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| Number | Title | Issue Date |
| 4871760 | Use of 2-(N-2,6-dichlorophenyl-N-allylamino)-2-imidazoline as cytoprotective agent The invention relates to the use of 2-[N-(2,6-dichlorophenyl)-N-allylamino]-2-imidazoline as a cytoprotective agent.... | 10/03/1989 |
| 4871735 | Naphthyl derivatives, pharmaceutical compositions containing these compounds and processes for preparing them The present invention relates to new naphthyl derivatives of general formula ##STR1## wherein N represents the number 1 or 2, A represents a --CH2 --, --CO--, --CH2 CH2 --, --CH.dbd.CH--, ##STR2## while the ... | 10/03/1989 |
| 4870076 | Sulphonamidoethyl compounds, pharmaceutical compositions comprising these compounds and processes for preparing them The invention relates to new sulphonamido-ethyl compounds having the following structure: ##STR1## wherein R1 is substituted or unsubstituted phenyl, benzyl, nitrophenyl, acetamidophenyl or thienyl, R2 is hydroxycarbonyl or ... | 09/26/1989 |
| 4868302 | Process for the preparation of TAHP The invention relates to an improved process for the catalytic hydrogenation of DAHNP and a new process for preparing 2,4-diamino-5-formylamino-6-hydroxypyrimidine.... | 09/19/1989 |
| 4861784 | Use of oxoquinazoline derivatives in the treatment of hyperuricaemia Oxoquinazoline derivatives of formulae ##STR1## (the symbols are defined in the specification) are well-tolerated drugs for treating hyperuricaemia.... | 08/29/1989 |
| 4857528 | Substituted pyrrolidinones, pharmaceutical compositions and use The invention relates to substituted pyrrolidinones of general formula ##STR1## wherein R1 represents a phenyl group which may be mono- or di-substituted by methyl, methoxy, fluorine, chlorine, bromine or trifluoromethyl, or a pyridyl grou... | 08/15/1989 |
| 4843086 | Tetrahydro-benzthiazoles, the preparation thereof and their use as intermediate products or as pharmaceuticals This invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the abo... | 06/27/1989 |
| 4831027 | Imidazo-benzoxazinones, the preparation thereof and pharmaceutical compositions containing these compounds The invention relates to new imidazo-benzoxazinones of formula ##STR1## wherein the substituents are defined herein below, which compounds are useful in the treatment of cardiovascular disorders.... | 05/16/1989 |
| 4829058 | Substituted bis-(4-aminophenyl)-sulfones Disclosed are substituted bis(4-aminophenyl)-sulfones of general formula ##STR1## wherein R1 is hydrogen, alkyl or cycloalkyl; group, R2 is hydrogen or C1 -C3 alkyl, R3 is nitrile, C1 -C3 | 05/09/1989 |
| 4826686 | Therapeutic system This invention relates to the transdermal administration of compounds of general formula I ##STR1## wherein R1, R2 and X have the meanings given in the text, and to a therapeutic system for the transdermal administration of this... | 05/02/1989 |
| 4824674 | Stable alpha-interferon dosage forms Stable, dosage forms of -interferons, particularly alpha-2-interferon, are described, which comprise a non-lyophilized dry film of acid-stabilized -interferons, e.g. alpha-2-interferon, on inert carriers.... | 04/25/1989 |
| 4820705 | Benzenesulphonamidoindanyl compounds, medicaments thereof, and processes of preparation The invention relates to new benzenesulphonamidoindanyl compounds having the following formula ##STR1## wherein the substituents are defined herein useful in the treatment and prophylaxis of thromboembolic diseases, arteriosclerosis and tumor me... | 04/11/1989 |
| 4812460 | 3-[2-(3',5'-di-t-butyl-4'-hydroxyphenyl)ethenyl]pyridine The present invention discloses 3-[2-(3',5'-di-tert-butyl-4'-hydroxyphenyl)ethenyl]pyridine and its use in treating inflammation, particularly chronic inflammatory diseases such as arthritis, and allergic disorders.... | 03/14/1989 |
