Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 8114661 | Electronic methods for the detection of analytes The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques. ... | 02/14/2012 |
| 8088376 | Fc variants with altered binding to FcRn The present application relates to a variant Fc region comprising the double mutation 428L/434S that increases serum half-life and the numbering is according to the EU index. ... | 01/03/2012 |
| 8084582 | Optimized anti-CD20 monoclonal antibodies having Fc variants The present invention relates to optimized CD20 antibodies having Fc variants, methods for their generation, and method for their application, such as methods of enhancing macrophage activation, particularly for therapeutic purposes. ... | 12/27/2011 |
| 7960104 | Self-assembled single molecule arrays and uses thereof The present invention provides methods of making and using self-assembled arrays of single polynucleotide molecules for carrying out a variety of large-scale genetic measurements, such as gene expression analysis, gene copy number assessment, and the like. Random ar... | 06/14/2011 |
| 7935481 | Sequence determination of nucleic acids using electronic detection The present invention is directed to methods and compositions for the use of self-assembled monolayers to electronically detect nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide polymorphisms (SNPs). ... | 05/03/2011 |
| 7910354 | Efficient arrays of amplified polynucleotides The present invention is related generally to analysis of polynucleotides, particularly polynucleotides derived from genomic DNA. The invention provides methods, compositions and systems for such analysis. Encompassed by the invention are arrays of polynucleotides i... | 03/22/2011 |
| 7910304 | Random array DNA analysis by hybridization The invention relates to methods and devices for analyzing single molecules, i.e. nucleic acids. Such single molecules may be derived from natural samples, such as cells, tissues, soil, air and water without separating or enriching individual components. In certain ... | 03/22/2011 |
| 7910302 | Efficient arrays of amplified polynucleotides The present invention is related generally to analysis of polynucleotides, particularly polynucleotides derived from genomic DNA. The invention provides methods, compositions and systems for such analysis. Encompassed by the invention are arrays of polynucleotides i... | 03/22/2011 |
| 7906285 | Random array DNA analysis by hybridization The invention relates to methods and devices for analyzing single molecules, i.e. nucleic acids. Such single molecules may be derived from natural samples, such as cells, tissues, soil, air and water without separating or enriching individual components. In certain ... | 03/15/2011 |
| 7901891 | Nucleic acid analysis by random mixtures of non-overlapping fragments The invention provides methods and kits for ordering sequence information derived from one or more target polynucleotides. In one aspect, one or more tiers or levels of fragmentation and aliquoting are generated, after which sequence information is obtained from fra... | 03/08/2011 |
| 7901890 | Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation Aspects described and claimed herein provide methods to insert multiple DNA adaptors into a population of circular target DNAs at defined positions and orientations with respect to one another. The resulting multi-adaptor constructs are then used in massively-parall... | 03/08/2011 |
| 7897344 | Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs Aspects described and claimed herein provide methods to insert multiple DNA adaptors into a population of circular target DNAs at defined positions and orientations with respect to one another. The resulting multi-adaptor constructs are then used in massively-parall... | 03/01/2011 |
| 7863035 | Fluidics devices The invention relates to fluidics as used in medical and diagnostic equipment and relates further to means for purifying, abstracting, filtering, detecting and/or measuring analytes in liquid samples. ... | 01/04/2011 |
| 7851146 | Nucleic acid mediated electron transfer The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic ac... | 12/14/2010 |
| 7820391 | Baseless nucleotide analogues and uses thereof A method of detecting a target nucleic acid. ... | 10/26/2010 |
| 7759073 | Electronic methods for the detection of analytes The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques. ... | 07/20/2010 |
| 7713711 | Electronic methods for the detection of analytes The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques. ... | 05/11/2010 |
| 7709197 | Nucleic acid analysis by random mixtures of non-overlapping fragments The invention provides methods and kits for ordering sequence information derived from one or more target polynucleotides. In one aspect, one or more tiers or levels of fragmentation and aliquoting are generated, after which sequence information is obtained from fra... | 05/04/2010 |
| 7655129 | Binding acceleration techniques for the detection of analytes The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either dire... | 02/02/2010 |
| 7601507 | Electronic methods for the detection of analytes The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques. ... | 10/13/2009 |
| 7595153 | Detection of analytes using reorganization energy The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process. ... | 09/29/2009 |
| 7582419 | Detection of analytes using reorganization energy The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process. ... | 09/01/2009 |
| 7579145 | Detection of analytes using reorganization energy The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process. ... | 08/25/2009 |
| 7566534 | Detection of analytes using reorganization energy The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process. ... | 07/28/2009 |
| 7560237 | Electronics method for the detection of analytes The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques. ... | 07/14/2009 |
| 7534331 | Use of microfluidic systems in the electrochemical detection of target analytes The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes. ... | 05/19/2009 |
| 7514228 | Detection of analytes using reorganization energy The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process. ... | 04/07/2009 |
| 7399829 | Variants of RANKL protein The present invention relates to novel, soluble, recombinant variants RANKL (Receptor Activator of Nuclear Factor—κB Ligand) proteins, which may be expressed solubly in E. coli, variants that act as RANKL antagonists, and methods for generating the same. | 07/15/2008 |
| 7393645 | Compositions for the electronic detection of analytes utilizing monolayers The present invention relates to the use of self-assembled monolayers with mixtures of conductive oligomers and insulators to detect target analytes. ... | 07/01/2008 |
| 7384749 | Electrodes linked via conductive oligomers to nucleic acids The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class o... | 06/10/2008 |
| 7381525 | AC/DC voltage apparatus for detection of nucleic acids The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class o... | 06/03/2008 |
| 7381792 | Variants of RANKL protein The present invention relates to novel, soluble, recombinant RANKL (Receptor Activator of Nuclear Factor—κB Ligand) variant proteins which may be expressed solubly in E. coli, variants that have substantially reduced binding to OPG, variants that act as RA... | 06/03/2008 |
| 7381533 | Electrodes linked via oligomers to nucleic acids The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class o... | 06/03/2008 |
| 7354568 | Magnetic resonance imaging agents for the detection of physiological agents The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances. ... | 04/08/2008 |
| 7312087 | Devices and methods for biochip multiplexing The invention is directed to devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the plurality of biochips includes inserting a first biochp into a first station of an analysis device, inserting a second biochip into a ... | 12/25/2007 |
| 7267939 | Detection of analytes using reorganization energy The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process. ... | 09/11/2007 |
| 7208473 | Nucleic acids and protein variants of hG-CSF with granulopoietic activity The invention relates to novel granulopoietic activity (GPA) proteins and nucleic acids. The invention further relates to the use of the GPA proteins in the treatment of G-CSF related disorders. ... | 04/24/2007 |
| 7192939 | isolates and compounds derived therefrom The present invention relates to the novel isolated 12–30 strain of Pestalotiopsis microspora capable of producing novel antioxidant and antimycotic agents. The present invention also relates to the novel isolated 3,5,7 trisubstituted isobenzofuranone and d... | 03/20/2007 |
| 7172897 | Devices and methods for biochip multiplexing The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysi... | 02/06/2007 |
| 7160678 | Compositions for the electronic detection of analytes utilizing monolayers The present invention relates to the use of self-assembled monolayers with mixtures of conductive oligomers and insulators to detect target analytes. ... | 01/09/2007 |
