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| Number | Title | Issue Date |
| 5391157 | End of dose indicator The present invention provides an improvement in injection syringes by providing for an end of dose indicator which is operatively associated with the dose knob of an injection syringe. The instant end of dose indicator works by providing a sound as an in... | 02/21/1995 |
| 5308340 | Multiple dose injection pen The present invention relates to a hypodermic syringe having the same general appearance as a pen which is specifically adapted to provide for multiple measure injections of materials such as insulin or human growth hormone.... | 05/03/1994 |
| 5295976 | Dose indicating injection pen Two embodiments of a multi-dose syringe both include structure for indicating the selected amount of liquid to be injected. A first element and a second element coupled respectively to the syringe housing and the plunger rod are adapted for calibrated mov... | 03/22/1994 |
| 5286753 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes and pharmaceutical compositions thereof The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones, which ring-substituted compounds exhibit agonist activity at t... | 02/15/1994 |
| 5281623 | Method for treating inflammation Provided are methods of treating inflammation, arthritis and muscular dystrophy and preventing ischemia-induced cell damage employing certain phenol and benzamide compounds.... | 01/25/1994 |
| 5226895 | Multiple dose injection pen The present invention relates to a hypodermic syringe having the same general appearance as a pen which is specifically adapted to provide for multiple measured injections of materials such as insulin or human growth hormone.... | 07/13/1993 |
| 5226896 | Dose indicating injection pen Two embodiments of a multi-dose syringe both include structure for indicating the selected amount of liquid to be injected. A first element and a second element coupled respectively to the syringe housing and the plunger rod are adapted for calibrated mov... | 07/13/1993 |
| 5223608 | Process for and intermediates of 2',2'-difluoronucleosides The present invention provides a process for preparing lactone intermediates to 2',2'-difluoronucleosides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enan... | 06/29/1993 |
| 5216002 | Method of treating inflammatory bowel disease Provided is a method of treating inflammatory bowel disease in mammals utilizing certain benzyl-substituted rhodanine derivatives. Also provided are novel benzyl-substituted rhodanine derivatives and pharmaceutical compositions thereof, as well as a novel... | 06/01/1993 |
| 5204340 | Tetrahydrobenz(c,d)indole serotonin agonists This invention provides 6-substituted-4-(amino or substituted amino)tetrahydrobenz[c,d]indole serotonin agonists useful in treating a variety of conditions associated with serotonin function.... | 04/20/1993 |
| 5166063 | Immobolization of biomolecules by enhanced electrophoretic precipitation The present invention provides a method for immobilizing biomolecules on a conductive substrate to produce a biosensor.... | 11/24/1992 |
| 5161528 | Defibrillation method and apparatus The present invention provides a method, and apparatus for accomplishing same, for defibrillating a mammal in need of defibrillation employing multiple bursts of electrical current delivered to the mammal, the timing between said bursts being based upon t... | 11/10/1992 |
| 5158966 | Method of treating type I diabetes Provided is a method for treating Type I diabetes in mammals utilizing certain aryl-substituted rhodanine derivatives.... | 10/27/1992 |
| 5134143 | BCD tricyclic ergoline part-structure analogues 7- or 8-Substituted, partially hydrogenated pyrazolo[3,4-g]quinoline, thiazolo[4,5-g]quinoline, oxazolo[4,5-g]quinoline, and pyrrolo[3,4-g]quinoline derivatives, and 8- or 9-substituted, partially hydrogenated pyrido[2,3-g]quinazoline derivatives are D-2 ... | 07/28/1992 |
| 5112619 | Orally administerable sustained release pharmaceutical formulation This invention provides orally administerable pharmaceutical formulations having a semi-solid matrix containing a hydrophilic substance capable of creating channels in a hydrophobic carrier matrix thereby providing a sustained rate of release of an active... | 05/12/1992 |
| 5108819 | Thin film electrical component A biocompatible thin film electrical component is configured for use in a human body or other ionic liquid environment. A polyimide substrate is bonded to a glass carrier plate sized for handling by automatic equipment and a multiple-layer metal conductor... | 04/28/1992 |
| 5093324 | Thiadiazole antiviral agents Ribosylated 2-amino-1,3,4-thiadiazoles having antiviral activity, methods of use and pharmaceutical formulations therefor.... | 03/03/1992 |
| 5061793 | 2-deoxy-2',2'-difluoro-inosine and 5'O-derivatives 2'-deoxy-2',2'-difluoro-inosine and 5'-O alkyl derivatives are disclosed as inhibitors of neoplasms.... | 10/29/1991 |
| 5057515 | Method for agonizing a dopamine receptor Trans-(&#b1;)-2-(substituted)-6-(substituted)-5,5a,6,7,8,9,9a,10-octahydropy rido[2,3-g]quinolines are useful in treating a variety of disorders including Parkinsonism, anxiety, depression, hypertension, glaucoma, sexual dysfunction, and prolactin mediated... | 10/15/1991 |
