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Attorney: Van Dyke; Timothy H.


Number of patents: 115
Last date: April 10, 2012

1      
NumberTitleIssue Date
8153158Tissue substitutes comprising stem cells and reduced ceria
A biocompatible composite includes a solid biocompatible material and a plurality of living human progenitor or living stem cells attached thereto. The composition resulting in accelerated repair to damaged bones and tissues. ...
04/10/2012
8137110Dielectric properties models and methods of using same
Disclosed herein are dielectric properties models that are designed to enable simulated use testing by medical device companies, medical device designers, individual inventors, or any other entity interested in the performance of medical devices. These models are un...
03/20/2012
8105832Methods for modifying stem cell characteristics
The invention provides a method of up-regulating genes in cultured human bone marrow mesenchymal stem cells, the method comprising culturing the stem cells in a nutrient medium together with cells from a limb of a limb-regenerating animal. In the method, the limb-re...
01/31/2012
8096807Dental instrumentation unit
An instrumentation delivery unit which supports hand-held dental instruments. In one example first and second housing members form a sealed chamber. When the members are separated, access is permitted to the interior of the chamber, e.g., for maintenance purposes. A...
01/17/2012
8080420Methods and products for biasing cellular development
Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, huma...
12/20/2011
8074989Puzzle for the physically or visually impaired
A puzzle, including a closed perimeter including a plurality of segments, wherein each segment includes on a segment upper surface raised indicia different than the raised indicia present on any other segment, and a plurality of uniquely shaped game pieces. The game...
12/13/2011
8070322Examination light with readily accessible controls
Disclosed herein are examination light embodiments. A light having a frame for holding the light has a frontal support member with first and second lateral sides. Disposed on each first and lateral sides are one or more actuators for controlling functionality of the...
12/06/2011
8062428Solid acid catalyzed hydrolysis of cellulosic materials
Provided are methods for the solubilization of cellulose into soluble sugars without the need for high temperatures, high pressures, strong acid solutions, and/or added water. The produced sugars can be fermented into ethanol. In one embodiment, the method comprises...
11/22/2011
8039605Targeting of long chain triacylglycerol hydrolase gene for tuberculosis treatment
Disclosed herein are novel methods for screening for compounds useful in treating or preventing tuberculosis. In exemplary embodiments, screening methods are based on the implementation or manipulation of triacylglycerol hydrolase like polypeptides or polynucleotide...
10/18/2011
7993658Targeting of triacylclycerol synthase gene for tuberculosis treatment
Disclosed herein are novel methods for screening for compounds useful in treating or preventing tuberculosis. In exemplary embodiments, screening methods are based on the implementation or manipulation of triacylglycerol synthase like polypeptides or polynucleotides...
08/09/2011
7993140Models and methods of using same for testing medical devices
Disclosed herein are synthetic anatomical models that are designed to enable simulated use testing by medical device compam'es, medical device designers, individual inventors, or any other entity interested in the performance of medical devices. These models are uni...
08/09/2011
7945078User accessible tissue sample image database system and method
Disclosed herein is a user-accessible tissue image database system. The system is searchable using a query image provided by a user. The query image is matched with images in the database based on common visual features. Specifically exemplified is the matching of i...
05/17/2011
7927585Production of recombinant AAV virions
Stocks of infectious rAAV are generated using yeast strains, bacterial strains, and bacteriophages engineered to express the required AAV proteins and harboring rAAV vector sequences. Stocks of rAAV virions of all serotypes and pseudotypes can be generated in prokar...
04/19/2011
7922138Dental apparatus having an adjustable articulated arm
Disclosed herein is a dental apparatus having a flexible arm for a dental apparatus. A benefit of the inventive flexible arm is the ability to make fine adjustments in orientation of one end of the arm relative to the other. More specifically, the ability to adjust ...
04/12/2011
7914460Condensate glucose analyzer
The present invention provides systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments of the invention, electrochemical- or coulometric-based sensing technologies are used to analyze EBC for the presence and/or c...
03/29/2011
7908908Materials and methods for identifying biointeractive nanostructures and/or nanoparticles
Disclosed herein are surface force microscope probes comprising living cells adhered thereto, as well as methods of making same. Also disclosed is a system for high throughput screening of nanostructures having biological relevance through use of surface force micro...
03/22/2011
7901906Targeting of MKRN1 for identifying cancer treatment agents
Disclosed herein are novel methods for screening for compounds useful in treating telomerase positive cancers. In exemplary embodiments, screening methods are based on the implementation or manipulation of therapeutic agents that up-regulate activity or expression o...
03/08/2011
7888119Tissue substitutes comprising stem cells and reduced ceria
A biocompatible composite includes a solid biocompatible material and a plurality of living human progenitor or living stem cells attached thereto. The biocomposite provides a stable interface with endogenous tissue and the implanted composition resulting in acceler...
