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| Number | Title | Issue Date |
| 6943184 | 1,1- and 1,2-disubstituted cyclopropane compounds A compound selected from those of formula (I): wherein: p represents an integer of from 0 to 6 inclusive, n represents an integer of from 0 to 6 inclusive, R1, and R | 09/13/2005 |
| 6930098 | Use of polysulphated cyclodextrins for treating osteoarthritis The present invention relates to the method of using polysulphated cyclodextrins or addition salts thereof for use in the treatment of arthrosis, and pharmaceutical compositions thereof. ... | 08/16/2005 |
| 6919362 | Heterocyclic derivatives, preparation method and pharmaceutical compositions containing same Compounds of formula (I): wherein: X represents an oxygen or a sulphur or CH2 or R1 and R2 rep... | 07/19/2005 |
| 6913752 | Modified Vaccinia Ankara virus variant The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus... | 07/05/2005 |
| 6908922 | Linear cyclic ureas Compound of formula (I): wherein: V represents a single bond or an alkylene chain, M represents a single bond or an alkylene chain, A and E each repr... | 06/21/2005 |
| 6903103 | Linear cyclic ureas Compound of formula (I): wherein: V represents a single bond or an alkylene chain, M represents a single bond or an alkylene chain, A and E each repr... | 06/07/2005 |
| 6894043 | Benzothiadiazine derivatives, preparation method and pharmaceutical compositions containing same Compound selected from those of formula (I): wherein: X represents flourine, bromine, iodine or methyl, each of R1 and R2, which may be identica... | 05/17/2005 |
| 6878746 | Carbamate and thiocarbamate podophyllotoxin derivatives, preparation method and pharmaceutical compositions containing them A compound selected from these of formula (I): wherein: R1 represents hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocy... | 04/12/2005 |
| 6875788 | Imidazoline compounds Compounds of formula (I): wherein: R1 represents an optionally substituted heteroaryl group, R2 represents an optionally substituted cycloalkyl ... | 04/05/2005 |
| 6872851 | Substituted cyclic compounds, preparation method and pharmaceutical compositions containing them The invention concerns compounds of formula (I): R—A—R′ wherein: A is as defined in the description; R represent, a group (V), wherein R′a and R″a are as defined in the description, or R forms with A a cyclic structure as defined in t... | 03/29/2005 |
| 6846833 | Vitronectin receptor antagonist bicyclic compounds, preparation method and compositions containing same Compounds of formula (1): wherein: G represents an optionally substituted phenyl or optionally substituted heterocycle, G1 and G2 being N or C, ... | 01/25/2005 |
| 6844445 | Indenoindolone compounds Compound of formula (I): wherein: R represents hydrogen or a group selected from alkenyl and optionally substituted alkyl, each of R1 to R8, whi... | 01/18/2005 |
| 6835843 | Method for synthesis of perindopril and its pharmaceutically acceptable salts The invention concerns a method for synthesis of perindopril of formula (I) and its pharmaceutically acceptable salts ... | 12/28/2004 |
| 6828462 | Unsaturated 1-amino-alkylcyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists Unsaturated 1-Amino-alkylcyclohexane compounds which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which invo... | 12/07/2004 |
| 6818788 | Method for synthesis of n-[(s)-1-carboxybutyl]-(s)-alanine esters and use in synthesis of perindopril Stereoselective process for the industrial synthesis of compounds of formula (I): wherein R represents linear or branched (C1-C6)alkyl. Application in the synthesis of perindopril and phar... | 11/16/2004 |
| 6818657 | Bioprecursors of a retinoic derivative and pharmaceutical and/or cosmetic compositions The present invention relates to a ternary glucosyl complex which is a bioprecursor of at least one retinoic active ingredient for percutaneous application, having formula (I), wherein E represents a linear hydrocarbon spacer group that is branched or cyclized and h... | 11/16/2004 |
| 6784183 | Diphenylurea compounds Compounds of formula (I): and medicinal products containing the same which are useful as dual α2/5-HT2c antagonists. ... | 08/31/2004 |
| 6780868 | Linear cyclic ureas Compounds of formula (I): wherein: V represents a single bond or a linear or branched (C1-C6)alkylene chain, M represents a single bond or a linear or branched (C1-C6 | 08/24/2004 |
| 6774259 | Method for synthesis of n-[(s)]-1-carboxybutyl-(s)-alanine esters and use in synthesis of perindopril A stereoselective process for the industrial synthesis of compounds of formula (I): wherein R represents linear or branched (C1-C6)alkyl, and application in the synthesis of perindopril and p... | 08/10/2004 |
| 6761893 | Modified vaccinia ankara virus variant The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus... | 07/13/2004 |
| 6759421 | Indoline compounds, a process for their preparation and pharmaceutical compositions containing them A compound of formula (I): wherein: R1 and R2 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifl... | 07/06/2004 |
