Quotables
"We are probably nearing the limit of all we can know about astronomy."
Simon Newcomb, astronomer ; 1888
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8183282 | Therapeutic uses of urolithins The subject invention is drawn to ellagitannin metabolites (e.g., urolithin) that find use in treating or preventing a neoplastic disease in a subject. ... | 05/22/2012 |
| 8183010 | Cell-free synthesis of membrane bound polypeptides Methods are provided for the utilization of bacterial cell-free extracts in the synthesis of high yields of membrane-associated polypeptides. ... | 05/22/2012 |
| 8163305 | Targeted cross-linked nanoparticles and their use in vivo gene delivery The in vivo delivery of nucleic acids is targeted by delivery of the nucleic acid in a complex with cross-linked nanoparticles; where the nanoparticles comprise cross-linked neutral amphipathic molecules, cationic amphipathic molecules and targeting amphipathic mole... | 04/24/2012 |
| 8153593 | Transglutaminase inhibitors and methods of use thereof Transglutaminase inhibitors and methods of use thereof are provided. ... | 04/10/2012 |
| 8153388 | Methods for phenotyping of leukemias Isolated populations of leukemic stem cells are provided. The cells are useful for experimental evaluation, and as a source of lineage and cell specific products, and as targets for the discovery of factors or molecules that can affect them. Detection of leukemic st... | 04/10/2012 |
| 8148105 | Scaleable manufacturing process for cysteine endoprotease B, isoform 2 Methods are provided for the production of gram to kilogram quantities of pro-EP-B2 (proenzyme form of EP-B2) in a lyophilized form. The methods include scalable fermentation, refolding and purification processes, which processes may be combined with lyophilization ... | 04/03/2012 |
| 8143241 | DNA damage repair inhibitors for treatment of cancer The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR d... | 03/27/2012 |
| 8143210 | Enzyme treatment of foodstuffs for celiac sprue Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten. ... | 03/27/2012 |
| 8119125 | Compositions and methods for enhanced gastrointestinal stability of oligopeptides and polypeptides Methods and compositions are provided for stabilizing polypeptides for oral administration, particularly where enteric delivery is desirable. By administering the polypeptides with a bile sequestering agent, the stability of the polypeptide can be increased. Pharmac... | 02/21/2012 |
| 8071579 | DNA damage repair inhibitors for the treatment of cancer The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR d... | 12/06/2011 |
| 8071316 | Diagnostic method for celiac sprue Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue. ... | 12/06/2011 |
| 8063192 | Microbial reductive dehalogenation of vinyl chloride Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides-like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that met... | 11/22/2011 |
| 8038992 | Target for regulating multiple sclerosis Methods are provided for decreasing demyelinating inflammatory disease in a subject by inhibiting the activity of chemokine-like receptor 1 (CMKLR1). Methods are also provided for screening for agents that find use in treating demyelinating inflammatory disease in a... | 10/18/2011 |
| 8021851 | Thr51 phosphorylated HP 1β protein for the assessment of DNA damage This invention relates to the finding that HP1β is phosphorylated at Thr51 at an early stage in the DNA damage response in cells. Thr51P HP1β is therefore a biomarker for DNA damage which may be useful, for example, in assessing DNA damage, cancer susceptibility o... | 09/20/2011 |
| 8019551 | Biological dataset profiling of asthma and atopy Methods and systems for evaluating biological dataset profiles relating to asthma and other atopic conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate ph... | 09/13/2011 |
| 7973130 | Mammalian tumor susceptibility genes and their uses TSG101 is a tumor susceptibility gene whose homozygous functional knock out in fibroblasts leads to transformation and the ability of these cells to form metastatic tumors in nude mice. The cellular transformation that results from inactivation of TSG101 is reversib... | 07/05/2011 |
| 7973011 | Blockade of gamma-secretase activity to promote myelination by oligodendrocytes Methods are provided for enhancing myelination. Myelination is enhanced by administration of agents that are inhibitors of γ-secretase. Methods of screening for pharmaceutically active compounds that enhance myelination, and for genes involved in myelination are al... | 07/05/2011 |
| 7964369 | Polypeptide complex that regulates cell cycle and anergy An active ubiquitin E3 ligase, GRAIL, is crucial in the induction of anergy in cells of the immune system, and in the regulation of cellular proliferation. GRAIL is shown to associate with, and be regulated by Otubain isoforms, including OTUBAIN-1 (DOG, the Destabil... | 06/21/2011 |
| 7960125 | Identification of thymically derived CD4 T cells by protein tyrosine kinase 7 expression The invention provides methods of identifying naïve T cells by expression of PTK7. ... | 06/14/2011 |
| 7947280 | Apelin and uses thereof The invention provides a method of treating or preventing heart failure or a disease or condition associated with heart failure comprising administering an effective dose of an apelin peptide or APJ receptor ligand to the subject. According to certain embodiments of... | 05/24/2011 |
