |
| 5891882 | Benzopyranopyrrole and benzopyranopyridine -1 adenergic compounds The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are -1 adrenergic antagonists and are useful in the treatment... | 04/06/1999 |
| 5879676 | Bacillus thuringiensis strains active against lepidopteran and coleopteran pests The invention is related to a novel biologically pure Bacillus thuringiensis (B.t.) strains active against lepidopteran and coleopteran pests which produces a bipyramidal crystal consisting essentially of at least two delta-endotoxins having a molecular w... | 03/09/1999 |
| 5874289 | Bacillus thuringiensis mutants which produce high yields of crystal delta-endotoxin The invention relates to a mutant of Bacillus thuringiensis which produces a larger amount of crystal delta-endotoxin with a greater pesticidal activity as compared to the corresponding parental strain. The mutant may also have a larger crystal size as co... | 02/23/1999 |
| 5874601 | Process of protecting a 1,2-aminoalcohol for reductive amination coupling A process of protecting a 1,2- or 1,3-aminoalcohol for reductive amination coupling is provided. The alcohol is protected with trimethylsilyl chloride. Trimethylsilyl protected norepinephrine derivatives useful in the preparation of arbutamine are also pr... | 02/23/1999 |
| 5807574 | Homogeneous mixtures of low temperature-melting drugs and additives for controlled release The present invention relates to novel compositions of and methods of manufacture of controlled release formulations obtained by mixing molten drugs with molten additives to produce homogeneous drug-additive composites.... | 09/15/1998 |
| 5801250 | Process for the stereoselective production of nitro-enamine compounds The present invention relates to an asymmetric Michael Addition reaction to produce nitro ketone diasteroisomers with enhanced stereoselectivity.... | 09/01/1998 |
| 5770431 | Bacillus thuringiensis strains active against lepidopteran and coleopteran pests The invention is related to a novel biologically pure Bacillus thuringiensis (B.t.) strains active against lepidopteran and coleopteran pests which produces a bipyramidal crystal consisting essentially of at least two delta-endotoxins having a molecular w... | 06/23/1998 |
| 5756715 | Process for making crystalline iron dextran A process for the crystallization of an iron-dextran complex in readily-filterable form comprising adding slowly, with stirring, an acidified aqueous iron-dextran solution to a vessel containing a water miscible organic solvent such as methanol, as well a... | 05/26/1998 |
| 5731463 | Selective alkylation of an alcohol substituted phenol compound The present invention relates to a process for the selective alkylation of intermediates of betaxolol.... | 03/24/1998 |
| 5698676 | Use of propylene oxide as an acid scavenger in peptide synthesis A process of synthesizing a peptide using an alkylene oxide as an acid scavenger is provided. A process of the present invention can be used in a solid phase or solution phase synthetic process where peptide synthesis occurs by the sequential addition of ... | 12/16/1997 |
| 5698440 | Bacillus thuringiensis mutants which produce high yelds of crystal delta-endotoxin The invention relates to a mutant of Bacillus thuringiensis which produces a larger amount of crystal delta-endotoxin with a greater pesticidal activity as compared to the corresponding parental strain. The mutant may also have a larger crystal size as co... | 12/16/1997 |
