Teskin; Robin L. - US Patent Attorneys and Agents

Attorney: Teskin; Robin L.

Number of patents: 38
Last date: April 24, 2007

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Number	Title	Issue Date
7208290	Methods of co-expressing umami taste receptors and chimeric Gαvariants The invention provides a series of chimeric Gα15 protein variants that couple to certain GPCRs more efficiently than the native Gα15 protein. These chimeric Gα15 protein variants can be used to discover and analyze modulators of G...	04/24/2007
7108866	Chronotherapeutic diltiazem formulations and the administration thereof A controlled-release Galenical preparation of pharmaceutically acceptable Diltiazem including the pharmaceutically acceptable salts thereof, suitable for evening dosing every 24 hours containing from about 120 mg to about 540 mg or more (as desired) of the form of D...	09/19/2006
7052857	Expression of functional human olfactory cyclic nucleotide gated (CNG) channel in recombinant host cells and use thereof in cell based assays to identify GPCR modulators The present invention relates to isolated nucleic acid sequences that encode human olfactory cyclic nucleotide gated (CNG) channel subunits, and the corresponding polypeptides. The invention further relates to the use of human CNG channels to profile, screen for, an...	05/30/2006
7041457	Gα protein variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors The invention provides a series of Gαq protein variants that functionally couple to sensory cell receptors such as taste GPCRs (TRs) and olfactory GPCRs (ORs) in an overly promiscuous manner. According to the invention, the functional coupling can be det...	05/09/2006
7022488	Functional coupling of T1Rs and T2Rs by Gi proteins, and cells-based assays for the identification of T1R and T2R modulators The invention resides in part in the discovery that G proteins other than Gα15 couples to T1R and T2R taste receptors, particularly Gi proteins such as Gαi. Related to this discovery, the invention provides cell-based assay methods...	04/04/2006
6970791	Tailored user interfaces for molecular modeling The present invention provides a method of carrying out a molecular modeling calculation and displaying the results thereof through a task-oriented user interface. The overall computational task is divided into subtasks, each of which is outfitted with a tailored gr...	11/29/2005
6967218	Pravastatin pharmaceutical formulations and methods of their use The present invention relates to formulations comprising a therapeutically effective amount of pravastatin, or a pharmaceutically acceptable salt thereof, and methods of their use. The present formulations and methods are designed to release little or no pravastatin...	11/22/2005
6682734	Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma Disclosed herein are therapeutic treatment protocols designed for the treatment of B cell lymphoma. These protocols are based upon therapeutic strategies which include the use of administration of immunologically active mouse/human chimeric anti-CD20 anti...	01/27/2004
6559129	Cationic liposomal delivery system and therapeutic use thereof The invention relates to novel cationic lipid formulations and use thereof for treatment of cancer, especially in combination with radiation....	05/06/2003
6506383	Methods of suppressing immune responses to transplanted tissues and organs with gp39-specific antibodies The present invention is directed to humanized antibodies which bind human gp39 and their use as therapeutic agents. These humanized antibodies are especially useful for treatment of autoimmune diseases....	01/14/2003
6485728	Formalin-Inactivated human papillomavirus L1 protein vaccine Recombinantly produced L1 major capsid proteins which mimic conformational naturalizing epitopes on human and animal papilloma virions including canine and equine papilloma virions are provided. These recombinant proteins are useful as vaccines for confer...	11/26/2002
6455265	Method for obtaining vaccines for preventing the pathogenic effects related to a retroviral infection A method of searching for and obtaining a vaccine against the pathogenic effects related to the infection of an animal or human host by a retrovirus that penetrates into a target cell of the host, and a vaccine obtained by the method are provided. The met...	09/24/2002
6455043	Combination therapies for B-cell lymphomas comprising administration of anti-CD20 antibody New combined therapeutic regimens for treatment of B-cell lymphomas are disclosed which comprise in particular administration of anti-CD20 antibodies to patients having low-, intermediate- or high-grade non-Hodgkins lymphomas....	09/24/2002
6451284	Clinical parameters for determining hematologic toxicity prior to radioimmunotheraphy New clinical parameters are reported which may serve as predictors of the hematological toxicity associated with therapeutic radiolabeled antibodies, particularly those antibodies which target lymphoma cells which have a tendency to localize to the bone m...	09/17/2002
6440418	Methods of treating autoimmune diseases with gp39-specific antibodies The present invention is directed to humanized antibodies which bind human gp39 and their use as therapeutic agents. These humanized antibodies are especially useful for treatment of autoimmune diseases; and an immunosuppressant during transplantation of ...	08/27/2002
6437099	Fluorescene--activating antisera and IgG fraction therefrom An antiserum containing an antibody, which when combined with an immunogen having a nonfluorescent dye, confers fluorescent ability to the dye. In particular, an antiserum which confers fluorescent ability on a conjugate of an immunogenic substance and Ma...	08/20/2002
6418934	Use of polymeric materials for enlarging human glans and method of performing a surgery for enlarging a human glans with the said materials The present invention relates to the use of polymeric materials for enlarging the glans of the male genital organ and the method of performing a surgery for enlarging the glans of the male genital organ with any of the said material. A material selected f...	07/16/2002
6416951	Screening for functional antisense agents Provided is a method for identifying a functional antisense agent, which method comprises hybridizing an RNA with an aligonucleotide probe and measuring in real time the kinetics of hybridization, wherein the kinetics are measured by either hybridizing in...	07/09/2002
