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| Number | Title | Issue Date |
| 8008286 | Method for treatment of neuropathic pain Compounds and methods useful for preventing and treating pain, e.g., neuropathic pain, in a subject in need thereof are provided. The compounds can be “S1P modulating” agents that are capable of inducing a detectable change in S1P receptor activity. ... | 08/30/2011 |
| 7960588 | Benzyl cycloalkyl sphingosine 1-phosphate receptor modulators Sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type are provided. The disclosed compounds include an optional phosphate moiety as well as compounds with hydrolysis-resis... | 06/14/2011 |
| 7955861 | Luminescent diketonate polymers The present invention provides in one aspect polymeric luminescent dye compounds having fluorescent properties, phosphorescent properties, or both fluorescent and phosphorescent properties. ... | 06/07/2011 |
| 7932227 | Lacritin-syndecan fusion proteins The present invention relates to methods and compositions useful for the regulation of lacritin, syndecan, and lacritin-syndecan interactions and the signaling pathway downstream of lacritin-syndecan interactions. The invention also relates to regulating lacritin-sy... | 04/26/2011 |
| 7915315 | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity Benzocycloheptyl analogs that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs, which, after phosphorylation, can behave as agonists at S1P receptors. ... | 03/29/2011 |
| 7888527 | Aryl amide sphingosine 1-phosphate analogs The present invention provides compounds that have antagonist activity at the S1P1 and/or S1P3 receptors. These compounds have enhanced selectivity and potency at the S1P1 and/or S1P3 receptors. ... | 02/15/2011 |
| 7875604 | Compounds that inhibit HIV particle formation The present invention describes novel methods of identifying compounds which inhibit HIV particle formation and Rev-dependent HIV production. The present invention also provides methods and compounds for inhibiting HIV particle formation and or treating patients inf... | 01/25/2011 |
| 7871978 | Bone tropic peptides The present invention is directed to the use of bone tropic peptides identified through the use of a phage display library. More particularly, the invention is directed to compositions comprising the bone tropic peptides and methods for using such compositions to re... | 01/18/2011 |
| 7763472 | Methods for identifying and measuring S-nitrosothiol bonds in heme-containing cells and molecules The invention provides a method of detecting an S-nitrosothiol in a sample which includes treating the sample with a transition metal such as copper (I) and cysteine in the presence of a substance capable of blocking interactions between iron-containing compounds an... | 07/27/2010 |
| 7749765 | Quantitative detection of lead in water The present invention provides compositions and methods for extracting, isolating, and measuring lead dissolved in aqueous solutions, including water. ... | 07/06/2010 |
| 7648964 | Use of lacritin in promoting ocular cell survival The present invention relates to the use of lacritin, and fragments, derivatives, and homologs thereof, and nucleic acid sequences encoding that protein. The invention relates to the use of lacritin as a growth factor human corneal epithelial cells and other select ... | 01/19/2010 |
| 7527021 | Non-invasive drug self-administration system for animals A system for allowing animals to self administer drugs via intranasal absorption. The system comprises an aerosol dispersing apparatus (1) connected to a source of pressurized air (5) for ejecting a pharmaceutical composition contained in a reservoir (... | 05/05/2009 |
| 7503322 | Methods for the treatment of HIV and other viruses A treatment for the persons infected with viruses such as HIV. The method takes advantage of the anesthetic membrane effect brought about by certain gases under pressure. A patient infected with HIV, for example, is placed in a pressurized chamber and exposed to one... | 03/17/2009 |
| 7459440 | Ocular tear growth factor-like protein The present invention relates to a novel lacrimal gland protein (designated lacritin) and the nucleic acid sequences encoding that protein. Lacritin has activity as a growth factor on both human corneal epithelial cells and on the lacrimal acinar cells that produce ... | 12/02/2008 |
| 7439383 | Sodium channel blockers The present invention is directed to novel phenytoin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be used to limit or prevent PCa growth and/or metastasis. ... | 10/21/2008 |
| 7432301 | Use of S-nitrosothiol signaling to treat disordered control of breathing The present invention is directed to a method of treating disordered control of breathing including the treatment of apnea and hypoventilation associated with congenital or acquired brain stem abnormalities. Specifically the invention is directed to treating disorde... | 10/07/2008 |
| 7414078 | Oral general anesthetics and metabolitically resistant anticonvulsants The present invention is directed to novel themisone derivative compounds that have been modified to prevent the formation of the toxic metabolite, 2-phenyl-acrylamide. Compositions comprising such derivative compounds have activity as anesthetics and as neuroprotec... | 08/19/2008 |
