Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 7850973 | Peptide conjugate compositions and methods for the prevention and treatment of alzheimer's disease The invention provides compositions and methods for the treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient, such as Alzheimer's disease. Such methods entail administering an immunogenic fragment of Aβ, lacking a T-cell epitope, ... | 12/14/2010 |
| 7479372 | Beta-secretase substrates and uses thereof The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed... | 01/20/2009 |
| 7432414 | Transgenic mouse having an amyloid precursor protein with a modified beta secretase cleavage site The present invention provides transgenic animals having an amyloid precursor protein wherein the amino acids flanking the &bgr; secretase cleavage site are NF and EV. The invention also provides tissues and cell lines derived from such animals. The invention furthe... | 10/07/2008 |
| 7414110 | Human calcium channel compositions and methods Isolated DNA encoding each of human calcium channel α1-, α2-, β- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compound... | 08/19/2008 |
| 7368541 | Trace amine receptor 1 of the African green monkey A trace amine receptor 1 has been isolated from the genome of Cercopithecus aethiops (African green monkey). Described is the amino acid sequence of the receptor, the nucleic acid encoding the receptor, and methods for using the receptor to identify analytes ... | 05/06/2008 |
| 7276206 | Electrical field stimulation of eukaryotic cells Methods of identifying activators and inhibitors of voltage-gated ion channels are provided in which the methods employ electrical field stimulation of the cells in order to manipulate the open/close state transition of the voltage-gated ion channels. This allows fo... | 10/02/2007 |
| 7179620 | Gene responsible for stargardt-like dominant macular dystrophy The gene responsible for Stargardt-like macular dystrophy has been identified, along with its normal allelic form. The mutant gene encodes a mutant protein containing a frameshift mutation, resulting in abnormal fatty acid synthesis and transport in the retina. Also... | 02/20/2007 |
| 7157443 | exopolysaccharide and process A high molecular weight polysaccharide intracellular adhesin (SAE) antigen having the general structure of poly-1,6,β-2-amidoglucopyranoside, which is variable substituted with N-acetyl and O-succinyl substituents is described. Also, a method is given for isolating... | 01/02/2007 |
| 7135307 | Gamma three protease Gamma three protease is provided, a novel aspartyl class protease that is capable of taking part in the processing of amyloid precursor protein (APP) to Aβ peptide. Gamma three protease may be involved in the development and/or progression of Alzheimers disease. Me... | 11/14/2006 |
| 7132401 | Beta-secretase substrates and uses thereof The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed... | 11/07/2006 |
| 7091005 | Gene responsible for Stargardt-like dominant macular dystrophy The gene responsible for Stargardt-like macular dystrophy has been identified, along with its normal allelic form. The mutant gene encodes a mutant protein containing a frameshift mutation, resulting in abnormal fatty acid synthesis and transport in the retina. Also... | 08/15/2006 |
| 7029868 | Cell fusion assays using fluorescence resonance energy transfer Methods of identifying inhibitors of the fusion of two types of cells, particularly when fusion is mediated by the interaction of a viral protein and such cellular proteins as CD4 and chemokine receptors, are disclosed. The methods are suitable for identifying subst... | 04/18/2006 |
| 6472510 | CD40 receptor ligands The present invention relates to a counter-receptor, termed CD40CR, for the CD40 B-cell antigen, and to soluble ligands for this receptor, including fusion molecules comprising at least a portion of CD40 protein. It is based, at least in part, on the disc... | 10/29/2002 |
| 6413514 | Methods of using antibodies against human CD40 A method for the treatment of T cell mediated disorders is described. The method involves administering to a subject a therapeutically effective amount of an anti-human CD40 antibody. Disease states suitable for treatment with this method include graft ve... | 07/02/2002 |
| 6376459 | Inhibiting B cell activation with soluble CD40 or fusion proteins thereof The present invention relates to a counter-receptor, termed CD40CR, for the CD40 B-cell antigen, and to soluble ligands for this receptor, including fusion molecules comprising at least a portion of CD40 protein. It is based, at least in part, on the disc... | 04/23/2002 |
| 6312693 | Antibodies against human CD40 The Applicants have discovered humanized anti-human CD40 antibodies which block the interaction between gp39 and CD40. The anti-CD40 antibodies of the present invention are effective in modulating humoral immune responses against T cell-dependent antigens... | 11/06/2001 |