6416945	Vitro method for disassembly/reassembly of papillomavirus virus-like particles (VLPS) A method of disassembly/reassembly of papillomavirus VLPs is provided. The resultant VLPs have enhanced homogeneity, present conformational, neutralizing PV epitopes, and therefore are useful prophylactic and diagnostic agents. Further, these VLPs can be ...	07/09/2002
6413777	Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same A method for achieving site specific integration of a desired DNA at a target site in a mammalian cell via homologous recombination is described. This method provides for the reproducible selection of cell lines wherein a desired DNA is integrated at a pr...	07/02/2002
6413771	Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof A highly efficient method for generating human antibodies in particular which are specific to be RSV fusion protein which combines in vitro priming of human spleen cells and antigen boosting in SCID mice is taught. This method provides for very high human...	07/02/2002
6399061	Chimeric and radiolabelled antibodies specific to human CD20 antigen and use thereof for treatment of B-cell lymphoma Disclosed herein are therapeutic treatment protocols designed for the treatment of B cell lymphoma. These protocols are based upon therapeutic strategies which include the use of administration of immunologically active mouse/human chimeric anti-CD20 anti...	06/04/2002
6391560	Screening for functional antisense agents Provided is a method for identifying a functional antisense agent, which method comprises contacting an RNA with an oligonucleotide probe to form a duplex-containing RNA, contacting the duplex-containing RNA with an RNAase to cleave the duplex-containing ...	05/21/2002
6375950	Methods for inducing T cell unresponsiveness to donor tissue or organ in a recipient with gp39 antagonists Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell...	04/23/2002
6333314	Liposomes containing oligonucleotides It is possible to radiosensitize tumor cells by administration of compositions containing the Human antisense c-raf-1 oligodeoxyribonucleotide (ODN/oligo) sequence: 5'-GTGCTCCATTGATGC-3' (seq. ID No. 1) wherein only the end bases are phosphorylated is a p...	12/25/2001
6328964	Method to treat multiple sclerosis with GP39-specific antibodies Method for the treatment of multiple sclerosis and other T cell mediated autoimmune disorders is described. The method involves administering to a subject a therapeutically effective amount of an antagonist of a receptor on a surface of a T cell which med...	12/11/2001
6316189	Evaluation of changes in breast cells using nipple aspirate fluid This invention provides a method for studying chromosomal gains and losses in cells from nipple aspirate fluid comprising the steps of: (1) aspirating fluid from breasts; (2) placing the samples of fluid obtained in step 1 onto dishes containing condition...	11/13/2001
6312692	Method of treating graft-versus-host disease with anti-GP39 antibodies and bone marrow cells A method of treating graft-vs-host diseases by administration of bone marrow and an anti-gp39 antibody specific to human gp39 is provided....	11/06/2001
6310095	Inhibitors of protein isoprenyl transferases Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2 --, and (i) heterocyclic-L	10/30/2001
6300143	Electrochemiluminescent assays for eukaryotic cells Disclosed are immunomagnetic electrochemiluminescence assays for eukaryotic cells, particularly human cells. A competitive binding assay is disclosed which enables affinity measurements of antibodies specific for eukaryotic cell membrane proteins. Such an...	10/09/2001
6261765	In vitro method for disassembly/reassembly of papillomavirus virus-like particles (VLPs) A method of disassembly/reassembly of papillomavirus VLPs is provided. The resultant VLPs have enhanced homogeneity, present conformational, neutralizing PV epitopes, and therefore are useful prophylactic and diagnostic agents. Further, these VLPs can be ...	07/17/2001
6248598	Immunoassay that provides for both collection of saliva and assay of saliva for one or more analytes with visual readout A device that provides for both the collection of saliva and detection of at least one analyte therein, e.g., a drug, is provided. This device provides for rapid analysis of saliva samples, while also providing a convenient assay method that does not requ...	06/19/2001
6245754	Inhibitors of phosphatidyl myo-inositol cycle The present invention relates to the preparation and biological activity of 3-deoxy-D-myo-inositol ether lipid analogs as inhibitors of phosphatidylinositol-3-kinase signaling and cancer cell growth. The compounds of the present invention are useful as an...	06/12/2001
6245748	Inhibition of an FGF-binding protein using ribozymes Increased expression of a secreted FGF-binding protein (FGF-BP) occurs in certain autoimmune and malignant disease conditions. It is found, for example, that tumor secretions of FGF-BP results in mobilization and activation of locally-stored FGFs that can...	06/12/2001
6235970	CICM cells and non-human mammalian embryos prepared by nuclear transfer of a proliferating differentiated cell or its nucleus An improved method of nuclear transfer involving the transplantation of donor differentiated cell nuclei into enucleated oocytes of the same species as the donor cell is provided. The resultant nuclear transfer units are useful for multiplication of genot...	05/22/2001
6235969	Cloning pigs using donor nuclei from non-quiescent differentiated cells An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes ...	05/22/2001
6215041	Cloning using donor nuclei from a non-quiesecent somatic cells Methods and cell lines for cloning bovine embryos and offspring are provided. The resultant embryos or offspring are especially useful for the expression of desired heterologous DNAs....	04/10/2001
6207858	Regioselective synthesis of DTPA derivatives The present invention provides a process for high yield regioselective synthesis of DTPA derivatives that eliminates the need for ion exchange chromotographic separation of intermediates. Moreover, as this process yields a single regioisomer of the chelat...	03/27/2001

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Attorney: Teskin; Robin L.