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| Number | Title | Issue Date |
| 8137904 | Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue Described is the use of a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable signal, e.g., a luminescent or fluorescent protein for the preparation of a diagnostic composition for diagnosis and... | 03/20/2012 |
| 8124811 | Fragrance and methods for production of 5-epi-β-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one, and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one The present invention is directed to novel methods for production of 5-epi-β-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one, which are useful for their fragrant qualities. In one embodim... | 02/28/2012 |
| 8114839 | Protease resistant modified erythropoietin polypeptides Modified erythropoietin polypeptides that include the mutation R131Q, and uses thereof are provided. Also provided are pharmaceutical compositions, including compositions formulated for oral administration, that contain the modified erythropoietin polypeptides and u... | 02/14/2012 |
| 8106260 | Chimeric isoprenoid synthases and uses thereof Disclosed is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the product... | 01/31/2012 |
| 8105586 | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally a... | 01/31/2012 |
| 8066984 | Modified vaccinia virus strains for use in diagnostic and therapeutic methods Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti... | 11/29/2011 |
| 8052968 | Modified vaccinia virus strains for use in diagnostic and therapeutic methods Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agent... | 11/08/2011 |
| 8021662 | Microorganisms for therapy Methods for production of tumor-specific antibodies are provided. The methods employ microorganisms that are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tis... | 09/20/2011 |
| 7998930 | Modified growth hormones Provided are modified growth hormone polypeptides, nucleic acid molecules encoding modified growth hormone polypeptides and methods of generating modified growth hormone polypeptides. Also provided are methods of treatment using modified growth hormone polypeptides.... | 08/16/2011 |
| 7939641 | Motif-grafted hybrid polypeptides and uses thereof Provided herein are hybrid polypeptides that specifically bind to a disease-associated isoform of a polypeptide involved in diseases of protein aggregation. The hybrid polypeptides can be used for diagnosis and treatment of such diseases. In a particular embodiment,... | 05/10/2011 |
| 7939304 | Mutant MT-SP1 proteases with altered substrate specificity or activity MT-SP1 mutein proteases with altered specificity for the target molecules they cleave can be used to treat human diseases, such as cancer. Cleaving VEGF or VEGFR at certain substrate sequences with wild-type and mutein MT-SP1 proteases can be used to treat pathologi... | 05/10/2011 |
| 7906140 | Compositions for mucosal delivery of agents Compositions and methods for mucosal delivery of agents are provided. The compositions are intended for administration to mucosal surface, such as oral and nasal mucosa. The compositions provided contain one or more mucoadhesive proteins and an agent to be delivered... | 03/15/2011 |
| 7888092 | Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon Provided herein is are polypeptides that include the protease domain of a type II transmembrane serine protease (MTSP) as a single chain. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP are provided. Also provided ... | 02/15/2011 |
| 7884073 | Modified growth hormone Provided are modified growth hormone polypeptides, nucleic acid molecules encoding modified growth hormone polypeptides and methods of generating modified growth hormone polypeptides. Also provided are methods of treatment using modified growth hormone polypeptides.... | 02/08/2011 |
| 7883688 | Polycationic polyrotaxanes capable of forming complexes with nucleic acids A polycation capable of forming a complex with a nucleic acid for carriage thereof. The polycation comprising at least one cyclic compound having a cavity. A polymer backbone is threaded into the cavity of the cyclic compound. A pair of bulky moieties cap the termin... | 02/08/2011 |
| 7846431 | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally a... | 12/07/2010 |
| 7871607 | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally a... | 01/18/2011 |
| 7858560 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions Capture Collections of capture compounds and collections thereof and methods using the compounds collections for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as... | 12/28/2010 |
| 7829081 | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally a... | 11/09/2010 |
| 7825084 | Methods and compositions for increasing the anaerobic working capacity in tissues Provided are compositions comprising beta-alanylhistidine peptides and beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods cause an increase in the blood plasma concentrations of beta-alanine and/o... | 11/02/2010 |
