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| Number | Title | Issue Date |
| 8389929 | Quadrupole mass spectrometer with enhanced sensitivity and mass resolving power A novel method and mass spectrometer apparatus is introduced to spatially and temporally resolve images of one or more ion exit patterns of a multipole instrument. In particular, the methods and structures of the present invention measures the ion current as a funct... | 03/05/2013 |
| 8316314 | Intelligent multi-functional macros language for analytical measurements A novel software application method, as integrated with various scientific instruments, is introduced herein that allows new capabilities to be added to the language at runtime without, if desired, having to re-compile the application. As part of the software capabi... | 11/20/2012 |
| 8223338 | Optical path length sensor and method for optimal absorbance measurements An apparatus is described in which an optical fiber is mounted within a fiber optic holder which includes the non-rotating shaft of a linear actuator. The fiber holder may be held captive in order to restrain the fiber holder and, consequently, the fiber mounted the... | 07/17/2012 |
| 8189199 | Dual sample mode spectrophotometer A dual-mode method and apparatus of selectively measuring samples in either a vessel or as a surface tension retained sample held between two opposing pedestals is introduced. In either configuration, such modes further contain optical paths from a source system thr... | 05/29/2012 |
| 8155270 | Synergistic energy-dispersive and wavelength-dispersive X-ray spectrometry An X-ray spectroscope collects an energy-dispersive spectrum from a sample under analysis, and generates a list of candidate elements that may be present in the sample. A wavelength dispersive spectral collector is then tuned to obtain X-ray intensity measurements a... | 04/10/2012 |
| 8148677 | Peptide identification and quantitation by merging MS/MS spectra The present invention is directed to methods of merging spectral data resulting from collision fragmentation processes, such as, for example, Pulsed Q Dissociation (PQD), high-energy collision-induced dissociation (HCD), electron transfer disassociation (ETD), colli... | 04/03/2012 |
| 8140500 | Spectral measurement with assisted data analysis A system is provided wherein spectrometer measurements, and/or measurements from other analytical instruments, are transmitted to a processing station which determines the component substances of the sample(s) subjected to the measurements. The names of the componen... | 03/20/2012 |
| 8111392 | Raman spectrometer with display of laser power at the sample A Raman optical method and apparatus is utilized to automatically and accurately recognize laser power measurements made at a desired illumination sample plane. From such a configuration, the methods and systems disclosed herein, enable the support of multiple optic... | 02/07/2012 |
| 8101908 | Multi-resolution scan A multi-resolution mass spectrometer system and intra-scanning method is introduced to enhance the measured peak resolution at different regions of a given mass spectrum while not significantly increasing the total duration of the scan. Such an arrangement enables e... | 01/24/2012 |
| 8058611 | System for preventing backflow in an ion source A system for preventing backflow as part of an ion source arrangement is introduced. Such a system incorporates a novel continuous flow guide within a source, such as an API ion source. In the spray direction, the cross-sectional area that defines the first portion ... | 11/15/2011 |
| 8053723 | Intrascan data dependency A mass spectrometer data dependent method and apparatus is introduced to alter scanning parameters based upon data acquired during that scan. Such a method an apparatus may include the identification of ion species of interest meeting user specified criteria so that... | 11/08/2011 |
| 8027811 | Processing of spectrometer pile-up events In an energy dispersive spectrometer wherein event (particle/photon) detection is performed by counting events spaced by greater than a shaping time, events which are spaced by less than the shaping time are also collected and counted. These “combined events” ar... | 09/27/2011 |
| 7982181 | Methods for identifying an apex for improved data-dependent acquisition A method of analyzing data from a mass spectrometer provides data-dependent acquisition. An extracted ion chromatogram (XIC) is created for each m/z data point of mass spectral scans and the XIC for each m/z data point are correlated to a model function to obtain a ... | 07/19/2011 |
