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Attorney: Smith; Michael G.


Number of patents: 29
Last date: May 08, 2012

NumberTitleIssue Date
81736896-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling
Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one addi...
05/08/2012
8168794Pim kinase inhibitors and methods of their use
The present invention relates to new compounds of Formulas I and II, their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmaceutically accep...
05/01/2012
8163785Pyrazolo[5,1b]oxazole derivatives as CRF-receptor antagonists
There are described 4-difluoromethoxyphenyl pyrazolo[5.1-b]oxazole derivatives of Formula I: which are useful as corticotropin releasing factor (CRF) receptor antagonists and as pharmaceuticals. ...
04/24/2012
8129394Heteroaryl-substituted imidazole compounds and uses thereof
Novel imidazole compounds of the general formula are disclosed, wherein R1 and R2 comprise heteroaryl groups. These compounds and compositions containing them are useful in met...
03/06/2012
8129358Substituted pyrazole and triazole compounds as KSP inhibitors
Disclosed are new substituted pyrazole and triazole compounds of Formula (I) and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses thereof: ...
03/06/2012
8098060Systems, methods and apparatus for position sensor digital conditioning electronics
Systems, methods and apparatus are provided through which in some implementations determine the amplitude of an amplitude modulated signal, modulated by the position of an object being sensed. In some aspects, the apparatus accepts an excitation signal and the ampli...
01/17/2012
8053574Organic compounds
Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptabl...
11/08/2011
8039472Pyrazine-2-carboxamide derivatives to treat diseases mediated by blockade of the epithelial sodium channel
A compound of Formula I in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R...
10/18/2011
8008335Indole and benzimidazole derivatives
The present invention relates to new indole and benzimidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compou...
08/30/2011
79989721H-imidazo[4,5-c]quinoline derivatives in the treatment of protein kinase dependent diseases
The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of pro...
08/16/2011
7994203Organic compounds
There are described pyrazolo[5.1-b]oxazole derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists. ...
08/09/2011
7989458Pyrimidine derivatives as alk-5 inhibitors
Compounds of formula (I) in free or salt or solvate form, where T1, T2, Ra and Rb have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pu...
08/02/2011
7908079Portable runway intersection display and monitoring system
Systems, methods and apparatus are provided through which an apparatus located on an airfield provides information to pilots in aircraft on the ground and simultaneously gathers information on the motion and position of the aircraft for controllers. ...
03/15/2011
7858641Substituted dihydroisoquinolinone compounds
A variety of low molecular weight, guanidino-containing dihydroisoquinolinoines capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure ID where the values of the variable are d...
12/28/2010
7858631Substituted pyrido [2,3-d] pyrimidinone compounds
A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure of Formulas (IA), (IB), or (IC): where the values of th...
12/28/2010
7607832Apparatus for medical imaging
Embodiments provide apparatus for medical imaging which includes: a base assembly including a set of wheels for rolling movement on a floor to transport the base assembly between locations; an imaging assembly for imaging the subject; and a movable support assembly ...
10/27/2009
7607183Braking system for a positioner in a medical imaging apparatus
In one embodiment, a braking system for a positioner unit in a medical imaging apparatus includes a first brake coupled to a drive unit that is configured to drive the positioner unit along an axis susceptible to influence of gravity. A second brake is coupled to th...
10/27/2009
7599728Magnetic resonance imaging
A neonate imaging system is provided. The neonate imaging system includes a neonate magnetic resonance imaging system and a mobile neonate incubator system adapted for connection to the neonate magnetic resonance imaging system. The mobile neonate incubator system h...
10/06/2009
7567651Directional antenna system for wireless X-ray devices
Systems and techniques are provided for a directional antenna system that employs a wireless link between x-ray apparatus. The system includes a host computer, an x-ray tube with an emission scan channel, a first directional antenna connected to the x-ray tube and w...
07/28/2009
7566877Systems, methods, and apparatus for a kinetic energy absorbing device
Systems, methods and apparatus are provided through which an impact absorbing material is affixed to a transportable device to protect the transportable device from impact with another object. In some embodiments, the impact absorbing material is a crumple zone mate...
07/28/2009
7566170Systems, methods and apparatus of an image receptor arm
Systems, methods and apparatus are provided through which in some embodiments, a medical imaging apparatus includes a medical image receptor, a wallstand, and a mechanism that provides at least 3 degrees of freedom. The mechanism is operably coupled to the medical i...
07/28/2009
7412835Apparatus and method for controlling a cryocooler by adjusting cooler gas flow oscillating frequency
Systems and methods are provided for a variable cooling capacity cryocooler for a superconducting magnetic resonance imaging device having a liquid cryogen pressure vessel to provide cryogenic temperatures to a magnet assembly, a vacuum vessel surrounding the pressu...
08/19/2008
7409564Digital radiography detector with thermal and power management
Systems and methods are provided for managing power consumption of a medical imaging detector by the use of triggering signals, environmental condition data, and/or determination of a variable time interval triggering event that is unique for each power consumption ...
08/05/2008
7138636Systems, methods and apparatus to calibrate a solid state X-ray detector
Systems, methods and apparatus are provided through which a solid-state X-Ray detector is electronically scrubbed and a flat-field X-Ray exposure of the solid-state X-Ray detector is simulated in reference to an adjusted bias of the solid-state X-Ray detector. The s...
11/21/2006
7103931Table drive system for medical imaging apparatus
A drive system for a patient support table in a medical imaging apparatus is provided. In some embodiments, the system comprises at least one first drive means for driving a patient support surface in at least one first direction, at least one second drive means for...
09/12/2006
7095000Radio-frequency driven dielectric heaters for non-nuclear testing in nuclear core development
Apparatus and methods are provided through which a radio-frequency dielectric heater has a cylindrical form factor, a variable thermal energy deposition through variations in geometry and composition of a dielectric, and/or has a thermally isolated power input. ...
08/22/2006
7090396Systems, methods and apparatus of a radiographic positioner
Systems, methods and apparatus are provided through which, in one embodiment, an X-ray source and collimator are positioned relative to an image receptor for imaging of a subject. ...
08/15/2006
6800835Radio-frequency driven dielectric heaters for non-nuclear testing in nuclear core development
Apparatus and methods are provided through which a radio-frequency dielectric heater has a cylindrical form factor, a variable thermal energy deposition through variations in geometry and composition of a dielectric, and/or has a thermally isolated power input. ...
10/05/2004
6631053Actuator pivot assembly that pivotally connects an actuator to a base of a disk drive
A disk drive includes an actuator with a shaft and a base with a sleeve that receives the shaft and includes as least one bearing. The shaft extends into the sleeve and through the bearing where it supports the actuator and allows it to pivot in response ...
10/07/2003
 
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