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| Number | Title | Issue Date |
| 7737163 | Benzimidazolone carboxylic acid derivatives This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions co... | 06/15/2010 |
| 7705020 | Benzimidazolone carboxylic acid derivatives This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions co... | 04/27/2010 |
| 7524860 | Antibacterial agents The present invention is directed to a new class of triazolopyridine derivatives, to their use as antimicrobials, and to pharmaceuticals containing these compounds. ... | 04/28/2009 |
| 7473790 | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention a... | 01/06/2009 |
| 7468375 | Inhibitors of the HIV integrase enzyme The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme. ... | 12/23/2008 |
| 7435728 | Pyrazole derivatives This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to processes for the preparation ther... | 10/14/2008 |
| 7435751 | 7-Fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R1 is C1-4alkyl, optionally substituted with a fluoro atom, or R1 is a cyclopropy... | 10/14/2008 |
| 7429665 | Heteroaromatic quinoline compounds The invention pertains to heteroaromatic compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE10. The invention also relates to intermediates for preparation... | 09/30/2008 |
| 7368460 | Tropane derivatives useful in therapy The present invention provides compounds of the formula: wherein R1 is C3-6 cycloalkyl optionally substituted by one or more fluorine atoms, or C1-6 alkyl optionally substituted by one or mo... | 05/06/2008 |
| 7322965 | Infection-resistant medical devices A method for preventing medical device-associated microorganism infection includes the steps of providing a medical device and incorporating an effective amount of an oxazolidinone compound, such as linezolid, into the medical device. ... | 01/29/2008 |
| 7183414 | Processes for the preparation of benzoimidazole derivatives The present invention relates to a process for preparing a compound of the formula I or a pharmaceutically acceptable salt, prodrug, hydrate or solvate thereof, wherein R1, R2, R3 | 02/27/2007 |
| 7176315 | Enantiomers of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-[3-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-1-methyl-1H-quinolin-2-one and salts thereof, useful in the treatment of cancer This invention relates to the enantiomers of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-[3-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-1-methyl-1H-quinolin-2-one, prodrugs thereof, and pharmaceutically acceptable salts and solvates of said compou... | 02/13/2007 |
| 7019002 | Pyridopyrimidinones derivatives as telomerase inhibitors The invention provides pyrido[2,3-d]pyrimidin-7(8H)-one telomerase inhibitors of the formula where R1, R2 are as defined herein. The invention also provides methods for preparing the compounds of formula I, methods of u... | 03/28/2006 |
| 6927220 | Bicyclic-substituted 4-amino-pyridopyrimidine derivatives The invention relates to 6- or 7-bicyclic-substituted 4-amino-subsituted pyridopyrimidines and to pharmaceutically acceptable salts, prodrugs and hydrates thereof. The invention also relates to pharmaceutical compositions containing the compounds and to methods of t... | 08/09/2005 |
| 6916800 | Combination therapy including a matrix metalloproteinase inhibitor and an antineoplastic agent The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of a matrix metalloproteinase inhibitor and an antineoplastic agent. ... | 07/12/2005 |
