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| Number | Title | Issue Date |
| 6649756 | PROCESS IMPROVEMENT IN THE PREPARATION OF (4R, 5S, 6S)-3-[[(2R,3R)-2-[[[(S)-2-AMINO-3-METHYL-1-OXOBUTYL]AMINO]METHYL]TETRAHYD RO-3-FURANYL]THIO]-6-[(R)-1-HYDROXYETHYL]-4-METHYL-7-OXO-1-AZABICYCLO[3.2. 0]HEPT-2-ENE-2-CARBOXYLIC ACID The invention is a process improvement for producing the carbapenem antibacterial agent (4R, 5S, 6S)-3-[[2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydr o-3-furanyl]thio]-6-[R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2. 0]hept... | 11/18/2003 |
| 6635261 | Adjuvant and vaccine compositions containing monophosphoryl lipid A The invention pertains to adjuvant and vaccine compositions of monophosphoryl lipid A, sugar and optionally an amine based surfactant, which when frozen and thawed or lyophilized and reconstituted reform a colloidal suspension having a light transmission ... | 10/21/2003 |
| 6306404 | Adjuvant and vaccine compositions containing monophosphoryl lipid A The invention pertains to adjuvant and vaccine compositions of monophosphoryl lipid A, sugar and optionally an amine based surfactant, which when frozen and thawed or lyophilized and reconstituted reform a colloidal suspension having a light transmission ... | 10/23/2001 |
| 5442059 | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines The invention provides compounds of the formula: ##STR1## wherein R, and R1 and W are defined in the specification. These compounds are useful as antibiotic agents.... | 08/15/1995 |
| 5430150 | Retroviral protease inhibitors Compounds of the formula I: ##STR1## wherein X, Y, Z, a, b, c, R1, R2, R3, R4 and R5 are defined in the specification are provided. The compounds are useful as inhibitors of retroviral protease e... | 07/04/1995 |
| 5428167 | Asymmetric synthesis of intermediates for retroviral protease inhibitor compounds The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: ##STR1## wherein... | 06/27/1995 |
| 5407917 | Compositions and methods for the enhancement of performance in meat-producing animals and for the treatment and control of disease therein Methods for increasing the growth rate and increasing the efficiency of food utilization of meat-producing animals and for treating bacterial infections in said animals by administering an effective amount of selected antibiotics derived from the microorg... | 04/18/1995 |
| 5405849 | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones Novel quinazolinone compounds of the formula: ##STR1## wherein R5, R6, R7, R8, R and X are defined in the specification, which have angiotensin II (AII) antagonizing activity, intermediates useful in the pr... | 04/11/1995 |
| 5401729 | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines The invention provides compounds of the formula: ##STR1## wherein R, R3, R4 and W are defined in the specification. These compounds are useful as antibiotic agents.... | 03/28/1995 |
| 5401863 | 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines Novel 9-amino-7-(substituted amino)-6-demethyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the no... | 03/28/1995 |
| 5381912 | Package having a press-and-turn type cap and bottle with ramped gripping portions An improved child-resistant package allowing improved access and closure by the user is provided. The improved packages is of the press-and-turn type and features ramped gripping portions on the perimeter of the side of the press-and-turn cap and on the b... | 01/17/1995 |
| 5380888 | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines The invention provides compounds of the formula: ##STR1## wherein R, R3, R4 and W are defined in the specification. These compounds are useful as antibiotic agents.... | 01/10/1995 |
| 5371076 | 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines The invention provides compounds of the formula: ##STR1## wherein R, R1, R2 and W are defined in the specification. These compounds are useful as antibiotic agents.... | 12/06/1994 |
| 5369102 | 2-substituted alkyl-3-carboxy carbopenems as antibiotics and a method of producing them The invention relates to new 2-substituted alkyl-3-carboxy carbapenems having the formula: ##STR1## with R1, R2, R3, X and Y defined hereafter as antibiotics and beta lactamase inhibitors produced by a novel Michael ... | 11/29/1994 |
| 5358947 | Angiotensin II receptor blocking 2,3-substituted pyrazolo[1,5-a]-1,3,5-triazin-4(3H)-ones The invention provides novel 2,3-substituted pyrazolo[1,5-a]-1,3,5-triazin-4(3H)-ones having the formula: ##STR1## wherein R1, R2 and R3 are described in the specification which have activity as angiotensin II (AII) a... | 10/25/1994 |
| 5358951 | Angiotensin II receptor blocking 2, 3, 6 substituted quinazolinones This disclosure describes novel 2,3,6, substituted quinazolinones of the formula: ##STR1## wherein R1, R6 and X are described in the specification which have activity as angiotensin II (AII) antagonistis.... | 10/25/1994 |
| 5296480 | Angiotensin II receptor blocking 2,3,6-substituted 5,6,7,8-tetra-hydro-pyrido[4,3]pyrimidin-4(3H)-ones The invention provides compounds having the formula ##STR1## wherein R, X and R6 are defined in the specification which have activity as angiotensin II antagonists.... | 03/22/1994 |
| 5292742 | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones The invention provides novel 2,3,6-substituted quinazolinones having the formula ##STR1## wherein X, R, R6 are described in the specification which have activity as angiotensin II (AII) antagonists.... | 03/08/1994 |
| 5290780 | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones Novel quinazolinone compounds of the formula: ##STR1## wherein R5, R6, R7, R8, R and X are defined in the specification, which have angiotensin II (AII) antagonizing activity, intermediates useful in the pr... | 03/01/1994 |
| 5288720 | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones Novel 2, 3, 6 substituted quinazolinones of the formula: ##STR1## wherein R, R6 and X are described in the specification are disclosed. The compounds which have activity as angiotensin II (AII) antagonists.... | 02/22/1994 |
