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| Number | Title | Issue Date |
| 8163743 | 4-carboxamide indazole derivatives useful as inhibitors of PI3-kinases The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of P13-kinase activity. ... | 04/24/2012 |
| 8161968 | Medicament dispenser There is provided a medicament dispenser for containing plural elongate form medicament carriers, each having multiple distinct medicament dose portions carried thereby, the dispenser having a housing of generally non-circular form, and within said housing a dispens... | 04/24/2012 |
| 8093281 | Indazoles as glucocorticoid receptor ligands A compound of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; X represents —C(R3)— or nitrogen; | 01/10/2012 |
| 8084449 | Dual pharmacophores—PDE4-muscarinic antagonistics The present invention is directed to novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions and their use as dual chromaphores having inhibitory ac... | 12/27/2011 |
| 8071588 | Dual pharmacophores—PDE4-muscarinic antagonistics The present invention relates to novel compounds of Formula (I) and their use in the treatment of respiratory diseases, including anti-inflammatory and allergic diseases such as chronic obstructive pulmonary disease (COPD),... | 12/06/2011 |
| 8067408 | Dual pharmacophores—PDE4-muscarinic antagonistics The present invention is directed to novel compounds of Formula (I), pharmaceutical compositions and their use in therapy, for example as inhibitors of phosphodiesterase type IV (PDE4) and as antagonists of muscarinic acetylcholine receptors (mAChRs), in the treatme... | 11/29/2011 |
| 7985740 | Purine derivatives as agonists of the adenosine A2A receptor The invention provides novel compounds which are agonists of the adenosine 2A receptor along with pharmaceutical compositions thereof, and methods of administering such compounds. ... | 07/26/2011 |
| 7982067 | Phenethanolamine derivatives for treatment of respiratory diseases Compounds of the formula (II) and (IV) are provided, which may be employed as intermediates for making compounds useful in treating respiratory diseases. ... | 07/19/2011 |
| 7977359 | 5-lipdxygenase-activating protein (FLAP) inhibitors Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other co... | 07/12/2011 |
| 7960551 | Compound A succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof, for use in treating pulmonary disorders. ... | 06/14/2011 |
| 7947727 | Compounds The present invention provides compounds of formula (I): a process for their preparation, pharmaceutical compositions comprising the compounds and the preparation of said compositions, intermediates and use of the compounds... | 05/24/2011 |
| 7902224 | Tetrahydro-naphthalene derivatives as glucocorticoid receptor modulators The present invention is directed to compounds of formula (I): wherein R represents a methyl or an ethyl group X represents N, C—H or C—CH3 when X represents C—H or C—CH | 03/08/2011 |
| 7834037 | 5-lipoxygenase-activating protein (FLAP) inhibitors Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other co... | 11/16/2010 |
| 7795274 | 5-lipoxygenase-activating protein (FLAP) inhibitors Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other co... | 09/14/2010 |
| 7776895 | Inhalation devices for delivering phenethanolamine derivatives for the treatment of respiratory diseases The invention provides inhalation devices comprising a compound which is 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; or a salt or solvate thereof, inhalation devices comprising formulations and combinations ... | 08/17/2010 |
| 7759370 | Sphingosine-1-phosphate (SIP) receptor agonists The invention provides compounds formula I, their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as o... | 07/20/2010 |
| 7749998 | Morpholinyl and pyrrolidinyl analogs The present invention relates to morpholinyl, and pyrrolidinyl analogs, pharmaceutical compositions containing them, and their use as antagonists of urotensin II. ... | 07/06/2010 |
| 7737126 | Purine derivative A compound of formula (I) and salts and solvates thereof are disclosed. Compounds of formula (I) are agonists of the adenosine A2A receptor and are believed to be of potential use in the treatment of inflammatory... | 06/15/2010 |
| D606861 | Compliance dose indicator | 12/29/2009 |
| 7538127 | Medicinal compounds A compound of formula (I) or a salt, solvate, or physiologically functional derivative thereof, wherein: m is an integer of from 2 to 8; n is an integer of from 2 to 5; with the proviso that m+n is 4 to 10; R4 and R5 are independently selected ... | 05/26/2009 |
| 7467629 | Medicament dispenser with magneto-rheological fluid actuator A medicament dispenser that includes a body, a medicament container, a source of magnetic radiation, and actuation means that includes a magneto-rheological fluid is described. ... | 12/23/2008 |
