Thomas; Paul D. - US Patent Attorneys and Agents

Attorney: Thomas; Paul D.

Number of patents: 29
Last date: July 14, 1987

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Number	Title	Issue Date
4680404	Benzopyrans Bicyclic fused benzenoid compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, where M is O, CH2 or NR6 ; R6 is hydrogen, formyl, carbobenzyloxy or certain carboal...	07/14/1987
4656265	Cyclic prodrugs of antiinflammatory oxicams Compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof wherein R is 2-pyridyl, 6-chloro-2-pyridyl, 6-methyl-2-pyridyl or 5-methylisoxazol-3-yl; useful as prodrug forms of the corresponding known oxicam anti...	04/07/1987
4625041	Acidic polycyclic ether antibiotic A new acidic polycyclic ether antibiotic, CP-63,517, having the formula: ##STR1## and cationic salts thereof produced by submerged aerobic propagation of Streptomyces endus subsp. aureus, ATCC-39574, a new strain of microorganism isolated from a soil...	11/25/1986
4616027	Antifungal 1-aryl-1-fluoroalkyl-2-(1H-1,2,4-triazol-1-yl)ethanols Compounds of the general formula ##STR1## or a pharmaceutically or agriculturally acceptable acid addition salt thereof wherein R is 5-chloro-2-pyridyl, phenyl or phenyl substituted by from one to three substituents, each independently selected from ...	10/07/1986
4616026	Antifungal 2-aryl-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)2-propanols Compounds of the formula ##STR1## a pharmaceutically or agriculturally acceptable acid addition salt thereof wherein R is 5-chloro-2-pyridyl, phenyl or phenyl substituted by from 1 to 3 substituents, each independently selected from F, Cl, Br, I, CF	10/07/1986
4601897	Prazosin-pirbuterol combination for bronchodilation A method for relaxing bronchial tissue in mammals, including humans, by use of a combination of prazosin and pirbuterol or their pharmaceutically acceptable acid addition salts....	07/22/1986
4582907	2-(2-amino-2-thiazolin-4-yl)acetic acid 2-(2-Amino-2-thiazolin-4-yl)acetic acid or a pharmaceutically acceptable acid addition or cationic salt thereof useful in removal of excessive levels of certain metal ions from animals, including humans, and in protection of said animals from exposure to ...	04/15/1986
4576964	Substituted hexahydrobenzo[e]indene and octahydrophenanthrene CNS agents and pharmaceutical compositions thereof Tricyclic benzo fused compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, wherein n is zero, 1 or 2, and t is 1 or 2; M is CH or N, R1 is H or certain acyl groups; Q is CO2...	03/18/1986
4560697	1,3-Bis-(1H-1,2,4-triazol-1-yl)-2-perfluoro-alkylpropan-2-ol antifungal agents Compounds of the formula ##STR1## or a pharmaceutically or agriculturally acceptable acid addition salt thereof wherein R is (C1 -C5) perfluoroalkyl and R1 is H or CH3, method for their use in combatting fu...	12/24/1985
4560690	2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents 2,4-Disubstituted thiazole compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof wherein X is NH and Y is CH or N, or X is S and Y is CH; R1 is certain straight or branched chain alkyl groups, (R3	12/24/1985
4552843	Process for producing an acidic polycyclic ether antibiotic by cultivation of a novel strain of Streptomyces endus subspecies aureus A new acidic polycyclic ether antibiotic, CP-63,517, having the formula: ##STR1## and cationic salts thereof produced by submerged aerobic propagation of Streptomyces endus subsp. aureus, ATCC-39574, a new strain of microorganism isolated from a soil...	11/12/1985
4530792	Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate A process for the preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate which comprises reacting 1,1-dioxopenicillanoyloxymethyl 6-phenylacetamidopenicillanate or the corresponding phenoxyacetamidopenicillanate under anhydrous condition...	07/23/1985
4529732	2-[2-hydroxy-4-(substituted)phenyl]piperidines 2-[2-Hydroxy-4-(substituted)phenyl]piperidines and derivatives thereof of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R1 is H, benzyl or certain acyl groups, R2 is H, certain alkyl, ...	07/16/1985
4526579	Method for graft copolymerization to natural rubber articles A process for grafting a hydrophilic polymer of a carboxylic acid or a salt thereof onto the surface of a natural rubber article by contacting said article in reaction inert solvent with a vinyl carboxylic acid anhydride and initiator, and subsequent wash...	07/02/1985