02/15/2011
7887502Method for using photoplethysmography to optimize fluid removal during renal replacement therapy by hemodialysis or hemofiltration
Disclosed herein are methods, systems and devices to monitor vascular volume status during renal replacement therapy utilizing at least one oximetry/photoplethysmography sensor. The methods, systems and devices provide an alternative to conventional vascular volume ...
02/15/2011
7838659Herpesvirus ribozymes and vectors
Hammerhead ribozymes that target components critical to HSV replication (ICP4, UL20, UL30, and UL54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these components in in vitro assays. Several clone...
11/23/2010
7824202Dental lamp with improved lamp socket
Disclosed herein is a dental lamp socket assembly especially adapted for use with dental lamps. The dental lamp socket assembly is configured to dramatically increase the ease at which bulbs can be placed and/or replaced in and out of the socket assembly. ...
11/02/2010
7820108Marker detection method and apparatus to monitor drug compliance
The present invention includes a method and apparatus for monitoring drug compliance by detecting markers, such as odors, upon exhalation by a patient after medication is taken, wherein such markers result either directly from the medication itself or from an additi...
10/26/2010
7807178Muteins of placental growth factor type I, preparation method and application thereof
The present invention relates to chemically stable muteins of type 1 Placental Growth Factor (PLGF-1) bearing the substitution or elimination of a cysteine residue from the wild type protein amino acid sequence, their preparation, their therapeutic and cosmetic uses...
10/05/2010
7803991Universal chloroplast integration and expression vectors, transformed plants and products thereof
The invention provides universal chloroplast integration and expression vectors which are competent to stably transform and integrate genes of interest into chloroplast genome of multiple species of plants. Transformed plants and their progeny are provided. Monocoty...
09/28/2010
7802909Multifunctional medical examination instrument
Disclosed herein are various embodiments of a medical instrument used for conducting eye, ear, mouth examinations of a patient. The instrument is connectable with a remote power supply. In an exemplified embodiment, instrument comprises an elongated, rigid body defi...
09/28/2010
7799794Treatment for cardiovascular disease
This invention relates to a method for treating and preventing hypertension by administering a therapeutically effective amount of an agent capable of reducing uric acid levels in a patient in need of such treatment. Additionally, the scope of the invention includes...
09/21/2010
7795497Marker free transgenic plants: engineering the chloroplast genome without the use of antibiotic selection
The present invention provides for a method to circumvent the problem of using antibiotic resistant selectable markers. In particular, target plants are transformed using a plastid vector which contains heterologous DNA sequences coding for a phytotoxin detoxifying ...
09/14/2010
7785262Method and apparatus for diagnosing respiratory disorders and determining the degree of exacerbations
Disclosed herein are apparatuses and methods to monitor respiration and abnormal respiration events utilizing plethysmography. The apparatuses and methods provide an alternative to conventional respiration monitoring methods while enabling accurate yet minimally int...
08/31/2010
D622897Dental examination light reflector
08/31/2010
7767885Plastid genetic engineering via somatic embryogenesis
A method of transforming plant plastids and regenerating fertile transplastomic plants by somatic embryogenesis is disclosed. The method involves transforming a plant plastid in a plant cell capable of being regenerated through somatic embryogenesis with a plastid e...
08/03/2010
7763722Small interference RNA gene therapy
Gene expression is inhibited in a cell by introducing into the cell a lentiviral vector encoding a siRNA specific for the gene. Lentiviral vectors encoding siRNA specific for a cancer-associated gene inhibited expression of the gene and caused cell death after being...
07/27/2010
D620628Examination light
07/27/2010
7755494Hand washing compliance detection system
Systems and methods are provided for monitoring use of hand washing agents to determine compliance with hand hygiene guidelines. A hand washing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using t...
07/13/2010
7744862Production process of recombinant placental growth factor
Process for extracting and purifying the recombinant Placental Growth Factor (PLGF) expressed in inducible prokaryotic expression systems comprising the following steps: I) fermentation of the bacterial cells, II) extraction and purification of the inclusion bodies,...
06/29/2010
7741536Expression of human serum albumin in plastids
Humans Serum Albumin (HSA) or an HSA fusion protein is expressed in plant plastids. A plastid transformation vector is made which contains an expression cassette that contains regulatory sequences, the coding region for HSA or an HSA fusion protein and a selectable ...
06/22/2010
D618345Stethoscope wall mount
06/22/2010
D618277Document organizer
06/22/2010
D617457Medical instrument
06/08/2010
7728041Motuporamine mimic agents
Disclosed herein are motuporamine mimic agents and methods of making and using same. Particularly exemplified are motuporamine mimic agents comprising cytotoxic activity and/or anti-metaplastic activity. ...
06/01/2010
7699615Joint replica models and methods of using same for testing medical devices
Disclosed herein are joint replica models that are designed to enable simulated use testing by medical device companies, medical device designers, individual inventors, or any other entity interested in the performance of medical devices. These models are unique in ...
04/20/2010
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