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| Number | Title | Issue Date |
| 8119797 | Production method The present invention relates to a process for preparing compounds of general formula I wherein R1 and R2 are defined as in claim 1, the pharmaceutically acceptable salts and the solvates thereo... | 02/21/2012 |
| 8110575 | Compounds The present invention relates to new CGRP-antagonists of general formula I wherein U, V, X, Y, R1, R2, R3 and R4 are defined as in the description, the tautomers, the isomers, the... | 02/07/2012 |
| 8084634 | Production method The present invention relates to a process for preparing compounds of general formula I wherein R1 and R2 are defined as in claim 1, the pharmaceutically acceptable salts and the solvates thereo... | 12/27/2011 |
| 8071583 | Pyrrolo[3,2-D] pyrimidines as DPP-IV inhibitors for the treatment of diabetes mellitus The present invention relates to substituted pyrrolo[3,2-d]pyrimidines of formula (I), wherein R1 and R2 are defined as in claim 1, including the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularl... | 12/06/2011 |
| 8067617 | Indolinone derivatives and process for their manufacture The present invention relates to specific indolinone derivatives, namely the compounds of formula, in which R1 represents an hydrogen atom or a group, and R2 and R3 each represent an hydrogen atom or R2 and R3 t... | 11/29/2011 |
| 8039638 | Inhibitors of HIV replication The present invention relates to compounds of formula (I) wherein R1, R2, R3 and R4 are as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present... | 10/18/2011 |
| 8034941 | Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula wherein Y and R1 to R4 are defined as in claim 1, the tautomers, enantiomers, diaste... | 10/11/2011 |
| 7989474 | Use of Lck inhibitors for treatment of immunologic diseases The invention relates to a method of treating immunologic diseases or pathological conditions involving an immunologic component using certain Lck inhibitors already known as kinase inhibitors for therapy in oncology, optionally in combination with one or more other... | 08/02/2011 |
| 7985747 | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions The present invention relates to the CGRP antagonists of general formula wherein A, X, D, E, G, M, Q and R1 to R3 are defined as in claim 1, the tautomers, the isomers, the diastereom... | 07/26/2011 |
| 7956068 | Inhibitors of human immunodeficiency virus replication The present invention relates to compounds of formula (I) wherein c, X, Y, R2, R3, R4 and R6 are as defined herein, compositions and uses thereof for treating human immunodeficien... | 06/07/2011 |
| 7939545 | Inhibitors of human immunodeficiency virus replication Compounds of formula I: wherein a, b, c, X, R2, R3, R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication. ... | 05/10/2011 |
| 7906539 | Imidazoles and triazoles, their preparation, and their use as pharmaceutical compositions The present invention relates to imidazoles and triazoles of general formula wherein R1 to R4 and X are defined as in claims 1 to 8, the tautomers, the enantiomers, the diastereomers, the... | 03/15/2011 |
| 7897603 | Selected CGRP-antagonists, processes for preparing them and their use as pharmaceutical compositions The present invention relates to the CGRP-antagonists of general formula I wherein R1, R2, R3 and R4 are defined as in claim 1, the tautomers, the isomers, the diastereomer... | 03/01/2011 |
| 7858622 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions The present invention relates to the CGRP antagonists of general formula I wherein R1, R2, R3 and R4 are as defined in claim 1, the tautomers, the isomers, the diastereomer... | 12/28/2010 |
| 7858618 | Compounds The present invention relates to compounds of general formula I wherein A, B, D, Y, R1, R2, R3, R4 and R5 are defined as in the specification, the enantiomers, the dias... | 12/28/2010 |
| 7838529 | Xanthine derivates, their preparation and their use in pharmaceutical compositions Compounds of formula (I) wherein R1 is a phenylcarbonylmethyl group wherein the phenyl moiety is substituted by R10 and R11 and R2 to R4 and R | 11/23/2010 |
| 7807666 | CGRP antagonists The invention relates to a method for treating irritable bowel syndrome through the use of effective amounts of a compound acting as CGRP antagonist. ... | 10/05/2010 |
| 7754756 | Indol-containing beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 and R2 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, di... | 07/13/2010 |
| 7750009 | Substituted pteridines for the treatment of inflammatory diseases The invention relates to new pteridines which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases o... | 07/06/2010 |
| 7732466 | Substituted thiophene carboxamides, process for their preparation and their use as medicaments The present invention relates to new substituted thiophene-2-carboxylic acid amides of general formula wherein A, and R1 to R8c are defined as in claim 1, the tautomers, the enantiomers, the dia... | 06/08/2010 |
| 7718654 | Substituted pteridines for the treatment of inflammatory diseases The invention relates to new pteridine compounds of formula 1 wherein R1, R2 , R3 and R4 have the meanings given herein, which are useful for the treatment of respiratory or gastroi... | 05/18/2010 |
