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| Number | Title | Issue Date |
| 7579010 | Botulinum toxin pharmaceutical compositions with a recombinant human serum albumin A botulinum toxin pharmaceutical formulation free of animal derived proteins, comprising a botulinum toxin and a recombinant albumin, suitable for therapeutic administration to a human patient, and methods for treating patients with various diseases and afflictions ... | 08/25/2009 |
| 7514462 | ω-Cycloalkyl 17-heteroaryl prostaglandin Eanalogs as EP-receptor agonists The invention relates to the use of derivatives of E-type prostaglandins as EP2 agonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the invention are represented by the following formula I: | 04/07/2009 |
| 7507833 | Therapeutic N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives A compound having a structure and therapeutic methods, compositions, and medicaments related thereto are disclosed herein. ... | 03/24/2009 |
| 7507817 | Prostaglandin prodrugs Novel compounds, and therapeutic methods, compositions and medicament related thereto are disclosed herein. ... | 03/24/2009 |
| 7501393 | Pharmaceutical compositions comprising cyclosporins A composition is described herein comprising cyclosporin A, polysorbate 80, a polyoxyethylene stearate, and an oil; wherein the composition is an emulsion which is ophthalmically acceptable. Methods of treating diseases or conditions using said compositions, and med... | 03/10/2009 |
| 7501130 | Methods for treating myofascial pain A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount of a neurotoxin selected from a group consisting of Botulinum toxin ty... | 03/10/2009 |
| 7498447 | Therapeutic compounds Disclosed herein is a compound having a structure or a pharmaceutically acceptable salt, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also disclosed. ... | 03/03/2009 |
| 7494654 | Compositions and methods for treating cardiovascular conditions with botulinum toxin The present invention provides for methods of treating cardiovascular diseases in a mammal. The methods include a step of administering an effective amount of a botulinum toxin directly to a blood vessel of a mammal thereby treating a cardiovascular disease. ... | 02/24/2009 |
| 7491844 | Therapeutic cyclopentane derivatives Described herein are compounds having a formula and therapeutic methods, compositions, and medicaments, related thereto. ... | 02/17/2009 |
| 7491383 | Compositions having enhanced pharmacokinetic characteristics Compositions comprising a therapeutic component and an efficacy enhancing component, that enhances the pharmacokinetic disposition of the therapeutic component, are disclosed. The therapeutic component may include an alpha-2-adrenergic agonist and the efficacy enhan... | 02/17/2009 |
| 7485624 | Method for treating cardiac muscle disorders Methods for treating cardiac muscle disorders, such as cardiac arrhythmias, by administration of a neurotoxin to cardiac muscle are disclosed. Bradycardia can be alleviated for several months by a single intrapericardial or intracardiac injection or infusion of a bo... | 02/03/2009 |
| 7482475 | Therapeutic lactams Disclosed herein is a compound having a structure Therapeutic methods, compositions, and medicaments related thereto are also disclosed. ... | 01/27/2009 |
| 7476755 | Therapeutic compounds Therapeutic substituted cyclopentane compounds, and compositions, medicaments, and therapeutic methods related thereto are disclosed herein. ... | 01/13/2009 |
| 7476747 | Substituted gamma lactams as therapeutic agents A compound comprising or a pharmaceutically acceptable salt, prodrug, or a metabolite thereof is disclosed herein. Y, A, and B are as described herein. Methods, compositions, and medicaments related to these compoun... | 01/13/2009 |
| 7473702 | Substituted gamma lactams as therapeutic agents A compound comprising or a pharmaceutically acceptable salt, prodrug, or a metabolite thereof is disclosed herein. Y, A, and B are as described herein. Methods, compositions, and medicaments related to these compoun... | 01/06/2009 |
| 7473704 | Cyclohexyl prostaglandin analogs as EP-receptor agonists The invention relates to the use of novel cyclohexyl analogues of E-type prostaglandins as EP4 agonists, in general, and, in particular as ocular hypotensives. The cyclohexyl analogues used in accordance with the invention are represented by the following... | 01/06/2009 |
| 7468065 | Apparatus for delivery of ocular implants An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be eje... | 12/23/2008 |
| 7468360 | Therapeutic amides and related compounds Disclosed herein is a compound having a structure: Therapeutic methods, compositions, and medicaments relating thereto are also disclosed. ... | 12/23/2008 |
| 7468189 | Neuropathic pain treatment method Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... | 12/23/2008 |