4518604	Antifungal 1-aryl-2-(1H-1,2,4-triazol-1yl)-1-perfluoroalkylethyl halides Compounds of the formula ##STR1## or a pharmaceutically or agriculturally acceptable acid addition salt thereof wherein R is 5-chloro-2-pyridyl, phenyl or phenyl substituted by from 1 to 3 substituents selected from F, Cl, Br, I, CF3, (C	05/21/1985
4503063	N-Acyl 3-aryl-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-butyramide antifungal agents Compounds of the formula ##STR1## a pharmaceutically or agriculturally acceptable salt thereof, wherein R is 5-chloro-2-pyridyl or phenyl optionally substituted by one to three substituents, each independently selected from F, Cl, Br, I, CF3	03/05/1985
4486428	Bicyclic benzo fused compounds Bicyclic fused benzenoid compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, where M is O, CH2 or NR6 ; R6 is hydrogen, formyl, carbobenzyloxy or certain carboal...	12/04/1984
4483862	2-(1H-1,2,4-triazol-1-yl)-1,1-bis-(perfluoro-alkyl)ethanol antifungal agents Compounds of the formula ##STR1## or a pharmaceutically or agriculturally acceptable acid addition salt thereof wherein m and n are independently 0, 1, 2, 3 or 4; method for their use in combatting fungal infections in plants, seeds and animals, ...	11/20/1984
4482723	Process for preparation of 4-acetyl-2-substituted-imidazoles Novel intermediates of the formula ##STR1## where R1 and R2 are each (C1 -C4)alkyl or taken together are (C2 -C4)alkylene, and their use in a process for preparation of compounds of th...	11/13/1984
4482558	Antifungal amide and urea derivatives of (3-amino-2-aryl-2-hydroxyprop-1-yl)-1H-1,2,4-triazoles Compounds of the general formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R is naphthyl, biphenylyl, phenyl or substituted phenyl; and R1 is ##STR2## where X is O or S, R2 is H, or C	11/13/1984
4476131	Substituted hexahydropyrrolo[1,2-a]-quinolines, hexahydro-1H-pyrido[1,2-a]- q Tricyclic benzo fused compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, wherein n is zero, 1 or 2, and t is 1 or 2; M is CH or N, R1 is H or certain acyl groups; Q is CO2...	10/09/1984
4457924	1,1-Alkanediol dicarboxylate linked antibacterial agents Useful antibacterial agents in which a penicillin and/or a beta-lactamase inhibitor are linked via 1,1-alkanediol dicarboxylates are of the formula ##STR1## where A is the residue of certain dicarboxyic acids, R3 is H or (C1 -C	07/03/1984
4432987	Crystalline benzenesulfonate salts of sultamicillin Novel benzenesulfonic acid addition salts of sultamicillin of the formula ##STR1## and hydrated forms thereof, where X is hydrogen or chloro, especially the crystalline dihydrate salts, having advantages over the prior art forms of sultamicillin in p...	02/21/1984
4419284	Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide Process for preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide of the formula ##STR1## where X is Cl, Br, I, certain alkylsulfonyloxy or arylsulfonyloxy groups, useful as intermediates in production of antibiotics ...	12/06/1983
4393001	Intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates Compounds of the formula ##STR1## wherein R1 is H or HO; Y and Z are each Cl, Br or I, or Y is H and Z is Cl, Br or I; Q is N3 or NHCO2 CH2 C6 H4 R4 where R4 is H...	07/12/1983
4359472	Bis-hydroxymethyl carbonate bridged antibacterial agents Antibacterial agents in which a penicillin and a beta-lactamase inhibitor are linked by means of a bis-hydroxymethyl carbonate bridge are of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R1...	11/16/1982
4351833	9-Amino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof as analgesics and anti-emetics 9-Amino-1-hydroxyoctahydrobenzo[c]quinoline derivatives of formula ##STR1## and pharmaceutically acceptable acid addition salts thereof wherein R is hydrogen, COR7 or SO2 R8 where R7 is hydrogen, alkyl, hav...	09/28/1982
4309545	Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof 9-Amino-1-hydroxyoctahydrobenzo[c]quinoline derivatives of formula ##STR1## and pharmaceutically acceptable acid addition salts thereof wherein R is hydrogen, COR7 or SO2 R8 where R7 is hydrogen, alkyl, hav...	01/05/1982
4251563	Compositions containing N-nitrosamine formation or oxidation inhibitors and the use thereof Compositions of nitrite preserved food, emulsified preparations, breakfast cereal or food premixes and erythorbyl or ascorbyl laurate or erythorbyl caprate show substantial inhibition of potentially harmful or objectionable degradation arising from N-nitr...	02/17/1981

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Attorney: Thomas; Paul D.