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| Number | Title | Issue Date |
| 4526754 | Sample transport system A transport system is provided in which a plurality of samples are introduced into a carrier stream flowing through a conduit, whose inner surface is coated with an immiscible liquid film. The carrier stream can be a sequence of alternating gas and liquid... | 07/02/1985 |
| 4517302 | Continuous flow metering apparatus Continuous flow metering apparatus and methods using liquid position sensors in conjunction with flow-stopping valves control (meter) fluid, e.g. sample/reagent/air, aspiration into a single conduit, such as in a continuous flow system. Air or other gas s... | 05/14/1985 |
| 4455381 | Immunoassay of proteins In the immunoassay of a particular protein in a biological fluid, there is frequently interference in the assay by other proteins present in the fluid, e.g. by complement factors or antibodies in human serum. The interference so caused can be avoided by s... | 06/19/1984 |
| 4447883 | Coincidence-error correcting apparatus and method New and improved method and apparatus for the correction of coincident errors attendant the automated detection and counting of mixed particles having detectable characteristics of different levels in particle counting applications wherein the detection o... | 05/08/1984 |
| 4418039 | Solute transfer technique Transferring a solute from a first to a second liquid solvent, utilizing a membrane selectively permeable by a gas and impermeable by the liquids, which method includes the steps of: flowing the first liquid along said membrane, evaporating the first liqu... | 11/29/1983 |
| 4397960 | Immunoassays using F(AB')2 fragments Immunoassays for antigens or haptens are effected using, instead of an immunoglobulin antibody, the F(ab')2 fragments thereof. In this way, interference from endogenous RF and Clq in the fluid under assay is avoided without the necessity of pre... | 08/09/1983 |
| 4333918 | Radioassay for vitamin B12 The amount of vitamin B12 in solution in a liquid is determined by mixing a sample of the solution with vitamin B12 -binding proteins from chicken serum in a pH of about 12.8 to 13.2, and then analyzing a component of the mixture. In... | 06/08/1982 |
| 4307190 | Immunoassay using ascitic fluid A liquid, particularly but not exclusively a liquid of human origin such as blood serum or urine, is immunoassayed for antibodies, antigens or antibody: antigen complexes, using as a reagent in the analysis an active fraction from mouse ascitic fluid. Thi... | 12/22/1981 |
| 4307070 | Methods and apparatuses for performing immunoassays Methods and apparatuses are featured for preconcentrating immunological reactants prior to their contact and reaction to enhance the rate of reaction for separating reacted and unreacted reactants and, also, to increase the sensitivity at the detector-mea... | 12/22/1981 |
| 4300906 | Method for the operation of automated analysis apparatus Method is provided for the operation of substantially constant flow rate sample analysis apparatus in such manner that the adverse effects upon sample analysis accuracy of periodic variations in analysis apparatus flow rate and/or sample-analysis reagent ... | 11/17/1981 |
| 4288425 | Method and apparatuses for electrophoretic immunoassay Methods and apparatuses are featured for preconcentrating immunological reactants prior to their contact and reaction, to greatly enhance the rate of reaction and the sensitivity. The preconcentration is accomplished within the reaction medium and is foll... | 09/08/1981 |
| 4288228 | Whole blood analyses and diffusion apparatus therefor Methods and apparatuses are featured for analyzing whole blood samples by diffusion techniques in porous media. A fluid component of the whole blood is diffused into a thin-film porous medium of a given predetermined volume. Hematocrit dependent errors in... | 09/08/1981 |
| 4283383 | Analysis of biological fluids Biological fluids, such as serum, are analyzed for the presence, nature and/or amount of antibodies, antigens and antibody:antigen complexes therein using as a reagent, insolubilized rheumatoid factor or insolubilized Clq. These reagents are themselves no... | 08/11/1981 |
| 4280815 | Electrochemiluminescent immunoassay and apparatus therefor A method and apparatus for performing a chemiluminescent immunoassay featuring electrochemical techniques to generate an oxidant used to trigger the chemiluminescence of the labelled immunoreactant. The generation of the oxidant is precisely controlled an... | 07/28/1981 |
| 4279617 | Iummunoassay involving agglutination A particle agglutination assay for antigens, antibodies and other binding proteins such as rheumatoid factor, uses two different, microscopic or submicroscopic particulate reagents. The first particulate reagent binds with the antigen or antibody under as... | 07/21/1981 |
| 4278887 | Fluid sample cell A fluid sample cell comprising a sample compartment of precisely predetermined depth bounded by opposed surfaces of a transparent window and a diffuse mirror is disclosed, and comprises inlet and outlet ports for the flow of a series of successive samples... | 07/14/1981 |
| 4276253 | Method for histology specimen labelling A method for labelling a histological specimen, wherein such specimen is embedded in a paraffin block along with an integral set of supported elongated elements identifying such specimen for subsequent sectioning on a microtome. The identification element... | 06/30/1981 |
| 4274967 | Chromatographic apparatus and method An apparatus and method for increasing the throughput of a chromatographic system by passing several samples in seriatim through tandemly connected first and second chromatographic columns. The eluant from the first column is sampled, or fractionated, and... | 06/23/1981 |
| 4274093 | Keyboard-display combination A keyboard is constructed as an integral member of a display screen. The keyboard comprises a number of keys which are back-lighted upon the screen when they are enabled, but which are otherwise invisible to the viewer when disabled. When a key is depress... | 06/16/1981 |
| 4272505 | Competitive binding analysis by fluorescence Thyroid hormones such as thyroxine and triiodothyronine are assayed in biological fluid samples by a competitive binding analysis in which a fluorescent label is used. Upon formation of complexes, the fluorescence of the labelled compound is released, and... | 06/09/1981 |
