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| Number | Title | Issue Date |
| 8124731 | Optimized Fc variants and methods for their generation The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. ... | 02/28/2012 |
| 8101720 | Immunoglobulin insertions, deletions and substitutions An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more FcγRs, wherein said Fc variant comprises at least one amino acid insertion in the Fc region of said parent Fc polypeptide. ... | 01/24/2012 |
| 8093359 | Optimized Fc variants and methods for their generation The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. ... | 01/10/2012 |
| 8093357 | Optimized Fc variants and methods for their generation The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. ... | 01/10/2012 |
| 8039592 | Optimized Fc variants and methods for their generation The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. ... | 10/18/2011 |
| 7930107 | Methods of generating variant proteins with increased host string content The present invention relates to novel methods for generating variant proteins with increased host string content, and proteins that are engineered using these methods. ... | 04/19/2011 |
| 7749956 | Method of treatment using adiponectin variants A method of treating a mammal with an adiponectin mediated disorder comprising administering a therapeutically effective amount of an adiponectin variant with at least a 3-fold increased solubility relative to residues 110-244 of human adiponectin. ... | 07/06/2010 |
| 7709607 | Adiponectin variants An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the solubility of the variant is improved by at least 3-fold relative to residues 110-244 of human adiponectin. ... | 05/04/2010 |
| 7687461 | Treatment of TNF-α related disorders with TNF-α variant proteins The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders. ... | 03/30/2010 |
| 7678886 | Pharmaceutical compositions of adiponectin variants and methods of storage A composition comprising an adiponectin variant at a concentration of at least 2.0 mg/mL, and a pharmaceutically acceptable carrier, wherein less than 20% of said adiponectin variant would aggregate after storage at 4° C. for one week in 10 mM PO4, 150 m... | 03/16/2010 |
| 7662925 | Optimized Fc variants and methods for their generation The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. ... | 02/16/2010 |
| 7662367 | Pharmaceutical compositions for the treatment of TNF-α related disorders The invention relates to a pharmaceutical composition comprising a variant TNF-α protein that inhibits the activity of soluble TNF-α while substantially maintaining the activity of transmembrane TNF-α a buffer and a tonicity agent wherein said composition has a p... | 02/16/2010 |
| 7657380 | Methods of generating variant antibodies with increased host string content The present invention relates to novel methods for generating variant proteins with increased host string content by comparing a parent protein sequence with two or more natural protein sequences from a host species, analyzing one or more amino acid strings of the p... | 02/02/2010 |
| 7642340 | PEGylated TNF-α variant proteins The present invention relates to the use of simulation technology to rationally optimize the locations and sizes of attached polymeric moieties for modification of therapeutic proteins and the proteins generated from this method. ... | 01/05/2010 |
| 7610156 | Methods for rational pegylation of proteins The present invention relates to the use of simulation technology to rationally optimize the locations and sizes of attached polymeric moieties for modification of therapeutic proteins and the proteins generated from this method. ... | 10/27/2009 |
| 7587286 | Methods for rational pegylation of proteins The present invention relates to the use of simulation technology to rationally optimize the locations and sizes of attached polymeric moieties for modification of therapeutic proteins and the proteins generated from this method. ... | 09/08/2009 |
| 7553930 | BAFF variants and methods thereof The invention relates to novel proteins with BAFF dominant negative antagonist, receptor antagonist activity and agonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of BAFF or AP... | 06/30/2009 |
| 7446174 | Protein based TNF-α variants for the treatment of TNF-α related disorders The invention relates to novel proteins with TNF-α antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-α related disorders. ... | 11/04/2008 |
| 7379822 | Protein design automation for protein libraries The invention relates to the use of protein design automation (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries. ... | 05/27/2008 |
| 7317091 | Optimized Fc variants The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. ... | 01/08/2008 |
