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An armor with rollers is provided that enables a user to move in all positions by rolling on a hard and smooth surface while constantly varying his bearing points on the ground.
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| Number | Title | Issue Date |
| 7705168 | Manufacturing process for tigecycline Disclosed herein is a manufacturing process for the preparation of tigecycline suitable for intravenous infusion. ... | 04/27/2010 |
| 6989388 | Thieno[2,3-c]iosquinolines for use as inhibitors of PARP The present invention relates to compounds for the inhibition of poly(ADP-ribose) polymerase (PARP). In some embodiments, the compounds have the Formula: wherein the constituent variables are as defined herein. The invention furth... | 01/24/2006 |
| 7368471 | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) This invention provides compounds of the formula: wherein: X is a chemical bond, —CH2— or —C(O)—; R1 is alkyl, cycloalkyl, —CH2-cycloalkyl, pyridinyl, —CH2-pyridinyl, ... | 05/06/2008 |
| 7345032 | Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl}phosphonic acid and esters thereof The present invention provides methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl}phosphonic acid, and esters thereof. ... | 03/18/2008 |
| 7129258 | Substituted benzoxazoles as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X a... | 10/31/2006 |
| 7126683 | Direct method for the correction of pressure induced scrambling of polarized fluorescence intensities The present invention provides a simple and direct method for the simultaneous correction of steady-state polarized fluorescence intensities, depolarized (or scrambled) by the effects of applied hydrostatic pressure without having to first determine the scrambling f... | 10/24/2006 |
| 7101875 | Methods for treating arthritic disorders This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods ... | 09/05/2006 |
| 7097969 | Non-endogenous, constitutively activated known G protein-coupled receptors The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is known (“known GPCRs”), and most particularly to mutated (non-endogenous) versions of th... | 08/29/2006 |
| 7094469 | Porous or non-porous substrate coated with an immobilized polymeric composition having sulfonyl groups and hydrophilic functional groups and process A porous or non-porous polymeric substrate having its surface modified with an immobilized fluorocarbon such as perfluorocarbon, polymeric composition is provided. The immobilized fluorocarbon is formed from a monomer having formula: [T—SO2Y—SO2 | 08/22/2006 |
| 7053083 | Cyclohexylphenyl vasopressin agonists The present invention provides compounds of the general formulas: wherein Y is NR or —(CH2)n; R is H or alkyl “Z” represents optionally substituted phenyl or a 6-membered aromatic ring... | 05/30/2006 |
| 7022733 | Substituted 2-phenyl benzofurans as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R, R′, A, A′, X, Y, and Y are as defined in the specification, or a pharmaceutically acceptable salt there... | 04/04/2006 |
| 6960607 | Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, and R4, and X as defined in the specification, or a p... | 11/01/2005 |
| 6956646 | Direct method for the correction of pressure induced scrambling of polarized fluorescence intensities The present invention provides a simple and direct method for the simultaneous correction of steady-state polarized fluorescence intensities, depolarized (or scrambled) by the effects of applied hydrostatic pressure without having to first determine the scrambling f... | 10/18/2005 |
| 6914074 | Substituted phenyl naphthalenes as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R6, R7, R | 07/05/2005 |
| 6903091 | Biphenyl vasopressin agonists A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH2)n; wherein R is hydrogen or (C1-C6 | 06/07/2005 |
| 6902902 | Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In preferred embodiments, the GPCR is human. In other preferred embodiments, the GPCR is coupled to Gi and lowers the level of... | 06/07/2005 |
| 6884814 | Phenyl benzisoxazoles as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, and R3 are as defined in the specification, o... | 04/26/2005 |
| 6858226 | Fusogenic lipids and vesicles Novel lipid compounds are provided that may be termed “pro-cationic” in that they are neutral or negatively charged until they are either brought into contact with cellular membranes or are internalized by cells. The lipids have a hydrophobic tail group and a hy... | 02/22/2005 |
| 6849660 | Antimicrobial biaryl compounds Provided are antibacterial compounds having Formula I: In such compositions, X is O or S; Y is CH2; n is 0 or 1. One of R1 and R1′ is —C(O)NR5R5′ | 02/01/2005 |
| 6841539 | Compositions and methods for topical delivery of oligonucleotides The present invention relates to compositions and methods which enhance the delivery of oligonucleotides and other nucleosidic moieties via topical routes of administration. Preferred compositions include liposomes or penetration enhancers for the delivery of such m... | 01/11/2005 |
| 6841349 | Methods for the reduction of stutter in microsatellite amplification The invention provides a method for reducing stutter in the amplification of a microsatellite comprising the steps of providing a sample comprising a microsatellite having a G+C content of 50% or less; contacting the sample with at least one enzyme having nucleic ac... | 01/11/2005 |
| 6806054 | Non-endogenous, constitutively activated known G protein-coupled receptors The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is known (“known GPCRs”), and most particularly to mutated (non-endogenous) versions of th... | 10/19/2004 |
| 6774248 | Substituted 2-phenyl benzofurans as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R, R′, A, A′, X, Y, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.... | 08/10/2004 |
| 6753423 | Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals The invention is directed to oligonucleotides and oligonucleosides functionalized to include lipophilic moieties and having improved biostability and altered biodistribution in mammals. In one embodiment, such lipophilic oligonucleotide conjugates are used in a meth... | 06/22/2004 |
| 6747014 | Compositions and methods for non-parenteral delivery of oligonucleotides The present invention relates to compositions and methods which enhance the local and systemic uptake and delivery of oligonucleotides and nucleic acids via non-parenteral routes of administration. Pharmaceutical compositions comprising oligonucleotides disclosed he... | 06/08/2004 |
| 6721754 | System and method for database similarity join Disclosed herein are systems and methods for information organization whereby characteristics regarding entities are inferred from the characteristics of similar entities. This is referred to herein as a “fuzzy similarity join” and is exemplified using a chemica... | 04/13/2004 |
| 6653086 | Endogenous constitutively activated G protein-coupled orphan receptors Disclosed herein are techniques for directly identifying candidate compounds as agonists, partial agonists and/or, most preferably, inverse agonists, to endogenous, constitutively activated orphan G protein-coupled receptors. Such directly identified comp... | 11/25/2003 |
| 6546786 | Methods and apparatus for detection of radioactivity in liquid samples Methods and devices for stop flow detection and measurement of radioactivity in liquid samples are provided. In some embodiments, the invention includes precise positioning of fractions within a flow cell detection area. Novel flow cells and methods provi... | 04/15/2003 |
