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| Number | Title | Issue Date |
| 7541164 | Mammalian cell culture processes for protein production The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, preferably, but not limited to, fed-batch cell cultures. In one aspect, the methods comprise at least two temp... | 06/02/2009 |
| 7439230 | Methods of treatment using CTLA4 mutant molecules The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domai... | 10/21/2008 |
| 7332303 | Product quality enhancement in mammalian cell culture processes for protein production The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, illustratively, but not limited to, fed-batch cell cultures. The methods comprise feeding the cells with D-gal... | 02/19/2008 |
| 7307064 | Methods for treating cardiovascular disease using a soluble CTLA4 molecule The present invention relates to compositions and methods for treating cardiovascular system diseases by administering to a subject soluble CTLA4 molecules that block endogenous B7 molecules from binding their ligands. ... | 12/11/2007 |
| 7094874 | Soluble CTLA4 mutant molecules The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domai... | 08/22/2006 |
| 7087418 | Pichia pastoris formate dehydrogenase and uses therefor This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also re... | 08/08/2006 |
| 7070776 | Methods for blocking binding of CD28 receptor to B7 The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. The invention further provides methods for using antibodies to B7, or fragments thereof, to regulate CD28 positive T cell response and immune responses mediated b... | 07/04/2006 |
| 7060720 | Inhibitors of IMPDH enzyme The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH associated disorders, such as tr... | 06/13/2006 |
| 6929935 | Gluconobacter oxydans 2-ketoreductase enzyme and applications thereof This invention relates to an novel Gluconobacter oxydans 2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encoding G. oxydans 2-ketoreductase enzymes, and enzyme fragments and variants thereof, as wel... | 08/16/2005 |
| 6887471 | Method to inhibit T cell interactions with soluble B7 This invention provides methods for regulating T cell interactions with B7 positive cells. Methods are provided for using B7 antigen, its fragments and derivatives reactive with CTLA4 receptor, to regulate CTLA4 positive T cell responses, and immune responses mediat... | 05/03/2005 |
| 6869956 | Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) The present invention describes methods of preventing and treating inflammatory and immune-related diseases or disorders using inhibitors of IκB kinase (IKK). Also described are IKK inhibitors effective for the prevention and treatment of inflammatory and immune-re... | 03/22/2005 |
| 6759509 | Branched peptide linkers Conjugates containing a targeting ligand, such as an antibody, a therapeutically active drug and a branched peptide linker. The branched peptide linker contains two or more amino acid moieties that provide an enzyme cleavage site. The number of drugs capable of bein... | 07/06/2004 |
| 6730302 | Intracellular targeted delivery of compounds by 70 kD heat shock protein The present invention provides a carrier for the delivery of molecules with biological function into both cellular and nuclear compartments. The carrier disclosed is heat shock protein 70 (“Hsp70”), or a fragment of Hsp70 as described herein, as a vehicle for di... | 05/04/2004 |
| 6713515 | Retinoic acid receptor antagonists as promoters of angiogenesis Methods and compositions for treating various disorders by administering a therapeutically effective amount of a retinoic acid receptor antagonist alone or in combination or in conjunction with other therapeutic agents to promote angiogenesis are provided. Also prov... | 03/30/2004 |
| 6699702 | Prokaryotic system designed to monitor protease activity The invention relates to a prokaryotic cell system for monitoring protease activity. The invention also includes assays for identifying protease inhibitors and protease modulators, determining the amino acid sequence of a protease cleavage site for a know... | 03/02/2004 |
| 6692934 | Organic anion transport proteins The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins ("OATPs"). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the... | 02/17/2004 |
| 6559287 | Artificial proteoglycans Novel articifial proteoglycans containing a GAG assembly site and a control sequence required for assembly, method for enhancing the biological activity of a glycosaminoglycan binding protein using artificial proteoglycans, DNA constructs of artificial pr... | 05/06/2003 |
| 6518014 | Hepadnavirus cores Provided in one embodiment is a non-infectious, recombinant hepadnavirus core particle composition comprising isolated hepadnavirus core particles, template RNA encapsidated in the same core particles and hepadnavirus polymerase encapsidated in the same c... | 02/11/2003 |
| 6482919 | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell The present invention provides novel soluble CTLA4Ig molecules having modified Ig domains.... | 11/19/2002 |
| 6468781 | Stereoselective reductive amination of ketones Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid... | 10/22/2002 |
| 6455683 | DNA molecules encoding human CLAX proteins and their soluble fusion proteins Isolated novel cDNA sequences encoding a human C-type lectin and three homologues are provided. They are referred to herein as "CLAX" (C-type Lectin, Activation Expressed) proteins. The invention also includes methods of using the nucleic acid sequences, ... | 09/24/2002 |
| 6333186 | Modified forms of Hepatitis C NS3 protease for facilitating inhibitor screening and structural studies of protease: inhibitor complexes The present invention relates to modified Hepatitis C NS3 proteases and modified Hepatitis C NS4a-NS3 fusion proteases. These proteins are highly soluble and are useful for NMR spectroscopy, X-ray crystallography, and inhibitor screening. DNA constructs a... | 12/25/2001 |
| 6132992 | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell The present invention provides an expression vector encoding monospecific or bispecific fusion protein. In one embodiment the expression vector encodes a monospecific fusion protein, which vector comprises a recombinant monospecific single chain cassette ... | 10/17/2000 |
| 5990109 | Heterocyclo-substituted imidazopyrazine protein tyrosine kinase inhibitors Novel heterocyclo-substituted imidazopyrazines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.... | 11/23/1999 |