| 7700598 | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions The present invention relates to the CGRP antagonists of general formula wherein A, X, D, E, G, M, Q and R1 to R3 are defined as in claim 1, the tautomers, the isomers, the diastereome... | 04/20/2010 |
| 7700589 | CGRP antagonists CGRP antagonists of the formula of which the following are exemplary: (1) 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-... | 04/20/2010 |
| 7699052 | Apparatus for the dispensing of liquids, container cartridge suitable for this, and system comprising the apparatus for the dispensing of liquids, and the container cartridge The present invention relates to a propellant-gas-free apparatus for the dispensing of liquids, a container cartridge suitable for this for storing the liquid and the ensemble comprising both. The invention comprises a device for the exertion of pressure and for acc... | 04/20/2010 |
| 7696346 | Production method The present invention relates to a process for preparing compounds of general formula I wherein R1 and R2 are defined as in claim 1, the pharmaceutically acceptable salts and the solvates thereo... | 04/13/2010 |
| 7696209 | CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions The present invention relates to the CGRP-antagonists of general formula I wherein R1, R2, R3, R4 and X are defined as in claim 1, the tautomers, the isomers, the diastereo... | 04/13/2010 |
| 7696196 | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions The present invention relates to the CGRP antagonists of general formula wherein A, X, D, E, G, M, Q and R1 to R3 are defined as in claim 1, the tautomers, the isomers, the diastereomers, ... | 04/13/2010 |
| 7696195 | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions The present invention relates to the CGRP antagonists of general formula wherein A, X, Q and R1 to R3 are defined as in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, t... | 04/13/2010 |
| 7681811 | System comprising a nozzle and a fixing means therefor The invention relates to a nozzle system for a delivery device for liquids, wherein the nozzle system comprises a nozzle and a device which fixes the nozzle in the delivery device. The delivery device, an atomizer, has a liquid reservoir from which a liquid is force... | 03/23/2010 |
| 7648988 | Substituted pteridines for the treatment of inflammatory diseases Described are new pteridine compounds of the formula 1, where the variables are as described herein. The compounds are useful for the treatment of: respiratory or gastrointestinal complaints or diseases; inflammatory diseas... | 01/19/2010 |
| 7642277 | Non-nucleoside reverse transcriptase inhibitors Disclosed herein are compounds of formula Ar1—X—W—Ar2 wherein Ar1 and Ar2 represent aryl groups characterized generally as aromatic heterocycles (e.g. imidazolyl or tetrazolyl) or carbocycles (e.g. phenyl or naphthal... | 01/05/2010 |
| 7638625 | Crystalline compounds The present invention relates to the new crystalline compounds A of general formula I wherein A1, A2, A3, X, Y1, Y2 and Y3 are defined as in claim 1, ... | 12/29/2009 |
| 7625886 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions The present invention relates to the CGRP antagonists of general formula I wherein R1, R2, R3 and R4 are defined as in claim 1, the tautomers, the isomers, the diastereomer... | 12/01/2009 |
| 7615549 | Substituted pyrrolidinones, their manufacture and their use as medicaments The present invention relates to new substituted pyrrolidinones of general formula wherein A, X, B and R1 to R9 are as defined above, or a tautomer or salt thereof, particularly the physiologically acc... | 11/10/2009 |
| 7595312 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions The present invention relates to CGRP antagonists of general formula wherein A, U, V, W, X and R1 to R3 are defined as in claim 1, the tautomers, diastereomers, enantiomers, hydrates,... | 09/29/2009 |
| 7582625 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions The present invention relates to the CGRP-antagonists of general formula I wherein R1, R2, R3 and R4 are defined as in claim 1, the tautomers, the isomers, the diastereomer... | 09/01/2009 |
| 7579341 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions The present invention relates to the CGRP antagonists of general formula I wherein R1, R2, R3 and R4 are as defined in claim 1, the tautomers, the isomers, the diastereomer... | 08/25/2009 |
| 7569723 | Benzoic acid derivatives as non nucleoside reverse-transcriptase inhibitors Compounds of formula (I): wherein R1, R2, R3, R4, R5 and R6 are as defined herein. The compounds are useful as reverse transcriptase inhibitors against HIV. ... | 08/04/2009 |
| 7563786 | Substituted thiophenecarboxamides, their preparation and their use as medicaments The present invention relates to novel substituted thiophene-2-carboxamides of the general formula in which A, Ar and R1 to R5 are as defined in claim 1, their tautomers, their enantiomers, thei... | 07/21/2009 |
| 7550472 | Substituted pteridines for the treatment of inflammatory diseases The invention relates to new pteridines which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases o... | 06/23/2009 |