| 4269139 | Transfer apparatus A method of transferring a substance adhering to the surface of a substrate to a receiving surface of a backing element which includes locating the substrate surface in juxtaposition with the receiving surface, supplying a transfer medium on the receiving... | 05/26/1981 |
| 4260392 | Method and apparatus for obtaining an aliquot of a liquid in a gel medium There is disclosed a method and apparatus for obtaining a precise aliquot of a sample by diffusing the sample into a gel mass for a controlled period of time. The sample may comprise a liquid containing an unknown quantity of a diffusible, to-be-assayed, ... | 04/07/1981 |
| 4259291 | Metering device Contamination between successive aqueous samples in a continuous-flow analytical system is eliminated by the careful and precise application of a thin, uniform film of immiscible fluid upon the outer surface of an aspirating probe of a metering system. Th... | 03/31/1981 |
| 4257346 | Apparatus for mounting tissue sections with an U.V. light curable mounting medium Apparatus for permanently and protectively mounting "wet" thin sections of biological specimens on microscope slides, wherein each specimen is initially bathed in a low-volatile solvent containing a low concentration of first polymerizable material. Such ... | 03/24/1981 |
| 4253846 | Method and apparatus for automated analysis of fluid samples A sample analyzing system features a number of discrete sample segments continuously conveyed along a conduit. Each sample segment receives a precise aliquot of one or more reagents on a selective basis, and in any particular sequence. Selective injection... | 03/03/1981 |
| 4253844 | Insolubilized proteins and immunoassays utilizing them Insolublized antibodies, F(ab')2 fragments thereof and protein antigens are made by coupling to a water-insoluble substrate using a bridging agent which covalently binds to sulphur atoms in antibody, fragment or protein rather than to free amin... | 03/03/1981 |
| 4250257 | Whole blood analyses in porous media Method and apparatus for analyzing whole blood samples which feature impregnating a gel medium used for the analysis of the whole blood sample with an inert substance. When the whole blood sample is placed on the gel medium, the inert substance diffuses f... | 02/10/1981 |
| 4247647 | Apparatus for the quantitative determination of saccharides A method for the quantitative determination of sugars in a fluid sample. The sugar sample, which may contain free glucose, is passed through a scavenger stage where substantially all of the glucose is removed, so that it does not interfere with the determ... | 01/27/1981 |
| 4239494 | Phase separator for continuous-flow analytical systems A separator and method, particularly for use in continuous-flow analysis, for separating liquid from a mixture of a liquid phase and a solid phase. The separator includes a first conduit, and a second conduit which communicates with the first conduit acro... | 12/16/1980 |
| 4236076 | Infrared analyzer An infrared analyzer is described which analyzes constituents of a sample. The sample and/or reference signals are synchronously averaged to provide unisonous sample and reference values. This processing eliminates drift and signal noise from the measurem... | 11/25/1980 |
| 4233144 | Electrode for voltammetric immunoassay Immunoassays featuring voltammetric measurements wherein at least one of the immunoreactants is labelled with an electroactive substance. Measurement is effectedon a pulsed-basis to maximize the signal change due to the electron transfer capabilities of t... | 11/11/1980 |
| 4227810 | Cuvette and method of use A multichamber cuvette for maintaining in independent and separate condition at least two reactants until such time that it is desired to mix them for reaction with each other and a reactant liquid sample while in the cuvette for analysis in the cuvette, ... | 10/14/1980 |
| 4225410 | Integrated array of electrochemical sensors A disposable integrated miniaturized array of chemical sensors for analyzing concurrently a number of analytes in a fluid sample is described. Each sensor is a complete electrochemical cell consisting of its own individual reference and indicator electrod... | 09/30/1980 |
| 4217415 | Immobilization of an enzyme substrate A carbohydrate substrate such as starch for a carbohydrate hydrolyzing enzyme is immobilized on a solid inorganic porous support to form a stable substrate-support composite useful in affinity chromatography and in methods where a precise amount of substr... | 08/12/1980 |
| 4210809 | Method and apparatus for the non-invasive determination of the characteristics of a segmented fluid stream New and improved method and apparatus for the non-invasive detection of the respective segments and segment interfaces, and the non-invasive determination of the respective segment volumes, of a continuous segmented fluid stream flowing in a transparent c... | 07/01/1980 |
| 4206353 | Analyzing system A system for detecting live insects in a commodity sample features forming a closed-loop between a stored quantity of fluid and a sample cell and a reference cell. The closed-loop and the stored fluid ensure a controlled environment during incubation and ... | 06/03/1980 |
| 4206286 | Immobilization of proteins on inorganic supports A method of producing an immobilized protein composite, i.e. enzymes such as glucose oxidase, on an alumina support, comprising modifying some of the free functional groups of the protein such as amino groups, by reaction with an acid or anhydride, deposi... | 06/03/1980 |
| 4204952 | Chromatographic apparatus and method An apparatus and method for increasing the throughput of a chromatographic system by passing several samples in seriatim through tandemly connected first and second chromatographic columns. The eluant from the first column is sampled, or fractionated, and... | 05/27/1980 |
| 4199260 | Apparatus and method for determining the concentration in a sample Apparatus and method for determining the concentration of a constituent in a sample using chromatographic and optical measuring techniques. A sample containing a constituent to be analyzed is fractionated by a chromatographic column. A light beam is passe... | 04/22/1980 |
| 4194067 | Process for the purification of carbohydrate containing enzymes This invention relates to a method for purifying a carbohydrate containing enzyme which is a desired enzyme preferred to be separated from a mixture. The method comprises the steps of mixing a solution containing the carbohydrate containing enzyme with a ... | 03/18/1980 |
