Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 7432369 | Pyridyl-substituted porphyrin compounds and methods of use thereof The present invention relates to Pyridyl-Substituted Porphyrin Compounds, compositions comprising an effective amount of a Pyridyl-Substituted Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactive species, erectile dysfunctio... | 10/07/2008 |
| 7427627 | N-(4-(4-methylthiazol-5-yl) pyrimidin-2-yl)-N-phenylamines as antiproliferative compounds The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders suc... | 09/23/2008 |
| 7425541 | Enzyme-cleavable prodrug compounds The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are m... | 09/16/2008 |
| 7390629 | Tumor-activated prodrug compounds and treatment Methods of screening and identifying tumor-activated prodrug forms of therapeutic agents are described. ... | 06/24/2008 |
| 7329507 | Prodrug compounds with isoleucine The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is clea... | 02/12/2008 |
| 7329489 | Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 02/12/2008 |
| 7326696 | Amino-methyl substituted tetracycline compounds Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed. ... | 02/05/2008 |
| 7312356 | Medicament The present invention relates to 3β,28-diacetoxy-18-oxo-19,20,21,29,30-pentanorlupan-22-oic acid methanol solvate, its use in medicine and processes for its preparation. ... | 12/25/2007 |
| 7304032 | CD-10 activated prodrug compounds The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Met... | 12/04/2007 |
| 7244764 | Methods and compositions for treating amyloid-related diseases Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-+related disease. ... | 07/17/2007 |
| 7241924 | Industrial process for the production of diphenyl sulfone compounds A process for producing 4-isopropoxy-4′-hydroxydiphenyl sulfone useful as the developer for leuco dyes to be used in thermosensible papers, which is excellent in productivity, economical efficiency and safety and permits the production of the compounds from consta... | 07/10/2007 |
| 7223795 | Modified peptide derivatives and methods of use thereof The present invention relates to a compound of formula I wherein (i) when a and c are double bonds, R2 is absent, b is a single bond, | 05/29/2007 |
| 7214663 | Tripeptide prodrug compounds The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide of three amino acids, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by a trouase enzyme such as Thimet oligopept... | 05/08/2007 |
| 7208482 | 9-aminoacyl tetracycline compounds and methods of use thereof A compound of formula (I): ... | 04/24/2007 |
| 7202339 | Crystals of MarR polypeptides, regulators of multiple antibiotic resistance The crystal structure of the product, crystals of the MarR protein, a regulator of multiple antibiotic resistance in Escherichia coli, and methods of crystallization of the MarR protein are described. ... | 04/10/2007 |
| 7202235 | Tetracycline compounds for treatment of cryptosporidium parvum related disorders Methods and compositions for treating Cryptosporidium parvum related disorders in a mammal are discussed. Several novel tetracycline compounds useful for treating Cryptosporidium parvum related disorders are also included. ... | 04/10/2007 |
| 7160857 | Methods for increasing schwann cell survival Methods for increasing Schwann cell survival are disclosed. The methods of the invention are useful for the treatment of conditions such as peripheral neuropathies, including diabetic neuropathies. ... | 01/09/2007 |
| 7115573 | Prodrug compounds with an isoleucine The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is clea... | 10/03/2006 |
| 7075582 | Methods for identifying and using MarR family polypeptide binding compounds Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides. ... | 07/11/2006 |
| 7056902 | 4-dedimethylamino tetracycline compounds The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well a... | 06/06/2006 |
| 7045507 | Substituted tetracycline compounds as synergistic antifungal agents Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed. ... | 05/16/2006 |
| 7041701 | Triterpenoid derivatives The present invention relates to the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in therapy. Preferably, the compound may be used for treating a patient suffering from leukaemia, cancer or other proliferative disorder. A further ... | 05/09/2006 |
| 7037898 | Tumor-activated prodrug compounds and treatment The compound (W-Z-M) according to the invention comprises a component (M) chosen from the group consisting of markers and therapeutic agents possessing an intracellular active site (A.S.), linked to a ligand (W-Z) comprising an arm (Z) linked to a terminal group (W)... | 05/02/2006 |
| 7005255 | Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 02/28/2006 |
| 7001918 | 7-pyrrolyl tetracycline compounds and methods of use thereof A compound of Formula (I): wherein variables R, R1, R2, R3 and A are as defined in the ... | 02/21/2006 |
| 6897034 | CD10-activated prodrug compounds The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Met... | 05/24/2005 |
| 6861416 | Oxazinones and methods for their use and synthesis The invention pertains, at least in part, to new intermediates and synthetic methods for the stereospecific synthesis of oxazinone compounds, which are useful, for example, as antibiotics. The invention also pertains to novel olefinic oxazinone compounds, methods fo... | 03/01/2005 |
| 6849615 | 13-substituted methacycline compounds 13-substituted methacycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 13-substituted methacycline compounds are described. ... | 02/01/2005 |
| 6846939 | 9-substituted minocycline compounds The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known appl... | 01/25/2005 |
| 6841546 | Substituted tetracycline compounds as antifungal agents Methods and compositions for treating fungal associated disorders in subjects are discussed. ... | 01/11/2005 |
| 6833365 | Tetracycline compounds for treatment of Cryptosporidium parvum related disorders Methods and compositions for treating Cryptosporidium parvum related disorders in a mammal are discussed. Several novel tetracycline compounds useful for treating Cryptosporidium parvum related disorders are also included. ... | 12/21/2004 |
| 6818635 | 7-substituted tetracycline compounds The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known ap... | 11/16/2004 |
| 6818634 | 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.... | 11/16/2004 |
| 6706764 | Use of creatine or creatine analogs for the treatment of diseases of the nervous system The present invention relates to the use of creatine compounds including creatine, creatine phosphate or analogs of creatine, such as cyclocreatine, for treating diseases of the nervous system. Creatine compounds can be used as therapeutically effective agents again... | 03/16/2004 |