| 7315786 | Protein design automation for protein libraries The invention relates to the use of protein design automation (P DA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries. ... | 01/01/2008 |
| 7276585 | Immunoglobulin variants outside the Fc region The present invention relates to antibody variants outside the Fc region that alter binding affinity to one or more effector ligands, methods for their generation, and their therapeutic application. ... | 10/02/2007 |
| 7244823 | TNF-alpha variants proteins for the treatment of TNF-alpha related disorders The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders. ... | 07/17/2007 |
| 7234828 | Integrated systems with electroluminescent illumination and methods thereof An illumination device comprising a protective casing that comprises an illumination system of at least two band members and an illumination coating that has a communications line component with a first end and a second end, and a first power source connected to sai... | 06/26/2007 |
| 7204534 | Smoke detector changing device The invention relates to a novel device for easy maintenance of smoke detectors, comprising a three dimensional “receptacle” that attaches to a pole and fits around a smoke detector housing to easily remove it from its mounting plate. ... | 04/17/2007 |
| 7029655 | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits The invention relates to a novel class of magnetic resonance imaging agents that can cross the blood brain barrier and provide accurate magnetic resonance imaging of the brain, especially magnetic resonance images of amyloid deposits associated with Alzheimer's dise... | 04/18/2006 |
| 6951927 | Proteins with integrin-like activity The invention relates to novel proteins with novel integrin and I domain activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of integrin related disorders. | 10/04/2005 |
| 6942771 | Microfluidic systems in the electrochemical detection of target analytes The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes. ... | 09/13/2005 |
| 6890764 | Encoding and decoding of array sensors utilizing nanocrystals Described herein are assays and components for encoding and decoding microspheres. Each assay or component described utilizes at least one nanocrystal. ... | 05/10/2005 |
| 6875619 | Microfluidic devices comprising biochannels The present invention is directed to a variety of microfluidic devices with configurations including the use of biochannels or microchannels comprising arrays of capture binding ligands to capture target analytes in samples. The invention provides microfluidic casse... | 04/05/2005 |
| 6864359 | Structure-based screening techniques for drug discovery The invention relates to novel non-naturally occurring cell surface receptor analogs, ligand analogs and nucleic acids encoding them. The invention further provides methods for screening of ligand analogs and bioactive agents capable of modulating the signaling acti... | 03/08/2005 |
| 6824669 | Protein and peptide sensors using electrical detection methods The present invention provides an apparatus and methods for the electrical detection of molecular interactions between a probe molecule and a protein or peptide target molecule, but without requiring the use of electrochemical or other reporters to obtain measurable... | 11/30/2004 |
| 6804611 | Apparatus and method for automated protein design The present invention relates to apparatus and methods for quantitative protein design and optimization. ... | 10/12/2004 |
| 6801861 | Apparatus and method for automated protein design The present invention relates to apparatus and methods for quantitative protein design and optimization. ... | 10/05/2004 |
| 6792356 | Apparatus and method for automated protein design The present invention relates to apparatus and methods for quantitative protein design and optimization. ... | 09/14/2004 |
| 6770261 | Magnetic resonance imaging agents for the detection of physiological agents The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances. ... | 08/03/2004 |
| 6761816 | Printed circuit boards with monolayers and capture ligands The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either dire... | 07/13/2004 |
| 6753143 | Target analyte detection using asymmetrical self-assembled monolayers The present invention relates to the use asymmetric monolayer forming species and electroconduit forming species to detect target analytes. ... | 06/22/2004 |
| 6620584 | Combinatorial decoding of random nucleic acid arrays The invention provides methods and compositions for combinatorially decoding arrays.... | 09/16/2003 |
| 6326151 | Screening methods to identify agents that selectively inhibit hepatitis C virus replication The present invention relates to novel methods for identifying antiviral agents which selectively interfere with viral proteins that override the interferon(IFN)-induced cellular defense mechanisms against viral infection. In particular, the present inven... | 12/04/2001 |
