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| Number | Title | Issue Date |
| 8071101 | Antibody therapy for treatment of diseases associated with gluten intolerance The present invention includes a pharmaceutical compositions and methods for treating diseases associated with gluten intolerance in a patient, comprising: administering to the patient an effective amount of an antibody having specific activity against gluten or glu... | 12/06/2011 |
| 8034388 | Anthocyanin-rich compositions and methods for inhibiting cancer cell growth The present invention provides compositions and methods for inhibiting the growth and cell cycle progression in carcinoma cells comprising the step of contacting the cells with an anthocyanin rich extract (ARE) in an amount effective to inhibit the growth and cell c... | 10/11/2011 |
| 7954491 | Low dose pharmaceutical powders for inhalations The invention relates to a method of delivering an agent to the pulmonary system of a compromised patient, in a single breath-activated step, comprising administering a particle mass comprising an agent from an inhaler containing less than 5 milligrams of the mass, ... | 06/07/2011 |
| 7947742 | Inhalable epinephrine The present invention is directed toward particles for delivery of epinephrine to the respiratory system and methods for treating a patient in need of epinephrine. The particles and respirable compositions comprising the particles of the present invention described ... | 05/24/2011 |
| 7919499 | Naltrexone long acting formulations and methods of use The inventions described herein arose from unexpected discoveries made during clinical trials with a long acting formulation of naltrexone. As such, the invention includes a method for treating an individual in need of naltrexone comprising the step of parenterally ... | 04/05/2011 |
| 7915387 | Monoclonal antibody Sc104 and derivative thereof specifically binding to a sialyltetraosyl carbohydrate as a potential anti-tumor therapeutic agent The present invention provides an isolated specific binding member capable of binding a sialyltetraosly carbohydrate and directly inducing cell death without the need for immune effector cells. Such a binding member may be an antibody or a part thereof. Also provide... | 03/29/2011 |
| 7888556 | Root cap specific promoter and methods of use in plants The invention provides an AtCel5 promoter isolated from Arabidopsis thaliana that is expressed exclusively in root cap cells of both primary and secondary roots. AtCel5 is believed to be a soluble and secreted protein that plays a role in the sloughing of roo... | 02/15/2011 |
| 7879358 | Pulmonary delivery for levodopa In one aspect, the invention is related to a method of treating a patient with Parkinson's disease, the method including administering to the respiratory tract of the patient particles that include more than about 90 weight percent (wt %) of levodopa. The particles ... | 02/01/2011 |
| 7754242 | Inhalable sustained therapeutic formulations The present invention is based, in part, on the unexpected discovery that particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that comprise a phospholipid and a sufficient amount of leucine can produce sustained effect of the agent. S... | 07/13/2010 |
| 7718624 | Modulation of immune response and inflammation by targeting hypoxia inducible factors Methods for modulating inflammation by administering HIF-1α inhibitors or compounds affecting HIF-1α expression and/or transcriptional activities are disclosed. HIF-1α affecting compounds include compounds that directly inhibit HIF-1α and/or interfere into expre... | 05/18/2010 |
| 7709449 | Nucleic acid-based compounds and methods of use thereof The invention provides compounds capable of treating against hepatitis infections, particularly hepatitis B viral infections. Compounds of the invention are nucleic acid-based and preferably comprise 2, 3, 4, 5 or 6 nucleoside units. ... | 05/04/2010 |
| 7678364 | Particles for inhalation having sustained release properties The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention rel... | 03/16/2010 |
| 7628977 | Particles for inhalation having sustained release properties The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention rel... | 12/08/2009 |
| 7557181 | Pan-HER antagonists and methods of use The present invention features human epidermal receptor (HER) antagonists. These antagonists are polypeptide variants of ligands of HER. The HER ligand polypeptide variants of the invention possess Pan-HER antagonistic properties and can inhibit at least one HER-med... | 07/07/2009 |
| 7556798 | Highly efficient delivery of a large therapeutic mass aerosol A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less tha... | 07/07/2009 |
| 7550283 | Bacteriophage for lysis of and compositions and uses thereof The invention relates to a novel bacteriophage which is lytic for species of the genus Methylobacterium, Human Blood Bacterium (HBB) or both, and derivatives, progeny and recombinant and mutated forms thereof. The invention further relates to compositions, me... | 06/23/2009 |
