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| Number | Title | Issue Date |
| 7432260 | Pyrimidine compounds The present invention relates to substituted pyrimidines of formula I, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders and/o... | 10/07/2008 |
| 7423144 | Purine Derivatives as adenosine Areceptor agonists and methods of use thereof The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or p... | 09/09/2008 |
| 7419999 | Gamma lactams as prostaglandin agonists and use thereof 1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing pr... | 09/02/2008 |
| 7414041 | Reducing tetracycline resistance in living cells The present invention provides an improved methodology by which therapeutically to overcome resistance to tetracycline in living cells including bacteria, parasites, fungi, and rickettsiae. The methodology employs a blocking agent such as C5 ester derivatives, or 6-... | 08/19/2008 |
| 7405235 | Transcription factor modulating compounds and methods of use thereof Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reduci... | 07/29/2008 |
| 7402556 | Prodrugs activated by plasmin and their use in cancer chemotherapy The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or di-peptide linkage, a stabilizing group and, optionally, a linker group. The ... | 07/22/2008 |
| 7388015 | N-(4-(4-methylthiazol-5-yl)pyrimidin-2-yl)-N-phenylamines as antiproliferative compounds The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders suc... | 06/17/2008 |
| 7374739 | Calcium phosphate bone replacement materials and methods of use thereof Methods of making porous calcium phosphate bone replacement materials are discussed. ... | 05/20/2008 |
| 7361674 | 7, 8 and 9-substituted tetracycline compounds 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described. ... | 04/22/2008 |
| 7323492 | 7-pyrollyl 9-aminoacyl tetracycline compounds and methods of use thereof A compound of formula (I): wherein: A represents an aromatic 5 membered heterocycle, optionally containing, in addition to the nitrogen atom indicated in formula (I), one to thr... | 01/29/2008 |
| 7311893 | Amyloid targeting imaging agents and uses thereof Amyloid-targeting imaging agents such as radiolabeled amyloid targeting molecules and amyloid targeting molecule-chelator conjugates for imaging, e.g., amyloid plaques in vivo, and/or for the treatment of amyloidosis disorders. The invention provides amyloid-targeti... | 12/25/2007 |
| 7294592 | Photocatalyst-carrying tent cloth canvas and production method therefor A tent cloth canvas coated on the surface thereof with a photocatalyst, wherein (1) the adhesiveness between a photocatalyst and the tent cloth canvas is kept satisfactorily for an extended time, (2) an anti-fouling capability is kept for a long time, and (3) the ph... | 11/13/2007 |
| 7208468 | Verotoxin pharmaceutical compositions and medical treatments therewith Pharmaceutical compositions comprising known verotoxins, particularly, verotoxin 1, have been found to be useful in the treatment of mammalian neoplasia, particularly, ovarian cancer and skin cancer. Surprisingly, although verotoxin 1 has previously been shown to ha... | 04/24/2007 |
| 7186754 | Use of creatine or creatine compounds for skin preservation The present invention relates to the use of creatine compounds such as, for example, creatine, creatine phosphate or analogs of creatine, such as creatine-pyruvate, creatine-ascorbate, cyclocreatine, 3 guanidinopropionic acid, guanidinoacetate, homocyclocreatine, gu... | 03/06/2007 |
| 7094806 | 7, 8 and 9-substituted tetracycline compounds 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described. ... | 08/22/2006 |
| 7045105 | Calcium phosphate bone replacement materials and methods of use thereof Methods of making porous calcium phosphate bone replacement materials are discussed. ... | 05/16/2006 |
| 6835710 | Verotoxin pharmaceutical compositions and medical treatments therewith Pharmaceutical compositions comprising known verotoxins, particularly, verotoxin 1, have been found to be useful in the treatment of mammalian neoplasia, particularly, ovarian cancer and skin cancer. Surprisingly, although verotoxin 1 has previously been shown to ha... | 12/28/2004 |
| 6777447 | Derivatives of benzylidene cyclohexanone, benzylidene cyclopentanone, and benzylidene acetone, and therapeutic uses thereof Benzylidene cyclohexanone, cyclopentanone and acteone derivatives and therapeutic methods of using same are disclosed. The compounds are non-toxic and exhibit potent anti-inflammatory, antibacterial and antioxidation activity. Also, certain compounds of the inventio... | 08/17/2004 |
| 6660734 | Oxazinones having antibacterial activity The invention relates to novel oxazinones designed to bind to the penicillin receptor, methods of synthesizing the compounds, and the use of the compounds as antibacterial agents. The compounds have the general formula (I) ##STR1## Preferably the com... | 12/09/2003 |
| 6642270 | 7-substituted fused ring tetracycline compounds 7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described.... | 11/04/2003 |
| 6624168 | 7,8 and 9-substituted tetracycline compounds 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.... | 09/23/2003 |
| 6617318 | Methods of preparing substituted tetracyclines with transition metal-based chemistries The present invention relates to 7-phenyl substituted tetracycline derivatives and compositions thereof.... | 09/09/2003 |
| 6613882 | Chimeric polypeptide comprising the fragment B of shiga toxin and peptides of therapeutic interest The invention pertains to chimeric polypeptides of the formula: wherein B represents the B fragment of Shiga toxin or a functional equivalent thereof, and X represents one or more polypeptides of therapeutic significance. Compositions for therapeutic use compr... | 09/02/2003 |
