Quotables
"The Americans have need of the telephone, but we do not. We have plenty of messenger boys."
Sir William Preece, chief engineer, British Post Office ; 1878
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 5252565 | Haloethyl-substituted steroid enzyme inhibitors The present invention is directed to a group of compounds which are haloethyl substituted steroidal enzyme inhibitors. These compounds are useful as aromatase, 19-hydroxylase, and aldosterone biosynthesis inhibitors and they are prepared from the correspo... | 10/12/1993 |
| 5166211 | Method of using 1,4-disubstituted piperidinyl compounds in the treatment of coronary vasospasons and variant angina The present invention pertains to a new class of compounds which can be characterized as 1,4-disubstituted piperidinyl compounds useful as antiarrhythmics, analgesics, and serotonin 5HT2 antagonists.... | 11/24/1992 |
| 5134154 | Phenoxy-heterocyclic compounds The present invention is directed to a new class of phenoxy-heterocyclic compounds and to their use as anti-depressants and as anxiolytics.... | 07/28/1992 |
| 5112852 | Allenyl amines The present invention relates to allenyl amines, more specifically, ଲ-ethenylidene(substituted) ethanamines, possessing antihypertensive activity, and having the general formula ##STR1## wherein n is the integer 0, 1 or 2; each X independently ... | 05/12/1992 |
| 5109010 | Dibenzofuranyl substituted 1,5-dihydro-4-(N-methylhydroxylamino)-2H-pyrrol-2-ones Novel cyclic vinylogous N-hydroxy-N-methylureas are useful in the treatment of leukotriene mediated conditions such as asthma and rheumatoid arthritis.... | 04/28/1992 |
| 5106861 | Method of using certain tetralin derivatives to produce analgesic relief This invention relates to novel derivatives of tetralin, to the processes for their preparation, to their use as amino-peptidase inhibitors and to their end-use application as immunomodulators and as analgesic agents.... | 04/21/1992 |
| 5095110 | Process for the preparation of sulfhydryl containing tricyclic lactams This invention relates to a process for preparing an olifinated tricyclic lactam which comprises reacting an amine with alkylnitrite to form a diazoamide compound which is further reacted with strong acid and phosphine, and finally with a strong base and ... | 03/10/1992 |
| 5093341 | N-aralkyl piperidine derivatives useful as antithrombolytic agents The present invention is directed to a new class of compounds useful as antiarrhythmics, analgesics and serotonin 5HT2 antagonists, which compounds have the following formula: ##STR1## wherein; Y is represented by H, CO(CH2) | 03/03/1992 |
| 5068465 | Pharmaceutically active 3-aryl-2-fluoro-1-olefins This invention relates to novel 3-aryl-2-fluoro-1-olefins and their pharmacological use as dopamine beta-hydroxylase DBH inhibitors in the treatment of DBH mediated conditions such as hypertension.... | 11/26/1991 |
| 5041673 | Novel tetralin derivatives This invention relates to novel derivatives of tetralin, to the processes for their preparation, to their use as aminopeptidase inhibitors and to their end-use application as immunomodulators and as analgesic agents.... | 08/20/1991 |
| 5041554 | Novel aryl-or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds useful in treating interleukin-1 mediated conditions This invention relates to novel aryl- or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds useful in treating interleukin-1 mediated conditions.... | 08/20/1991 |
| 5039695 | Method of using aryl-or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds in the treatment of interleukin-1 mediated conditions This invention relates to the method of using aryl- or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds to treat interleukin-1 mediated conditions.... | 08/13/1991 |
