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| Number | Title | Issue Date |
| 7390824 | Method for treating diabetes employing an aP2 inhibitor and combination A method is provided for treating diabetes and related diseases, especially Type II diabetes, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antidiabetic agent such as metformin, glyburide, troglitazone and/or insulin. ... | 06/24/2008 |
| 7388009 | Heteroaryl-substituted pyrrolo-triazine compounds useful as kinase inhibitors Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R | 06/17/2008 |
| 7378430 | Quinoline inhibitors of cGMP phosphodiesterase Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5. ... | 05/27/2008 |
| 7358254 | Method for treating atherosclerosis employing an aP2 inhibitor and combination A method is provided for treating atherosclerosis and related diseases, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antiatherosclerotic agent, for example, an HMG CoA reductase inhibitor such as pravastatin. ... | 04/15/2008 |
| 7332640 | Light hydrocarbon separation using 8-member ring zeolites The present invention is related to a method for kinetically separating a light hydrocarbon mixture comprising at least two components by preferentially adsorbing a first component on a zeolite adsorbent comprising 8-member rings of tetrahedra as the pore opening co... | 02/19/2008 |
| 7323482 | Thiazolyl-based compounds useful as kinase inhibitors The present invention provides thiazolyl-based compounds of formula (I), useful for treating p38 kinase-associated conditions, wherein ring A is phenyl or pyridyl, and X, Y, B, R2, R3, Z | 01/29/2008 |
| 7314876 | Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are surprisingly advantageous as p38 kinase inhibitors, wherein R3 is hydrogen, methyl, perfluor... | 01/01/2008 |
| 7253174 | N-heterocyclic inhibitors of TNF-α expression N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): Methods of production, pharm... | 08/07/2007 |
| 7253167 | Tricyclic-heteroaryl compounds useful as kinase inhibitors The present invention relates to compounds having the formula, wherein, Q is optionally substituted aryl or heteroaryl, R1 is hydrogen or C1-4alkyl, and R2, R3, R4... | 08/07/2007 |
| 7211666 | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R1 through R6 and Z are as described... | 05/01/2007 |
| 7173042 | Quinoline inhibitors of cGMP phosphodiesterase Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5. ... | 02/06/2007 |
| 7169771 | Thiazolyl-based compounds useful as kinase inhibitors The present invention provides thiazolyl-based compounds of formula (I), useful for treating p38 kinase-associated conditions, wherein ring A is phenyl or pyridyl, and X, Y, B, R2, R3, Z | 01/30/2007 |
| 7160883 | Pyrrolo-triazine aniline compounds useful as kinase inhibitors Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R... | 01/09/2007 |
| 7151113 | Pyrazole-amine compounds useful as kinase inhibitors The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where W, X, R1, R2, R3, R4, R5... | 12/19/2006 |
| 7148348 | Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors A process is provided for the process for preparing a pyrrolotriazine aniline p38 kinase inhibitor such as amide II by the direct aminolysis of the ester I w... | 12/12/2006 |
| 7034151 | Process for preparing pyrrolotriazine kinase inhibitors An improved process for the preparation of certain pyrrolotriazine compounds is disclosed. The compounds exhibit utility as kinase inhibitors. ... | 04/25/2006 |
| 6984645 | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein Compounds that are dual aP2/k-FABP inhibitors are provided having the formula wherein A, B, X, Y, R1, R2 and R3 are as described herein. A method is also provided for treating diabetes ... | 01/10/2006 |
| 6962915 | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors Compounds having the formula (I), and pharmaceutically acceptable salts or prodrugs thereof, are useful as kinase inhibitors, wherein Y is —C(═O)NR1—, —NR1C(═O)—, —NR1C(... | 11/08/2005 |
| 6927227 | Heterocyclic containing biphenyl aP2 inhibitors and method aP2 inhibiting compounds are provided having the formula wherein R1, R2, R3, R4, X—Z and are as described herein. A ... | 08/09/2005 |
| 6919323 | Pyridazinone inhibitors of fatty acid binding protein and method aP2 inhibiting compounds are provided having the formula wherein A, X, R and Z are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employi... | 07/19/2005 |
| 6906067 | N-heterocyclic inhibitors of TNF-α expression N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutica... | 06/14/2005 |
| 6864334 | Multi-dentate late transition metal catalyst complexes and polymerization methods using those complexes The instant invention provides a late transition metal complex which can be used with an activating cocatalyst to produce polymers and copolymers. The invention also provides methods for polymerizing olefins, as well as copolymers having polar monomers incorporated ... | 03/08/2005 |
| 6809058 | Multi-dentate late transition metal catalyst complexes and polymerization methods using those complexes The instant invention provides a late transition metal complex which can be used with an activating cocatalyst to produce polymers and copolymers. The invention also provides methods for polymerizing olefins, as well as copolymers having polar monomers incorporated ... | 10/26/2004 |
| 6777584 | Selective coupling of terminal olefins with ethylene to manufacture linear α-olefins A process for producing a linear α-olefin which comprises: reacting a stoichiometric excess of a terminal Cn olefin with ethylene in the presence of an organometallic catalyst to produce a Cn+2 linear α-olefin, wherein the catalyst is capable... | 08/17/2004 |
