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| Number | Title | Issue Date |
| 7273739 | Nucleic acid molecules encoding endonucleases and methods of use thereof We describe here an in vitro method of increasing complementarity in a heteroduplex polynucleotide sequence. The method uses annealing of opposite strands to form a polynucleotide duplex with mismatches. The heteroduplex polynucleotide is combined with an effective ... | 09/25/2007 |
| 7270825 | Production of a parvovirus vaccine in plants as viral coat protein fusions The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in plants at high levels by biologically contained tobamoviruses. The fusio... | 09/18/2007 |
| 7235386 | Method of increasing complementarity in a heteroduplex We describe here an in vitro method of increasing complementarity in a heteroduplex polynucleotide sequence. The method uses annealing of opposite strands to form a polynucleotide duplex with mismatches. The heteroduplex polynucleotide is combined with an effective ... | 06/26/2007 |
| 7217514 | Method of increasing complementarity in a heteroduplex We describe here an in vitro method of increasing complementarity in a heteroduplex polynucleotide sequence. The method uses annealing of opposite strands to form a polynucleotide duplex with mismatches. The heteroduplex polynucleotide is combined with an effective ... | 05/15/2007 |
| 7179638 | Microarrays and their manufacture by slicing Microarrays are prepared by using a separate fiber for each compound being used in the microarray. The fibers are bundled and sectioned to form a thin microarray that may be glued to a backing. ... | 02/20/2007 |
| 7084256 | Self antigen vaccines for treating B cell lymphomas and other cancers A polypeptide self-antigen useful in a tumor-specific vaccine mimics one or more epitopes of an antigen uniquely expressed by cells of the tumor. The polypeptide is preferably produced in a plant that has been transformed or transfected with nucleic acid encoding th... | 08/01/2006 |
| 7078211 | Nucleic acid molecules encoding endonucleases and methods of use thereof We describe here an in vitro method of increasing complementarity in a heteroduplex polynucleotide sequence. The method uses annealing of opposite strands to form a polynucleotide duplex with mismatches. The heteroduplex polynucleotide is combined with an effective ... | 07/18/2006 |
| 7070739 | Detection and characterization of microorganisms A method for separating microorganisms, especially infectious agents, from a mixture by two dimensional centrifugation on the basis of sedimentation rate and isopycnic banding density, for sedimenting such microorganisms through zones of immobilized reagents to whic... | 07/04/2006 |
| 7056740 | Mismatch endonucleases and methods of use We describe here restriction endonucleases and their uses. Restriction endonucleases are useful in finding single nucleotide polymorphisms. They are also useful in an in vitro method of redistributing sequence variations between non-identical polynucleotide sequence... | 06/06/2006 |
| 6980674 | Reference database Data acquisition and cataloging are used to classify polypeptides into a reference index or database. The database can be used to identify previously unidentified samples. New polypeptides are characterized and added to the database. ... | 12/27/2005 |
| 6939453 | Electrophoresis process using ionic liquids Highly hydrophobic compounds and hydrophobic proteins are solubilized in a non-aqueous solvent containing an electrolyte for electrophoretic separation. The non-aqueous solvent is an ionic liquid or a mixture of an organic solvent containing an ionic liquid in an am... | 09/06/2005 |
| 6933109 | Rapid particle detection Methods and reagents for rapid purification and/or identification of particles in a liquid sample are described. The technique uses centrifugation to concentrate particles against a slanted surface having an agent specifically binding to the particles. This method i... | 08/23/2005 |
| 6932895 | Automated electrophoresis gel manipulation apparatus An automated, computer controlled assembly is provided for continuously processing a large number of electrophoresis gels. The assembly includes a loading assembly for loading a gel onto a carrier, a gel staining assembly and a scanning and cutting assembly. The sta... | 08/23/2005 |
| 6911312 | Detection and characterization of microorganisms A method for separating microorganisms, especially infectious agents, from a mixture by two dimensional centrifugation on the basis of sedimentation rate and isopycnic banding density, for sedimenting such microorganisms through zones of immobilized reagents to whic... | 06/28/2005 |
| 6890748 | Production of lysosomal enzymes in plants by transient expression The invention relates to α-galactosidase truncated at the carboxy terminus and the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequenc... | 05/10/2005 |
| 6887701 | Microarrays and their manufacture The microarrays of the present invention are prepared by using a separate fiber for each compound being used in the microarray. The fibers are bundled and sectioned to form a thin microarray that is glued to a backing. ... | 05/03/2005 |
