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| Number | Title | Issue Date |
| 7871625 | HCV multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof Modified HCV multiple epitope fusion antigens (MEFAs) are described. The proteins include modified sequences such that proteolytic cleavage of the MEFAs by HCV NS3 protease is inhibited. HCV immunoassays including the modified MEFAs are also described. ... | 01/18/2011 |
| 7867731 | HX2004-6 polypeptide expressed in cancerous cells The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides me... | 01/11/2011 |
| 7863423 | Pancreatic cancer genes The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dys... | 01/04/2011 |
| 7855058 | Human cyclin-dependent kinase (hPNQALRE) A human gene encoding a novel cyclin-dependent kinase termed hPNQALRE and its expression products can be used to provide reagents and methods for detecting neoplasia. Compositions and methods for treating proliferative disorders and neoplasia are also provided. ... | 12/21/2010 |
| 7820106 | Sensor platform, apparatus incorporating the platform and process using the platform A sensor platform for use in sample analysis comprises a substrate (30) of refractive index (n1) and a thin, optically transparent layer (32) of refractive index (n2) on the substrate, (n2) is greater than (n1 | 10/26/2010 |
| 7807438 | Preparation of purified exosomes comprising HCV RNA The invention relates to a method for isolation of hepatitis C virus. The method comprises the separation of particles termed exosomes from the blood plasma of an individual infected with hepatitis C virus (HCV) and the extraction or RNA from these exosome particles... | 10/05/2010 |
| 7795407 | Metastatic breast and colon cancer regulated genes Gene sequences as shown in SEQ ID NO:1-18 have been discovered and isolated, and found to be significantly associated with metastatic spread of breast and colon cancer cells to other organs. Methods are provided for determining the risk of metastasis of a breast or ... | 09/14/2010 |
| 7795037 | Methods for verifying fluid movement Methods for using semiconductor nanocrystals for determining fluid movement, fluid dilution and fluid removal are described. Methods for using semiconductor nanocrystals for monitoring and quantifying the amounts of solid materials dissolved in a liquid are also des... | 09/14/2010 |
| 7785782 | Device and method for in-line blood testing using biochips A device for in-line blood screening and testing using biochips is disclosed. The screening methods include nucleic acid amplification techniques and antibody/antigen assays to detect target molecules and agents indicative of infectious diseases or metabolic disease... | 08/31/2010 |
| 7704756 | Fluorogenic dyes Fluorogenic or chromogenic dyes are useful as reporter molecules for detecting cell entry by a specific molecule. ... | 04/27/2010 |
| 7700359 | Gene products differentially expressed in cancerous cells The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides me... | 04/20/2010 |
| 7657385 | Structure-based hepatitis C virus drug design The extracellular loop of CD81 is a cellular receptor for the E2 protein of hepatitis C virus. A CD81 crystal structure has been elucidated and is provided for use in the structure-based design of compounds which bind to CD81 and thus block the binding of HCV. Metho... | 02/02/2010 |
| 7491808 | HCV non-structural protein mutants and uses thereof Modified HCV non-structural proteins are described. The proteins include modified NS3 domains such that proteolytic activity of the NS3 molecule is inhibited. The modified proteins retain conformational epitopes. HCV immunoassays including the modified NS3 molecules... | 02/17/2009 |
| 7462592 | Compositions and methods for polynucleotide delivery This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency o... | 12/09/2008 |
| 7439058 | HBV/HCV virus-like particle Chimeric antigens derived from hepatitis B virus (HBV) and hepatitis C virus (HCV) are described which form virus-like particles when co-expressed with an excess of hepatitis B virus surface antigen (HBsAg). The chimeric antigens are fusion proteins containing an im... | 10/21/2008 |
| 7439040 | Protease regulator screening assay A polypeptide containing an anchor region, a protease recognition site, and a detectable signal region can be produced recombinantly and directly attached to a solid support. The polypeptide is useful for screening protease regulators, especially protease inhibitors... | 10/21/2008 |
| 7422861 | Oligonucleotide transfection screening method Different-sequence peptoids, including lipid- and sterol-conjugated peptoids, are found to be effective in transfection of cells with oligonucleotides. Combinatorial libraries of such peptoids can be screened efficiently in a high-throughput format, and selected pep... | 09/09/2008 |
| 7408023 | Peptoids incorporating chemoselective functionalities Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made e... | 08/05/2008 |
| 7285271 | Antigenic composition comprising an HIV gag or env polypeptide Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare... | 10/23/2007 |
