Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 4226887 | Anti-inflammatory agents This invention is directed to the use of certain arylacetylene compounds, principally as anti-inflammatory agents but also as anti-pyretic agents and as analgesic agents.... | 10/07/1980 |
| 4219652 | N-Methyl and N-phenethyl-cis-decahydroisoquinolines 1-Methyl and 1-phenethyl-3a-hydroxy or alkoxy phenyl-cis-decahydroisoquinolines, useful as analgetics.... | 08/26/1980 |
| 4208524 | N-Alkenyl decahydroisoquinolines 1-Alkenyl-3a-substituted-phenyl decahydroisoquinolines, useful as analgetic agonists or analgetic antagonists.... | 06/17/1980 |
| 4208515 | 3-Halo cephalosporins 7-Acylamido- and 7-amino-3-halo-3-cephem-4-carboxylic acids, esters and pharmaceutically-acceptable salts and esters thereof are new cephalosporin compounds provided by the reaction of a 7-acylamido-3-hydroxy-3-cephem-4-carboxylic acid ester or a 7-a... | 06/17/1980 |
| 4208419 | N-Heterocyclic ureas as immune regulants Benzimidazolyl, benzothiazolyl and benzoxazolyl ureas and thioureas are employed as immune regulatory agents, as agents capable of altering the immune response in mammals.... | 06/17/1980 |
| 4196125 | Substituted 1-sulfonylbenzimidazoles Certain 1-sulfonyl-2,5(6)-substituted-benzimidazole compounds are useful as antiviral agents.... | 04/01/1980 |
| 4194899 | Fluoroalkoxyphenyl-substituted nitrogen heterocycles There is disclosed a class of fluoroalkoxyphenyl-substituted nitrogen-containing heterocycles which are useful as herbicides, plant fungicides, and plant growth regulators. Internodal elongation of plants is inhibited by treatment with compounds of this i... | 03/25/1980 |
| 4194009 | Aryloxyphenylpropylamines for obtaining a psychotropic effect 3-Aryloxy-3-phenylpropylamines and acid additions salts thereof, useful as psychotropic agents, particularly as anti-depressants.... | 03/18/1980 |
| 4193935 | Novel oxiodinium and thiaiodinium compounds Novel oxiodinium and thiaiodinium compounds having a superior inhibitory effect against micro-organisms coupled with outstanding stability and low toxicity are described.... | 03/18/1980 |
| 4192670 | Acetal derivatives of 4-(substituted amino)-3,5-dinitrobenzaldehydes Novel compounds identified as acetal derivatives of 4-(substituted amino)-3,5-dinitrobenzaldehydes, effective as herbicides, and intermediates for their preparation.... | 03/11/1980 |
| 4191763 | Antibiotic A16886 and process for production thereof Antibiotic A16886I and antibiotic A16886II and their salts, having antibacterial and anthelmintic activity, prepared by fermentation of Streptomyces clavuligerus NRRL 3585.... | 03/04/1980 |
| 4190725 | 5,6-Diaryl-1,2,4-triazines 5,6-Diaryl-1,2,4-triazines, topically-active anti-inflammatory agents, having the formula, ##STR1## wherein R is hydrogen or -(X)n R1, in which X is either O or S, n is an integer which is either 0 or 1, and R1 is C | 02/26/1980 |
| 4187232 | Acylamino derivatives Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 5-membered ring containing a single heteroatom, which may be oxygen, or sulphur, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds ha... | 02/05/1980 |
| 4186204 | Acylamino derivatives Acylamino tetrazolyl compounds having anti-allergic activity, methods of making the compounds and pharmaceutical formulations containing the compounds.... | 01/29/1980 |
| 4180568 | Control of phytopathogens with certain 2,6-dinitroanilines It has been discovered that fungal foliar phytopathogens may be controlled by the use of a broad class of 2,6-dinitroanilines. The fungicidally-effective compounds may bear a broad range of substituent groups on the anilino nitrogen and in the 3- and 4-po... | 12/25/1979 |
| 4175131 | Oxazole ureas formulations and asthma treatment A class of novel 2-oxazolyl ureas and carbamates having anti-allergic activity are described together with methods of making such compounds and pharmaceutical compositions containing the active compounds of the invention.... | 11/20/1979 |
| 4175125 | Method for treating methicillin resistant staphylococcus aureus Certain halogenated phenylthioacetamido cephalosporanic acids and derivatives thereof, e.g., 7-[2'-(2",5"-dichlorophenylthio)acetamido]cephalosporanic acid, are effective antibiotics against Staphylococcus aureus cultures which show heterogeneous res... | 11/20/1979 |
| 4175197 | 1,3,4-Trisubstituted-4-aryl-1,4,5,6-tetra-hydropyridines Novel 1,3,4-trisubstituted-4-arylpiperidines are prepared by alkylating a 2,3-disubstituted-3-arylpyrroline to afford a 1,2,3-trisubstituted-3-aryl-1-pyrrolinium salt, reacting the salt with diazomethane to provide a 1,2,3-trisubstituted-3-aryl-1,2-m... | 11/20/1979 |
| 4173702 | 7-(5-Amino-5-carboxyvaler-amido)-3-(carbamoyloxymethyl)-7-methoxy-3-cep hem-4-carboxylic acid Antibiotic A16886I and antibiotic A16886II and their salts, having antibacterial and anthelmintic activity, prepared by fermentation of Streptomyces clavuligerus NRRL 3585.... | 11/06/1979 |
| 4172831 | Thieno-benzodiazepines Thieno[1,5]benzodiazepines having useful CNS activity containing the novel tricyclic ring system: ##STR1## the 10-position being substituted by an amino, preferably a piperazino, group.... | 10/30/1979 |
| 4171358 | Novel contraceptive method Progestational agents administered daily to female mammals during the follicular phase only of the cycle prevents uterine development associated with implantation in the luteal phase, thereby preventing conception.... | 10/16/1979 |