| 6777514 | Geminally disubstituted olefin-carbon monoxide-ethylene polymer useful as a polyvinyl chloride plasticizer and a method of making same The invention is related to a geminally disubstituted olefin-carbon monoxide-ethylene polymer. The invention is also related to a method for preparing geminally disubstituted olefin-carbon monoxide-ethylene polymers by reacting a geminally disubstituted olefin feed,... | 08/17/2004 |
| 6750278 | Polyvinyl chloride resins The invention is directed towards a PVC resin composition comprising polyvinyl chloride and a plasticizer selected from the group consisting of: i) a non-linear, paraffin-soluble olefin-CO copolymer; ii) an olefin-CO-X terpolymer derived from non-pure feeds; iii) a ... | 06/15/2004 |
| 6743960 | Method for oligomerizing olefins to form higher olefins using sulfur-containing and sulfur-tolerant catalysts The present invention is related to a method for oligomerizing olefinic monomers under oligomerization conditions to form higher olefins. The novel method comprises contacting a feed comprising the olefinic monomers with a catalyst composition comprising the reactio... | 06/01/2004 |
| 6740718 | Non-linear polymer product derived from dilute multi-component feeds The invention relates to a method of forming carbon monoxide-containing polymers from multi-component syngas feeds and at least one vinyl comonomer. Feeds useful in the practice of the invention comprise ethylene in an amount ranging from about 5 to about 40 mole %,... | 05/25/2004 |
| 6730142 | Separation of propylene from hydrocarbon mixtures In a process for separating propylene from a mixture comprising propylene and propane, the mixture is passed through a bed of an adsorbent comprising a porous crystalline material having (i) a diffusion time constant for propylene of at least 0.1 sec−1,... | 05/04/2004 |
| 6730757 | Sulfur-containing and sulfur-nitrogen-containing catalysts for polymerization of olefins and polar monomers The inventions disclosed herein are catalyst systems comprising a complex having one of the formulas LMX1X2 and LML′ and an activating cocatalyst, and use of the catalyst system in polymerizing olefinic monomers. In either of the foregoing fo... | 05/04/2004 |
| 6689852 | Modifiers for improved olefin polymerization with activated neutral aluminum compounds The present invention is for a transition metal-free catalyst system for synthesizing high molecular weight, linear polymers. The system comprises a catalyst composition having: (a) a neutral compound having the formula AlR3, wherein R is an al... | 02/10/2004 |
| 6677279 | Use of carbon monoxide containing polymers as, adhesive additives, and fluids The invention relates to a variety of uses for novel carbon monoxide containing polymers. More specifically, the invention employs the use of low molecular weight polymers containing carbon monoxide for use as adhesive additives and as fluids (e.g., solve... | 01/13/2004 |
| 6673737 | Ionic liquid compositions A novel supported ionic liquid moiety which may further comprise immobilized ionic fluids and catalytic material is described. A method for making the composition is also described.... | 01/06/2004 |
| 6642328 | Process for making olefin-carbon monoxide copolymers from synthesis gas The invention is related to non-linear olefin-carbon monoxide copolymer composition which is derived from an olefin feedstream and a synthesis gas feedstream. The invention is also related to a method for preparing olefin-carbon monoxide copolymers by hea... | 11/04/2003 |
| 6642327 | Late transition metal complexes, their use as catalysts and polymers therefrom The invention provides a novel metal complex which, when used with an activating cocatalyst, provides a novel catalyst composition. The invention also provides a polymerization method which utilizes the catalyst composition to produce polymers and copolym... | 11/04/2003 |
| 6624228 | Synthesis of microporous ceramics The present invention provides for microporous ceramic materials having a surface area in excess of 50 m2 /gm and an open microporous cell structure wherein the micropores have a mean width of less than 20 Angstroms and wherein said microporous... | 09/23/2003 |
| 6552232 | Process for conducting aldol condensation reactions in ionic liquid media The present invention is related to a method for forming aldol condensation products, comprising reacting at least one aldehyde starting material in the presence of an ionic liquid medium and a basic catalyst at a temperature range of from about -20° C. ... | 04/22/2003 |
| 6506859 | Polymerization using late transition metal catalyst complexes formed in situ The invention is directed towards the formation of polymers and copolymers using late transition metal polymerization catalyst complexes which are formed in situ. In the first process step of the instant invention, a composition having the formula MXZ | 01/14/2003 |
| 6501000 | Late transition metal catalyst complexes and oligomers therefrom The invention is directed towards a composition comprising the formula LMX(X')n wherein n equals 0 or 1; X and X' are independently selected from the group consisting of halides, hydride, triflate, acetates, borates, C1 through C | 12/31/2002 |
| 6417303 | Substantially linear copolymers The invention is directed towards substantially linear copolymers formed using a metal complex having the formula LMX1 X2. L is a bidentate nitrogen-containing ligand with more than 2 nitrogens. M is copper, silver, or gold. X1 | 07/09/2002 |