| 7461650 | Medicament dispenser A medicament dispenser including a housing, a medicament container having a dispensing outlet; an agitator for agitating the contents; and a driver for driving the agitator independent of any container movement. The driver includes an energy storeage for storing ene... | 12/09/2008 |
| 7456952 | System for real-time fluorescent determination of trace elements A system for use in in-situ analysis of pharmaceutical samples, said system comprising means for holding a plurality of said samples, wherein said samples are present in the form of a powder formulation; means for moving said plurality of samples along a sample path... | 11/25/2008 |
| 7442837 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. ... | 10/28/2008 |
| 7442836 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. ... | 10/28/2008 |
| 7442719 | Methods using phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. ... | 10/28/2008 |
| 7442839 | Phenethanolamine derivative for the treatment of respiratory diseases The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis an... | 10/28/2008 |
| 7439393 | Phenethanolamine derivatives for treatment of respiratory diseases The invention relates to 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; and salts and solvates thereof, including those which are pharmaceutically acceptable, along with formulations thereof, combinations there... | 10/21/2008 |
| 7429127 | Magnetoacoustic sensor system and associated method for sensing environmental conditions A remote sensor system (60) and method for passively sensing environmental conditions, such as temperature and humidity, uses a magnetic impulse from an AC interrogation coil (68) to stimulate a magnetoelastic sensor (62) to generate an acoustic... | 09/30/2008 |
| 7402598 | Arylethanolamine β-adrenoreceptor agonist compounds The present invention relates to compounds of formula (I) as defined herein and salts or solvates thereof. Processes for preparing these compounds and pharmaceutical formulations containing them are also disclosed, as well as methods for the prophylaxis of treatment... | 07/22/2008 |
| 7389775 | Inhalation device An inhalation device is described for use with a medicament pack in which at least one container for medicament in powder form is defined between two sheets peelably secured to one another. The device comprises means for peeling the sheets apart at an opening statio... | 06/24/2008 |
| 7361787 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases ... | 04/22/2008 |
| 7328802 | Child resistant blister packages utilizing walled structures enclosing medicament therein A child resistant blister package includes a film having a surface wherein a plurality of cavities are formed therein containing at least one medicament; a cover sheet which overlies the cavities and is bonded to the film; and a wall structure raised above the surfa... | 02/12/2008 |
| 7294725 | Process for preparing salmeterol A process for the preparation of a compound of formula (I) or a single enantiomer thereof, or a salt or a solvate thereof, wherein W is a chiral auxiliary or hydrogen and P1 and P2 are each ... | 11/13/2007 |
| 7294650 | Benzothiophen and thiochrone containing phenethanolamine derivatives for the treatment of respiratory disorders Compounds of formula (I): and salts, solvates, and physiologically functional derivatives thereof, useful for the prophylaxis or treatment of a clinical condition for which a selective β2-adrenorecept... | 11/13/2007 |
| 7271197 | Phenethanolamine derivatives The present invention relates to novel compounds of formula (I), or a salt, solvate, or physiologically functional derivative thereof, to a process for their manufacture, to pharmaceutical compositions containing... | 09/18/2007 |
| 7249687 | Medicament dispenser A medicament dispenser for use with a medicament carrier having multiple distinct medicament doses carried thereby and an internal mechanism for dispensing the distinct medicament doses carried by the medicament carrier. The mechanism comprises receiving means for r... | 07/31/2007 |
| 7231920 | Medicament dispenser According to the invention there is provided a medicament dispenser for use with a medicament carrier having a plurality of pockets for containing medicament wherein said pockets are spaced along the length of and defined between two peelable sheets secured to each ... | 06/19/2007 |
| 7225808 | Inhalation device An inhalation device is described for use with a medicament pack in which at least one container for medicament in powder form is defined between two sheets peelably secured to one another. The device comprises means for peeling the sheets apart at an opening statio... | 06/05/2007 |
| 7185648 | Medicament dispenser A medicament dispenser including a medicament container having a dispensing outlet; an agitator for agitating the contents; and a driver for driving the agitator independent of any container movement. The medicament container may be a metered dose inhaler or deliver... | 03/06/2007 |