| 7468188 | Multi-step therapy for injured muscles Methods for treating an injured muscle by local administration of a neurotoxin, such as a botulinum toxin, to promote healing and/or to reduce the pain associated with an injured muscle. ... | 12/23/2008 |
| 7465458 | Methods for treating eye disorders The present invention provides methods of treating an eye disorder. The methods comprise a step of locally administering a Clostridial toxin to the eye of a patient to treat the disorder. The eye disorder may be associated with an inflammation of the eye, inc... | 12/16/2008 |
| 7452697 | Chromatographic method and system for purifying a botulinum toxin Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium. ... | 11/18/2008 |
| 7445914 | Animal product free media and processes for obtaining a botulinum toxin Media and processes for the fermentation of Clostridium botulinum and obtaining a botulinum toxin for use in formulating botulinum toxin pharmaceutical compositions. The growth media can contain significantly reduced levels of meat or dairy by-p... | 11/04/2008 |
| 7439386 | Therapeutic substituted cyclopentanones Compounds are disclosed herein comprising or a pharmaceutically acceptable salt, or a metabolite or a prodrug thereof; wherein a dashed line indicates the presence or absence of a bond; Y, A, an... | 10/21/2008 |
| 7439372 | Therapeutic compounds A compound having a structure is disclosed herein. Compositions, medicaments, and therapeutic methods related thereto are also disclosed. ... | 10/21/2008 |
| 7438921 | Buttock deformity treatment Methods for treating a buttock deformity or for preventing development of a buttock deformity by local administration of a Clostridial toxin, such as a botulinum neurotoxin, to a buttock deformity or to the vicinity of a buttock deformity. ... | 10/21/2008 |
| 7435746 | 5-thiopiperdinyl prostaglandin E analogs A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. Y and R are described in detail herein A compound having an ω chain comprising ... | 10/14/2008 |
| 7429386 | Stretch mark treatment Methods for treating stretch marks by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a stretch mark. ... | 09/30/2008 |
| 7429615 | Cyclohexyl prostaglandin analogs as EP-receptor agonists The invention relates to the use of novel cyclohexyl analogues of E-type prostaglandins as EP4 agonists, in general, and, in particular as ocular hypotensives. The cyclohexyl analogues used in accordance with the invention are represented by the following... | 09/30/2008 |
| 7429669 | Therapeutic compounds Disclosed herein are compounds of the formula or salts or bioisosteres thereof. Therapeutic methods, medicaments, and compositions related thereto are also disclosed. ... | 09/30/2008 |
| 7427614 | Prostaglandin analogs Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. A, X, J, E, and Z are as described herein. These compounds are useful for treating diseases. ... | 09/23/2008 |
| 7427685 | Therapeutic substituted cyclopentanes Therapeutic compounds according to one of the structures below are disclosed herein. ... | 09/23/2008 |
| 7422110 | Titration/compliance pack with increasing doses A titration package and method for enabling compliance with a regime of changing dosage of medication over a period of time includes a backing having an array of receivers with the array including a plurality of columns and a plurality of rows. A plurality of sets o... | 09/09/2008 |
| 7422753 | Methods for treating trichotillomania Methods for treating trichotillomania by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration of a low dose of botulinum toxin. ... | 09/09/2008 |
| 7419994 | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2- thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cyloalkenylmethyl) imidazol-2-ones and related compounds Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in ... | 09/02/2008 |
| 7419675 | Method for treating peritoneal adhesions Methods for treating peritoneal adhesions by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a peritoneal adhesion. ... | 09/02/2008 |
| 7405240 | Substituted cyclopentanes or cyclopentanones as therapeutic agents The compounds disclosed herein are useful for treating glaucoma, ocular hypertension, and baldness. ... | 07/29/2008 |
| 7399868 | 4-(Heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B | 07/15/2008 |
| 7396849 | 4-(Condensed cyclicmethyl)-imidazole-2-thiones acting as αadrenergic agonists Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or s... | 07/08/2008 |
| 7393537 | Botulinum toxin for treatment of obsessive compulsive finger biting disorder Methods for treating obsessions and compulsions by local administration of a Clostridial toxin. The obsessions or compulsions can be eye poking, body rocking, finger biting, counting, checking and related disorders treated by low dose, intramuscular administration o... | 07/01/2008 |