| 7524487 | Compositions and methods for modulating interleukin-10 The present invention provides compositions and methods for upregulating IL-10 production in a stimulated cell. In one aspect, the invention provides methods of identifying ERK activating agents capable of activating and amplifying the ERK MAPK pathway in a cell. Su... | 04/28/2009 |
| 7491348 | Composition of matter tailoring: system I The present invention relates to new compositions of matter, particularly metals and alloys, and methods of making such compositions. The new compositions of matter exhibit long-range ordering and unique electronic character. ... | 02/17/2009 |
| 7470769 | Epidermal growth factor receptor antagonists and methods of use The present invention features epidermal growth factor receptor (EGFR) antagonists. These EGFR antagonists are polypeptide variants of ligands of EGFR. The EGFR ligand polypeptide variants of the invention possess EGFR antagonistic properties and can inhibit at leas... | 12/30/2008 |
| 7469488 | Control of process humidity to produce large, porous particles Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, fo... | 12/30/2008 |
| 7435408 | Porous particles comprising excipients for deep lung delivery Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm... | 10/14/2008 |
| 7419962 | 3,6-bicyclolides The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical com... | 09/02/2008 |
| 7407942 | 3,6-bridged 9,12-oxolides The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical com... | 08/05/2008 |
| 7402568 | Bicyclic 9a-azalide derivatives The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceuti... | 07/22/2008 |
| 7393443 | Methods of identifying kinetically stable proteins The present invention provides a fast and efficient means for identifying kinetically stable proteins. As used herein the term “kinetically stable protein” means a protein that is trapped in a specific conformation due to an unusually high unfolding barrier that... | 07/01/2008 |
| 7384649 | Particulate compositions for pulmonary delivery This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant inven... | 06/10/2008 |
| RE39941 | Amelioration of Dupuytren's disease The cords of Dupuytren's disease are injected with collagenase, the hand is immediately immobilized and maintained immobile for several hours. The cord becomes relaxed or ruptured, relieving the hand contracture of the disease. ... | 12/18/2007 |
| 7281845 | Watchcase adapted for a removable ornamental top The invention relates to a watchcase comprising: (a) a lower case characterized by a first annular recess for receiving an optically transparent cylinder and a timepiece support for receiving a timepiece mechanism; | 10/16/2007 |
| 7279579 | Polymorphic forms of naltrexone This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorpora... | 10/09/2007 |
| 7279182 | Formulation for spray-drying large porous particles Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solution can al... | 10/09/2007 |
| 7273853 | 6-11 bicyclic ketolide derivatives The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmace... | 09/25/2007 |
| 7267958 | Biocatalytic solgel microarrays A system and method for conducting high-throughput interactions between test compositions and analytes, comprising one or more test compositions, and a plurality of independent micromatrices, wherein each said micromatrix encapsulates at least one said test composit... | 09/11/2007 |
| 7265094 | 9-substituted 6-11 bicyclic erythromycin derivatives The present invention discloses compounds of formula I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention furthe... | 09/04/2007 |
| 7256179 | Nucleic acid-based compounds and methods of use thereof The invention provides compounds capable of treating against hepatitis infections, particularly hepatitis B viral infections. Compounds of the invention are nucleic acid-based and preferably comprise 2, 3, 4, 5 or 6 nucleoside units. ... | 08/14/2007 |
| 7252840 | Use of simple amino acids to form porous particles Particles having a tap density of less than 0.4 g/cm3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred particles include a phospholipid, have a median geometric diam... | 08/07/2007 |
| 7238297 | Composition of matter tailoring: system I The present invention relates to new compositions of matter, particularly metals and alloys, and methods of making such compositions. The new compositions of matter exhibit long-range ordering and unique electronic character. ... | 07/03/2007 |
| 7230019 | Imidazo [2,1-b]-1,3,4-thiadiazole sulfonamides This invention relates to compounds of Formula (I) and the use of compounds of Formula (I) as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems. ... | 06/12/2007 |
| 7229972 | 3,6-Bicyclolides The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmac... | 06/12/2007 |
| 7189704 | 6-11 bicyclic ketolide derivatives The present invention discloses, inter alia, a compound of the following formula, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention f... | 03/13/2007 |
| 7182961 | Particulate compositions for pulmonary delivery This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant inven... | 02/27/2007 |
