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| Number | Title | Issue Date |
| 6986169 | Sport protective headgear A sport protective headgear comprising a main section that is to be placed on the occiput of a head from which extends a parietal section that is to be placed against the parietal of a head. Also, integrally connected to the main section is a right side section that... | 01/17/2006 |
| 6905612 | Plasma concentrate apparatus and method A plasma concentrator for producing plasma concentrate from a plasma from which erythrocytes have been substantially removed. The device comprises a concentrating chamber having an inlet port and an concentrate outlet, the concentrating chamber containing hydrogel b... | 06/14/2005 |
| 6691324 | Sport protective headgear A goggle retention system which also acts as a sport protective headgear. The headgear takes the form of a main section which is to be placed on the occiput of a head from which extends a parietal section which is to be placed against the parietal of a he... | 02/17/2004 |
| 6455692 | Method of concentrating polynucleotides using MIPC The present invention is directed to improved methods for detection of mutations in DNA using Denaturing Matched Ion Polynucleotide Chromatography (DMIPC). The invention includes the following aspects: analysis of PCR amplification products to identify fa... | 09/24/2002 |
| 6419824 | Apparatus and method for separating and purifying polynucleotides The disclosure describes an ambient or low pressure device for separating polynucleotide fragments from a mixture of polynucleotide fragments comprises a tube having an upper solution input chamber, a lower eluant receiving chamber, and a fixed unit of se... | 07/16/2002 |
| 6372130 | Non-polar media for polynucleotide separations Nonporous beads having an average diameter of about 0.5-100 microns are suitable for chromatographic separation of mixtures of polynucleotides when the beads comprise a nonporous particle which are coated with a polymer or which have substantially all sur... | 04/16/2002 |
| 6372142 | Column for DNA separation by matched ion polynucleotide chromatography An improved separation column and method for separating a mixture of double stranded DNA fragments by Matched Ion Polynucleotide Chromatography. The cylindrical column has an ID greater than about 5 mm and contains polymer beads. The beads have an average... | 04/16/2002 |
| 6361672 | Multiple laser diode electromagnetic radiation source in multiple electrophoresis channel systems The present invention is a multiple channel electrophoresis system which includes a multiple laser diode illumination source. The multiple laser diode illumination source has a plurality of individual laser diodes, each of which is situated so as to provi... | 03/26/2002 |
| 6355791 | Polynucleotide separations on polymeric separation media Non-polar polymeric separation media, such as beads or monoliths, are suitable for chromatographic separation of mixtures of polynucleotides when the surface of the media are unsubstituted or substituted with a hydrocarbon group having from one to 1,000,0... | 03/12/2002 |
| 6355417 | Band array display of polynucleotide separations A method and apparatus for representing double stranded nucleic acid fragments which have been separated by a chromatographic process as an array of bands which can be accurately quantified, optimized and stored. Using, for example, a Matched Ion Polynucl... | 03/12/2002 |
| 6355165 | MIPC chromatographic apparatus with improved temperature control A liquid chromatography apparatus with stationary and mobile phase temperature controls suitable for polynucleotide separations by MIPC and DMIPC processes. The apparatus includes heater means with a temperature control system; a matched ion polynucleotid... | 03/12/2002 |
| 6342161 | Method for high resolution liquid chromatographic separation of double-stranded DNA Mixtures of dsDNA fragments are separated by Matched Ion Polynucleotide Chromatography (MIPC) using an isocratic mobile phase to elute polynucleic acid from an MIPC column. The use of isocratic elution conditions provides a marked improvement in the separ... | 01/29/2002 |
| 6309549 | Polynucleotide separations on polymeric separation Non-polar polymeric separation media, such as beads or monoliths, are suitable for chromatographic separation of mixtures of polynucleotides when the surfaces of the media are unsubstituted or substituted with a hydrocarbon group having from one to 1,000,... | 10/30/2001 |