| 4812453 | Use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants The invention relates to the use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants.... | 03/14/1989 |
| 4810775 | Process for purifying resorbable polyesters The invention relates to the purification of polymers, particularly resorbable polyesters, using shear fields produced mechanically or by fluid dynamics.... | 03/07/1989 |
| 4798226 | Charging valve A charging valve consisting of a valve sleeve and a valve stem fixed in the interior thereof comprises a valve which acts by compression and tension, the tension or compression being exerted by resilient parts of the valve stem adjacent to both valves.... | 01/17/1989 |
| 4785014 | Use of clonidine in memory enhancement Disclosed is a method of treating cognitive decline in a normal aged primate by administering thereto a therapeutically effective amount of 2-[(2,6-dichlorophenyl)-amino]-2-imidazoline or a nontoxic, pharmaceutically acceptable salt thereof. Administratio... | 11/15/1988 |
| 4762832 | Morpholine containing pyrrolidinones pharmaceutical compositions and use The invention relates to new substituted pyrrolidinones of general formula ##STR1## wherein R1 represents a phenyl group which may be mono- or di-substituted by methyl, methoxy, fluorine, chlorine, bromine or trifluoromethyl, or a pyridyl ... | 08/09/1988 |
| 4755385 | Oral pharmaceutical preparations containing 9-deoxo-11-deoxy-9,11-[imino[2-(2-methoxyethoxy)-ethylidene]-oxy]-(9S)-e rythromycin There is described a solid pharmaceutical preparation for oral administration which produces high and long-lasting blood and tissue levels, containing 9-deoxo-11-deoxy-9,11-[imino[2-(2-methoxyethoxy)-ethylidene]oxy]-(9S)-eryt hromycin as active substa... | 07/05/1988 |
| 4743606 | 3-[2-(3',5'-di-t-butyl-4'-hydroxyphenyl)ethenyl]pyridine having anti-inflammatory and anti-arthritic properties The present invention discloses 3-[2-(3',5'-di-tert-butyl-4'-hydroxyphenyl)ethenyl]pyridine and its use in treating inflammation, particularly chronic inflammatory diseases such as arthritis, and allergic disorders.... | 05/10/1988 |
| 4737495 | (2H)-3-benzazepin-2-ones, their pharmaceutical compositions and their pharmaceutical uses The invention relates to new heteroaromatic amine derivatives of formula ##STR1## wherein A represents a --CH2 --CH2 --, --CH.dbd.CH--or ##STR2## group and B represents a methylene, carbonyl or thiocarbonyl group or A repr... | 04/12/1988 |
| 4724236 | 5,11-dihydro-6H-pyrido(2,3-B)(1,4)benzodiazepin-6-ones substituted in the 11-position, processes for preparing them and pharmaceutical compositions containing these compounds Compounds of general formula I are described, ##STR1## wherein X represents the group .dbd.CHR, .dbd.NR or an oxygen atom and A represents the groups --NR1 R2, wherein R1 and R2 represent alkyl, cycloalkyl or phenyla... | 02/09/1988 |
| 4722926 | Substituted phenylalkyl-(piperazinyl or homopiperazinyl)alkyl thiols and thiocarbamates useful for the treatment of immunological, inflammatory, and allergic disorders Compounds of the formula ##STR1## wherein R is hydrogen or ##STR2## A is alkyl of 1 to 8 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; phenyl; or phenyl mono-, di- or tri-substituted independently with alkyl of 1 to 4 carbon atoms, halog... | 02/02/1988 |
| 4716169 | Imidazo[1,2a]pyridines and their use as cardiotonic agents The invention relates to new imidazo derivatives of the formula ##STR1## wherein "A-D and R1 -R3 are as defined in the specification". The new compounds have valuable pharmacological properties, particularly antithrombotic and c... | 12/29/1987 |