| 7981268 | Deionization and desalination using electrostatic ion pumping The present invention provides a new method and apparatus/system for purifying ionic solutions, such as, for example, desalinating water, using engineered charged surfaces to sorb ions from such solutions. Surface charge is applied externally, and is synchronized wi... | 07/19/2011 |
| 7960690 | Automatic gain control (AGC) method for an ion trap and a temporally non-uniform ion beam An automatic gain control (AGC) technique and apparatus is introduced herein for any temporally non-uniform ion beam, such as, for example, an ion beam produced by a MALDI ion source so as to minimize space charge effects. The disclosed configurations and techniques... | 06/14/2011 |
| 7952070 | Interlaced Y multipole A method and apparatus of combining two independent multipoles in an interlaced fashion to form a resultant multipole structure is introduced. Such an arrangement enables ions from two separate sources to be merged along a predetermined longitudinal direction but al... | 05/31/2011 |
| 7943899 | Method and apparatus for identifying the apex of a chromatographic peak A technique for mass spectrometry includes: receiving first time domain data generated from a chromatographic output, the first time domain data including mass spectra; extracting second time domain data from the first time domain data, the second time domain data c... | 05/17/2011 |
| 7915580 | Electro-dynamic or electro-static lens coupled to a stacked ring ion guide A device for improved transportation and focusing of ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from one or more electro-dynamic or electrostatic focusing lenses that is/are coupled to the first electrode of a stacked r... | 03/29/2011 |
| 7902529 | Method and apparatus for selectively providing electrons in an ion source An electron source can selectively provide a first stream of electrons that travels in a direction along an imaginary line to a location remote from the electron source, or a second stream of electrons that travels in the direction along the line to the location. Th... | 03/08/2011 |
| 7872749 | Instrument for making optical measurements on multiple samples retained by surface tension The invention is an installment for making multi-channel spectroscopic measurements on a plurality of nanodrop samples held by surface tension between opposing optical fibers wherein a single fiber is scanned across a linear spaced array of receiving, detecting fibe... | 01/18/2011 |
| 7812939 | Spectrometric measurements during blending / mixing A mixing bin for the blending of materials (e.g., pharmaceuticals, foodstuffs, etc.) bears a spectrometer which monitors the characteristics of the material being tumbled within the bin interior to thereby obtain an indication of the degree to which the material is ... | 10/12/2010 |
| 7791042 | Method and apparatus for selectively performing chemical ionization or electron ionization An ion source includes structure having separate first and second ion volumes therein, and electron source structure having first and second portions that selectively supply electrons to the first and second ion volumes, respectively. The electron source structure h... | 09/07/2010 |
| 7709790 | Removable ion source that does not require venting of the vacuum chamber A method and apparatus of combining an ion volume, a lens stack, and an ion optic that similarly cooperates with a detached multipole ion guide is herein incorporated into a single sub-assembly that can be removed from a mass spectrometer instrument without venting.... | 05/04/2010 |
| 7698098 | Efficient spectral matching, particularly for multicomponent spectra An unknown spectrum obtained from infrared or other spectroscopy can be compared to spectra in a reference library to find the best matches. The best match spectra can then each in turn be combined with the reference spectra, with the combinations also being screene... | 04/13/2010 |
| 7688530 | Mounting system for precision mounting of interchangeable optical components A mounting system allowing rapid removal and replacement of optical components within an instrument includes a base unit connected to the instrument, and a carrier unit which includes an optical component. The carrier unit is magnetically attracted to the base unit,... | 03/30/2010 |
| 7675031 | Auxiliary drag field electrodes Auxiliary electrodes for creating drag fields may be provided as arrays of finger electrodes on thin substrates such as printed circuit board material for insertion between main RF electrodes of a multipole. A progressive range of voltages can be applied along lengt... | 03/09/2010 |
| 7672430 | Area X-ray or UV camera system for high-intensity beams A system in one embodiment includes a source for directing a beam of radiation at a sample; a multilayer mirror having a face oriented at an angle of less than 90 degrees from an axis of the beam from the source, the mirror reflecting at least a portion of the radia... | 03/02/2010 |
