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| Number | Title | Issue Date |
| 5929247 | Heterocyclic compounds and their preparation and use The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nerv... | 07/27/1999 |
| 5776928 | Method for treating dyskinesias with olanzapine The invention provides a method for treating a dyskinesias comprising administering an effective amount of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno2,3-b!1,5! benzodiazepine.... | 07/07/1998 |
| 5726193 | Method for treating anxiety The present invention provides a method for treating anxiety in humans using heterocyclic compounds.... | 03/10/1998 |
| 5708014 | Method for treating anxiety The present invention provides a method for treating anxiety in humans using of Formula I herein disclosed compounds.... | 01/13/1998 |
| 5705519 | Method for treating 5-HT2B receptor related conditions The present invention provides methods for binding a 5-HT2B receptor in mammals using a both known and novel compounds. Further, the invention provides a method for treating or preventing 5-HT2B related conditions. Finally, the inven... | 01/06/1998 |
| 5703232 | Process and solvate of 2-methyl-thieno-benzodiazepine The invention provides lower alcohol solvates of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno2,3-b!1,5!benzodiazepine (olanzapine) and a process for making such lower alcohol solvates of olanzapine. The invention provides a method for using such sol... | 12/30/1997 |
| 5696115 | Method for treating nicotine withdrawal The invention provides a method for treating a condition resulting from the cessation and withdrawal of nicotine comprising administering an effective amount of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno2,3-b!1,5!-benzodiazepine.... | 12/09/1997 |
| 5688807 | Method for treating 5HT2B receptor related conditions The present invention provides methods for binding a 5-HT2B receptor in mammals using a both known and novel compounds. Further, the invention provides a method for treating or preventing 5-HT2B related conditions. Finally, the inven... | 11/18/1997 |
| 5672709 | Heterocyclic compounds and their preparation and use The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nerv... | 09/30/1997 |
| 5670684 | Process and intermediates for the preparation of excitatory amino acid receptor antagonists The present invention provides novel intermediates which are useful for the preparation of excitatory amino acid receptor antagonists. Further provided is a process to enatioselectively prepare hydroisoquinoline compounds with central nervous system activ... | 09/23/1997 |
| 5665745 | Heterocyclic compounds and their preparation and use The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nerv... | 09/09/1997 |
| 5663178 | Tetrahydro-beta carbolines The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. Further, there is provided tetrahydro-beta-carboline related compounds which are useful intermediates and have beneficial central nervo... | 09/02/1997 |
| 5635528 | Intermediates to tetrahydro-beta-carbolines 3-Ethanamine and 3-ethanamine related compounds are provided that are useful intermediates and have beneficial central nervous system activity.... | 06/03/1997 |
| 5631265 | 8-substituted tetrahydro-beta-carbolines The present invention provides novel tetrahydro-beta-carboline compounds and intermediates having useful central nervous system activity. The invention provides formulations and methods for using the tetrahydro-beta-carboline and related intermediate comp... | 05/20/1997 |
| 5631250 | Process and solvate of 2-methyl-thieno-benzodiazepine The invention provides lower alcohol solvates of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) and a process for making such lower alcohol solyates of olanzapine. The invention provides a method for using such solya... | 05/20/1997 |
| 5627178 | 2-methyl-thieno-benzodiazepine 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders of the central nervous system. The compound has the following structu... | 05/06/1997 |
| 5605908 | Heterocyclic compounds and their use The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nerv... | 02/25/1997 |
| 5605897 | 2-methyl-thieno-benzodiazepine Olanzapine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders of the central nervous system. The compound has the following structure: ##STR1##... | 02/25/1997 |
| 5605701 | Transdermal formulation The present invention provides a method for treating a condition associated with muscarinic receptor modulation using a 3-[4-(butylthio)-1,2,5-thiadiazol-3-yl]-1-azabicyclo-[2.2.2]octane transdermal formulation. The invention provides desired transdermal ... | 02/25/1997 |
| 5538981 | Tetrahydro-pyrido-indole The present invention provides novel tetrahydrobeta-carboline compounds and intermediates having useful central nervous system activity. The invention further provides formulations and methods for using the novel tetrahydrobeta-carboline compounds.... | 07/23/1996 |
| 5508284 | Tetrahydro-beta-carbolines The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. Further, there is provided 3-ethanamine and 3-ethanamine related compounds which are useful intermediates and have beneficial central n... | 04/16/1996 |
