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| Number | Title | Issue Date |
| 8178651 | Somatostatin-dopamine chimeric analogs Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2. ... | 05/15/2012 |
| 8138305 | Analogues of GLP-1 The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefore comprising said analogues. ... | 03/20/2012 |
| 7977455 | Analogues of GLP-1 The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues. ... | 07/12/2011 |
| 7932231 | Compositions and methods for stimulating gastrointestinal motility The present invention relates to a method of treating a transient impairment of the motility of the gastrointestinal system resulting from postoperative ileus in a patient wherein said method includes the step of administering a therapeutically effective amount of a... | 04/26/2011 |
| 7897566 | Analogues of GLP-1 Disclosed are peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, methods of using such analogues to treat mammals and pharmaceutical compositions useful therefor comprising said analogues. ... | 03/01/2011 |
| 7811989 | Peptide YY analogs The invention provides analogs of PYY. The invention also provides compositions and methods useful for controlling biological activities such as cell proliferation, nutrient transport, lipolysis, and intestinal water and electrolyte secretion. ... | 10/12/2010 |
| 7691859 | Prenyl transferase inhibitors A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH | 04/06/2010 |
| 7638546 | Imidazolyl derivatives The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonist or antagonists of somatostatin receptors. ... | 12/29/2009 |
| 7632811 | Analogs of parathyroid hormone The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pha... | 12/15/2009 |
| 7589058 | Ghrelin analogs The invention comprises peptidyl analogs that possess agonist or antagonist ghrelin activity, along with therapeutic and non-therapeutic uses thereof. ... | 09/15/2009 |
| 7566734 | Imidazolyl derivatives The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors. ... | 07/28/2009 |
| 7553975 | Farnesyl transferase inhibitors A family of compounds capable of inhibiting the activity of farnesyl transferase. ... | 06/30/2009 |
| 7550423 | Somatostatin antagonists The invention features somatostatin antagonists having a D-amino acid at the second residue. ... | 06/23/2009 |
| 7531621 | PTH2 receptor selective compounds This invention relates to a series of PTH and PTHrP analogues that selectively bind to PTH2 receptors and as such may be useful in treating abnormal CNS functions; abnormal pancreatic functions; divergence from normal mineral metabolism and homeostasis; male inferti... | 05/12/2009 |
| 7517853 | Somatostatin-dopamine chimeric analogs The invention features somatostatin-dopamine chimeric analogs and methods relating to their therapeutic use for the treatment of neoplasia, acromegaly, and other conditions. ... | 04/14/2009 |
| 7456253 | Growth hormone releasing peptides Disclosed are peptide and peptidomimetic compounds generally according to formula (I), and pharmaceutically acceptable salts thereof, that are useful as GHRP analogs: R1-A2-A3-A4-A5-R2 (I) or a pharma... | 11/25/2008 |
| 7410948 | Analogs of parathyroid hormone The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pha... | 08/12/2008 |
| 7368427 | GLP-1 analogues The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues. ... | 05/06/2008 |
| 7361656 | Prenyl transferase inhibitors A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH | 04/22/2008 |
| 7323484 | Farnesyl transferase inhibitors The present invention is directed to compounds of the formula wherein the variables are as defined in the specification. The compounds are useful for inhibiting farnesyl transferase and for the treatment of tumor... | 01/29/2008 |
| 7268213 | Analogues of GLP-1 The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues. ... | 09/11/2007 |
| 7241737 | Urotensin-II agonists and antagonists The present invention is directed to a novel class of cyclic polypeptides of the formula: (R1)a-AA1-cyclo[AA2-AA3-AA4-AA5-AA6-Cys]-AA7-R2, pharmaceutically ... | 07/10/2007 |
| 7238695 | Imidazolyl derivatives The present invention is directed to imidazolyl derivatives or pharmaceutically acceptable salts thereof which are useful as agonists or antagonists of somatostatin receptors, having the following formula (I), wh... | 07/03/2007 |
| 7235628 | Analogues of GLP-1 The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful thereof comprising said analogues. ... | 06/26/2007 |
| 7205378 | Lactone bearing absorbable polymers The present invention pertains to biodegradable polymers comprising a non-polymerizable lactone, biodegradable compositions comprising the polymer and a therapeutic agent, the use of the compositions for the sustained release of therapeutic agents, wherein the thera... | 04/17/2007 |
| 7179490 | Sustained release ionic conjugate A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing biodegradable polymer and a free amino group-containing drug which are ionically bonded to each other. ... | 02/20/2007 |
| 7067055 | Trickling alter tank with top side load cell assembly In one embodiment, a filter media tower assembly is provided comprising a first portion and a second portion, wherein the first portion is suspended within the second portion. The first portion is a removable media tower or cage for holding filter media, whereas the... | 06/27/2006 |
| 7052385 | Self-aligning blade angle guide A device for use in the manual sharpening of arrow broadheads, razor blades and the like includes a unique symmetrical clamp and axle assembly having interchangeable, matched pairs of special purpose jaw members for gripping blades of differing configurations. When ... | 05/30/2006 |
