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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 5200411 | Heteroatoms-containing tricyclic compounds The compounds of formula I ##STR1## wherein the substituents have various significances, possess pharmacological, particularly antiinflammatory and immunosuppressant activity. They can be prepared by one or more of the following process variants: ... | 04/06/1993 |
| 5190941 | Use of naphthoxazines for the treatment of conditions associated with cerebral ischaemia Compounds of formula I ##STR1## wherein R1, R2, R3 and R4 are as defined in the description, are useful for the treatment of conditions associated with cerebral ischaemia, e.g. stroke.... | 03/02/1993 |
| 5182383 | Stable, crystalline form of a cephalosporin intermediate product The invention relates to new stable, crystalline forms of the t-butylester of ceftazidime of formula ##STR1## and the production thereof.... | 01/26/1993 |
| 5166181 | Halogenoalkylphenyl-alcohols, ketones and hydrates thereof Halogenoalkylphenyl-alcohols, ketones and their hydrates of formula I, ##STR1## wherein R1 to R8 are as defined in the description, are useful as acetylcholinesterase inhibitors.... | 11/24/1992 |
| 5164526 | Pleuromutilins Compounds of formula I ##STR1## wherein R1 and R2 are the same or different and each represent hydrogen, alkyl, alkenyl, cycloalkyl, aryl or aralkyl are produced by a new environmentally acceptable process.... | 11/17/1992 |
| 5145837 | Treatment of arthritis Somatostatin analogues and derivatives in free form or in pharmaceutically acceptable salt or complex form are useful for treating degenerative and inflammatory processes in bone or catilage, e.g. arthritic conditions or diseases.... | 09/08/1992 |
| 5141951 | 5-phenyl-1H-pyrazol-4-propionic acid derivatives, compositions and use Compounds of formula I ##STR1## wherein R1 is alkyl, alkoxy, alkylthio, alkylamino, aryl, aryloxy, arylthio, arylamino, aralkyl, aralkoxy, aralkylthio or aralkylamino, R2 and R3 are each independently hydrogen, halogen, hy... | 08/25/1992 |
| 5138049 | Cephalosporin derivative The invention relates to a nitrate of (6R,7R)-7-{[2-(2-amino-4-thiazolyl)]-2-oxoacetamido}-3-(1,2,3-thiadizol-5- yl)thiomethyl-3-cephem-4-carboxylic acid, a process for its production and its use.... | 08/11/1992 |
| 5132459 | Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals Compounds of formula I ##STR1## wherein R1 represents a group of formula ##STR2##... | 07/21/1992 |
| 5112851 | Amine derivatives, processes for their production and their use Compounds of formula I ##STR1## wherein R1 represents a group of formula ##STR2## and R2 represents hydrogen or lower alkyl, or R1 and R2 together with the carbon atom to which they are attached repres... | 05/12/1992 |
| 5096921 | Organic compounds -[10-oxy-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene]-carboxyli c acids, or physiologically-hydrolysable and -acceptable esters or pharmaceutically acceptable salts thereof are useful for effecting monokine inhibition, in particular interleukin... | 03/17/1992 |
| 5077298 | Novel 8-acylaminoergolines Compounds of formula I ##STR1## wherein R1 is hydrogen or C1-4 alkyl, R2 is hydrogen, chlorine, bromine or methyl, R3 is C1-5 alkyl or C3-5 alkenyl and R4 is C3-7... | 12/31/1991 |
| 5075318 | 8-acylaminoergoline, its preparation and pharmaceutical compositions containing it 8-Acylaminoergoline useful in the treatment of psychotic disorders and Parkinson's disease.... | 12/24/1991 |
| 5071871 | Pharmaceutically useful benzo(ଲ)pyranes and pyranopyridines New benz[b]pyranes and pyranopyridines of formula I, ##STR1## wherein the significances of substituents V, T, W, R3 to R5, R9, R10, m, X, Y and Z are given in claim 1 and their N-oxides and their salts and ... | 12/10/1991 |
| 5066643 | Fluorine and chlorine statine or statone containing peptides and method of use A peptide optionally in isosteric form wherein a methylene group in the backbone chain is disubstituted, one or both substituents being fluorine and/or chlorine, in free form or in pharmaceutically acceptable salt form, such as a compound of formula I ... | 11/19/1991 |
| 5066798 | Crystalline cephalosporin derivative The invention provides crystallilne (6R, 7R)-7-[[2 ( 2-Amino-4-thiazolyl)-(Z)-2-(1-diphenylmethoxycarbonyl-1-methylethoxy)imino ]acetamido]-3-(1--pyridiniummethyl)-3-cephem-4-carboxylate and a process for its production.... | 11/19/1991 |
| 5045537 | Hydrophilic renin inhibitors, their preparation and use Hydrophilic renin inhibitors, especially of formula ##STR1## wherein R1, W, o, m, n, A, B, C and D possess the definitions given in claim 2, processes for their production and their use in the treatment of hypertension, cardiac insufficien... | 09/03/1991 |
