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| Number | Title | Issue Date |
| 8058425 | Purine derivatives as kinase inhibitors The present invention provides kinase inhibitors of Formula I. ... | 11/15/2011 |
| 8022065 | Purine derivatives as kinase inhibitors The present invention provides kinase inhibitors of Formula I. ... | 09/20/2011 |
| 7863310 | Kinase inhibitors The present invention provides kinase inhibitors of Formula I: ... | 01/04/2011 |
| 7745438 | 3-(2-acylamino-1-hydroxyethyl)-morpholine derivatives and their use as bace inhibitors The present invention provides BACE inhibitors of Formula (I); methods for their use and preparation, and intermediates useful for their preparation. ... | 06/29/2010 |
| 7618978 | Amides as BACE inhibitors The present invention provides BACE inhibitors of Formula (I): methods for their use, and intermediates and methods for their preparation. ... | 11/17/2009 |
| 7585885 | Pyrrolidine derivatives useful as BACE inhibitors The present invention provides BACE inhibitors of Formula I: methods for their use and preparation, and intermediates for their preparation. ... | 09/08/2009 |
| 7582652 | Kinase inhibitors The present invention provides kinase inhibitors of Formula I. ... | 09/01/2009 |
| 7491716 | Purine derivatives as kinase inhibitors The present invention provides kinase inhibitors of Formula I. ... | 02/17/2009 |
| 7468365 | Lactam compound The present invention provides crystalline (N)-((S)-2-hydroxy-3-methyl-butyryl)-1-(L-alaninyl)-(S)-1-amino-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one, a crystalline anydrate and dihydrates thereof, compositions comprising (N)-((S)-2-hydroxy-3-methyl-butyryl)-... | 12/23/2008 |
| 7417064 | 3-aryloxy/thio-3-substituted propanamines and their use in inhibiting serotonin and norepinephrine reuptake There is provided a compound of formula (I) wherein A is selected from —O— and —S—; X is selected from C2-C8 alkyl, C2-C8 alkenyl, C3-C8 cycloalkyl and C4-C8 cycloalkylal... | 08/26/2008 |
| 7410982 | Propanamine derivatives as serotonin and norepinephrine reuptake inhibitors There is provided a heretoaryloxy/thio 3-substituted propanamine compound of formula (I) wherein A is selected from —O— and —S—; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C1-C... | 08/12/2008 |
| 7410996 | 3-aryloxy/thio-2,3-substituted propanamines and their use in inhibiting serotonin and norepinephrine reuptake There is provided a compound of formula (I) wherein A is selected from —O— and —S—; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C1-C4 alkyl and C1-C4 ... | 08/12/2008 |
| 7405305 | Pyrrole-2, 5dione derivatives and their used as GSK-3 inhibitors The present invention provides kinase inhibitors of Formula (I) ... | 07/29/2008 |
| 7390801 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/... | 06/24/2008 |
| 7384934 | Piperazine substituted aryl benzodiazepines Described herein are compounds of formula (I) wherein: is an optionally benzo-fused five or six member aromatic ring having zero to three hetero atoms independently selected from N, S, and O; Alk is (C1-4) alkylene or hydroxy substituted (C1-4)... | 06/10/2008 |
| 7320995 | Benzimidazoles and benzothiazoles as inhibitors of map kinase The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of m... | 01/22/2008 |
| 7294623 | Benzyl morpholine derivatives A compound of formula (I) (I) wherein R is H; Ar is an aromatic group selected from phenyl; X is a phenyl group; R′ is H or C1-C4 alkyl; each R1 is independently H or C1-C4 alkyl; and pharmaceutically acceptable salts thereof | 11/13/2007 |
| 7250430 | Thiophene-and thiazolesulfonamides as antineoplastic agents The present invention provides antineoplastic compounds of the formula: and antineoplastic methods. ... | 07/31/2007 |
| 7214673 | Piperazine substituted aryl benzodiazepines and their use as dopamine receptor antagonists for the treatment of psychotic disorders Described herein are antipyschotic compounds of formula (I) wherein, A is an optionally benzo-fused five or six member aromatic ring having zero to three hetero atoms independen... | 05/08/2007 |
| 7153847 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/... | 12/26/2006 |
