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| Number | Title | Issue Date |
| D658204 | Portion of a display screen with an icon | 04/24/2012 |
| 8158585 | Cross-β structure comprising amyloid-binding proteins and methods for detection of the cross-β structure, for modulating cross-β structures fiber formation and modulating cross-β structure-mediated toxicity The invention relates to the field of biochemistry, molecular biology, structural biology and medicine. More in particular, the invention relates to cross-β structures and the biological role of these cross-β structures. In one embodiment, the invention discloses ... | 04/17/2012 |
| RE43309 | Immunoregulatory compositions The invention relates to compounds exhibiting immuno-regulatory activity as determined by measuring the compound's ability to modulate production of NO by a cell. Preferred compounds include or consist of a sequence AAL AAQ AAG AAV wherein AAL is... | 04/10/2012 |
| D656544 | Bookmark | 03/27/2012 |
| 8114832 | Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition The invention relates to the detection and/or removal of conformationally altered proteins and/or molecules comprising a cross-β structure from a pharmaceutical composition. Disclosed is that unwanted and/or toxic side effects of pharmaceuticals are caused by prote... | 02/14/2012 |
| 8093775 | Magnetic rotor assembly A device for inducing the rotation of a plurality of rotors by use of magnetically charged materials includes at least a pair of rotors rotatably mounted. Each rotor includes at least one outwardly extending element having magnetic material attached to the opposing ... | 01/10/2012 |
| 8084441 | Cystitis treatment with high dose chondroitin sulfate Interstitial cystitis and related GAG-deficient conditions of the bladder and urinary tract are treated by instillation of high dose chondroitin sulfate, such as 400 mg/20 mL. The higher dose of chondroitin is effective for the rapid reduction of symptoms, particula... | 12/27/2011 |
| 8076131 | Settings for recombinant adenoviral-based vaccines The present invention provides new uses of recombinant adenoviral vectors in vaccination regimens, such as prime/boost set-ups and subsequent vaccinations and applications for gene therapy. Moreover, the invention provides new assays to determine the best regimen fo... | 12/13/2011 |
| 8052967 | Stable adenoviral vectors and methods for propagation thereof Provided are methods and means to increase the stability and/or the packaging capacity of recombinant adenoviruses, by overexpression of pIX in an adenoviral packaging cell, by retaining at least a part of the E1B-55K region in the recombinant adenoviral vector or b... | 11/08/2011 |
| 8052671 | Intra-abdominal pressure monitoring device and method An apparatus for monitoring the intra-abdominal pressure of a patient includes a urinary catheter (102) connected to a urine valve (250) providing selectable communication between a discharge end of the urinary catheter (102) and either a drain ... | 11/08/2011 |
| D648395 | Book holder | 11/08/2011 |
| RE42882 | Fractal device for mixing and reactor applications Two or more independent and offset fluid transporting fractals allow the scaling and intermingling of two or more fluids separately and simultaneously prior to contacting the fluids with one another. The device provides rapid and homogeneous mixing and/or reaction. | 11/01/2011 |
| 8039230 | Selection of host cells expressing protein at high levels The invention provides a DNA molecule comprising an open reading frame sequence that encodes a selectable marker polypeptide, wherein said DNA molecule in the coding strand comprises a translation start sequence for the selectable marker polypeptide having a GTG sta... | 10/18/2011 |
| 8038667 | Catheter connection hub Fluid communication to an end of a catheter is afforded through a connection hub selectively attachable thereto. The connection hub includes a catheter receiving element and a fluid coupling element that are relatively rotatable coaxially between a catheter receivin... | 10/18/2011 |
| 8034786 | Methods and means for controlling the endocytosis and subsequent degradation of growth hormone receptor The invention relates to the field of regulating metabolic processes, for example, to regulate the presence and/or activity of a receptor at the surface of a cell. The invention provides a method for controlling the presence of a receptor at the surface of a cell co... | 10/11/2011 |
| 8034047 | Catheter connection hub Fluid communication to an end of a catheter is afforded through a connection hub selectively attachable thereto. The connection hub includes a catheter-receiving element and a fluid-coupling element that are relatively rotatable coaxially between one of two states b... | 10/11/2011 |
| 8004339 | Apparatuses and methods for a level shifter with reduced shoot-through current A level-shifting circuit with reduced shoot-through current includes an output circuit comprising high-voltage devices with a pull-up circuit configured for pulling up a voltage on an output signal to a high voltage responsive to a high-side control signal. The outp... | 08/23/2011 |
| 8003757 | Receptor-based interaction trap Described is a recombinant receptor comprising an extracellular ligand-binding domain and a cytoplasmic domain that comprises a heterologous bait polypeptide. The recombinant receptor is activated by binding of a ligand to the ligand-binding domain and by binding of... | 08/23/2011 |