| 7638766 | Compact quadrupole mass spectrometer The current invention facilitates the construction of a compact high performance quadrupole mass analyzer which has the operational characteristics of a modern research grade system and the ergonomic and cost structure of a moderate benchtop system. A multipole fiel... | 12/29/2009 |
| 7623225 | Photometer with modular light emitter A photometer is provided with modular lighting units wherein each lighting unit includes one or more light emitters. A user may select a desired lighting unit and install it within a photometer base unit, and thereafter activate one or more of the emitters (which ma... | 11/24/2009 |
| 7605918 | Spectrometer signal quality improvement via exposure time optimization A spectrometer operator may specify a desired signal to noise ratio (SNR) to be attained when collecting spectra from a sample. The SNR from a single brief sample exposure is used to determine the maximum exposure time achievable without overloading the spectrometer... | 10/20/2009 |
| 7595873 | Rapid spatial averaging over an extended sample in a Raman spectrometer An optical method and apparatus is utilized to provide rapid spatial averaging over a large sample area in a Raman spectrometer, without defocusing of the optical source or the collection optics. Spatial averaging provides a representative spectrum of a sample that ... | 09/29/2009 |
| 7593817 | Calculating confidence levels for peptide and protein identification Computer programs and methods for defining a misidentification probability for an experimental protein divisible into experimental peptides. The invention receives data representing a set of matches of experimental peptides to reference peptides that can be derived ... | 09/22/2009 |
| 7587236 | Optical spectroscopy for the detection of ischemic tissue injury An optical method and apparatus is utilized to quantify ischemic tissue and/or organ injury. Such a method and apparatus is non-invasive, non-traumatic, portable, and can make measurements in a matter of seconds. Moreover, such a method and apparatus can be realized... | 09/08/2009 |
| 7567871 | Automatic material labeling during spectral image data acquisition A system for performing spectral microanalysis delivers analysis results during the course of data collection. As spectra are collected from pixels on a specimen, the system periodically analyzes the spectra to statistically derive underlying spectra representing pr... | 07/28/2009 |
| 7564241 | Isotopic imaging via nuclear resonance fluorescence with laser-based Thomson radiation The present invention utilizes novel laser-based, high-brightness, high-spatial-resolution, pencil-beam sources of spectrally pure hard x-ray and gamma-ray radiation to induce resonant scattering in specific nuclei, i.e., nuclear resonance fluorescence. By monitorin... | 07/21/2009 |
| 7555393 | Evaluating the probability that MS/MS spectral data matches candidate sequence data In one aspect of the present invention a new database search methodology is provided that provides a probability that spectral data from a non-ergodic reaction via mass spectrometry matches a candidate sequence from a set of sequences in a database by random. The me... | 06/30/2009 |
| 7554091 | Feedback circuit for output control in a semiconductor X-ray detector An X-ray detector using a semiconductor detector, most preferably a Silicon Drift Detector, utilizes a field effect transistor or other voltage-controlled resistance to generate an output voltage proportional to its input charge (which is generated by the X-ray phot... | 06/30/2009 |
| 7548576 | Self organization of wireless sensor networks using ultra-wideband radios A novel UWB communications method and system that provides self-organization for wireless sensor networks is introduced. The self-organization is in terms of scalability, power conservation, channel estimation, and node synchronization in wireless sensor networks. T... | 06/16/2009 |
| 7535029 | Material system for tailorable white light emission and method for making thereof A method of processing a composite material to tailor white light emission of the resulting composite during excitation. The composite material is irradiated with a predetermined power and for a predetermined time period to reduce the size of a plurality of nanocrys... | 05/19/2009 |
| 7496220 | Spectroscopic microscopy with image-driven analysis In a spectroscopic microscope, a video image of a specimen is analyzed to identify regions having different appearances, and thus presumptively different properties. The sizes and locations of the identified regions are then used to position the specimen to align ea... | 02/24/2009 |