| 6759406 | Quaternary ammonium compounds Compounds of formula corresponding to either formula (Ia) or (Ib): wherein: M represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, R1 | 07/06/2004 |
| 6747032 | Pyrimidin-4-one compounds Compound of formula (I): wherein: R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen atom, a halogen atom or a group selected from alkyl, a... | 06/08/2004 |
| 6743818 | Cyclobutaindolecarboxamide compounds A compound selected from those of formula (I): wherein: n represents integer from 0 to 6, R1 represents a group selected from hydrogen, hydroxy, cyano, alkoxy, alkoxycarbonyl, carboxy, optionally... | 06/01/2004 |
| 6734196 | Substituted pyridine or piperidine compounds The invention relates to a compound of formula (I): wherein: A represents pyridine, pyridinium or piperidine R1, R2, R3 and R4 are as defined in the description | 05/11/2004 |
| 6733782 | Core tablet for controlled release of gliclazide after oral administration The invention relates to a matrix tablet for the prolonged release of gliclazide which ensures continuous and consistent release of the active ingredient after administration by the oral route, the release being insensitive to variations in the pH of the dissolution... | 05/11/2004 |
| 6716852 | Amino acid derivatives and use thereof as NEP, ACE and ECE inhibitors The invention relates to compounds of formula (I): wherein 0≦n≦3, 0≦m≦6, R3 and R4 together form phenyl, B represents heteroaryl, R1 and R2... | 04/06/2004 |
| 6716843 | Alpha-amino acid sulphonyl compounds Compound of formula (I): wherein: represents an optionally substituted, 5-membered, nitrogen-containing heterocycle, R1 represents hydrogen, alkyl, acyl,... | 04/06/2004 |
| 6709675 | Thixotropic formulations for filling capsules The invention concerns liquid or pasty thixotropic compositions containing an active substance for filling capsules at room temperature. The compositions become fluid by the effect of shearing when they pass through the filling nozzle, then recover their consistency... | 03/23/2004 |
| 6706742 | Alpha-amino-acid compounds Compound selected from those of formula (I): wherein: represents an optionally substituted 5-membered nitrogen-containing heterocycle, Ak represents an alkylene chain,... | 03/16/2004 |
| 6699876 | Camptothecin analogue compounds Compound of formula (I): ##STR1## wherein: n is 0, 1 or 2, R1 represents (C3 -C11)cycloalkyl or (C3 -C11)cycloalkylalkyl, R2, R3, R4 and R5 are selec... | 03/02/2004 |
| 6699506 | Pharmaceutical composition with extended release of Milnacipran The invention concerns a pharmaceutical composition with prolonged release, for oral administration of a single daily dose of 60 to 140 mg of Milnacipran, having a multi-particulate form containing a plurality of microgranules each comprising an active mi... | 03/02/2004 |
| 6696481 | Salt of perindopril and pharmaceutical compositions containing it The present invention relates to a new salt of perindopril and to pharmaceutical compositions containing it, and Medicaments for treatment of hypertension and heart failure.... | 02/24/2004 |
| 6696469 | Cyclobutenedione compounds Compounds of formula (I): ##STR1## wherein: X represents a heterocycle bonded to the remainder of the molecule by a nitrogen atom of the heterocycle, or an --NR2 R3 group wherein R2 represents hydrogen or alkyl, and R | 02/24/2004 |
| 6689808 | Substituted phthalides, a process for their preparations and pharmaceutical compositions containing them The invention relates to compounds of formula (I): ##STR1## wherein R1 represents alkyl or ureido, R2 represents alkyl or hydrogen, or R1 and R2 together form a 5- or 6-membered ring, R3 represents CN, NO | 02/10/2004 |
| 6686378 | Derivatives of 3-imino-1,2-dithioles, method for producing them and pharmaceutical compositions containing the same Compound of formula (I): ##STR1## wherein: Het1 and Het2, which may be identical or different, each represents an optionally substituted pyridyl, A represents a bond or linear or branched (C1 -C6)alkylene, its optica... | 02/03/2004 |
| 6686360 | N-benzylpiperazine compounds The present invention relates to a compound selected from those of formula (I): ##STR1## wherein: R1 represents alkyl, R2 represents hydroxy, alkoxy, or amino, n represents an integer from 1 to 12 inclusive, R3 represents: hydr... | 02/03/2004 |
| 6686358 | Bicyclic amino-pyrazinone compounds A compound of formula (I): ##STR1## wherein: R1 represents hydrogen, or linear or branched (C1 -C6)alkyl optionally substituted by one or more identical or different groups selected from aryl, heteroaryl, cycloalkyl and he... | 02/03/2004 |
| 6686348 | Metalloprotease inhibitors A compound of formula (I): ##STR1## wherein: R1 represents hydrogen, halogen, alkyl or alkoxy, X represents oxygen, sulphur or NR wherein R represents hydrogen or alkyl, A represents any one of the groups described in the description, their isomers and a... | 02/03/2004 |
| 6667304 | Polycyclic azaindole compounds The invention relates to compound of formula (I): ##STR1## wherein: G1 represents an alkylene chain as defined in the description, A represents ##STR2## R2 and R3 represent hydrogen, alkyl, alkoxy or hydroxy or ... | 12/23/2003 |