| 6887696 | Production of lysosomal enzymes in plants by transient expression The invention relates to α-galactosidase truncated at the carboxy terminus and the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequenc... | 05/03/2005 |
| 6846635 | Microarrays and their manufacture Microarrays are prepared by using a separate fiber for each compound being used in the microarray. The fibers are bundled and sectioned to form a thin microarray that is glued to a backing. ... | 01/25/2005 |
| 6804410 | System for optimizing alignment of laser beam with selected points on samples in MALDI mass spectrometer A mass spectrometry apparatus uses image processing of output signals of a camera in a mass spectrometer to provide feedback for directing the laser. The present invention provides for the determination of where samples have actually been deposited on a plate, and f... | 10/12/2004 |
| 6783648 | Method and apparatus for unloading gels from isoelectric gel tubes An apparatus for expressing and unloading an isoelectric focusing gel from an electrophoresis gel tube includes a first support for supporting the gel tube, a plunger rod and a second support for supporting the plunger rod. The first support is mounted on a movable ... | 08/31/2004 |
| 6761810 | Automated apparatus including a robotic arm for loading samples into wells for first dimension electrophoresis separation An automated assembly for performing first dimension electrophoresis is described herein that includes a supply magazine, an electrophoresis tank and an automated transferring device that robotically transfers biological samples from sample vials retained in the sup... | 07/13/2004 |
| 6758804 | Method and apparatus for unloading gradients Devices and methods for removing portions of gradients relate to a float with an upper concave surface for collecting the gradient portion. ... | 07/06/2004 |
| 6734424 | Method for microdispensing of fluids from a pipette An automated pipetting apparatus and method for forming sample spots on a support include a pipette. A robotic assembly moves a sample container, such as a multiwell microtiter plate, and the support to the pipette for receiving and dispensing liquid samples. The pi... | 05/11/2004 |
| 6730306 | Parvovirus vaccine as viral coat protein fusions The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in plants at high levels by biologically contained tobamoviruses. The fusio... | 05/04/2004 |
| 6713309 | Microarrays and their manufacture The microarrays of the present invention are prepared by using a separate fiber for each compound being used in the microarray. The fibers are bundled and sectioned to form a thin microarray that is glued to a backing. ... | 03/30/2004 |
| 6709871 | Precision fluid gradient formation Ways for reproducibly making liquid gradients with a high degree of precision are provided. Different regions in the gradient are preformed by premixing liquids usable for other components of the gradient to form an intermediate gradient component that is then added... | 03/23/2004 |
| 5158940 | Use of suramin to treat rheumatologic diseases Polysulfonated compounds such as suramin are used to treat immunoregulatory isorders. Particular use in the treatment of rheumatologic diseases such as rheumatoid arthritis is shown.... | 10/27/1992 |
| 5114973 | Method for treating autoimmune disease using succinylacetone The invention is a method of modulating or controlling autoimmune disease in a host. The method includes the step of administering to the diseased host a pharmaceutical effective amount of succinylacetone. The pharmaceutically effective amount of succinyl... | 05/19/1992 |
| 5104898 | Method of preventing graft rejection in solid organ transplantation A method is disclosed for preventing graft rejection of transplanted solid organs, in mammal recipients thereof, by administering an effective graft rejection preventative amount of succinylacetone to said mammals.... | 04/14/1992 |
| 5052997 | Diathermy coil A short but large apertured coil of the sloped-helix type allows deep heating of a part of the human body by RF waves, for example with a three-turn coil having a central part wherein parts of a pair of turns are parallel. The length of the coil equals tw... | 10/01/1991 |
| 5050609 | Magnetization transfer contrast and proton relaxation and use thereof in magnetic resonance imaging A nuclear magnetic resonance method is provided for monitoring and imaging the exchange of magnetization between protons in free water and protons in a relatively immobilized pool of protons in a sample. The method provides a new form of contrast for nucl... | 09/24/1991 |
| 5010020 | Quick color test to detect lead release from glaze and enamel coatings A color test is presented for the purpose of quickly identifying glaze or enamel coatings which releases excessive Pb. Citric acid solution on filter paper is used to extract Pb from the coatings and a Pb sensitive chromogen indicates the presence of Pb o... | 04/23/1991 |
| 5008262 | Method of treating trichotillomania and onchyphagia The instant invention is drawn to the use of clomipramine for treating trichotillomania and onchyphagia.... | 04/16/1991 |
