Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 8176951 | Versatile systems for continuous in-line blending of butane and petroleum A system and method are provided for in-line processes of blending butane into gasoline streams, and for blending butane into a gasoline stream at any point along a petroleum pipeline. The invention additionally provides a method for measuring the vapor pressure and... | 05/15/2012 |
| 8097651 | Diclofenac formulations and methods of use Methods and formulations are provided for treating migraine and other acute pain episodes using diclofenac, and formulations of diclofenac that provide both rapid and sustained relief from acute pain. Methods and formulations are also provided for treating symptoms ... | 01/17/2012 |
| 8097267 | Moisture resistant container systems for rapidly bioavailable dosage forms Provided are rapidly bioavailable solid oral dosage forms of acute pain medications, and moisture resistant packaging that enables the formulation of such rapidly bioavailable dosage forms. ... | 01/17/2012 |
| 8084225 | Methods for diagnosing cerebrovascular events based on NR2 peptides Methods and kits for diagnosing and treating cerebrovascular events, and for defining the time and anatomical location of an event, are provided based on the detection and quantification of bound or total and unbound NR2 peptides in biological fluids. The methods ar... | 12/27/2011 |
| 8066089 | Dual powered full suspension tricycle A cycling vehicle is provided in which a first rear wheel is powered exclusively by a bicycle pedal, and a second rear wheel is powered exclusively by an electric motor. The cycling vehicle includes bicycle suspension comprising a seat tube, a paired rear triangle w... | 11/29/2011 |
| 8057819 | Stability additives for dry DHA dosage forms The use of additives to stabilize DHA when compressed into tablets, or filled as a powder into capsules, for oral administration. ... | 11/15/2011 |
| 8039457 | Method of stimulating the motility of the gastrointestinal system using growth hormone secretagogues The present invention relates to a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders or diseases) of the gastrointestinal system. The method comprises administer... | 10/18/2011 |
| 8039456 | Method of stimulating the motility of the gastrointestinal system using ipamorelin The present invention provides a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders, diseases, conditions, or drug- or surgery-induced dysfunction) of the gastroi... | 10/18/2011 |
| 8039024 | Device and composition for the delivery of a preservative-free balsamic cream A device and composition for delivering menthol, camphor, eucalyptus essential oils, and other essential oils with balsamic benefits, to be used for the relief of symptoms of common cold. ... | 10/18/2011 |
| 7994329 | Growth hormone secretagogue receptor type 1A agonists Compounds that are ligands for the growth hormone secretagogue receptor type 1A (GHS-R 1A), as well as pharmaceutically acceptable salts of such compounds, are useful for the manufacture of medicaments for the regulation of food intake. ... | 08/09/2011 |
| 7960424 | Liquid pharmaceutical formulations of palonosetron The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.... | 06/14/2011 |
| 7947725 | Liquid pharmaceutical formulations of palonosetron The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.... | 05/24/2011 |
| 7947724 | Liquid pharmaceutical formulations of palonosetron The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.... | 05/24/2011 |
| 7939561 | Blister packaging for acute pain regimens Provided are rapidly bioavailable solid oral dosage forms of acute pain medications, and moisture resistant packaging that enables the formulation of such rapidly bioavailable tablet dosage forms. Also provided is packaging that discourages the use of rapidly bioava... | 05/10/2011 |
| 7825138 | Crystal forms of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide Crystalline polymorphs of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide which are useful as pharmaceutical agents are disclosed. Methods of production and isolation of these polymorphs and pharmaceutical c... | 11/02/2010 |
| 7820398 | Immunosorbent blood tests for assessing paroxysmal cerebral discharges Immunosorbents, kits and compositions for diagnosing a central nervous system disorder, particularly paroxysmal cerebral discharges and epilepsy, comprising measuring the concentration of GluR1 or fragment thereof and/or GluR1 antibodies in a biological sample from ... | 10/26/2010 |
| 7759394 | Diclofenac formulations and methods of use Methods and formulations are provided for treating migraine and other acute pain episodes using diclofenac, and formulations of diclofenac that provide both rapid and sustained relief from acute pain. Methods and formulations are also provided for treating symptoms ... | 07/20/2010 |
| 7700125 | Moisture resistant container systems for rapidly bioavailable dosage forms Provided are rapidly bioavailable solid oral dosage forms of acute pain medications, and moisture resistant packaging that enables the formulation of such rapidly bioavailable dosage forms. ... | 04/20/2010 |
| 7687542 | Rapidly bioavailable tablet and capsule formulations of diclofenac The present invention relates to excipients for the production of rapidly bioavailable solid oral dosage forms of diclofenac. In particular, the invention relates to the use of excipients that promote the bioavailability of such formulations, including alkaline buff... | 03/30/2010 |
| 7658911 | Antibody assay methods to assess risk for TIA/stroke A methods, kits and compositions for diagnosing a central nervous system disorder, particularly transient ischemic attack or stroke, comprising measuring the level of NR2A and/or NR2B NMDA receptor or fragment thereof, in a biological sample from a human subject, an... | 02/09/2010 |
| 7631671 | Versatile systems for continuous in-line blending of butane and petroleum A system and method are provided for in-line processes of blending butane into gasoline streams, and for blending butane into a gasoline stream at any point along a petroleum pipeline. The invention additionally provides a method for measuring the vapor pressure and... | 12/15/2009 |