| 7947278 | Methods of modulating angiogenesis The present invention provides methods of modulating angiogenesis in an individual, the methods generally involving administering to an individual an agent that modulates the expression or activity of Egfl7, where an agonist of Egfl7, including an Egfl7 polypeptide,... | 05/24/2011 |
| 7943312 | Enzyme treatment of foodstuffs for celiac sprue Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten. ... | 05/17/2011 |
| 7943306 | Gene expression signature for prediction of human cancer progression Methods are provided for classification of cancers by the expression of a set of genes referred to as the core serum response (CSR), or a subset thereof. The expression pattern of the CSR in normal tissues correlates with that seen in quiescent fibroblasts cultured ... | 05/17/2011 |
| 7928056 | Enzyme treatment of foodstuffs for Celiac Sprue Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten. ... | 04/19/2011 |
| 7923562 | Photocleavable linker methods and compositions Bifunctional linkers are provided that comprise a photocleavable moiety flanked by two different amine reactive moieties. In some embodiments the photocleavable moiety is a dimethoxynitrobenzyl moiety. In other embodiments the photocleavable moiety is 8-bromo-7-hydr... | 04/12/2011 |
| 7923532 | Methods for diagnosing celiac sprue and reagents useful therein Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten. ... | 04/12/2011 |
| 7922999 | Administration of growth factors for the treatment of CNS disorders A method and system that is directed to the local delivery of growth factors to the mammalian CNS to treat CNS disorders associated with neuronal death and/or dysfunction is described. ... | 04/12/2011 |
| 7919636 | Purifications of pomegranate ellagitannins and their uses thereof Compositions of purified and biologically active ellagitannins are provided by separation from pomegranate husk using a method of extraction and purification using a solid polymeric adsorbent and the uses of the said compounds. ... | 04/05/2011 |
| 7912651 | Function homology screening A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete paramete... | 03/22/2011 |
| 7910541 | Enzyme treatment of foodstuffs for celiac sprue Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten. ... | 03/22/2011 |
| 7908090 | Signatures for human aging Age and related conditions are assessed with a gene expression test that determines the expression levels of a panel of genetic markers. Each age signature contains expression information for genes in at least one functional group that is identified herein as having... | 03/15/2011 |
| 7908089 | Patient classification Clinical patient tissue samples are classified according to the physiological status of cells present in the sample. In some embodiments of the invention, such cells are classified according to their ability to respond to therapeutic agents and treatments. In other ... | 03/15/2011 |
| 7902121 | MHC-antigen arrays for detection and characterization of immune responses T cells are profiled with respect to their expression of antigen receptor. The cells are arrayed on a planar or three-dimensional substrate through binding to immobilized or partially diffused MHC-antigen complexes. The cells may further be characterized with respec... | 03/08/2011 |
| 7897791 | Purifications of pomegranate ellagitannins and their uses thereof Compositions of purified and biologically active ellagitannins are provided by separation from pomegranate husk using a method of extraction and purification using a solid polymeric adsorbent and the uses of the said compounds. ... | 03/01/2011 |
| 7892539 | Modulation of an innate immune response by altering TRIAL-R signaling Methods and composition are provided for modulating innate immunity by modulating activation of the TRAIL receptor. Signaling through the TRAIL-R inhibits the responsiveness of cells including dendritic cells, macrophages, and the like. The activity of these cells i... | 02/22/2011 |
| 7879326 | Human neutralizing monoclonal antibodies to H5N1 influenza A virus A panel of IgG1 human monoclonal antibodies (HMAbs) identified by hemagglutination inhibition (HI) assay has been produced from peripheral B cells of an individual immunized with prototype H5N1 vaccine. Sequence analysis of antibody clones showed three cl... | 02/01/2011 |
| 7875589 | Alpha B-crystallin as a therapy for rheumatoid arthritis The invention provides methods for treating inflammatory diseases by administering to the subject an effective amount of an agent that provides alpha B-crystallin activity, where the dose is effective to suppress or prevent initiation, progression, or relapses of di... | 01/25/2011 |
| 7875451 | Formulation to improve survival of transplanted cells The survival of cells during transplantation is enhanced. Cells to be transplanted are administered in a formulation that provides two ore more survival enhancing factors. Optionally, prior to administration, the cells are cultured in the presence of factors that en... | 01/25/2011 |
| 7871794 | Enhanced cell-free synthesis of active proteins containing disulfide bonds Compositions and methods are provided for the enhanced in vitro synthesis of active polypeptides containing disulfide bonds. In certain embodiments of the invention, the reaction mix includes a biological extract derived from a bacterial cell in which the glutathion... | 01/18/2011 |
| 7867976 | Nogo epitopic fragments for modulating immune response Epitopic fragments of Nogo, including Nogo 45-66, elicit a specific and strong T cell response, and a B cell response. T cells reactive to Nogo antigens are capable of ameliorating ongoing disease, which may be induced with other antigens. The present invention prov... | 01/11/2011 |