| 4171364 | N-heterocyclic ureas as immune regulants Benzimidazolyl, benzothiazolyl and benzoxazolyl ureas and thioureas are employed as immune regulatory agents, as agents capable of altering the immune response in mammals.... | 10/16/1979 |
| 4166818 | Acylamino derivatives Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,2,4-oxadiazole or 1,2,4-thiadiazole nucelus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.... | 09/04/1979 |
| 4166123 | Acylaminopyrazoles Acylamino pyrazolyl compounds of the formula: ##STR1## wherein Ar represents an optionally substituted pyrazolyl group, the acylamino group --NR1 COR2 being attached to a carbon atom of the pyrazolyl ring, which have anti-allerg... | 08/28/1979 |
| 4165316 | Process for preparing sulfinyl chlorides from penicillin sulfoxides A penicillin sulfoxide ester is reacted with an N-chloro halogenating agent at a temperature of from about 75° C. to about 135° C. and in the presence of an alkylene oxide and calcium oxide to produce a 2-chlorosulfinylazetidin-4-one intermediate. The i... | 08/21/1979 |
| 4165315 | Sulfinyl halides and their preparation from penicillin sulfoxides A penicillin sulfoxide ester is reacted with an N-chloro halogenating agent at a temperature of from about 75° C. to about 135° C. to produce a novel 2-chlorosulfinylazetidin-4-one intermediate. The intermediate can be treated with stannic chloride to p... | 08/21/1979 |
| 4163048 | Acylamino-1,2,4-oxadiazole or thiadiazole derivatives as anti-hypersensitivity agents Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,2,4-oxadiazole or 1,2,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds having anti-allergy activity.... | 07/31/1979 |
| 4159266 | Method of preparation of 3-methylenecephams Penicillin sulfoxide derived azetidinone sulfinyl chlorides and related sulfinic acid derivatives are cyclized to 3-methylenecephams by reaction with Friedel-Crafts catalysts or metathetic cation forming agents.... | 06/26/1979 |
| 4158659 | Acylamino derivatives Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,3,4-oxadiazole or 1,3,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.... | 06/19/1979 |
| 4156722 | Dinitroanilines for control of soil-borne phytopathogens A class of 2,6-dinitroanilines having a broad range of substituent groups on the anilino nitrogen and in the 3- and 4-positions of the phenyl ring are used for the protection of plants against soil-borne phytopathogens of the genus Phytophthora.... | 05/29/1979 |
| 4153709 | N-Heterocyclic ureas as immune regulants Benzimidazolyl, benzothiazolyl and benzoxazolyl ureas and thioureas are employed as immune regulatory agents, as agents capable of altering the immune response in mammals.... | 05/08/1979 |
| 4152442 | Certain acylamino-oxa (or thia) diazoles in treatment of hypersensitivity conditions Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,3,4-oxadiazole or 1,3,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.... | 05/01/1979 |
| 4151199 | Cyclopentone propanoic acid compounds Propanoic acid derivatives of the formula: ##STR1## where R1 is a C1-8 alkyl group optionally substituted by hydroxyl or --COOH and R2 is hydrogen or a protecting group, are useful as anti-thrombotic agents.... | 04/24/1979 |
| 4150143 | N-Substituted-acylamino-oxazoles as antiasthma agents Oxazoles which are substituted in the 2,4 or 5-position with an N-substituted-acylamino group have anti-allergic activity. Methods of making such compounds, pharmaceutical compositions containing the active compounds of the invention and methods of treati... | 04/17/1979 |
| 4148817 | Process and intermediates for preparing cephalosporin antibiotics The silylated and enamine protected D-3- or 4-hydroxyphenylglycine as the sodium salt of the formula ##STR1## wherein A is methyl or ethyl, are crystalline intermediates useful in a new process for the acylation of heterocyclic-thiomethyl-substituted... | 04/10/1979 |
| 4145557 | (Phenoxyphenyl) alkyl acetates, propionates, and carbamates Novel 3-phenoxyphenylalkyl amines and the amides, alcohols, tetrazoles, and carbamates related thereto as well as novel intermediates useful in the preparation of such compounds. The compounds of this invention are useful as anti-inflammatory, analgesic, ... | 03/20/1979 |
| 4145554 | 3-Nitropyrazole derivatives Novel 1,4-disubstituted-3-nitropyrazoles having antimicrobial, parasiticidal, and herbicidal activity are prepared by a reaction sequence of which the individual steps are conventional. The new 3-nitropyrazoles are characterized by a 1-substituent and a u... | 03/20/1979 |
| 4145538 | 3-Carbamyloxymethyl-cephalosporins The present invention is directed to 7-amino-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid: ##STR1## and to precursors and derivatives. The compound, its precursors, and its derivatives exhibit antibacterial activity, which, in the instance of ... | 03/20/1979 |
| 4143129 | Cephalexin tablets A small tablet containing over 90% by weight of an orally active cephalosporin such as cephalexin and which utilizes as a binder polyvinyl pyrrolidone having a number average molecular weight of from 500,000 to 1,500,000.... | 03/06/1979 |
| 4143047 | 2-Sulfinyl and 2-sulfonyl oxazoles Oxazoles having a sulfinyl or sulfonyl substituent at the 2-position are provided. Such compounds readily react with an alkali metal salt of a secondary amide in a method of making 2-acylamino oxazole derivatives having anti-allergic activity.... | 03/06/1979 |
