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| Number | Title | Issue Date |
| 8173821 | Serotonin and norepinephrine reuptake inhibitor A serotonin and norepinephrine reuptake inhibitor of the formula: its uses, and methods for its preparation are described. ... | 05/08/2012 |
| 8168659 | 1, 5-diphenyl-3-benzylamino-1, 5-dihydropyrrolidin-2-one as CB1 receptor modulators Compounds and pharmaceutical compositions comprising compounds of the Formula as CB1 receptor inverse agonists useful for reducing body weight in mammals, treating cognitive impairment associated with schizophren... | 05/01/2012 |
| 8129410 | Benzisoxazole piperidine compounds and methods of use thereof The invention includes benzisoxazole piperidine compositions and methods of using them for modulating sleep. ... | 03/06/2012 |
| 8110580 | Thiophene pyrazolopyrimidine compounds The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and the use of such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological d... | 02/07/2012 |
| 8101596 | Loxapine analogs and methods of use thereof The invention relates to novel compounds and methods of using them for modulating sleep. ... | 01/24/2012 |
| 8088778 | Benzisoxazole piperazine compounds and methods of use thereof The invention includes benzisoxazole piperazine compositions and methods of using them for modulating sleep. ... | 01/03/2012 |
| 8084261 | Method for predicting responsiveness to a pharmaceutical therapy for obesity Methods for using TRL V6 as a biomarker for the modulation of triglyceride and/or lipoprotein metabolism in a mammal induced by a weight loss pharmaceutical agent. The biomarker may be used for determining if an individual patient will likely respond favorably to a ... | 12/27/2011 |
| 8048884 | Substituted piperazinyl pyrazines and pyridines as 5-HTreceptor antagonists The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine: where A is —C(H)═ or —N═; m is 0, 1 or 2; R1 is optional... | 11/01/2011 |
| 8030304 | Thiazole pyrazolopyrimidines CRF1 receptor antagonists The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and m... | 10/04/2011 |
| 8022062 | 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HTreceptor agonists The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression... | 09/20/2011 |
| 7998985 | 1,5-diphenyl-3-pyridinylamino-1,5-dihydropyrrolidin-2-one as CB1 receptor modulator Compound and pharmaceutical compositions comprising the compounds of the Formula or a pharmaceutically acceptable salt thereof, as a CB1 receptor inverse agonist, useful for reducing body weight in mammals, treat... | 08/16/2011 |
| 7994163 | 6-substituted-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HTreceptor agonists The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula (I) as selective 5-HT2C receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: R6 D ... | 08/09/2011 |
| 7981882 | 6-N-linked heterocycle-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HTreceptor agonists The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression... | 07/19/2011 |
| 7910588 | 5-HT7 receptor antagonists The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine: where A is —C(H)═ or —N═ and R1-7 are as defined herein. | 03/22/2011 |
| 7700628 | Aromatic ether derivatives useful as thrombin inhibitors This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process fo... | 04/20/2010 |
| 7612067 | Imidazopyridazine compounds The present invention relates to novel substituted imidazo[1,2-b]pyridazine compounds of Formula (I): pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric diso... | 11/03/2009 |
| 7608629 | (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-HTagonists The present invention relates to compounds of formula 1: and pharmaceutically acceptable acid addition sails thereof. The compounds of the present invention are useful for activating 5-HT1F receptors, inhibiting neuronal protein extravasation, and for the... | 10/27/2009 |
| 7595339 | CB1 modulator compounds Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention ... | 09/29/2009 |
| 7557103 | Imidazopyridazine compounds The present invention relates to novel substituted imidazo[1,2-b]pyridazine compounds of Formula (I) pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric disor... | 07/07/2009 |
| 7381826 | Crystalline forms of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone The present invention provides novel crystalline forms of {2-[1-(3,5-bistrifluoromethylbenzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, compositions thereof, intermediates thereof, methods of using the same, processes for maki... | 06/03/2008 |
| 7378447 | Muscarinic agonists The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor ... | 05/27/2008 |
| 7326731 | Muscarinic agonists The present invention relates to compounds of Formula I: Formula I which are agonists of the M-1 muscarinic receptor. ... | 02/05/2008 |
| 7312236 | Substituted (4-aminocyclohexen-1-yl)phenyl and (4-aminocyclohexen-1-yl)pyridinyl compounds as 5-HTagonists The present invention relates to compounds of formula I: or a pharmaceutically acceptable acid addition salt thereof, where; X is —C(R4)═ or —N═; ... | 12/25/2007 |
| 7045545 | Aminoalkylbenzofurans as serotonin (5-HT(2c)) agonists The present invention provides serotonergic aminoalkylbenzofurans of Formula (I): where R, R1, R2, R3, R4, R4′, R5, R5′, and R12 are as described in the specification. | 05/16/2006 |
| 6967201 | Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists The present invention provides serotonergic benzofurylpiperazines of Formula I: where: A is a piperazine of formula: and R, R1... | 11/22/2005 |
| 6864262 | 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl) piperazine and pharmaceutically acceptable salts and solvents thereof The present invention provides a compound of the formula (I) and the pharmaceutically acceptable salts and solvates thereof, which is useful for treating bladder over-activity or urinary incont... | 03/08/2005 |
| 6696439 | 5-HT1F agonists The present invention relates to substituted furo[3,2-b]pyridine compounds of formula I: ##STR1## or a pharmaceutical acid addition salt thereof; where; R is ##STR2## E--D is C.dbd.CH or CH--CH2 ; R1 is hydrogen or C... | 02/24/2004 |
| 6638936 | Benzofurylpiperazine serotonin agonists The present invention provides serotonergic benzofurans of Formula I: ##STR1## where R is methyl or ethyl, or pharmaceutically acceptable acid addition salts thereof.... | 10/28/2003 |
| 6608079 | Indole derivatives and their use as 5-HT1F agonists The present invention relates to a compound of formula (I), or a pharmaceutical acid addition salt thereof, which are useful for activating 5-HT1F receptors and inhibiting neuronal protein extravasation in a mammal. ##STR1##... | 08/19/2003 |