| 5037988 | Process for preparing cephalosporins and intermediates therefor The invention relates to activated aminothiazolyl-oximinoacetic acid derivatives, their production and their use in the production of e.g. amides, in particular cephalosporin antibiotics.... | 08/06/1991 |
| 5030632 | Low dose temazepam This invention relates to a hard gelatin capsule containing no more than 5 to 10 milligrams of crystalline temazepam and its use in the treatment of transient insomnia.... | 07/09/1991 |
| 5015736 | Piperazine intermediates A new compound called N,N'-carbonyl-bis-(4-ethyl-2,3-dioxo)-piperazine of Formula I ##STR1## A process for the preparation thereof based on the reaction of 4-ethyl-2,3-dioxo-piperazine or a trimethylsilyl derivative thereof with carbonyl chlorid... | 05/14/1991 |
| 5011844 | Substituted 4-azatricyclo(22.3.1.04,9)octacos-18-ene derivatives, their preparation and pharmaceutical compositions containing them The compounds of formula I ##STR1## wherein either R1 is hydroxy, R2 is allyl or n-propyl and there is a single bond between the carbon atoms numbered 14 and 15 or R1 is missing, R2 is allyl and there is a double bon... | 04/30/1991 |
| 5003073 | Process for producing cephalosporin antibiotics, and novel intermediates for use in such process and their production Process for the production of known 2-oximinoacetamido-3-cephem-4-carboxylic derivatives comprising acylation of 7-amino-3-cephem-4-carboxylic acid derivatives with novel 2-oximinoacetic acid thio esters, as well as such thioesters and their producti... | 03/26/1991 |
| 4977176 | Pilocarpine compounds which are used as pharmaceutical agents Pilocarpine derivatives of formula I, ##STR1## wherein R1 to R5 are as defined in the description, are useful in the treatment of senile dementia, Alzheimer's disease, confusional conditions in the elderly, myasthenia gravis, sc... | 12/11/1990 |
| 4954624 | Process for the production of cephalosporin derivatives New process for the production of the pentahydrate of ceftazidime of formula ##STR1## characterized in that the ester group of the compound of formula ##STR2## or an acid addition salt thereof, is cleaved by the sole use of aqueous hydrochl... | 09/04/1990 |
| 4950672 | 2-substituted-8-branched chain acylaminoergolines Compounds of the formula I ##STR1## wherein R1 is hydrogen or C1-4 alkyl, R2 is hydrogen, chlorine, bromine or methyl, R3 is C1-5 alkyl or C3-5 alkenyl and R4 is C3-7 | 08/21/1990 |
| 4939148 | Amine derivatives, processes for their production and their use Compounds of formula I ##STR1## wherein R1 represents a group of formula ##STR2## and R2 represents hydrogen or lower alkyl, or R1 and R2 together with the carbon atom to which they are attached repre... | 07/03/1990 |
| 4935429 | Method of treating psychostimulant addiction A method of treating psychostimulant abuse with a therapeutically effective amount of a dopamine agonist.... | 06/19/1990 |
| 4093710 | Rapid dissolving effervescent granules Free flowing, rapid dissolving, effervescent granules in particular, potassium chloride granules, are prepared by granulating an alkali metal carbonate and/or bicarbonate and active ingredient with water containing a surfactant, such as polyethylene glyco... | 06/06/1978 |
| 4089891 | Pleuromutilin solvates The invention provides novel pleuromutilin solvates and a method of purifying pleuromutilin via such solvates.... | 05/16/1978 |
| 4087530 | Substituted 6-phenyl-octahydrobenzo [c] [1,6] naphthyridines This invention provides new compounds of formula I, ##STR1## wherein the indicated radical in the 8 or 9 position of the benzonaphthyridine structure (R1) is hydrogen, alkoxy of 1 to 4 carbon atoms or hydroxy, and R2, r3 | 05/02/1978 |
| 4086353 | Certain azolinylamino (azolidinylimino) indazoles The present invention provides compounds of formula I, ##STR1## wherein R1 is hydrogen or alkyl of 1 to 4 carbon atoms in position 1 or 2 of the indazole nucleus, R2 is hydrogen, halogen, trifluoromethyl, hydroxy or alkyl, alkylthio ... | 04/25/1978 |
| 4086342 | 6-(1-Piperazinyl)morphanthridine as a sleep inducing or prolonging agent 6-(1-Piperazinyl)morphanthridine is a useful sleep promoting agent.... | 04/25/1978 |
| 4085218 | Elevating mood in geriatric patients The present invention relates to the use of the known compounds of formula ##STR1## wherein R is lower alkyl, as mood elevating agents for geriatric patients.... | 04/18/1978 |
| 4036976 | Substituted imidazolinylamino-indazoles The present invention relates to indazole derivatives of formula ##STR1## wherein R1 is hydrogen or alkyl of 1 to 3 carbon atoms, R2 is hydrogen, halogen, hydroxy, or alkyl, alkoxy or alkylthio of 1 to 3 carbon atoms, and R3 | 07/19/1977 |
| 4020166 | Haloalkyl esters of 5-nitroimidazole-1-carboxylic acid derivatives This invention provides compounds of the formula, ##STR1## in which R1 signifies straight or branched chain alkyl in which a single methyl group is replaced by a mono-, di- or tri-halomethyl group; R2 signifies hydrogen or strai... | 04/26/1977 |
