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| Number | Title | Issue Date |
| 6979533 | Determination of endometrial receptivity toward embryo implantation Methods for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for β3 and detecting β3 in the endometrium. The inventio... | 12/27/2005 |
| 6964973 | Bicyclic androgen and progesterone receptor modulator compounds and methods The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agon... | 11/15/2005 |
| 6941950 | Bronchial flow control devices and methods of use Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. An identified region of t... | 09/13/2005 |
| 6936476 | Point of care diagnostic systems Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and operating rooms, or in any situation in which a rapid and accurate res... | 08/30/2005 |
| 6899723 | Transcutaneous photodynamic treatment of targeted cells The present invention is drawn to methods and compounds for photodynamic therapy (PDT) of a target tissue or compositions in a mammalian subject, using a light source that preferably transmits light to a treatment site transcutaneously. The method provides for admin... | 05/31/2005 |
| 6867051 | Point of care diagnostic systems Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and operating rooms, or in any situation in which a rapid and accurate res... | 03/15/2005 |
| 6840243 | Methods and devices for use in performing pulmonary procedures Systems, methods and devices for performing pulmonary procedures, and in particular treating lung disease. A flow control element includes a valve that prevents airflow in the inhalation direction but permits airflow in the exhalation direction. The flow control ele... | 01/11/2005 |
| 6828435 | Combinatorial protecting group strategy for multifunctional molecules The use of protection schemes and solid phase synthesis reactions to generate molecules of core structure M, which have a plurality of moieties, each of which can be individually deprotected or subsequently derivatized are provided. In one process, M is a multifunct... | 12/07/2004 |
| 6821726 | Method for quantitatively analyzing tumor cells in a body fluid and test kits suited therefor The invention relates to a method for quantitatively analyzing tumor cells in a body fluid. According to the inventive method, the test sample to be examined is first subjected to a method for accumulating or depleting tumor cells, and a reaction is carried out on t... | 11/23/2004 |
| 6818394 | High density immobilization of nucleic acids Processes and kits for immobilizing a high density of nucleic acids on an insoluble surface, which are particularly useful for mass spectrometric detection of nucleic acids, are disclosed. Arrays containing the immobilized nucleic acids and use of the immobilized nu... | 11/16/2004 |
| 6812455 | Method and apparatus for MALDI analysis Matrix assisted laser desorption/ionization (MALDI) is performed in a manner that thermalizes large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined ins... | 11/02/2004 |
| 6803194 | Use of ribozymes for functionating genes Double stranded DNAs, expression vectors and methods for their use are provided in which the intracellular expression of the double stranded DNAs is used to alter the phenotype of a target cell so that the function of a target nucleic acid that includes a nucleotide... | 10/12/2004 |
| 6790458 | Pharmaceutical compositions using semi-solid delivery vehicle A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is su... | 09/14/2004 |
| 6743967 | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods f... | 06/01/2004 |
| 6733979 | Determination of endometrial receptivity toward embryo implantation Methods for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for β3 and detecting β3 in the endometrium. The inventio... | 05/11/2004 |
| 6730517 | Automated process line Fully automated modular analytical systems with integrated instrumentation for analysis of biopolymer samples, such as nucleic acids, proteins, peptides and carbohydrates, are provided. Analytical methods of detection and analysis, such as mass spectrometry, radiola... | 05/04/2004 |
| 6723564 | IR MALDI mass spectrometry of nucleic acids using liquid matrices Mass spectrometry of large nucleic acids by infrared Matrix-Assisted Laser Desorption/Ionization (MALDI) using a liquid matrix is reported. ... | 04/20/2004 |
| 6706530 | IR-MALDI mass spectrometry of nucleic acids using liquid matrices Mass spectrometry of large nucleic acids by infrared Matrix-Assisted Laser Desorption/Ionization (MALDI) using a liquid matrix is reported. ... | 03/16/2004 |
| 6677473 | Plasminogen activator inhibitor antagonists Compounds and pharmaceutical compositions useful as plasminogen activator inhibitor (PAI) antagonists are provided. In particular, methods of antagonizing PAI with substituted and unsubstituted aryl and heteroaryl ethers and thioethers, benzils, benzyl et... | 01/13/2004 |
| 6678669 | Method for selecting medical and biochemical diagnostic tests using neural network-related applications Methods are provided for developing medical diagnostic tests using decision-support systems, such as neural networks. Patient data or information, typically patient history or clinical data, are analyzed by the decision-support systems to identify importa... | 01/13/2004 |
| 6670335 | Fluorouracil-containing formulation Oil-in-water emulsion formulations contain both free fluorouracil and fluorouracil impregnated in porous microparticles. The formulations are suitable for topical administration, and are useful for the treatment of solar keratoses, actinic keratoses, and ... | 12/30/2003 |
