Smith, Esq.; DeAnn F. - US Patent Attorneys and Agents

Attorney: Smith, Esq.; DeAnn F.

Number of patents: 21
Last date: May 04, 2010

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Number	Title	Issue Date
7709196	Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance Compositions and methods are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions and methods allow isolation and analysis of mutations that would normally be lethal and allow direct selection of rRNA mutants with prede...	05/04/2010
7566808	Management of ophthalmologic disorders, including macular degeneration A drug may be used in the preparation of a medicament for the treatment or prevention of an ophthalmologic disorder, wherein the drug inihibits, antagonizes, or short-circuits the visual cycle at a step of the visual cycle that occurs outside a disc of a rod photore...	07/28/2009
7153665	Methods and compositions for screening for modulators of IgE synthesis, secretion and switch rearrangement The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement. ...	12/26/2006
6936447	Autoinducer molecule Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the ...	08/30/2005
6908740	Methods and apparatus for gel-free qualitative and quantitative proteome analysis, and uses therefore Methods and apparatus for qualitative and quantitative proteome analysis are provided. The methods and apparatus allow for the isolation of a subset of peptides out of complex mixtures of peptides. The isolation is based on a specific chemical and/or enzymatic alter...	06/21/2005
6872391	PGC-1, a novel brown fat PPARγ coactivator The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipog...	03/29/2005
6870040	Nucleic acid sequence encoding lymphoma associated molecule BAL The invention provides isolated nucleic acids molecules, designated BAL nucleic acid molecules, which are differentially expressed in non-Hodgkin's lymphoma. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing BAL ...	03/22/2005
6838437	Inactivation resistant factor VIII The present invention provides novel purified and isolated nucleic acid sequences encoding procoagulant-active FVIII proteins. The nucleic acid sequences of the present invention encode amino acid sequences corresponding to known human FVIII sequences, wherein resid...	01/04/2005
6818669	Increasing cerebral bioavailability of drugs A method and compositions are provided for increased cerebral bioavailability of blood-born compositions by administering the composition of interest while increasing brain NO levels. This increase in NO levels may be accomplished by stimulating increased production...	11/16/2004
6783756	Methods for regulating gene expression A method for regulating expression of a tet operator-linked gene in a cell of a subject is disclosed. In one embodiment, the method involves introducing into the cell a nucleic acid molecule encoding a tetracycline-controllable transactivator (tTA), the tTA comprisi...	08/31/2004
6780583	DNA encoding canine von willebrand factor and methods of use The complete sequence of the canine von Willebrand Factor cDNA and deduced amino acid sequence is provided. The mutation which causes von Willebrand's Disease in Scottish Terriers, Doberman pinschers, Shetland sheepdogs, Manchester terriers and Poodles are also prov...	08/24/2004
6767707	DNA encoding canine von willebrand factor and methods of use The complete sequence of the canine von Willebrand Factor cDNA and deduced amino acid sequence is provided. The mutation which causes von Willebrand's Disease in Scottish Terriers, Doberman pinschers, Shetland sheepdogs, Manchester terriers and Poodles are also prov...	07/27/2004
6756404	Autoinducer compounds Autoinducer compounds which enhance gene expression in a wide variety of microorganisms, therapeutic compositions and therapeutic methods wherein gene expression within microorganisms is regulated are disclosed. ...	06/29/2004
6723705	Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor Tumor cells modified to express one or more T cell costimulatory molecules are disclosed. Preferred costimulatory molecules are B7-2 and B7-3. The tumor cells of the invention can be modified by transfection with nucleic acid encoding B7-2 and/or B7-3, by using an a...	04/20/2004
6723321	Autoinducer synthase modulating compounds and uses thereof Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifing modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can...	04/20/2004
6719972	Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies Isolated ligands which bind a molecule expressed on the surface of T cells and induce antigen specific apoptosis in activated T cells are disclosed. Preferably, the T cell surface molecule is CTLA4 and the ligand is a monoclonal anti-CTLA4 antibody that binds to an ...	04/13/2004
6706255	Liquid pharmaceutical compositions comprising thyroid hormones Liquid pharmaceutical compositions comprising at least one thyroid hormone, ethanol, a pH adjusting agent, and water are disclosed. The compositions may be delivered by a metered dosage delivery system such as an aerosol or pump-action spray, and are useful in the t...	03/16/2004
6693176	Antitumor antibodies, proteins, and uses thereof Antibodies that bind to a 40 kDa protein which is expressed on tumors, but is not expressed on normal adult hemopoietic cells are disclosed. Also disclosed are methods for production and the use of such antibodies....	02/17/2004
6645766	Shuttle vectors The invention provides shuttle vectors, and methods of using shuttle vectors, capable of expression in, at least, a mammalian cell. Furthermore, the shuttle vectors are capable of replication in at least yeast, and optionally, bacterial cells. Also provid...	11/11/2003
6632789	Methods for modulating T cell responses by manipulating intracellular signal transduction Methods for modulating T cell responses by manipulating intracellular signals associated with T cell costimulation are disclosed. The methods involve inhibiting or stimulating the production of at least one D3-phosphoinositide in a T cell. Production of D...	10/14/2003
6410237	DNA encoding canine von Willebrand factor and methods of use The complete sequence of the canine von Willebrand Factor cDNA and deduced amino acid sequence is provided. The mutation which causes von Willebrand's Disease in Scottish Terriers, a single base deletion in exon 4, has also been determined. Methods for de...	06/25/2002

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Attorney: Smith, Esq.; DeAnn F.