| 5026861 | Substituted 1,5-dihydro-4-(N-methylhydroxylamino)-2H-pyrrol-2-ones Novel cyclic vinylogous N-hydroxy-N-methylureas are useful in the treatment of leukotriene mediated conditions such as asthma and rheumatoid arthritis.... | 06/25/1991 |
| 5017591 | Thiazolyl methyl)-2-2'-Bi-1H-imidazoles and use as hypertensive agents This invention relates to novel (aryl or heteroaromatic methyl)-2,2'-1H-biimidazoles; to a process for their production comprising of reacting an appropriate alpha-brominated or alpha-chlorinated, substituted or nonsubstituted, methylated monoaromatic rin... | 05/21/1991 |
| 4999431 | Process for preparing quinoline aldehyde and ketone derivatives This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound inv... | 03/12/1991 |
| 4990519 | Method of using quinolyloxazole-2-ones as proteinkinase C inhibitors This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound inv... | 02/05/1991 |
| 4981868 | Pharmaceutically active 3-heteroaryl-2-fluoro-1-olefins This invention relates to novel 3-heteroaryl-2-fluoro-1-olefins and their pharmacological use as dopamine beta-hydroxylase DBH inhibitors in the treatment of DBH mediated conditions such as hypertension.... | 01/01/1991 |
| 4973585 | Tricyclic lactams active as antihypertensive agents This invention relates to derivatives of fused bicyclic or tricyclic lactams, to the intermediates and processes useful for their preparation and to their pharmacological effect in inhibiting the angiotensin converting enzyme and to their end-use applicat... | 11/27/1990 |
| 4970228 | Novel aminoalkyl-substituted heterocyclic sulfur compounds This invention relates to novel aminoalkyl substituted heterocyclic sulfur compounds which are useful as antihypertensive agents.... | 11/13/1990 |
| 4650907 | Nonaromatic fluoroallylamine MAO inhibitors Novel nonaromatic fluoroallylamines are potent MAO inhibitors and at low dose selectively inhibit MAO-B. They are useful in the treatment of depression and coadministered with L-dopa, in the treatment of Parkinsonism.... | 03/17/1987 |
| 4621145 | Process for preparing 5-vinyl-2-pyrrolidinone and intermediates therefor 4-Amino-5-hexenoic acid is prepared by: (a) reacting 5-oxo-2-pyrrolidine-acetonitrile with hydrogen and dimethylamine in the presence of a palladium catalyst to form N,N-dimethyl-2-[5'-oxo-2'-pyrrolidine]ethylamine; (b) oxidizing N,N-dimethyl-2-[5'-oxo-2'-pyrr... | 11/04/1986 |
| 4612312 | Glutarimide antianxiety and antihypertensive agents Glutarimide derivatives of the formula which are useful antihypertensive and antianxiety agents ##STR1## wherein R1 and R2 each independently represent hydrogen, a 1 to 4 carbon alkyl, a 1 to 4 carbon alkoxy, halogen, nitro, hyd... | 09/16/1986 |
| 4595697 | Treatment of seizure disorders and pharmaceutical compositions useful therein Glycine, sarcosine, or N,N-dimethylglycine exerts a synergistic effect upon gamma-vinyl GABA for the treatment of seizure disorders, in particular epilepsy.... | 06/17/1986 |
| 4594187 | Process for preparing antibiotic L 17054 The present invention is directed to a chemical process for preparing the antibiotic substance denominated antibiotic L 17054 and its pharmaceutically acceptable salts by selectively hydrolyzing teicoplanin or a factor or component thereof with a concentr... | 06/10/1986 |
| 4551550 | N-2,3-Butadienyl-1,4-butanediamine derivatives 1. A compound of the formula: wherein: Z is --CH2 CH2 -- or trans-CH.dbd.CH--, R is H, CH3 --, CH3 CH2, CH3 (CH2)2 --, --(CH2)3 NH2, --(CH2... | 11/05/1985 |
| 4540582 | Treatment of seizure disorders and pharmaceutical compositions useful therein Glycine, sarcosine, or N,N-dimethylglycine exerts a synergistic effect upon gamma-vinyl GABA for the treatment of seizure disorders, in particular epilepsy.... | 09/10/1985 |