| 7820184 | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders Methods for detecting a microorganism or cell in a subject and methods for detecting, imaging or diagnosing a site, disease, disorder or condition in a subject using microorganisms or cells and methods that microorganisms or cells for treating a disease, disorder or... | 10/26/2010 |
| 7816372 | 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR. Also provided are methods of making such compounds and pharmaceutical compositions. ... | 10/19/2010 |
| 7767429 | Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally ... | 08/03/2010 |
| 7763420 | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders Described herein are methods for detecting a microorganism or cell in a subject and methods for detecting, imaging or diagnosing a site, disease, disorder or condition in a subject using microorganisms or cells. Also described are methods which use microorganisms or... | 07/27/2010 |
| 7754221 | Microorganisms for therapy Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, ... | 07/13/2010 |
| 7727980 | Tricyclic androgen receptor modulator compounds and methods This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds. ... | 06/01/2010 |
| 7700341 | Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon Provided herein is are polypeptides that include the protease domain of a type II transmembrane serine protease (MTSP) as a single chain. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP are provided. Also provided ... | 04/20/2010 |
| 7696246 | Bicyclic androgen and progesterone receptor modulator compounds and methods The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agon... | 04/13/2010 |
| 7662398 | Microorganisms for therapy Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, ... | 02/16/2010 |
| 7650243 | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cy... | 01/19/2010 |
| 7647184 | High throughput directed evolution by rational mutagenesis Processes and systems for the high throughput directed evolution of peptides and proteins, particularly those that act in complex biological settings, are provided. The proteins and peptides include, but are not limited to, intracellular proteins, messenger/signalin... | 01/12/2010 |
| 7632858 | Open chain prolyl urea-related modulators of androgen receptor function The invention provides for a pharmaceutical composition capable of modulating the androgen receptor comprising a compound of formula I wherein R1, R2, R3, X, Y, Z and G are as described here... | 12/15/2009 |
| 7611700 | Protease resistant modified interferon alpha polypeptides Processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided is a rational method for generating protein variants and the resulting variants. | 11/03/2009 |
| 7588771 | Microorganisms for therapy Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, ... | 09/15/2009 |
| 7588767 | Microorganisms for therapy Therapeutic methods and microorganisms therefore are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs,... | 09/15/2009 |
| 7094943 | Solution phase biopolymer synthesis Multifunctional liquid phase carriers (LPCs) and methods of using LPCs for the preparation of biopolymers are provided. The LPCs are highly symmetrical compounds that possess more than two points of attachment for biopolymer synthesis. The LPCs have the formula Sp(X... | 08/22/2006 |
| 7504376 | Methods and compositions for increasing the anaerobic working capacity in tissues The invention provides compositions comprising beta-alanylhistidine peptides and beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods cause an increase in the blood plasma concentrations of beta-ala... | 03/17/2009 |
| 7442784 | Ligand activated transcriptional regulator proteins Fusion proteins for use as ligand-dependent transcriptional regulators are provided. The fusion proteins include a nucleotide binding domain operatively linked to a ligand-binding domain. They also can include a transcription regulating domain. The nucleotide bindin... | 10/28/2008 |
| 7414768 | Electro-optical transducer and jelly layer therefor, method for producing a jelly layer and a compound for carrying out said method The electrooptical converter comprises sequentially located on the optical axis: at least one optical lighter, a transparent support or M transparent supports, each in the form of at least one plane-parallel plate or at least one prism of total internal reflection, ... | 08/19/2008 |
| 7329728 | Ligand activated transcriptional regulator proteins Fusion proteins for use as ligand-dependent transcriptional regulators are provided. The fusion proteins include a nucleotide binding domain operatively linked to a ligand-binding domain. They also can include a transcription regulating domain. The nucleotide bindin... | 02/12/2008 |