| 5037698 | Capsule filling employing hygroscopic components Capsules containing a hygroscopic or deliquescent component are stabilized by a) forming a mixture of the hydrogscopic or deliquescent compound with a sufficient quantity of water to achieve an equilibrium, b) adding a thickening agent and c) heating the ... | 08/06/1991 |
| 5026869 | 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles (&#b1;)-4-substitutedamino-6-alkoxy, benzyloxy, acyloxy, or hydroxy-1,3,4,5-tetrahydrobenz[c,d]indoles, pharmaceutically acceptable salts thereof are, anti-depressants.... | 06/25/1991 |
| 5006525 | Dopamine agonists method Trans-(&#b1;)-2-(substituted)-6-(substituted)-5,5a,6,7,8,9,9a,10-octahydropy rido[2,3-g]quinolines are useful in treating a variety of disorders including Parkinsonism, anxiety, depression, hypertension, glaucoma, sexual dysfunction, and prolactin mediated... | 04/09/1991 |
| 4996984 | Defibrillation method The present invention provides a method for defibrillating a mammal in need of defibrillation employing multiple bursts of electrical current delivered to the mammal, the timing between said bursts being based upon the mammal's fibrillation cycle length.... | 03/05/1991 |
| 4997845 | ଲ-alkylmelatonins as ovulation inhibitors ଲ-Alkylmelatonins are useful as ovulation inhibitors.... | 03/05/1991 |
| 4996235 | 3,4-diphenylbutanamines The present invention provides 3,4-diphenylbutanamines capable of selectively inhibiting the uptake of serotonin and norepinephrine.... | 02/26/1991 |
| 4987233 | Process for preparing herbicidal ureas and insecticidal carbamates and carbamate derivatives The present invention provides a process for preparing herbicidal ureas and insecticidal carbamates and carbamate derivatives comprising reacting an amine, alcohol, or oxime nucleophile with a urea in an inert organic solvent.... | 01/22/1991 |
| 4983724 | Inversion of 2,2-difluororibose to a 2,2-difluoroxylose and intermediates therefor A process and intermediates useful for the invrsion of 2-deoxy-2,2-difluororibose analogs to provide 2-deoxy-2,2-difluoroxylose analogs is described.... | 01/08/1991 |
| 4977160 | BCD tricyclic ergoline part-structure analogues 7- or 8-Substituted, partially hydrogenated pyrazolo[3,4-g]quinoline, thiazolo[4,5-g]quinoline, oxazolo[4,5-g]quinoline, and pyrrolo[3,4-g]quinoline derivatives, and 8- or 9-substituted, partially hydrogenated pyrido[2,3-g]quinazoline derivatives are D-2 ... | 12/11/1990 |
| 4977149 | Pyridoquinoline dopamine agonists, compositions and use Trans-(&#b1;)-2-(substituted)-6-(substituted)-5,5a,6,7,8,9,9a,10-octahydropy rido[2,3-g]quinolines are useful in treating a variety of disorders including Parkinsonism, anxiety, depression, hypertension, glaucoma, sexual dysfunction, and prolactin mediated... | 12/11/1990 |
| 4965374 | Process for and intermediates of 2',2'-difluoronucleosides The present invention provides a process for preparing lactone intermediates to 2',2'-difluoronucleosides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enan... | 10/23/1990 |
| 4950629 | Process for catalyst recovery The present invention provides a process for recovering homogeneous metallic catalysts from catalytic reaction mixtures, in active form, suitable for immediate re-use. The process comprises removing the reaction solution solvent, adding a lower alkanoic a... | 08/21/1990 |
| 4939259 | 2-oxo-pyrido[2,3-g]quinoline derivatives Trans-(&#b1;)-2-(substituted)-6-(substituted)-5,5a,6,7,8,9,9a,10-octahydroph rido[2,3-g]quinolines are useful in treating a variety of disorders including Parkinsonism, anxiety, depression, hypertension, glaucoma, sexual dysfunction, and prolactin mediated... | 07/03/1990 |
| 4924001 | Process for preparing 5-cyano-4, 5-dihydro-3,4-dicarboxypyrazole derivatives The present invention provides 5-cyano-4,5-dihydro-3,4-dicarboxypyrazoles and a process for preparing such compounds which comprises reacting a dialkyl fumarate with diazoacetonitrile.... | 05/08/1990 |
| 4904792 | N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds N-alkyl-N'-(2-aminomethyl-4-thiazolylmethylthio)alkyl guanidines, thioureas, ethenediamines and related compounds, H2 -receptor antagonists, useful in inhibiting gastric acid secretion in mammals.... | 02/27/1990 |
| 4902710 | Serotonin and norepinephrine uptake inhibitors The present invention provides propanamines, substituted at the 3-position of the propanamine chain with a thio, sulfinyl or sulfonyl moiety, which are capable of selectively inhibiting the uptake of serotonin and norepinephrine.... | 02/20/1990 |
| 4892956 | 5-cyano-4,5-dihydro-3,4-dicarboxypyrazole derivatives The present invention provides 5-cyano-4,5-dihydro-3,4-dicarboxypyrazoles and a process for preparing such compounds which comprises reacting a dialkyl fumarate with diazoacetonitrile.... | 01/09/1990 |
| 4892766 | Capsules Hard gelatin capsules are made from gelatin containing up to 10% of a preferably hydrophilic fibrous material. They do not split after storage when filled with hygroscopic or deliquescent materials.... | 01/09/1990 |