| 7622114 | Assay methods for immediate diagnosis of cause of stroke A methods, kits and compositions for diagnosing a central nervous system disorder, particularly transient ischemic attack or stroke, comprising measuring the level of NR2A and/or NR2B NMDA receptor or fragment thereof, in a biological sample from a human subject, an... | 11/24/2009 |
| 7622100 | Rapid multiple panel of biomarkers in laboratory blood tests for TIA/stroke A methods, kits and compositions for diagnosing a central nervous system disorder, particularly transient ischemic attack or stroke, comprising measuring the level of NR2A and/or NR2B NMDA receptor or fragment thereof, in a biological sample from a human subject, an... | 11/24/2009 |
| 7547818 | Metaphase donor cells for effective nuclear reprogramming in mammals The present invention provides methods of producing a clone non-human mammalian nuclear transfer (NT) embryo and methods for producing a cloned non-human mammal. Embodiments of the methods include introducing doner genetic material into a metaphase I oocyte; introdu... | 06/16/2009 |
| 7146277 | NMR assisted design of high affinity ligands for structurally uncharacterized proteins Methods of using NMR spectroscopy for identifying ligands that bind to structurally uncharacterized proteins, and improving the binding affinity of ligands for biological targets are disclosed. One aspect of the method includes preparing first NMR spectra of a first... | 12/05/2006 |
| 7482377 | Pharmaceutical compositions and methods of treatment based on diclofenac New pharmaceutical compositions for oral use containing diclofenac together with alkali metal bicarbonates in amounts of from 20 to 80 by weight with respect to diclofenac are described. These compositions are entirely palatable and free from any unpleasant taste or... | 01/27/2009 |
| 7390511 | Compositions containing vitamin E and saw palmetto Mineral additives for preparing tablet compositions that comprise Vitamin E and optionally saw palmetto. The compositions are preferably formulated with a zinc compound and a selenium compound. ... | 06/24/2008 |
| 7351544 | Methods to identify and quantify oligosaccharide modifications of glycoproteins Methods are disclosed for identifying oligosaccharides found on proteins and identifying those that are modified in disease states. ... | 04/01/2008 |
| 7186421 | Mineral additives for improved processing of compositions containing vitamin E and saw palmetto Mineral additives for preparing tablet compositions that comprise Vitamin E and optionally saw palmetto. The compositions are preferably formulated with a zinc compound and a selenium compound. ... | 03/06/2007 |
| 7169257 | Method of deinking waste paper using a reduced alkali system The present invention relates to methods and compositions for deinking waste paper, optionally in non-alkaline or low-alkaline systems. Deinking compositions are provided that include a blend of an alkoxylated fatty alcohol and a fatty acid. The compositions may fur... | 01/30/2007 |
| 7163922 | Tripeptide derivatives for the treatment of postlesional diseases of the nervous system The invention relates to the use of specific tripeptides for the treatment of postlesional diseases of ischemic, traumatic or toxic origin. The tripeptide derivatives satisfy formula (I), wherein X represents OH, (C1-5)alkoxy, NH2, NH—C1... | 01/16/2007 |
| 7141172 | Versatile simulated moving bed systems Distributed valve simulated moving beds are described in which junctions located between successive columns interrupt the flow of process fluid between columns, and either transmit the process fluid through a zone bypass to a succeeding column within the same zone o... | 11/28/2006 |
| 7032629 | Method and system for blending gasoline and butane at the point of distribution A system and method is provided for blending butane with gasoline at petroleum tank farms, immediately before distribution to tanker trucks. The invention provides a method for blending gasoline and butane at a tank farm comprising: (a) drawing a gasoline stream fro... | 04/25/2006 |
| 6974595 | Pharmaceutical compositions based on Diclofenae New pharmaceutical compositions for oral use containing Diclofenac together with alkali metal bicarbonates in amounts of from 20 to 80 by weight with respect to Diclofenac are described. These compositions are entirely palatable and free from any unpleasant taste or... | 12/13/2005 |
| 6896872 | Rapid multiple panel of biomarkers in laboratory blood tests for TIA/stroke A methods, kits and compositions for diagnosing a central nervous system disorder, particularly transient ischemic attack or stroke, comprising measuring the level of NR2A and/or NR2B NMDA receptor or fragment thereof, in a biological sample from a human subject, an... | 05/24/2005 |
| 6784146 | Deinking method and composition for wastepaper The present invention is a deinking method and composition that uses at least 50% by weight based on the total weight of surfactants of non-ionic, C16 to C25 aliphatic, monohydric alcohol alkoxylates having 14 to 40 moles of ethylene oxide per mole of alcohol and 0 ... | 08/31/2004 |
| 6777401 | Aqueous solvent for corticosteroids A solvent comprising a combination of water and organic solvent(s) capable of dissolving a therapeutically effective amount of medicament(s) not readily soluble in aqueous solvents, said organic solvents including alcohol and glycol, and said medicaments including h... | 08/17/2004 |
| 6679302 | Method and system for blending gasoline and butane at the point of distribution A system and method is provided for blending butane with gasoline at petroleum tank farms, immediately before distribution to tanker trucks. The invention provides a method for blending gasoline and butane at a tank farm comprising: (a) drawing a gasoline... | 01/20/2004 |
| 6652633 | Fire retardant Improved fire retardants that include guanylurea phosphate [(H2 N--C(NH)--NH--C(O)--NH2).H3 PO4 ] (GUP) and boric acid, materials such as wood and composite wood products that include these fire retardants, and ... | 11/25/2003 |