| 5286729 | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones The invention provides novel 2,3,6 substituted quinazolinones having the formula ##STR1## wherein R, R5, R6, R7, R8 and X are described in the specification which have activity as angiotensin II (AII) antag... | 02/15/1994 |
| 5284853 | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones The invention provides novel 2, 3, 6 substituted quinazolinones of the formula ##STR1## wherein, R, R6 and X are defined in the specification which have activity as angiotensin II (AII) antagonists.... | 02/08/1994 |
| 5281603 | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones The invention provides novel 2,3,6-substituted quinazolinones having the formula ##STR1## wherein R6 is ##STR2## and X, R, R1, R2, R3, R4 and R8 are described in the specific... | 01/25/1994 |
| 5281628 | 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines 9-amino-7-(substituted amino)-6-demethyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the novel co... | 01/25/1994 |
| 5281604 | Angiotensin II receptor blocking 2,3,6-substituted quinazolinones The invention provides novel 2,3,6 substituted quinazolinones of the formula ##STR1## wherein X, R and R6 are defined in the specification which have activity as angiotensin II (AII) antagonists.... | 01/25/1994 |
| 5281602 | Angiotensin II receptor blocking 2,3,6-substituted 5,6,7,8-tetrahydro-pyrido[4,3-D]pyrimidin-4(3H)-ones The invention provides novel 2,3,6-substituted 5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4 (3H)-ones of the formula ##STR1## wherein X, R and R6 are described in the specification which have activity as angiotensin II (AII) antagonists.... | 01/25/1994 |
| 5262173 | Pulsatile once-a-day delivery systems for minocycline Pharmaceutical delivery systems containing 7-dimethyl-6-deoxy-6-demethyltetracycline or a non-toxic acid addition salt thereof comprising mixtures of a minor proportion of slow-release blended polymer coated spherical granules adapted to release part of t... | 11/16/1993 |
| 5248797 | Method for the production of 9-amino-6-demethyl-6-deoxytetracycline The invention relates to a novel method for producing [4S-(4alpha, 12aalpha)]-9-amino-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3, 10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide, hereinafter called 9-amino-6-demethyl-6-deoxytetracycline... | 09/28/1993 |
| 5229411 | Substituted benz[cd]indol-2-(1H)-ones and use as antihypertensive agents Compounds of the formula: ##STR1## wherein R1, R2 and m are defined in the specification are provided. These compounds are useful as antihypertensive agents.... | 07/20/1993 |
| 5222529 | Filling apparatus An apparatus for filling finely powdered material into a long and narrow cavity or hole having a relatively small opening is provided. The apparatus features a discharge port for a particulate laden gas stream directed toward the opening of the hole to be... | 06/29/1993 |
| 5212291 | Anthracycline derivatives as solubilized pro-drugs The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guanidine, isourea, isothiourea and biguanide functions ... | 05/18/1993 |
| 5208223 | Phosphocholine derivative inhibitors of phospholipase A2 Phospocholine derivatives having the formula: ##STR1## in which W, Z, Q and R are described in the specification are disclosed as useful for inhibiting the enzyme phospholipase A2. Methods of making and using the compounds are also disclos... | 05/04/1993 |
| 5173510 | Simplified thioester and isostere analogs of oleoyl coenzyme A as hypocholesterolemic agents New thioester and ester, amide and ketone isostere analogs of oleoyl coenzyme A, useful as antiatherosclerotic agents, are provided. The compounds have the formula: ##STR1## wherein A is selected from the group consisting of ##STR2## Y is s... | 12/22/1992 |
| 5173488 | Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method Injectable aqueous compositions comprising folic acid and leucovorin and their salts, optionally including benzyl alcohol, sodium chloride and agents for adjusting pH are stabilized and buffered in the range of 6 to 10 by adding a combination of trometham... | 12/22/1992 |
| 5162328 | N-[3-[2-(1H-imidazol-1-yl)ethoxy]phenyl]-4-(2-thienyl)-2-pyrimidinamine and pharmacologically acceptable salts N-[3-[2-(1H-Imidazol-1-yl)ethoxy]phenyl]-4-(2-thienyl)-2-pyrimidinamine and pharmacologicaly acceptable salts, useful as antiasthma agents and treatment of allergic diseases and exhibiting improved bioavailability properties.... | 11/10/1992 |
| 5144045 | Phosphocholine derivative inhibitors of phospholipase A2 Phospocholine derivatives having the formula: ##STR1## in which W, Z, Q and R are described in the specification are disclosed as useful for inhibiting the enzyme phospholipase A2. Methods of making and using the compounds are also disclos... | 09/01/1992 |
| 5116827 | Quinolinecarboxylic acid derivatives as solubilized pro-drugs The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guanidine, isourea, isothiourea and biguanide functions ... | 05/26/1992 |
| 5114720 | Gelatin coated tablets and method for producing same Pharmaceutical tablets having increased slipperiness and swallowability are provided. The enhanced swallowability is imparted by an overcoat of a low bloom gelatin, which overcoat has a lower coefficient of friction than other known coatings.... | 05/19/1992 |
| 5114946 | Transdermal delivery of pharmaceuticals Compositions and methods for the transdermal delivery of pharmacologically active chiral compounds are described which are based on the use of enantiomers or mixtures that contain a disproportionate amount of the enantiomers.... | 05/19/1992 |
| 5103015 | 5-(substituted)isoxazole compounds A novel process for producing -[(dialkylamino)substituted-methylene]ଲ-oxo-(substituted) propanenitriles of the formula: ##STR1## where R, R1 and R2 are defined in the specification by reacting a substituted iso... | 04/07/1992 |