| 7413894 | TAG-1 and TAG-2 proteins and uses thereof The present invention is directed to a newly discovered gene family with multiple isoforms, designated TAG-1, TAG-2a, TAG-2b, TAG-2c, and TAG-3, nucleic acid sequences encoding those proteins, and antibodies generated against said proteins. The genes, proteins, and ... | 08/19/2008 |
| 7381471 | Hybrid polymers for functional tuning of microfluidic device surfaces The present invention is directed to improved microdevices and methods of manufacturing such devices. More particularly the present invention is directed to the use of a compound having the general structure (formula (I)): wherein R is selected from the group consis... | 06/03/2008 |
| 7323542 | Bone targeting peptides The present invention relates to compositions comprising unique bone targeting peptides and the use of compositions comprising such peptides to induce bone repair and treat bone related diseases. ... | 01/29/2008 |
| 7320870 | Ocular tear growth factor-like protein The present invention relates to a novel lacrimal gland protein (designated lacritin) and the nucleic acid sequences encoding that protein. Lacritin has activity as a growth factor on both human corneal epithelial cells and on the lacrimal acinar cells that produce ... | 01/22/2008 |
| 7255858 | Enhancing the efficacy of immunotherapies by supplementing with complement The present invention is directed to a composition and method for enhancing the complement-mediated cytotoxicity of therapeutic antibodies for their target cells (i.e. those cells displaying the target epitope). More particularly the present invention enhances the e... | 08/14/2007 |
| 7230073 | Sperm specific proteins The present invention relates to sperm specific surface proteins, nucleic acid sequences encoding those proteins and antibodies raised against those proteins. Compositions comprising the sperm specific proteins or inhibitors of said proteins can be used in contracep... | 06/12/2007 |
| 7169818 | Lysophosphatidic acid receptor agonists and antagonists The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the invention is directed to LPA receptor agonists that vary in the degree of... | 01/30/2007 |
| 7129057 | Human testis specific serine/threonine kinase 3 The present invention relates to a family of testis specific kinases (the tssk family), nucleic acid sequences encoding those kinases and antibodies against the kinases. The invention is further directed to the use of thise kinases as targets for isolating specific ... | 10/31/2006 |
| 7125550 | Human sperm specific lysozyme-like proteins The present invention relates to two novel, testis-specific proteins (C19 and C23) that arc lysozyme paralogues. The proteins are believed to play a role in capacitation of sperm and the fertilization of the ovum. Therefore these compounds make ideal targets for the... | 10/24/2006 |
| 7094547 | Sperm specific proteins The present invention relates to sperm specific surface proteins, nucleic acid sequences encoding those proteins and antibodies raised against those proteins. Compositions comprising the sperm specific proteins or inhibitors of said proteins can be used in contracep... | 08/22/2006 |
| 7064217 | Agonists and antagonists of sphingosine-1-phosphate receptors The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure (I), wherein R1 | 06/20/2006 |
| 7026358 | Oral general anesthetics and metabolitically resistant anticonvulsants The present invention is directed to novel themisone derivative compounds that have been modified to prevent the formation of the toxic metabolite, 2-phenyl-acrylamide. Compositions comprising such derivative compounds have activity as anesthetics and as neuroprotec... | 04/11/2006 |
| 7026167 | Systems and methods for the analysis of protein phosphorylation The present invention relates to a method of applying mass spectrometry to analyzing peptides or proteins, especially in the proteome setting. More particularly, the invention relates to a mass spectrometry-based method for detection of protein/peptide phosphorylati... | 04/11/2006 |
| 6962988 | Egg specific surface proteins The present invention relates to proteins that are expressed in oocytes, nucleic acid sequences encoding those proteins and antibodies generated against those proteins. Composition and methods are provided for using the disclosed oocyte proteins as targets for contr... | 11/08/2005 |
| 6946275 | Human testis specific serine/threonine kinase 1 and 2 The present invention relates to a family of testis specific kinases (the tssk family), nucleic acid sequences encoding those kinases and antibodies against the kinases. The invention is further directed to the use of those kinases as targets for isolating specific ... | 09/20/2005 |
| 6924121 | Sperm specific proteins The present invention relates to sperm specific surface proteins, nucleic acid sequences encoding those proteins and antibodies raised against those proteins. Compositions comprising the sperm specific proteins or inhibitors of said proteins can be used in contracep... | 08/02/2005 |