| 6287822 | Mutation detection method The present invention is directed to improved methods for detection of mutations in DNA using Denaturing Matched Ion Polynucleotide Chromatography (DMIPC). The invention includes the following aspects: analysis of PCR amplification products to identify fa... | 09/11/2001 |
| 6265168 | Apparatus and method for separating and purifying polynucleotides A method for removing a target DNA fragment having a predetermined base-pair length from a mixture of DNA fragments comprises the following steps. A mixture of DNA fragments which may contain the target DNA fragments is applied to a separation column cont... | 07/24/2001 |
| 6258264 | Non-polar media for polynucleotide separations Nonporous beads having an average diameter of about 0.5-100 microns are suitable for chromatographic separation of mixtures of polynucleotides when the beads comprise a nonporous particle which are coated with a polymer or which have substantially all sur... | 07/10/2001 |
| 6251272 | System and column for performing polynucleotide separations using liquid chromatography Improved liquid chromatography systems having components made of titanium, stainless steel, or organic polymeric material are useful in the separation of polynucleotide fragments, particularly large fragments of double-stranded polynucleotides, by Matched... | 06/26/2001 |
| 6218153 | Target DNA amplification by MIPC and PCR A method for detecting a putative mutant DNA in a sample of DNA includes the steps of amplifying the sample of DNA using PCR; hybridizing the amplified sample to form a mixture of homoduplexes and heteroduplexes; separating the mixture into fractions by D... | 04/17/2001 |
| 6210885 | Modifying double stranded DNA to enhance separations by matched ion polynucleotide chromatography Covalently bound non-polar tags are used to increase the retention times of double stranded polynucleotides on Matched Ion Polynucleotide Chromatography (MIPC) columns. In doing so, separations of DNA mixture components is improved. Additionally, when the... | 04/03/2001 |
| 6187539 | Analysis of nicked DNA by matched ion polynucleotide chromatography The present invention provides a method for calibrating a MIPC column wherein the calibration relates to the determination of the organic solvent component in the mobile phase required to elute dsDNA fragments of different base pair lengths at specific re... | 02/13/2001 |
| 6174441 | Method for performing polynucleotide separations using liquid chromatography Improved liquid chromatography systems having components made of titanium, stainless steel, or organic polymeric material are useful in the separation of polynucleotide fragments, particularly large fragments of double-stranded polynucleotides, by Matched... | 01/16/2001 |
| 6156206 | Process for performing polynucleotide separations The invention recognizes the deleterious effects of trace, and even undetectable amounts of multivalent cations on the separation of mixtures of polynucleotides, especially double stranded polynucleotides, and provides an improved method for separating su... | 12/05/2000 |
| 6136195 | MIPC column cleaning system and process An apparatus for effecting base pair length separations of DNA fragments by matched ion paired chromatography comprising a separation column containing separation media having non-polar DNA separation surfaces, separation solution supply means, and a sepa... | 10/24/2000 |
| 6103112 | MIPC chromatographic apparatus with improved temperature control A liquid chromatography apparatus with stationary and mobile phase temperature controls suitable for polynucleotide separations by MIPC and DMIPC processes. The apparatus includes heater means with a temperature control system; a matched ion polynucleotid... | 08/15/2000 |
| 6074880 | Sample analyte containing solution fraction collection system, and method of use Disclosed is a system and method which allows user controlled formation, and ejection of droplets of sample analyte containing solutions, thereby enabling precise user directed fractionalization and distributed collection of sample analytes.... | 06/13/2000 |
| 6066258 | Polynucleotide separations on polymeric separation media Non-polar polymeric separation media, such as beads or monoliths, are suitable for chromatographic separation of mixtures of polynucleotides when the surfaces of the media are unsubstituted or substituted with a hydrocarbon group having from one to 1,000,... | 05/23/2000 |
| 6056877 | Non-polar media for polynucleotide separations Nonporous beads having an average diameter of about 0.5-100 microns are suitable for chromatographic separation of mixtures of polynucleotides when the beads comprise a nonporous particle which are coated with a polymer or which have substantially all sur... | 05/02/2000 |
