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| Number | Title | Issue Date |
| 8114844 | Linear and cyclic melanocortin receptor-specific peptidomimetics Linear and cyclic peptidomimetics which bind to one or more melanocortin receptors are provided, which peptidomimetics include at least one ring-constrained amino acid surrogate of formula I: where R1, R2 | 02/14/2012 |
| 7968548 | Melanocortin receptor-specific piperazine compounds with diamine groups Melanocortin receptor-specific compounds with diamine groups of the general formula and pharmaceutically acceptable salts thereof, where W is a diamine heteroatom unit with at least one cationic center, hydrogen bond donor ... | 06/28/2011 |
| 7964601 | Melanocortin receptor-specific compounds A melanocortin receptor-specific compound of the general formula of structure I: where X, R1, R2a, R2b, R3, R4a, R4b, R5a and R5b are a... | 06/21/2011 |
| 7964181 | Amino acid surrogates for peptidic constructs Ring-constrained amino acid surrogates of formula I: where R1, R2, R3, R4, R5, R6a, R6b, R7, and y are as defined in the specification,... | 06/21/2011 |
| 7938079 | Annular aerosol jet deposition using an extended nozzle Method and apparatus for improved maskless deposition of electronic and biological materials using an extended nozzle. The process is capable of direct deposition of features with linewidths varying from a few microns to a fraction of a millimeter, and can be used t... | 05/10/2011 |
| 7897721 | Cyclic peptide compositions for treatment of sexual dysfunction A cyclic peptide of the structural formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, m and p are as defined. Further pr... | 03/01/2011 |
| 7834017 | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents There is provided compounds having the formula of structure I: wherein the groups —C(R8)(CH2)vCH(R9)(CH2)y-Q and —C(R8)(CH2)v | 11/16/2010 |
| 7807678 | Peptidomimetics of biologically active metallopeptides The invention relates to a method of deriving a peptidomimetic of a biologically active metallopeptide, wherein the peptidomimetic includes at least one non-peptide ring structure defining a template space superimposable on a corresponding defined template space of ... | 10/05/2010 |
| 7795378 | Peptide compositions for treatment of sexual dysfunction A peptide of the structural formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, m and n are as defined. Further provided ... | 09/14/2010 |
| 7795221 | Linear natriuretic peptide constructs Linear constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z... | 09/14/2010 |
| 7754691 | Linear melanocortin receptor-specific peptides for cachexia Linear peptides with a C-terminus —OH group that are specific for one or more melanocortin receptors, and which may be used in the treatment of melanocortin receptor-mediated disorders, including a variety of body weight disorders including cachexia, and for treat... | 07/13/2010 |
| 7732451 | Naphthalene-containing melanocortin receptor-specific small molecule A method of modulating energy homeostasis in a mammal without eliciting a sexual response by administration of a therapeutically effective amount of a pharmaceutical composition including a melanocortin receptor compound of the formula: | 06/08/2010 |
| 7727991 | Substituted melanocortin receptor-specific single acyl piperazine compounds Melanocortin receptor-specific compounds of the general formula and pharmaceutically acceptable salts thereof, where J is a substituted or unsubstituted monocyclic or bicyclic ring structure, W is a heteroatom unit with at ... | 06/01/2010 |
| 7727990 | Melanocortin receptor-specific piperazine and keto-piperazine compounds Melanocortin receptor-specific compounds of the general formula and pharmaceutically acceptable salts thereof, where X, W, J, Q, L1, L2, L3, R1a, R1b, R2a, a... | 06/01/2010 |
| 7718802 | Substituted melanocortin receptor-specific piperazine compounds Melanocortin receptor-specific compounds of the general formulas and pharmaceutically acceptable salts thereof, where J is a substituted or unsubstituted monocyclic or bicyclic ring structure, L is a linker, W is a heteroat... | 05/18/2010 |
| 7709484 | Substituted melanocortin receptor-specific piperazine compounds A substituted piperazine compound having the structure I: or the structure IX: or an enantomeric, stereoisomeric or diastereomeric form of the foregoing, and pharmaceutically acce... | 05/04/2010 |
| 7655658 | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds A thienopyrimidine compound of the formula: wherein R1, R2, R3, and R4 are as defined herein, and methods of use of such compounds for the treatment of melanocortin receptor-assoc... | 02/02/2010 |
| 7649141 | Emitter wrap-through back contact solar cells on thin silicon wafers A thin emitter wrap-through solar cell and method for making a thin emitter wrap-through solar cell. The cell preferably includes a silicon wafer substrate having a thickness of less than 280 microns. The p-type area on the back side of the cell is minimized, which ... | 01/19/2010 |
| 7622440 | Cyclic natriuretic peptide constructs Cyclic constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J... | 11/24/2009 |
| 7601753 | Pyrrolidine melanocortin-specific compounds Melanocortin receptor-specific pyrrolidine compounds having the structure: and stereoisomer and pharmaceutically acceptable salts thereof, where R1, R2, and R3 are as described in the specif... | 10/13/2009 |
| 7550602 | Small molecule compositions for sexual dysfunction Compounds of the general formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, and X are as defined. Further provided are methods for treatment of sexual dysfunction, i... | 06/23/2009 |
