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| Number | Title | Issue Date |
| 8163698 | Dolastatin 15 derivatives Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and ... | 04/24/2012 |
| 8148526 | Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6. ... | 04/03/2012 |
| 8129407 | Hemiasterlin derivatives and uses thereof in the treatment of cancer The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1... | 03/06/2012 |
| 8129382 | Compounds, methods and pharmaceutical compositions for inhibiting PARP The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein. | 03/06/2012 |
| 8123819 | System and method for dry cleaning articles Systems and methods for dry cleaning articles using siloxane solvents are provided. In the systems and methods according to the present invention, the siloxane solvent suspends impurities extracted from the articles being cleaned, and the system filters off the impu... | 02/28/2012 |
| 8058275 | Diazabenzo[de] anthracen-3-one compounds and methods for inhibiting PARP The present invention relates to diazabenzo[de]anthracen-3-one compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of th... | 11/15/2011 |
| 8038840 | Process for refining and producing cellulose, lignin and xylose from biomass material A process for refining and producing cellulose, lignin and xylose from biomass material comprises the following steps: pulverizing and screening the biomass material; and then dipping the biomass material in organic acid with lower boiling point and decomposing it i... | 10/18/2011 |
| 8022056 | Compositions and methods for the treatment of cancer The present invention relates to the use of specific compounds related to the indolocarbazole K252a, for the preparation of pharmaceutical compositions for the treatment of various forms of cancer. ... | 09/20/2011 |
| 8003631 | Composition and method for the treatment of tauopathies The present invention refers to the use of a specific indolocarbazole compound of general formula (1) or a pharmaceutically-acceptable a salt thereof for the preparation of a pharmaceutical composition for the prevention or treatment of a neurodegenerative and/or de... | 08/23/2011 |
| 7927579 | Tandem analyses of noncovalently driven effectors for modulatory mapping of activities of protein sites The present invention provides methods of discovering and mapping secondary binding sites on biological molecules (e.g., proteins), the effects, if any, of site occupancy on the primary function of the molecule, and the screening of small molecules against the secon... | 04/19/2011 |
| 7915306 | Macrocyclic compounds useful as pharmaceuticals The present invention provides compositions comprising compounds having formula (I): and additionally provides methods for the use thereof in the treatment of various disorders including inflammator... | 03/29/2011 |
| 7902361 | Pyrimidin-4-yl-3, 4-thione compounds and their use in therapy The present invention relates to compounds of formula I, or pharmaceutically acceptable salts thereof, wherein R1 and R5 are each independently H, C(ORj′) or a hydrocarbyl group optionally... | 03/08/2011 |
| 7897605 | Pyrimidine compounds The present invention relates to substituted pyrimidines of formula I, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders and/o... | 03/01/2011 |
| 7893023 | Prodrugs activated by plasmin and their use in cancer chemotherapy The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or di-peptide linkage, a stabilizing group and, optionally, a linker group. The ... | 02/22/2011 |
| 7847105 | Methods and compounds for preparing CC-1065 analogs A method of forming a CBI CC-1065 analog utilizes NH2 as a starting material, where R3 is H or alkyl and R6 is H, substituted or unsubstituted lower alkyl, cyano, or alkoxy. Intermediates (I) are used and are claimed. ... | 12/07/2010 |
| 7868040 | Anti-cancer combinations The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and an alkylating agent, which has anti-tumour activity. Preferably, the present invention relates to synergistic combinations of the compound 5,6-... | 01/11/2011 |
| 7868039 | Anti-cancer combinations The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and vinca alkaloids, which have anti-tumour activity. Preferably, the present invention relates to synergistic combinations of the compound 5,6-dim... | 01/11/2011 |
| 7863322 | Anti-cancer combinations The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from platinum compounds, vinca alkaloids, alkylating agents, anthracyclines, topoisomerase I inhibitors, antimetabolites an... | 01/04/2011 |
| 7863321 | Anti-cancer combinations The present invention relates to synergistic combinations of the compound 5, 6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from anthracyclines and topisomerase II inhibitors, which have anti-tumor activity. Preferably, the present invention rela... | 01/04/2011 |
| 7863320 | Anti-cancer combinations The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a platinum compound which has anti-tumour activity. Preferably, the present invention relates to synergistic combinations of the compound 5,6-d... | 01/04/2011 |
