Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 8067420 | Substituted pyrazinone melanin concentrating hormone receptor-1 antagonists and methods The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I wherein R1 | 11/29/2011 |
| 8053450 | Amino-benzazoles as P2Yreceptor inhibitors with pyridine ring and heterocyclic components The present invention provides novel amino-benzazoles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases respo... | 11/08/2011 |
| 8044242 | 2-(aryloxy) acetamide factor VIIa inhibitors useful as anticoagulants The present invention relates generally to novel 2-(aryloxy)acetamides of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables W, Y, Z, R7 | 10/25/2011 |
| 8039506 | Bicyclic lactam factor VIIa inhibitors useful as anticoagulants The present invention provides novel bicyclic lactams derivatives, and analogues thereof, of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, ... | 10/18/2011 |
| 8012984 | Substituted pyrazinone melanin concentrating hormone receptor-1 antagonists and methods The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I wherein R1 | 09/06/2011 |
| 7989433 | Substituted thieno[3,2-D]pyrimidines as melanin concentrating hormone receptor-1 antagonists The present invention provides compounds having the following Formula IA and IB, which are useful as MCHR1 antagonists, and includes prodrugs and pharmaceutically acceptable salts thereof: ... | 08/02/2011 |
| 7973159 | Non-basic melanin concentrating hormone receptor-1 antagonists The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compo... | 07/05/2011 |
| 7960569 | Indole antagonists of P2Yreceptor useful in the treatment of thrombotic conditions The present invention provides indole compounds of Formula (I) or (II): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables ring A, X1, X2, X | 06/14/2011 |
| 7956049 | Melanin concentrating hormone receptor-1 antagonists The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I wherein R1a, R1b, R1c, Q, A, ... | 06/07/2011 |
| 7842708 | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIa inhibitors The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L1, M and R11 are as defined her... | 11/30/2010 |
| 7816382 | Linear urea mimics antagonists of P2Yreceptor useful in the treatment of thrombotic condition The present invention provides novel urea mimics and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, W, and R6 are as d... | 10/19/2010 |
| 7728008 | N-linked heterocyclic antagonists of P2Yreceptor useful in the treatment of thrombotic conditions The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variab... | 06/01/2010 |
| 7714002 | Carbocycle and heterocycle antagonists of P2Yreceptor useful in the treatment of thrombotic conditions The present invention provides novel urea mimics and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, W, and R6 are as d... | 05/11/2010 |
| 7709646 | Tetrahydroquinoline derivatives useful as serine protease inhibitors The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, B, L1, L2, X1, X2, X3 | 05/04/2010 |
| 7700620 | C-linked cyclic antagonists of P2Yreceptor useful in the treatment of thrombotic conditions The present invention provides novel C-linked cyclic compounds and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are as ... | 04/20/2010 |
| 7674828 | Urea antagonists of P2Yreceptor useful in the treatment of thrombotic conditions The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating disease... | 03/09/2010 |
| 7645799 | Substituted biaryl compounds as factor XIa inhibitors The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R3, and ring B are as defined herein.... | 01/12/2010 |
| 7645778 | Heteroaryl compounds as P2Yreceptor inhibitors The present invention provides novel heteroaryl compounds and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases r... | 01/12/2010 |
| 7626039 | Arylpropionamide, arylacrylamide, ayrlpropynamide, or arylmethylurea analogs as factor XIa inhibitors The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L1, M and R11 are as defined her... | 12/01/2009 |
| 7622585 | Phenylglycinamide derivatives useful as anticoagulants The present invention relates generally to phenylglycinamide derivatives that inhibit serine proteases. In particular it0 is directed to novel phenylglycinamide derivatives, and analogues thereof, which are useful as selective inhibitors of serine protease enzymes o... | 11/24/2009 |
| 7595317 | Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R | 09/29/2009 |
| 7592331 | Macrocyclic factor VIIa inhibitors useful as anticoagulants The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, L, M, W, Z, R1 | 09/22/2009 |
| 7579472 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inhibitors. | 08/25/2009 |
| 7576098 | Heterocyclic compounds as inhibitors of factor VIIa The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable salt, solvate, or prodrug form thereof, which are useful as selective i... | 08/18/2009 |
| 7550499 | Urea antagonists of P2Yreceptor useful in the treatment of thrombotic conditions The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of ... | 06/23/2009 |
| 7482372 | Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) The present application describes novel hydantoin derivatives of formula (I): or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R1, R2, R3, R4, R5 | 01/27/2009 |
| 7470712 | Amino-benzazoles as P2Yreceptor inhibitors The present invention provides novel amino-benzazoles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases respo... | 12/30/2008 |
| 7459564 | Substituted biaryl compounds as factor XIa inhibitors The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R3, and ring B are as defined herein.... | 12/02/2008 |
| 7456195 | Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants The present invention provides novel phenylglycinamide derivatives of Formula (I) or (IV): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables W, W1, ... | 11/25/2008 |
| 7453002 | Five-membered heterocycles useful as serine protease inhibitors The present invention provides a method for treating a thrombotic or an inflammatory disorder administering to a patient in need thereof a therapeutically effective amount of at least one compound of Formula (I) or Formula (V): | 11/18/2008 |
| 7435821 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inhibitors. ... | 10/14/2008 |
| 7429604 | Six-membered heterocycles useful as serine protease inhibitors The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, X1, X2, X3, X4 | 09/30/2008 |
| 7417063 | Bicyclic heterocycles useful as serine protease inhibitors The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, L1, L2, X1, X2,... | 08/26/2008 |
| 7388021 | Urea antagonists of P2Yreceptor useful in the treatment of thrombotic conditions The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating disease... | 06/17/2008 |
| 7388096 | Crystalline forms of a factor Xa inhibitor The instant invention provides crystalline forms of 1-(3-chlorophenyl)-7-oxo-6-[4-(2-oxo-1 (2H)pyridinyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide and its solvates thereof; processes for the production of such crystalline forms; pharmaceuti... | 06/17/2008 |
| 7381732 | Pyrazolobenzamides and derivatives as factor Xa inhibitors The present application describes pyrazolobenzamides and derivatives thereof of Formula I: P4-P-M-M4I or pharmaceutically acceptable salt forms thereof. Compounds of the present invention are useful as inhibitors of trypsin-... | 06/03/2008 |
| 7371864 | Crystalline forms of a factor Xa inhibitor The instant invention provides crystalline forms of 3-(1-hydroxy-1-methyl-ethyl)-1-(4-methoxy-phenyl)-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one and its solvates thereof; processes for the production of such crystalline form... | 05/13/2008 |
| 7312214 | 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors The present application describes 1,1-disubstituted cycloalkyl compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa. ... | 12/25/2007 |
| 7312218 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia-If: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or hetero... | 12/25/2007 |
| 7304157 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inh... | 12/04/2007 |