| 6949220 | Artificial heart-lung apparatus An integrated, artificial heart-lung machine and method for performing extracorporeal blood oxygenation and circulation. The heart-lung machine is a single unit in which a cylindrical artificial lung, preferably with a heat exchanger, is connected in series to an un... | 09/27/2005 |
| 7528105 | Heterodimeric chain synthetic heparin-binding growth factor analogs The invention provides synthetic heparin-binding growth factor analogs having at least two different peptide growth factor analog chains, or alternatively two groups of two different peptide chains branched from branch moieties including trifunctional amino acid res... | 05/05/2009 |
| 7482427 | Positive modulator of bone morphogenic protein-2 Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a lin... | 01/27/2009 |
| 7473760 | Cyclic peptide compositions for treatment of sexual dysfunction A cyclic peptide of the structural formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, R6, m, n and p are as defined. Further provided are c... | 01/06/2009 |
| 7468210 | Cross-linked heparin coatings and methods A thromboresistant coating for a medical device, method of coating and coated medical device, the coating including an in situ cross-linked co-polymer of a cross-linkable biomolecule, preferably an adsorbable biomolecule such as a heparin activity biomolecule with a... | 12/23/2008 |
| 7445619 | Devices for electrosurgery Devices for electrosurgery by means of oxy-hydro combustion and methods for use of such devices in electrosurgical procedures. Provided are devices for combustion of oxygen and hydrogen, or other hydrocarbon fuels, wherein oxygen and hydrogen may be generated by ele... | 11/04/2008 |
| 7425608 | Method of making metallopeptides Method of making metallopeptides is provided, for use in biological, pharmaceutical and related applications. The metallopeptides are made of peptides, peptidomimetics and peptide-like constructs, and include a metal ion-binding region thereof which includes at leas... | 09/16/2008 |
| 7417027 | Linear and cyclic melanocortin receptor-specific peptides Linear and cyclic peptides are provided specific to one or melanocortin receptors, and which exhibit agonist, antagonist, or mixed agonist-antagonist activity. In one embodiment, a linear peptide of the following general formula is provided: | 08/26/2008 |
| 7396814 | Metallopeptide compositions for treatment of sexual dysfunction Metallopeptide compositions are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. The metallopeptides include at least one, and preferably two, aromatic amino acid... | 07/08/2008 |
| 7385025 | Metallopeptide compounds Metallopeptides with a sequence of a biologically active alpha-melanocyte stimulating hormone (α-MSH), gamma-melanocyte stimulating hormone (γ-MSH), or bombesin sequence of length n residues, wherein a residue including a nitrogen atom and sulfur atom each availab... | 06/10/2008 |
| 7354438 | Devices for electrosurgery Devices for electrosurgery by means of oxy-hydro combustion. Deleterious effects to tissue are minimized by means of control of acid-base shift reactions, which reactions can further be employed to control oxy-hydro combustion reactions. In one embodiment, radiofreq... | 04/08/2008 |
| 7345144 | Cyclic peptides for treatment of cachexia A highly selective melanocortin-4 receptor antagonist cyclic hexapeptide of the formula where R1, R2, R3a, R3b, R4, R5, x, y and z are as defined in the spec... | 03/18/2008 |
| 7342089 | Cyclic peptides for treatment for cachexia A highly selective melanocortin-4 receptor antagonist cyclic peptide of the formula where R1, R2, R3, R4a, R4b, R5, R6, R7, x, y and z ... | 03/11/2008 |
| 7335555 | Buried-contact solar cells with self-doping contacts A buried-contact solar cell, in-process buried-contact solar cell components and methods for making buried contact solar cells wherein a self-doping contact material is placed in a plurality of buried-contact surface grooves. By combining groove doping and metalliza... | 02/26/2008 |
| 7307063 | Melanocortin metallopeptides for treatment of sexual dysfunction Metallopeptides are provided for use in treatment of sexual dysfunction in mammals. The metallopeptides are agonists for at least one of melanocortin-3 or melanocortin-4 receptors. The metallopeptides are conformationally fixed on complexation of a metal ion-binding... | 12/11/2007 |
| 7297343 | Bioactive medical films A wound dressing, method of making, and method of use, utilizing a polymeric film having complexed thereto by hydrophobic interaction a construct including a polyanion covalently bonded to a hydrophobic prosthetic moiety, with one or more bioactive molecules directl... | 11/20/2007 |
| 7235625 | Multiple agent therapy for sexual dysfunction Multiple agent therapy for treatment of sexual dysfunction, including male erectile dysfunction, with sequential administration a type V phosphodiesterase inhibitor (PDE-5), such as sildenafil, preferably wherein the PDE-5 inhibitor is administered by oral dose mean... | 06/26/2007 |
| RE39651 | Apparatus for rapid cooling of the brain and method of performing same Rather than cooling the brain by the relatively slow heat conduction through the low heat conductivity of the bony skull and hair covering the head, the present invention teaches the use of a light weight, easily applied neck encircling collar in firm contact with t... | 05/22/2007 |
| 7217769 | Medical device with plasma cross-linked hydrophilic coating A medical device with a hydrophilic and lubricious coating, wherein the coating includes a hydrophilic polymeric unit layer deposited on the medical device and cross-linked with a plasma deposited double bond monomer. The hydrophilic polymeric unit can include ethyl... | 05/15/2007 |