| 4483988 | Substituted derivatives of 4-t-alkoxycarbonyl-piperazin-2-ones Novel analgesic and antipsychotic agents having the formula ##STR1## in which R1 is hydrogen, hydroxy or halogen and R4 is hydrogen or, R1 and R4 are both hydroxy; Z is hydrogen or straight chain lower alky... | 11/20/1984 |
| 4454156 | 4-Amino-hepta-5,6-dienoic acid (R,S)- and (S)-4-amino-hepta-5,6-dienoic acid are novel inhibitors of gamma-aminobutyric acid transaminase (GABA-T).... | 06/12/1984 |
| 4439443 | Snake bite therapy A method of reducing local hemorrhage and tissue necrosis resulting from the bite or sting of a venomous animal whereby an envenomated mammal is treated with a compound of the formula ##STR1## or a corresponding disulfide wherein n is 1, 2 or 3; Z is... | 03/27/1984 |
| 4437873 | Method of inhibiting algae -Substituted amines are described which are useful in controlling the growth of algae.... | 03/20/1984 |
| 4411905 | Antisecretory 1,2,4-triazole-3-thiols Compounds of the formula ##STR1## wherein R1 is H or NH2 ; R2 is C1-6 straight or branched chain alkyl; --CH2 OH; --(CH2)n --O--(CH2)m --CH3... | 10/25/1983 |
| 4405530 | Process for preparing fluorinated amino-nitriles Certain -(fluoromethyl or difluoromethyl)--aminoacetonitriles are prepared by treating the appropriate -(fluoromethyl or difluoromethyl) ketimine magnesium halide with hydrogen cyanide or with an alkali metal cyanide or ammonium cyani... | 09/20/1983 |
| 4400380 | Antiviral 1-aryl-5-amino-1-penten-3-ones Compounds of the formula ##STR1## wherein R is H, halo, C1-4 alkyl, C1-4 alkoxy, 3,4-methylenedioxy, CF3, NO2, NH2, N(C1-4 alkyl)2, CN, OH, --S(C1-4 alkyl) or --S... | 08/23/1983 |
| 4388466 | -Halomethyl derivatives of amino acids Novel halomethyl derivatives of amino acids of the following general structure ##STR1## wherein Y is FCH2 --, F2 CH2 --, F3 C--, ClCH2 -- or Cl2 CH--; R1 is hydroxy, a strai... | 06/14/1983 |
| 4375477 | Fluorinated methyl beta-alanine derivatives Beta-monofluoromethyl beta-alanine, beta-difluoromethyl beta-alanine and pharmaceutically acceptable esters and amides derived from the acid group, amides derived from the amine group, and salts thereof are novel compounds which inhibit γ-aminobutyric ac... | 03/01/1983 |
| 4374128 | Substituted deoxyadenosine derivatives Novel compounds of the following general Formula I are useful pharmacological agents: ##STR1## wherein: Ado represents 5'-deoxyadenosin-5'-yl; R1 represents methyl, ethyl or, preferably hydrogen; R2 represents C1 -C8 | 02/15/1983 |
| 4353828 | Preparation of fluorinated methyl aminoalkanoic acids and novel process intermediates Fluorinated alkenylamines of the Formula V ##STR1## wherein n represents 0, 1, 2 or 3; R1 represents hydrogen or C1 -C10 alkyl and Y represents (a), when n represents O, CH2 F, (b), when n represents 1, CH | 10/12/1982 |
| 4347255 | Snake bite therapy A method of reducing local hemorrhage and tissue necrosis resulting from the bite or sting of a venomous animal whereby an envenomated mammal is treated with a compound of the formula: ##STR1## or a corresponding disulfide wherein n is 1, 2 or 3; Z i... | 08/31/1982 |
| 4342780 | Method of depleting endogenous monoamines 2-Amino-2-fluoromethyl-3-(substituted)phenyl propionic acids and derivatives thereof are coadministered with dopamine for the treatment of schizophrenia, mania, tardive dyskinesia, anxiety, or depression.... | 08/03/1982 |
| 4341698 | Enkaphalin derivatives Novel analgesic and antipsychotic agents having the formula ##STR1## wherein Q is ##STR2## in which R1 is hydrogen, hydroxy or halogen and R4 is hydrogen or, R1 and R4 are both hydroxy; Z is hydrogen o... | 07/27/1982 |
