Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 8178534 | cMET inhibitors Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; meth... | 05/15/2012 |
| 8163755 | Hexahydrooxazinopterine compounds The present invention provides mTOR inhibitors of the formula wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods o... | 04/24/2012 |
| 8088783 | MAPK/ERK kinase inhibitors Compounds of the substituted 1,3-dialkyl-2,4-dioxo-6-(pyrimidinylamino)-1,2,3,4-tetrahydropyrimidine-5-hydroxamic acids, show below: wherein the variables are as defined herein, and pharmaceutical compositions thereof, are ... | 01/03/2012 |
| 8071766 | HSP90 inhibitors The invention relates to HSP90 inhibiting compounds consisting of the formula: wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture compris... | 12/06/2011 |
| 8063066 | MAPK/ERK kinase inhibitors Compounds are provided for use with MEK that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and inte... | 11/22/2011 |
| 8030317 | MAPK/ERK kinase inhibitors Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; metho... | 10/04/2011 |
| 8026234 | Polo-like kinase inhibitors Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; m... | 09/27/2011 |
| 8022057 | MAPK/ERK kinase inhibitors Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; metho... | 09/20/2011 |
| 8003785 | Halo-substituted pyrimidodiazepines The present invention provides PLK1 inhibitor compounds of formula I: useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such ... | 08/23/2011 |
| 7943659 | MAPK/ERK kinase inhibitors Compounds, pharmaceutical compositions, kits and methods are provided for use with MEK that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. ... | 05/17/2011 |
| 7943626 | Substituted 1,3-dialkyl-2,4-dioxo-6-(pyridylamino)-1,2,3,4-tetrahydropyrimidine-5-hydroxamic acid inhibitors of MAPK/ERK kinase Compounds of the substituted 1,3-dialkyl-2,4-dioxo-6-(arylamino)-1,2,3,4-tetrahydropyrimidine-5-hydroxamic acids, show below: wherein the variables are as defined herein, and pharmaceutical compositions thereof, are provide... | 05/17/2011 |
| 7868014 | 1-(hetero)aryl-3-amino-pyrrolidine derivatives for use as mGluR3 antagonists The present invention relates to compounds of the Formula (I) which are useful for treating conditions associated with mGluR3 receptors, such as depression, schizophrenia and migraine, pharmaceutical compositions thereof, and methods of using the same. | 01/11/2011 |
| 7384983 | Inhibitor of monoamine uptake The present invention provides compounds and methods for the inhibition of monoamine uptake in mammals. ... | 06/10/2008 |
| 6559171 | 7-oxo-2-azabicyclo[2.2.1]heptanes as selective muscarinic receptor antagonist The present invention relates to muscarinic receptor modulators, specifically, 7-oxo-2-azabicyclo[2.2.1]heptanes of formula (I) which are useful for the treatment of various diseases and conditions, for example, Alzheimer's disease, glaucoma, psychosis, p... | 05/06/2003 |
| 6187776 | Heterocyclic compounds and their use The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nerv... | 02/13/2001 |
| 6034108 | Method for treating mental retardation The present invention is directed to a method for using 3-(4-hexyloxy-1,2,5-thiadiazol-3yl)-1,2,5,6-tetrahydro-1-methylpyridine, i.e., xanomeline, for the treatment of autism and mental retardation.... | 03/07/2000 |
| 6008412 | Process to make chiral compounds The present invention relates to processes for resolving N-methyl-3(R,S)-hydroxy-3-phenylpropylamine and N,N-dimethyl-3 (R,S) -hydroxy-3-phenylpropylamine with the isomers of mandelic acid and the resulting salts.... | 12/28/1999 |
| 5977139 | Carboxysubstituted cyclic carboxamide derivatives The present invention relates to novel carboxy substituted cyclic carboxamide derivatives of formula (1), ##STR1## and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are ... | 11/02/1999 |
| 5872251 | Process for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.... | 02/16/1999 |
| 5864045 | Heterocyclic substituted piperazinone derivatives The present invention relates to substituted piperazinone derivatives of formula (1) or stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykini... | 01/26/1999 |
| 5861417 | Heterocyclic substituted pyrrolidine amide derivatives The present invention relates to novel heterocyclic substituted pyrrolidine amide derivatives of formula (1), ##STR1## and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists ... | 01/19/1999 |
| 5861416 | Substituted pyrrolidin-3-yl-alkyl-piperidines The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their ... | 01/19/1999 |
| 5859252 | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.... | 01/12/1999 |
| 5849908 | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.... | 12/15/1998 |
| 5840726 | Heterocyclic substituted piperazinone derivatives The present invention relates to substituted piperazinone derivatives (compounds of formula (1)) or stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment ... | 11/24/1998 |
| 5824690 | Substituted pyrrolidin-3-yl-alkyl-piperidines The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their ... | 10/20/1998 |
| 5756739 | Process for preparing polyamine derivative and intermediates thereof The present invention provides a novel process for preparing polyamine derivatives and pharmaceutically acceptable salts thereof, which are useful as antineoplastic agents and to novel intermediates thereof.... | 05/26/1998 |
| 5756762 | (S)-4-amino-hepta-5,6-dienoic acid and intermediates therof The present invention relates to a novel enantiospecific processes for preparing (S)-4-amino-hepta-5,6-dienoic acid and pharmaceutically acceptable salts thereof, which is useful as an irreversible inhibitor of GABA-T, to novel intermediates thereof, and ... | 05/26/1998 |
| 5750521 | Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE The present invention relates to certain mercaptoacetylamide disulfide derivatives of Formula (I) ##STR1## useful as inhibitors of enkephalinase and ACE.... | 05/12/1998 |
| 5734049 | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.... | 03/31/1998 |
| 5693674 | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis The present invention relates to a method of using triaryl-ethylene derivatives in the treatment or prevention bone tissue loss or osteoporosis.... | 12/02/1997 |
| 5691384 | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis The present invention relates to a method of using triaryl-ethylene derivatives in the treatment or prevention bone tissue loss or osteoporosis.... | 11/25/1997 |
| 5684004 | Triaryl-ethylene derivatives The present invention relates to novel triaryl-ethylene derivatives that are useful as anti-neoplastic agents, antiatherosclerotic agents, and hypocholesterolemic agents.... | 11/04/1997 |
| 5679854 | Process for the preparation of (epsilon)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane and novel intermediate thereof The present invention relates to a novel process for preparing (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, also known in the art as (E)-(p-fluorophenethyl)-3-fluoroallylamine, novel intermediates thereof, a novel process for the preparing ... | 10/21/1997 |
| 5654477 | Processes for preparing (S)-4-amino-hepta-5,6-dienoic acid and intemediates thereof The present invention relates to a novel enantiospecific processes for preparing (S)-4-amino-hepta-5,6-dienoic acid and pharmaceutically acceptable salts thereof, which is useful as an irreversible inhibitor of GABA-T, to novel intermediates thereof, and ... | 08/05/1997 |
| 5641880 | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.... | 06/24/1997 |
| 5635510 | Substituted pyrrolidin-3-yl-alkyl-piperidines The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their ... | 06/03/1997 |
| 5629309 | 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE The present invention relates to certain novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and of ACE.... | 05/13/1997 |
| 5604221 | Indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase The present invention relates to certain novel indane-2-mercaptoacetylamide disulfide derivatives of the formula ##STR1## useful as inhibitors of enkephalinase.... | 02/18/1997 |
| 5599986 | Process for the preparation of alkali metal salts of diformylamide The present invention relates to a novel process for preparing alkali metal salts of diformylamide and a novel crystalline form of sodium diformylamide.... | 02/04/1997 |
