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| Number | Title | Issue Date |
| 8093255 | Imidazo[1,2-A]pyrimidines as orexin receptor antagonists This invention relates to imidazopyrimidine substituted piperidine derivatives and their use as pharmaceuticals. ... | 01/10/2012 |
| 8048907 | Receptor antagonists and their methods of use The present invention relates to novel oxo-prolinamide derivatives of formula (I) which modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor and the use of such compounds o... | 11/01/2011 |
| 8012981 | Benzylpiperazine derivatives as motilin receptor agonists The invention relates to compounds of formula (I): processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 rece... | 09/06/2011 |
| 7977337 | Quinoline derivatives and their use as 5-HT6 ligands Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, ... | 07/12/2011 |
| 7964602 | Biaryl compounds useful as agonists of the Gpr38 receptor The present invention relates to novel biaryl derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.... | 06/21/2011 |
| 7964597 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases Disclosed are motilin agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders. ... | 06/21/2011 |
| 7943645 | Piperidine compounds for use as orexin receptor antagonist This invention relates to N-aroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists. ... | 05/17/2011 |
| 7935832 | Pyrrole and isoindole carboxamide derivatives as P2X7 modulators The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein: R2 represents hydrogen, halogen, C1-6 alkyl, C6-10 arylmethyl-, C2-6 | 05/03/2011 |
| 7932282 | Imidazolidine carboxamide derivatives as P2X7 modulators The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: The compounds or salts modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7... | 04/26/2011 |
| 7928125 | N-aroyl cyclic amine derivatives as orexin receptor antagonists Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists. ... | 04/19/2011 |
| 7928124 | N-aroyl cyclic amine derivatives as orexin receptor antagonists Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists. ... | 04/19/2011 |
| 7928108 | Pyridinone derivative for the treatment of premature ejaculation The invention provides 3-(methyloxy)-1-{4-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]butyl}-2(1H)-pyridinone of formula (I), or a pharmaceutically acceptable salt thereof. ... | 04/19/2011 |
| 7919507 | N-aroyl cyclic amines Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals. ... | 04/05/2011 |
| 7902394 | Calcilytic compounds Novel calcilytic compounds of Formula (I), pharmaceutical compositions, methods of synthesis, and methods of using them are provided. ... | 03/08/2011 |
| 7897618 | N-aroyl cyclic amine derivatives as orexin receptor antagonists Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists. ... | 03/01/2011 |
| 7893090 | N-aroyl cyclic amine derivatives as orexin receptor antagonists Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists. ... | 02/22/2011 |
| 7888347 | Pyrazolo [3,4-D]azepine derivatives as histamine H3 antagonists The present invention relates to novel pyrazole derivatives of formula I having pharmacological activity as H3 antagonists processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders. | 02/15/2011 |
| 7799774 | Quinoline derivatives and their use as 5-HTligands Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, ... | 09/21/2010 |
| 7799773 | Benzazepine derivatives for the treatment of neurological disorders The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders. ... | 09/21/2010 |
| 7754733 | Crystalline topotecan hydrochloride product and process for making the same Disclosed is a novel crystalline form of topotecan monohydrochloride pentahydrate, which is a pentahydrate of 10-[(dimethylamino)methyl]4-ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H, 12H)dione monohydrochloride, corresponding pharm... | 07/13/2010 |
| 7741329 | N-aroyl cyclic amines Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals. ... | 06/22/2010 |
| 7732600 | Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors Disclosed are methods for the preparation of compounds of formula (I): wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the descrip... | 06/08/2010 |
| 7718693 | Receptor antagonists and their methods of use The present invention relates to novel oxo-prolinamide derivatives of formula (I) which modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor and the use of such compounds o... | 05/18/2010 |
| 7704994 | Benzazepine derivatives for the treatment of neurological disorders The present invention relates to benzazepine derivatives of formula (I) wherein: R1 represents —C3-7 cycloalkyl optionally substituted by C1-3 alkyl; having pharmacological activity, processes for their preparation, to compositions... | 04/27/2010 |
| 7700599 | Gpr38 Receptor Agonists The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 recep... | 04/20/2010 |
| 7696193 | Benzazepine derivatives for the treatment of neurological disorders The present invention relates to benzazepine derivatives of formula (I) wherein: R1 represents —C3-7 cycloalkyl optionally substituted by C1-3 alkyl; having pharmacological activity, processes for their preparation, to compositions... | 04/13/2010 |
| 7601837 | Quinoline derivatives and their use as 5-HT6 ligands The present invention relates to novel quinoline compounds having pharmacological activity, to processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders. ... | 10/13/2009 |
| 7592346 | Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors Disclosed are methods for use of compounds of formula (I) in combination with other active substances in the treatment of CNS disorders such as depression or anxiety. wherein R1, m, X, R2, n, W, p, Y, ... | 09/22/2009 |
| 7560586 | Acid and ester compounds and methods of using the same Disclosed is a compound of having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, ... | 07/14/2009 |
| 7560452 | Benzazepine derivatives for the treatment of neurological disorders The present invention relates to benzazepine derivatives of formula (I) wherein: R1 represents —C3-7 cycloalkyl optionally substituted by C1-3 alkyl; having pharmacological activity, processes for their preparation, to compositions... | 07/14/2009 |
| 7470710 | N-aroyl cyclic amine derivatives as orexin receptor antagonists This invention relates to N-aroyl cyclic amine derivatives of formula (I), wherein X represents a bond, oxygen, NR3 or a group (CH2), wherein n represents 1, 2 or 3; Y represents CH2, CO, CH(OH), or CH2CH(OH); Het is an op... | 12/30/2008 |
| 7468367 | Ethylene diamine derivatives and their use as orexin-receptor antagonists This invention relates to heterocyclic substituted ethylene diamine derivatives and their use as pharmaceuticals. ... | 12/23/2008 |
| 7459456 | Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined ... | 12/02/2008 |
| 7439244 | Quinoline compounds and pharmeceutical compositions containing them Disclosed are quinoline compounds of formula (I) having pharmacological activity, processes for their preparation, compositions containing them, and methods for the treatment of CNS and other disorders. ... | 10/21/2008 |
| 7439245 | Compounds Disclosed is a method for use of phenyl sulfone compounds of formula (I) in the treatment of anxiety. ... | 10/21/2008 |
| 7439243 | Piperazinyl-quinoline derivatives useful for the treatment of CNS disorders Disclosed are quinoline compounds of formula (I) having pharmacological activity, processes for their preparation, compositions containing them, and methods for the treatment of CNS and other disorders. ... | 10/21/2008 |
| 7432270 | N-aroyl cyclic amines This invention relates to N-aroyl cyclic amine derivatives and their use as orexin antagonists wherein: Y represents a bond, oxygen, or a group (CH2)n, wherein n represents 1, 2 or 3;... | 10/07/2008 |
| 7423052 | Piperidine compounds for use as orexin receptor antagoinst A invention relates to N aroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists. ... | 09/09/2008 |
| 7423004 | Solid dispersion compositions Disclosed is a water-dispersible solid composition of a sparingly water-soluble compound in a particulatable lipidic carrier, methods for the preparation and use of the same. The compositions of this intention provide improved solubility and dissolution characterist... | 09/09/2008 |
| 7405217 | N-aroyl piperazine derivatives as orexin receptor antagonists This invention relates to N-aroyl cyclic amino derivatives and their use as pharmaceuticals. ... | 07/29/2008 |
