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| Number | Title | Issue Date |
| 8173785 | Peptide nucleic acid probes for analysis of certain species The present invention relates to peptide nucleic acid (PNA) probes, PNA probe sets and methods for the analysis of certain Staphylococcus species optionally present in a sample. The invention further relates to diagnostic kits comprising such PNA probes or PN... | 05/08/2012 |
| 8067429 | Forms of rifaximin and uses thereof The present invention relates to Rifaximin polymorphic, salt, hydrate, and amorphous forms, to their use in medicinal preparations and to therapeutic methods using them. ... | 11/29/2011 |
| 8067041 | Method for treatment of constipation-predominant irritable bowel syndrome The present invention provides methods for treating constipation-predominant irritable bowel syndrome comprising administering to a patient in need thereof, a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amo... | 11/29/2011 |
| 7928115 | Methods of treating travelers diarrhea and hepatic encephalopathy Treatment of traveler's diarrhea in subjects having hepatic encephalopathy using rifaximin is disclosed. ... | 04/19/2011 |
| 7794948 | Biomarkers for alzheimer's disease The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Alzheimer's disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as Alzheimer's or non-Al... | 09/14/2010 |
| 7763716 | Antibody against NPW The antibody of the present invention, which specifically reacts with a partial peptide at the N-terminal region or the C-terminal region of NPW, which enables to quantify NPW with highly sensitivity and specifically. Moreover, this antibody is useful as an agent fo... | 07/27/2010 |
| 7749968 | Peptides for targeting the prostate specific membrane antigen The invention provides isolated PSMA binding peptides, as well as pharmaceutical compositions thereof. Also provided are diagnostic and therapeutic methods utilizing the PSMA binding peptides, as well as methods for identifying further PSMA binding peptides. ... | 07/06/2010 |
| 7749716 | Methods of detecting a fragment of neurosecretory protein VGF for diagnosing alzheimer's disease The present invention provides a neurosecretory protein VGF peptide useful in qualifying Alzheimer's disease status in a patient. In particular, this peptide and modified forms thereof may be used to classify a subject sample as Alzheimer's disease or non-Alzheimer'... | 07/06/2010 |
| 7732165 | Biomolecule partition motifs and uses thereof The invention provides amino acid sequence motifs (e.g., biomolecule partition motifs) that can direct targeting of intracellular polypeptides to and through membranes, including cell surface membranes. ... | 06/08/2010 |
| 7723505 | EAAT2 promoter and uses thereof The present invention provides nucleic acid molecules comprising the EAAT2 promoter, as well as screening assays useful for identifying compounds which modulate the activity of the EAAT2 promoter, and methods of treating neurological disorders comprising administrat... | 05/25/2010 |
| 7718385 | Bioactivation of alkylating agents for cancer treatment A rapid screening method for identifying acylfulvenes and acylfulvene analogs with improved chemotherapeutic properties has been developed. The mechanism of toxicity of irofulven, a potentially clinically useful member of the acylfulvene class, has been elucidated a... | 05/18/2010 |
| 7718197 | Colonic purgative composition with soluble binding agent This invention relates to novel colonic purgative compositions in a solid dosage form, comprising at least one purgative and at least one soluble, or soluble, nonfermentable binder, such as polyethylene glycol. Further, this invention relates to methods of using the... | 05/18/2010 |
| 7687075 | Colonic purgative composition with soluble binding agent This invention relates to novel colonic purgative compositions in a solid dosage form, comprising at least one purgative and at least one soluble, or soluble, nonfermentable binder, such as polyethylene glycol. Further, this invention relates to methods of using the... | 03/30/2010 |
| 7682678 | Optical information recording medium, recording and readout methods using the same, optical information recording device, and optical information readout device An optical information recording medium includes a substrate formed in a concave-convex state by providing pits or grooves corresponding to recorded information, used for optically reproducing the information by irradiation of a light beam, and may also include a re... | 03/23/2010 |
| 7662795 | Enhancement of adenoviral oncolytic activity by modification of the E1A gene product The present invention relates to compositions and methods for enhancing the oncolytic activity of replication-competent, target cell-specific adenovirus vectors by modification of the E1A gene product. The target cell-specific replication-competent adenovirus vector... | 02/16/2010 |
| 7605003 | Use of biomarkers for detecting ovarian cancer The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to ... | 10/20/2009 |
| 7604980 | Protein expression system The present invention relates to proteomics, especially downstream processing of proteins. The present invention also relates to novel expression cassettes having unique cleavage sites for efficient removal of purification tags. The invention further provides expres... | 10/20/2009 |
| 7604972 | Nicotianamine synthase A nicotianamine synthase is isolated and purified. Then the gene of this enzyme is cloned and the base sequence and amino acid sequence thereof are determined. This gene is employed in constructing plants, in particular, grass plants highly tolerant to iron-deficien... | 10/20/2009 |
| 7582290 | Packaging cell line for diphtheria toxin expressing non-replicating adenovirus The invention provides a packaging cell line for production of diphtheria toxin (DT) expressing, non-replicating adenovirus for use in suicide gene therapy of cancer cells, as well as production of immunotoxins. Also provided are methods for producing diphtheria tox... | 09/01/2009 |
| 7553936 | Anti-TREM-like transcript-1 (TLT-1) antibodies and compositions The present invention relates to methods and compositions for modulating platelet activity, and methods and compositions for treating a disease or disorder associated with platelet activity in a subject, comprising administering a single chain anti-TREM-like transcr... | 06/30/2009 |
