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| Number | Title | Issue Date |
| 6245357 | Extended release dosage form A dosage form comprising a composition comprising a drug surrounded by an interior and an exterior wall with an exit for administering the drug to a patient; and a method of using the dosage form are disclosed for an indicated therapy.... | 06/12/2001 |
| 6246904 | Electrotransport drug delivery reservoirs containing inert fillers A novel electrotransport drug delivery system (10) and therapeutic agent-containing reservoir (26, 28) for use therein are provided. An inert filler material effective to reduce the quantity of therapeutic agent otherwise present is incorporated in the re... | 06/12/2001 |
| 6238700 | Method for preventing crystal formation in a dispersion of a liquid in a matrix An improved method for the manufacture of transdermal drug delivery devices comprising liquid dispersions of a liquid in an aqueous or nonaqueous matrix is disclosed. More particularly, the invention relates to preventing the formation of a crystalline st... | 05/29/2001 |
| 6217905 | Antiparkinson dosage form A dosage form is disclosed comprising an anti-Parkinson's disease drug for administering to a patient in need of anti-Parkinson's disease therapy.... | 04/17/2001 |
| 6165497 | Subsaturated nicotine transdermal therapeutic system Rate controlled transdermal nicotine delivery systems are disclosed which utilize an in-line adhesive to maintain the systems on the skin. The initial equilibrated concentration of nicotine in the nicotine reservoir and the adhesive is below saturation, p... | 12/26/2000 |
| 6146662 | System for delaying drug delivery up to seven hours A dosage form is disclosed comprising means for delaying the delivery of drug from the dosage form following the administration of the dosage form to a patient in need of drug therapy.... | 11/14/2000 |
| 5776493 | Oral osmotic device for delivery of nystatin with hydrogel driving member An osmotic device (10) for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The dev... | 07/07/1998 |
| 5667804 | Banded prolonged release active agent dosage form The present invention is directed to an active agent dosage form which is useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a matrix that has on its surface two or more insolubl... | 09/16/1997 |
| 5508038 | Polyisobutylene adhesives for transdermal devices An in-line adhesive, useful for transdermal delivery devices comprising a mixture of high and low molecular weighted polyisobutylene having a ratio HMW PIB:LMW PIB in the range of about 5-40:95-60 which is substantially free of plasticizers and tackifiers... | 04/16/1996 |
| 5462745 | Subsaturated transdermal therapeutic system having improved release characteristics Rate controlled transdermal delivery devices are disclosed which utilize an in-line adhesive to maintain the device on the skin and deliver an agent which is a solvent or a plasticizer for the in-line adhesive. The initial equilibrated concentration of th... | 10/31/1995 |
| 5417976 | Density element and method of manufacture thereof A density element (12) for use in ruminal delivery devices (10) which is manufactured by partial sintering in such a manner as to fragment upon contact with the many parts in rendering machinery without damage to the blades. The density element (12) has d... | 05/23/1995 |
| 5372776 | Density element and method of manufacture thereof to achieve a particular transverse rupture strength A density element (12) for use in ruminal delivery devices (10) which is manufactured by partial sintering in such a manner as to fragment upon contact with the many parts in rendering machinery without damage to the blades. The density element (12) has d... | 12/13/1994 |
| 5364630 | Subsaturated nicotine transdermal therapeutic system Rate controlled transdermal nicotine delivery systems are disclosed which utilize an in-line adhesive to maintain the systems on the skin. The initial equilibrated concentration of nicotine in the nicotine reservoir and the adhesive is below saturation, p... | 11/15/1994 |
| 4871548 | Controlled release dosage form comprising different cellulose ethers A dosage form is disclosed comprising a low number average molecular weight hydroxypropylmethylcellulose, a high number average molecular weight hydroxypropylmethylcellulose, and a beneficial drug.... | 10/03/1989 |
| 4871544 | Ruminant dispensing device A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) an expandable composition comprising a dense member in the space, (3) a composition comprising a beneficial agent and a ... | 10/03/1989 |
| 4871360 | System for intravenous delivery of a beneficial drug at a regulated rates A formulation chamber is disclosed comprising a wall surrounding a space containing a beneficial agent. The formulation chamber has an inlet for admitting a fluid into the chamber and an outlet for letting the fluid containing the agent leave the chamber.... | 10/03/1989 |
| 4867969 | Hydrogel formulation for administering non-steroidal drugs A composition of matter comprising a drug, a neutral hydrogel and an ionic hydrogel. The composition can be administered from a delivery system to a biological receptor over time.... | 09/19/1989 |