| 7863253 | Purine Derivatives and methods of use thereof The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurolog... | 01/04/2011 |
| 7858606 | Triterpenoid derivatives The present invention relates to the use of a compound of formula (I), or a pharmaceutically acceptable salt, crystal form, complex, hydrate, or hydrolysable ester thereof, in the preparation of a medicament for treating a patient suffering from leukaemia, cancer or... | 12/28/2010 |
| 7834022 | Metabolites of the Janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile The present invention provides active metabolites of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases incl... | 11/16/2010 |
| 7833547 | Ibuprofen and narcotic analgesic compositions Provided herein are compositions and methods of making compositions of ibuprofen in combination with a narcotic analgesic. Specifically provided is a pharmaceutical tablet composition comprising ibuprofen; a narcotic analgesic; colloidal silicon dioxide; a filler se... | 11/16/2010 |
| 7820597 | Ordered two-and three-dimensional structures of amphiphilic molecules The invention pertains, at least in part, to a method for forming an ordered structure of amphiphilic molecules, such as proteins. The method includes contacting a population of amphiphilic molecules with a interface; compressing said population laterally to an appr... | 10/26/2010 |
| 7816350 | Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors The present invention relates to a compound of formula I, or a pharmaceutically acceptable acid salt thereof. The invention further relates to the use of such compounds in the treatment of hyperproliferative skin disorders, v... | 10/19/2010 |
| 7816317 | Tripeptide prodrug compounds The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide of three amino acids, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by a trouase enzyme such as Thimet oligopept... | 10/19/2010 |
| 7807779 | Antineoplastic peptides The present invention provides antineoplastic peptides of formula I, R1R2N—CHX—CO—A—B-D-E-(G)s-K wherein R1, R2, X, A, B, D, E, G, K and s have the meanings stated in the description.... | 10/05/2010 |
| 7807637 | Polymyxin derivatives and uses thereof The present invention relates to a polymyxin derivative wherein R1, R2 and R3 are optional and R1, R2, R3, R5, R8 and R9 are cationic or neutral amino acid residues selected so that the total number of positive charges at physiological pH is at least two but no more... | 10/05/2010 |
| 7799827 | Macrocyclic compounds useful as pharmaceuticals The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders includi... | 09/21/2010 |
| 7781535 | Proton conductor An acidic group-containing polymer which has an acidic group such as sulfonic acid group, phosphoric acid group, and phosphonic acid group, and a proton acceptor which has a boiling point at 1 atmosphere higher than 100° C. and which functions as a medium for condu... | 08/24/2010 |
| 7772207 | Combination of a CDK inhibitor and CS-682 or a metabolite thereof A first aspect of the invention relates to a combination comprising a CDK inhibitor and 1-(2-C-cyano-2-dioxy-β-D-arabino-pentofuranosyl)-N4-palmitoyl cytosine, or a metabolite thereof. A second aspect of the invention relates to a pharmaceutical product comprising ... | 08/10/2010 |
| 7771962 | CD10-activated prodrug compounds The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Met... | 08/10/2010 |
| 7767675 | Imidazotriazines and imidazopyrimidines as kinase inhibitors The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysr... | 08/03/2010 |
| 7749988 | Triterpenoid derivatives The present invention relates to the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in therapy. Prefereably, the compound may be used for treating a patient suffering from leukaemia, cancer or other proliferative disorder. A further... | 07/06/2010 |
| 7732424 | Purine derivatives and methods of use thereof The present invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's core body temperature, protecting an animal's heart against myocardial damage during cardioplegia; or for tr... | 06/08/2010 |
| 7727969 | Controlled release nanoparticle having bound oligonucleotide for targeted delivery The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that contains the conjugate, and methods of treatment using the conjugate. The controlled release polymer syst... | 06/01/2010 |
| 7718641 | Pyrrolo [3,4-H] isoquinoline compounds and methods for modulating gated ion channels The present invention relates to compositions and methods to modulate the activity of gated ion channels. ... | 05/18/2010 |
| 7696313 | Prodrug compounds with isoleucine The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is clea... | 04/13/2010 |
| 7682528 | Oxide ion conductor An La2O3 powder and an SiO2 powder are mixed with each other, and then heated. By heating, a porous material of LaXSi6O1.5X+12 (8≦X≦10) as a composite oxide is produced. Subsequently, the porous m... | 03/23/2010 |