| 6660229 | Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing Methods and kits that use nucleotide analogs to confer increased accuracy and improved resolution in the analysis and sequencing of oligonucleotide mixtures are provided.... | 12/09/2003 |
| 6635452 | Releasable nonvolatile mass label molecules Using nonvolatile, releasable, mass-labels, the present invention provides for the synthesis and use of mass-labeled compounds to specifically interact with biomolecular targets. Following binding of the mass-labeled compounds to the target molecule, the ... | 10/21/2003 |
| 6632829 | Sulfonamides and derivatives thereof that modulate the activity of endothelin Thienyl-, furyl- and pyrrolyl-sulfonamides, formulations of pharmaceutically-acceptable salts thereof and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, ... | 10/14/2003 |
| 6624187 | Long wave length absorbing bacteriochlorin alkyl ether analogs Novel compounds that either preferentially absorb into hyperproliferative tissue and absorb light efficiently at a wavelength of between about 700 and about 850 nm or act as intermediates for such absorbing compounds. More particularly, the compounds of t... | 09/23/2003 |
| 6613804 | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin Biphenylsulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, bicyclic or tricyclic carbon or heterocyclic ring biphenylsulfonamides and methods using these sulfonamides for inhi... | 09/02/2003 |
| 6602274 | Targeted transcutaneous cancer therapy The present invention is drawn to methods and compounds for photodynamic therapy (PDT) of a target tissue or compositions in a mammalian subject, using a light source that preferably transmits light to a treatment site transcutaneously. The method provide... | 08/05/2003 |
| 6602662 | DNA diagnostics based on mass spectrometry Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genet... | 08/05/2003 |
| 6582904 | Method of quantifying tumour cells in a body fluid and a suitable test kit A method for the quantification of tumor cells in a body fluid is disclosed and entails first carrying out a reaction with the sample to be investigated, in which the RNA component of telomerase is specifically amplified, and then the amount of amplified ... | 06/24/2003 |
| 6573282 | Peripherally active anti-hyperalgesic opiates Compositions and methods using the compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate rece... | 06/03/2003 |
| 6569385 | Systems and methods for preparing and analyzing low volume analyte array elements Serial and parallel dispensing tools that can deliver defined and controlled volumes of fluid to generate multi-element arrays of sample material on a substrate surface are provided. The substrates surfaces can be flat or geometrically altered to include ... | 05/27/2003 |
| 6566055 | Methods of preparing nucleic acids for mass spectrometric analysis This invention relates to methods for screening nucleic acids for polymorphisms by analyzing amplified target nucleic acids using mass spectrometric techniques and to procedures for improving mass resolution and mass accuracy of these methods of detecting... | 05/20/2003 |
| 6558902 | Infrared matrix-assisted laser desorption/ionization mass spectrometric analysis of macromolecules Mixtures containing a biological macromolecule, such as a nucleic acid molecule or a polypeptide, and a liquid matrix, which absorbs infrared (IR) radiation, are provided. These mixtures are useful for analysis of the biological macromolecule by IR matrix... | 05/06/2003 |
| 6556977 | Methods for selecting, developing and improving diagnostic tests for pregnancy-related conditions Methods are provided for developing medical diagnostic tests using decision-support systems, such as neural networks. Patient data or information, typically patient history or clinical data, are analyzed by the decision-support systems to identify importa... | 04/29/2003 |
| 6436635 | Solid phase sequencing of double-stranded nucleic acids This invention relates to methods for detecting and sequencing of target double-stranded nucleic acid sequences, to nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involv... | 08/20/2002 |
| 6428955 | DNA diagnostics based on mass spectrometry The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a gene... | 08/06/2002 |
| 6416960 | Detection and visualization of neoplastic tissues and other tissues Diagnostic systems that rely on bioluminescence for visualizing tissues in situ are provided. The systems are particularly useful for visualizing and detecting neoplastic tissue and specialty tissue during surgical procedures. Kits that provide the compon... | 07/09/2002 |
| 6394952 | Point of care diagnostic systems Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and operating rooms, or in any situation in which a rapid and a... | 05/28/2002 |
| 6376523 | Benzenesulfonamides and the use thereof to modulate the activity of endothelin N-(5-isoxazolyl)benzenesulfonamides and N-(3-isoxazolyl)benzenesulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(5-isoxazolyl)biphenylsulfonamides and N-(3-isoxazolyl... | 04/23/2002 |
| 6331637 | N-Alkyl, N-Alkenyl, N-Alkynyl, N-Aryl and N-fused bicyclo or tricyclo thienyl-, furyl-,and Pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin N-alkyl, N-alkenyl, N-alkynyl, N-aryl and N-fused bicyclo or tricyclo thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, (phenyl) and (phenoxy)th... | 12/18/2001 |