| RE39030 | Fluoxetine enteric pellets and methods for their preparation and use A superior enteric formulation of the antidepressant drug, fluoxetine, is in the form of enteric pellets of which the enteric layer comprises hydroxypropylmethylcellulose acetate succinate. ... | 03/21/2006 |
| 6951854 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/... | 10/04/2005 |
| 6683114 | Treatment of psoriasis Norepinephrine reuptake inhibitors are used to treat psoriasis.... | 01/27/2004 |
| 6521611 | Non-peptidyl vasopressin V1a antagonists This invention provides methods and 2-(azetidin-2-on-1-yl) acetic acid derivatives of Formula I ##STR1## for the antagonism of the vasopressin V1a receptor.... | 02/18/2003 |
| 6376230 | Stereoselective process for producing intermediates of cryptophycins This invention provides processes for preparing intermediates useful for the preparation of cryptophycin compounds.... | 04/23/2002 |
| 6372936 | Optical resolution of aminoisobobutyric acid A process for resolving amino protected racemic 3-amino-2-methylpropionic acid which comprises the steps of: (1) reacting said amino protected acid with a protected amino group with an enantiomer of a chiral amine to form diastereomeric salts; (2) recryst... | 04/16/2002 |
| 6242450 | 5-HT1F antagonists This invention provides 5-HT1f antagonists of Formula I: ##STR1## where AR1, AR2, R, and R' are as defined in the specification.... | 06/05/2001 |
| 6221884 | Carboxamides useful as 5-HT1F agonists The present invention provides novel 2-amino-1,2,3,4-tetrahydro-9H-carbazole-6-carboxamides and 3-amino-10H-cyclohepta[7,6-b]indole-7-carboxamides of Formula I: ##STR1## where R1, R2, R3 and n are as described in the ... | 04/24/2001 |
| 6204260 | Non-peptidyl vasopressin V1a antagonists This invention provides methods and 2-(azetidin-2-on-1-yl)acetic acid derivatives for the antagonism of the vasopressin V1a receptor.... | 03/20/2001 |
| 6184222 | Treatment of conduct disorder Norepinephrine reuptake inhibitors are used to treat conduct disorder.... | 02/06/2001 |
| 6180657 | Melatonin derivatives for use in treating desynchronization disorders The present invention provides a method of treating desynchronization disorders using various melatonin analogs.... | 01/30/2001 |
| 6150525 | Pyrrolo [3,2-b]pyridine processes and intermediates The present invention provides processes and intermediates of Formula I: ##STR1## where X and R are defined in the specification, for the preparation of 5-amino-3-(1-methylpiperidin-4-yl)pyrrolo-[3,2-b]pyridine.... | 11/21/2000 |
| 6147072 | Combination therapy for treatment of psychoses The invention relates to a method of treating psychosis, acute mania, mild anxiety states or depression in combination with psychotic episodes by administering to a patient a combination of an atypical antipsychotic and a serotonin reuptake inhibitor.... | 11/14/2000 |
| 6133290 | 5-HT1F agonists The present invention relates to a compound of formula I: ##STR1## or a pharmaceutical acid addition salt thereof; which are useful for activating 5-HT1F receptors and inhibiting neuronal protein extravasation in a mammal.... | 10/17/2000 |
| 6126932 | Polymer bound carbodiimide coupling reagent This invention provides novel 5-HT1F agonists of Formula ##STR1## where X, R1, R2, and R3 are defined in the specification, which are useful for the treatment of migraine and associated disorders.... | 10/03/2000 |
| 6107307 | Inhibition of serotonin reuptake This invention provides 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]oct-2-enes and 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]octanes which are useful for the inhibition of serotonin reuptake in mammals.... | 08/22/2000 |
| 6046193 | Treatment of attention-deficit/hyperactivity disorder Reboxetine is used to treat attention-deficit/hyperactivity disorder.... | 04/04/2000 |
| 6046215 | Inhibition of serotonin reuptake This invention provides compounds and a method for the inhibition of serotonin reuptake in mammals.... | 04/04/2000 |
| 6028070 | Treatment of oppositional defiant disorder Norepinephrine reuptake inhibitors are used to treat oppositional defiant disorder.... | 02/22/2000 |
| 5998630 | Carbodiimide coupling reagent The present invention relates to compounds used for increasing activation of the 5-HT1F receptor.... | 12/07/1999 |