| 8003392 | Diagnostic test for the detection of early stage liver cancer Described are methods and kits to detect early stage hepatocellular carcinoma or a change in the gradation of hepatocellular carcinoma in mammals. The diagnostic marker is based on the profiling and identification of diagnostic carbohydrates present in a body fluid,... | 08/23/2011 |
| 8003137 | Extracts of and uses thereof Methods of extracting from a part of a variety of the species Aristolochia paucinervis pomel, a biologically active extract, are disclosed. Methods of reducing cell growth in a subject and inducing apoptosis in a cell are also disclosed. ... | 08/23/2011 |
| 7993822 | Aging biomarker The present invention relates to a marker that can be used as aging biomarker. More specifically, the present invention relates to the analysis of N-glycans in serum and its relation to the virtual age of the subject. This aging biomarker can be used to study the ef... | 08/09/2011 |
| 7972993 | Identification of protein binding sites The invention relates to the field of molecular recognition or detection of discontinuous or conformational binding sites or epitopes corresponding to a binding molecule, in particular, in relation to protein-protein, protein-nucleic acid, nucleic acid-nucleic acid ... | 07/05/2011 |
| 7968700 | Expression augmenting DNA fragments, use thereof, and methods for finding thereof The invention provides recombinant DNA molecules comprising novel expression augmenting DNA fragments and an expression cassette, said expression cassette comprising a heterologous promoter linked to a nucleic acid of interest. The invention further provides uses of... | 06/28/2011 |
| 7968092 | Human binding molecule against CD1a The present invention provides human binding molecules that specifically bind to CD1a, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding m... | 06/28/2011 |
| 7968087 | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells A gene delivery vehicle having been provided with at least a tissue tropism for cells selected from the group of smooth muscle cells, endothelial cells, and/or liver cells. The tissue tropism is generally provided by a virus capsid, such as one comprising protein fr... | 06/28/2011 |
| 7964406 | Means and methods for producing a stabilized cell of interest The invention provides a method for producing a stabilized cell of interest, said method comprising providing a stem cell and/or a precursor cell of said cell of interest with a nucleic acid sequence which, when present in said cell of interest, is capable of stabil... | 06/21/2011 |
| 7960518 | Human binding molecules having killing activity against enterococci and uses thereof The present invention provides human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods o... | 06/14/2011 |
| 7960117 | Promoter mutations that increase amyloid precursor protein expression The present invention relates to mutations in the amyloid precursor protein (APP) promoter region, whereby the mutations cause a significant increase in APP expression. The increase in APP expression is related to Alzheimer's disease, and the mutations can be used i... | 06/14/2011 |
| 7959922 | Liquid anti-rabies antibody formulations The present invention provides pharmaceutical antibody formulations, in particular liquid pharmaceutical formulations comprising anti-rabies virus antibodies. The formulations can be used in the post exposure prophylaxis of rabies. ... | 06/14/2011 |
| 7959907 | Method of treating cancer by combination therapy using TNF and alpha-galactosylceramide The invention relates to the treatment of cancer. More specifically the invention shows that the anti-cancer activity in mammals can be augmented by administering to the mammalian host a combination of a synergistically effective amount of TNF and alfa-galactosylcer... | 06/14/2011 |
| 7957907 | Method for molecular genealogical research A genealogical research and record keeping system and method for identifying commonalities in haplotypes and other genetic characteristics of two or more individual members of a biological sample. Chromosomal fragments identical by descent identify family ties betwe... | 06/07/2011 |
| 7955618 | Composition for treatment of inflammatory disorders A pharmaceutical composition for parenteral administration, comprising liposomes composed of non-charged vesicle-forming lipids, including up to 20 mole percent of an amphipathic vesicle-forming lipid derivatized with polyethyleneglycol, and optionally including not... | 06/07/2011 |
| 7951586 | DNA sequences comprising gene transcription regulatory qualities and methods for detecting and using such DNA sequences The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory s... | 05/31/2011 |
| D544183 | Outsole of a shoe | 06/12/2007 |
| D543688 | Portion of a shoe upper | 06/05/2007 |
| D542516 | Outsole of a shoe | 05/15/2007 |
| D541520 | Portion of a shoe upper | 05/01/2007 |
| RE39289 | Apparatus and process for manufacturing asphalt An improved process for making asphalt involves incorporating tar sands into a hot asphalt mix process and modifying the process. The improved process involves using a heated asphalt counter-flow drum mixer to admix asphaltic cement, coarse aggregate, and fine aggre... | 09/19/2006 |
| D527514 | Outsole of a shoe | 09/05/2006 |
| D527175 | Portion of a shoe upper | 08/29/2006 |