| 6041260 | Method and apparatus for endometrial ablation An endometrial ablation apparatus and method wherein an RF current having a frequency of between 250 kHz and 100 MHz is passed through the entire surface of an endometrium in order to provide heating of the endometrium. An electroconductive expandable mem... | 03/21/2000 |
| 6030527 | Apparatus for performing polynucleotide separations using liquid chromatography Improved liquid chromatography systems having components made of titanium, stainless steel, or organic polymeric material are useful in the separation of polynucleotide fragments, particularly large fragments of double-stranded polynucleotides, by Matched... | 02/29/2000 |
| 6027898 | Chromatographic method for mutation detection using mutation site specifically acting enzymes and chemicals A method for analyzing a sample of double stranded DNA to determine the presence of a mutation therein comprises contacting the sample with a mutation site binding reagent, and chromatographically separating and detecting the product. The chromatographic ... | 02/22/2000 |
| 6024878 | Method for high resolution liquid chromatographic separation of polynucleotides Mixtures of dsDNA fragments are separated by Matched Ion Polynucleotide Chromatography (MIPC) using an isocratic mobile phase to elute polynucleic acid from an MIPC column. The use of isocratic elution conditions provides a marked improvement in the separ... | 02/15/2000 |
| 6017457 | Method for performing polynucleotide separations using liquid chromatography Improved liquid chromatography systems having components made of titanium, stainless steel, or organic polymeric material are useful in the separation of polynucleotide fragments, particularly large fragments of double-stranded polynucleotides, by Matched... | 01/25/2000 |
| 6008055 | Modular component fiber optic fluorescence detector system, and method of use Systems and methods for inducing and detecting sample analyte(s) identifying fluorescence are disclosed. In particular, a system which includes at least two fiber optic means, within a "throw-away" modular component system component with at least four por... | 12/28/1999 |
| 5997742 | Method for performing polynucleotide separations using liquid chromatography Improved liquid chromatography systems having components made of titanium, stainless steel, or organic polymeric material are useful in the separation of polynucleotide fragments, particularly large fragments of double-stranded polynucleotides, by Matched... | 12/07/1999 |
| 5989296 | Solvent process for recovering indigo dye from textile scrap A process for recovering a vat dye from a textile using a heated organic solvent. The textile is contacted with a heated organic solvent in which the dye is soluble until dye is extracted from the textile into the solvent to produce a dye-containing solve... | 11/23/1999 |
| 5986085 | Matched ion polynucleotide chromatography (MIPC) process for separation of polynucleotide fragments A batch process for obtaining polynucleotide fragments, such as dsDNA, having a selected size from a mixture of polynucleotide fragments including the steps of a) applying a solution of the mixture of polynucleotide fragments and a counterion agent to a b... | 11/16/1999 |
| 5972222 | Process for performing polynucleotide separations The invention recognizes the deleterious effects of trace, and even undetectable amounts of multivalent cations on the separation of mixtures of polynucleotides, especially double stranded polynucleotides, and provides an improved method for separating su... | 10/26/1999 |
| 5968758 | Method for detecting free IGFBP-1 Antibodies having binding affinity for free IGFBP-1, biological compositions including antibodies having binding affinity for free IGFBP-1, kits for detecting free IGFBP-1 using the antibodies, and cell lines for producing the antibodies are provided. Als... | 10/19/1999 |
| 5891722 | Antibodies to free IGFBP-1 Antibodies having binding affinity for free IGFBP-1, biological compositions including antibodies having binding affinity for free IGFBP-1, kits for detecting free IGFBP-1 using the antibodies, and cell lines for producing the antibodies are provided. Als... | 04/06/1999 |
| 5877029 | Device for detecting free IGFBP-1 Antibodies having binding affinity for free IGFBP-1, biological compositions including antibodies having binding affinity for free IGFBP-1, kits for detecting free IGFBP-1 using the antibodies, and cell lines for producing the antibodies are provided. Als... | 03/02/1999 |