| 4865845 | Release rate adjustment of osmotic or diffusional delivery devices A sleeve shaped structure covers a portion of the transport area of a diffusional or osmotic delivery device. The structure is durable and inert to the use environment. Markings on the structure indicate where breaking or cutting will produce a predictabl... | 09/12/1989 |
| 4865598 | Dispensing system for administering beneficial agent A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) an expandable composition in the space, (3) an aqueous sensitive beneficial agent formulation in the space, and (4) at l... | 09/12/1989 |
| 4863456 | Dosage form with improved delivery capability A dosage form is disclosed comprising a wall surrounding a compartment housing a first layer comprising a drug formulation, a middle layer comprising a hydrophobic composition, and a third layer comprising a hydrophilic composition.... | 09/05/1989 |
| 4863744 | Intestine drug delivery A delivery system is disclosed for delivering an agent to a selected environment of use having a pH of greater than 3.5.... | 09/05/1989 |
| 4863738 | Skin permeation enhancer compositions using glycerol monooleate A method for enhancing the flux of transdermally deliverable drugs through intact skin is described in which the drug is delivered simultaneously with glycerol monooleate. Preferred embodiments of therapeutic systems for delivering drug and glycerol monoo... | 09/05/1989 |
| 4859470 | Dosage form for delivering diltiazem A device is disclosed for delivering diltiazem at a controlled and substantially zero order rate over a prolonged period of time.... | 08/22/1989 |
| 4857052 | Intravenous system for delivering a beneficial agent A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chambe... | 08/15/1989 |
| 4857330 | Chlorpheniramine therapy An osmotic dosage form is disclosed for delivering chlorpheniramine.... | 08/15/1989 |
| 4855141 | Device comprising means for protecting and dispensing fluid sensitive medicament A delivery device is disclosed for delivering a beneficial agent to an animal. The device comprises a wall housing an internal space, a beneficial agent in the space, expandable means in the space for causing the beneficial agent to be delivered from the ... | 08/08/1989 |
| 4851232 | Drug delivery system with means for obtaining desirable in vivo release rate pattern A delivery device is disclosed for delivering a beneficial drug to a biological environment of use. The device comprises a hydrogel reservoir containing tiny pills. The tiny pills comprise a wall surrounding a drug core.... | 07/25/1989 |
| 4851229 | Composition comprising a therapeutic agent and a modulating agent An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.... | 07/25/1989 |
| 4851231 | System for delivering drug in selected environment of use A delivery system is disclosed for delivering an agent to a selected environment of use having a pH of greater than 3.5.... | 07/25/1989 |
| 4849226 | Method for increasing oxygen supply by administering vasodilator A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.... | 07/18/1989 |
| 4847093 | Dosage form with means for governing rate of gas formation An osmotic device is disclosed comprising a release rate controlling wall that surrounds a carbon dioxide generating compound.... | 07/11/1989 |
| 4846826 | Method for treating ischemic conditions A method is disclosed for treating an ischemic condition. The method comprises coadministering topically and internally a vasodilator to a patient having the condition for treating the condition.... | 07/11/1989 |
| 4844984 | Dispensing system with means for increasing delivery of beneficial agent from the system A dispensing system is disclosed comprising a wall surrounding a lumen. The lumen comprises (1) a thermo responsive composition comprising a beneficial agent, (2) means for occupying space in the lumen for pushing the thermo responsive composition from th... | 07/04/1989 |
| 4842867 | Pulsed drug delivery of doxylamine A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.... | 06/27/1989 |
| 4837111 | Dosage form for dispensing drug for human therapy An osmotic dosage system is disclosed for delivering the therapeutically beneficial drug doxazosin to an environment of use over time.... | 06/06/1989 |
| 4837027 | Transdermal drug delivery device A diffusional drug delivery device is described which can provide for stability of the adhesive and system components, elimination of the initial burst of drug and hence irritation, and to provide for delayed onset of therapeutic effect along with deliver... | 06/06/1989 |
| 4834979 | Medical bandage for administering beneficial drug A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.... | 05/30/1989 |
| 4824675 | Dispenser with movable matrix comprising a plurality of tiny pills A dispenser is disclosed for delivering tiny pills to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on le... | 04/25/1989 |
| 4822802 | Method of fentanly administration for postoperative pain relief A method of postoperative pain relief using transdermal delivery of fentanyl or its analgetically effective derivatives preceded by a dose of said material to increase the serum drug levels to steady state more quickly.... | 04/18/1989 |
| 4820720 | Transdermal drug composition with dual permeation enhancers A dosage form that coadministers a drug and two percutaneous absorption enhancers to a defined area of the skin is described. The dosage form comprises a body that contains supplies of drug and enhancers and has a basal surface that contacts the area of s... | 04/11/1989 |