| 7544470 | Method for finding mutations caused by the insertion of repeated DNAs The present invention provides a method for identifying repeat insertion mutation, a method for identifying or classifying genetic diseases characterized by genome rearrangement, as well as a method for mapping complex traits controlled by repeat insertion mutations... | 06/09/2009 |
| 7230094 | Neutral sphingomyelinase antisense ribozyme and uses thereof The present invention provides novel antisense ribozymes useful for inhibiting the activity of neutral sphingomyelinase. Also provided are methods for reducing the activity of neutral sphingomyelinase, as well as methods for reducing apoptosis and atherosclerosis us... | 06/12/2007 |
| 7534398 | Apparatus for the generation of chlorine dioxide The instant application provides apparatus and methods for the generation of chlorine dioxide. The methods and apparatus of the invention use a water dissolvable membrane to allow the reaction of precursor chemicals, e.g., chlorite salt and an acid. The methods and ... | 05/19/2009 |
| 7524630 | Functionalized nanoparticles and methods of use Silica-coated nanoparticles functionalized with biologically active molecules such as antibodies and nucleotides are used to label cells, to detect and isolate nucleic acid molecules having specific nucleotide sequences, and to separate a mixture of different nuclei... | 04/28/2009 |
| 7510842 | Biomarker for ovarian and endometrial cancer: hepcidin The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status as well as endometrical cancer status in a patient. In particular, it has been found that hepcidin is a biomarker for both ovarian ... | 03/31/2009 |
| 7510715 | Protozoan derived compositions and methods of use thereof The instant invention relates to methods for treating a subject suffering from or susceptible to an autoimmune disease or disorder, or a disease or disorder having an autoimmune component, comprising administering to the subject an effective amount of cyclophilin or... | 03/31/2009 |
| 7498337 | Acid secretion inhibitor The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R... | 03/03/2009 |
| 7491803 | Human anti-human interleukin-18 antibody, fragment thereof and method for using same A human-derived human anti-human IL-18 antibody of the present invention is an antibody against human IL-18, the antibody including: an H-chain complementarity determining region consisting of (a) a polypeptide consisting of amino-acid sequences represented by SEQ I... | 02/17/2009 |
| 7468274 | Single cell analysis of HIV replication capacity and drug resistance A novel single-cell-level phenotypic assay is described, which can simultaneously analyze HIV-1 drug susceptibility and intrinsic replication capacity. This allows quantitative dissection of the functions of antiretroviral drugs into suppression of viral replication... | 12/23/2008 |
| 7456263 | P53 binding T cell receptor molecules The invention provides T-cell receptor (TCR) molecules comprising a Vα chain and a Vβ chain that bind peptides derived from the p53 protein, preferably, the human p53 protein. The TCR molecules include both heterodimeric molecules and single chain molecules which ... | 11/25/2008 |
| 7452872 | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives A method of increasing the bioavailability of balsalazide by administration of an oral dosage form with food is provided, as well as an article of manufacture comprising an oral dosage form of balsalazide in a suitable container and associated with printed labeling ... | 11/18/2008 |
| 7441444 | AFM cantilevers and methods for making and using same The invention provides high performance cantilevers with optimal combinations of high resonant frequency and low force constant. In one aspect, AFM cantilevers with spring constants in the range 1-10−6 N/m with (fundamental) resonant frequencies in aque... | 10/28/2008 |
| 7408079 | Imaging agents and methods of imaging NAALADase or PSMA The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express NAALADase and/or PSMA. In anoth... | 08/05/2008 |
| 7396668 | Nicotianamine synthase and gene encoding the same A nicotianamine synthase is isolated and purified. Then the gene of this enzyme is cloned and the base sequence and amino acid sequence thereof are determined. This gene is employed in constructing plants, in particular, grass plants highly tolerant to iron deficien... | 07/08/2008 |
| 7378088 | Base material for regenerating an air sinus and regeneration method thereof The instant invention provides a base material characterized by having a continuous three-dimensional honeycomb structure for regenerating an air sinus. The invention further provides methods for regenerating an air sinus using the base material. The base material h... | 05/27/2008 |
| 7342105 | Antibody and use thereof The antibody of the present invention, which specifically reacts with the N-terminal or C-terminal partial peptide of TGR23-2 ligand, is useful in detecting and quantifying the TGR23-2 ligand. Moreover, it is useful as a preventing/treating agent and a diagnostic ag... | 03/11/2008 |
| 7332613 | Capture and release based isotope tagged peptides and methods for using the same The invention provides non-affinity based isotope tagged peptides, chemistries for making these peptides, and methods for using these peptides. In one aspect, tags comprise a reactive site (RS) for reacting with a molecule on a protein to form a stable association w... | 02/19/2008 |
| 7282488 | Genetic engineering of vascular grafts to resist disease Disclosed are methods for treating a vascular graft that include introducing an effective amount of at least one nucleic acid encoding at least one agent that increases activated protein C (APC), expressing the agent in the cells; and increasing the APC sufficient t... | 10/16/2007 |
| 7157260 | Nicotianamine synthase and gene encoding the same A nicotianamine synthase is isolated and purified. Then the gene of this enzyme is cloned and the base sequence and amino acid sequence thereof are determined. This gene is employed in constructing plants, in particular, grass plants highly tolerant to iron deficien... | 01/02/2007 |