| 4707475 | Agent for lowering serum prolactin levels Disclosed is a method of lowering the prolactin level in the blood or serum of a person which method comprises administering a therapeutically effective amount of 2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo-[5,4-d]azepine or a non-toxic, pharmaceu... | 11/17/1987 |
| 4699790 | Antibiotic LL-C19004 A new antibacterial agent designated LL-C19004 is described, which antibacterial agent is produced through microbiological fermentation, under controlled conditions using a new species of Saccharothrix, Saccharothrix espanaensis (NRRL 15764).... | 10/13/1987 |
| 4542145 | Substituted N-[(1H-1,2,4-triazol-1-yl)-alkyl]heteroarylcarboxamides Substituted N-[(1H-1,2,4-triazol-1-yl)-alkyl]heteroarylcarboxamides are inhibitors of thromboxane synthetase enzyme.... | 09/17/1985 |
| 4477388 | Vinylstannyl derivatives Vinylstannyl derivatives and the processes for their conversion to vinyliodides, vinylbromides and vinyllithium reagents. The vinylstannyl, vinyliodides, vinylbromide derivatives and vinyllithiums are useful as intermediates for the preparation of prostag... | 10/16/1984 |
| 4454336 | Derivatives of 3-(formylmethylthio)-propanoate This disclosure describes a novel process for the synthesis of 5-mercapto-1,2,3-thiadiazoles which are useful as intermediates in the preparation of antibacterial agents.... | 06/12/1984 |
| 4435329 | Substituted N-(ω-aroylpropionyl) derivatives of -amino acids and esters thereof Novel compounds are described having the formula ##STR1## wherein Z is ##STR2## R1 is hydrogen or a C1 -C4 lower alkyl; R2 is hydrogen, a C1 -C4 lower alkyl, hydroxy-R8... | 03/06/1984 |
| 4431661 | 5-Aryl-3-azabicyclo[3.2.0]heptan-6-one acetals, and analgesic use therefor Novel compounds are disclosed having the formula ##STR1## wherein R1, R2 and R3 are each individually selected from the class consisting essentially of hydrogen, hydroxy, chloro, bromo, an alkyl radical having up to 3... | 02/14/1984 |
| 4431833 | Prostaglandin and hydroxylated fatty acid ester formulations Degradation of E-type prostaglandin compounds is retarded by dissolving or suspending such compounds in formulations containing hydroxylated derivatives of fatty acids having the formula: ##STR1## wherein R1 is C2 -C24 | 02/14/1984 |
| 4404376 | Cephalosporanic acid derivatives 7-acetamidocephalosporins are disclosed herein which are substituted at position 3 of the cephalosporin nucleus with the group ##STR1## wherein R2 is selected from the group hydrogen, amino, C1 to C6 alkylamino and di... | 09/13/1983 |
| 4404375 | Cephalosporanic acid derivatives 7-acetamidocephalosporins are disclosed herein which are substituted at position 3 of the cephalosporin nucleus with the group ##STR1## wherein R2 is selected from the group hydrogen, amino, C1 to C6 alkylamino and di... | 09/13/1983 |
| 4404374 | Cephalosporanic acid derivatives 7-acetamidocephalosporins are disclosed herein which are substituted at position 3 of the cephalosporin nucleus with the group ##STR1## wherein R2 is selected from the group hydrogen, amino, C1 to C6 alkylamino and di... | 09/13/1983 |
| 4402958 | Novel (substituted phenyl)-1,2,4-triazolo (4,3-A)pyrazines and novel 2-hydrazino-(substituted phenyl)pyrazine intermediates This disclosure describes novel 5-,6- and 8-(phenyl and substituted phenyl)-1,2,4-triazolo[4,3-a]pyrazines which posses utility as anxiolytic agents.... | 09/06/1983 |
| 4389399 | Thiocarbamoyl heterocycle-anthraquinone derivatives Novel 1,4-di(substituted amino)-5,8-dihydroxyanthraquinones wherein the substituents are alkyl-oxazolidin-2-thion-3-yl or alkyl tetrahydro-2H-1,3-oxazine-2-thione-3-yl groups as antitumor agents and as chelating agents are described.... | 06/21/1983 |
