Did You Know...
...that Robert Adler has the dubious distinction of being the Father of the Couch Potato? Back in 1955 Adler was employed by what was then Zenith Radio Corp., where he was charged to invent something that would allow viewers to turn down the TV volume without leaving their chairs. After a series of flops (such as a wired contraption that people tripped over), Adler hit on the idea of using sound waves. Thus the Remote Control was born...
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| Number | Title | Issue Date |
| 7282366 | Hepatocytes for therapy and drug screening made from embryonic stem cells It has been discovered that when pluripotent stem cells are cultured in the presence of a hepatocyte differentiation agent, a population of cells is derived that has a remarkably high proportion of cells with phenotypic characteristics of liver cells. In one example... | 10/16/2007 |
| 7262288 | Nucleic acids encoding human telomerase reverse transcriptase and related homologs The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu... | 08/28/2007 |
| 7199234 | Regulatory segments of the human gene for telomerase reverse transcriptase The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu... | 04/03/2007 |
| 7195911 | Mammalian cells that have increased proliferative capacity The present invention is directed to cells comprising a recombinant polynucleotide sequence that encodes a telomerase reverse transcriptase protein, variant, or fragment having telomerase catalytic activity when complexed with a telomerase RNA. ... | 03/27/2007 |
| 7175839 | Cancer immunotherapy using allostimulated cells in a multiple sequential implantation strategy This invention provides medicaments and methods for managing cancer using donor cells that are alloactivated in culture. Alloactivated cells are implanted into the bed of a solid tumor and initiate a response by the host against the tumor. Subsequently, alloactivate... | 02/13/2007 |
| 7153650 | Marker system for preparing and characterizing high-quality human embryonic stem cells This disclosure provides a system for qualifying embryonic stem cells intended for human therapy. A large-scale sequencing project has identified important markers that are characteristic of undifferentiated pluripotent cells. Combinations of these markers can be us... | 12/26/2006 |
| 7091021 | Inactive variants of the human telomerase catalytic subunit The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. Catalytically active and inactive human telomerase reverse transcriptase variants comprising deletions or oth... | 08/15/2006 |
| 7067283 | Producing telomerase activators and inhibitors by screening with purified telomerase This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, inter... | 06/27/2006 |
| 7056513 | Telomerase The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa t... | 06/06/2006 |
| 7041438 | Use of human embryonic stem cells for drug screening and toxicity testing This disclosure provides an improved system for culturing human pluripotent stem (pPS) cells in the absence of feeder cells. The role of the feeder cells can be replaced by supporting the culture on an extracellular matrix, and culturing the cells in a conditioned m... | 05/09/2006 |
| 7033831 | Islet cells from human embryonic stem cells This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells. High qual... | 04/25/2006 |
| 7005262 | Methods for detecting nucleic acids encoding human telomerase reverse transcriptase The present invention is directed to methods of identifying in a sample nucleic acids that encode human telomerase reverse transcriptase (hTRT) or its fragments. The present invention is also directed to oligonucleotide primers used in such methods. The invention is... | 02/28/2006 |
| 6927285 | Genes for human telomerase reverse transcriptase and telomerase variants The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa t... | 08/09/2005 |
| 6921664 | Telomerase The present invention is directed to expression vectors comprising a polynucleotide that encodes a human telomerase reverse transcriptase (hTRT) protein, variant, or fragment. The present invention is also directed to host cells that comprise expression vectors comp... | 07/26/2005 |
| 6921665 | Selective antibody targeting of undifferentiated stem cells This invention provides a system for producing differentiated cells from a stem cell population for use wherever a relatively homogenous cell population is desirable. The cells contain an effector gene under control of a transcriptional control element (such as the ... | 07/26/2005 |
| 6833269 | Making neural cells for human therapy or drug screening from human embryonic stem cells This invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates diff... | 12/21/2004 |
| 6808880 | Method for detecting polynucleotides encoding telomerase The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa t... | 10/26/2004 |
| 6800480 | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture Methods and materials for culturing primate-derived primordial stem cells are described. In one embodiment, a cell culture medium for growing primate-derived primordial stem cells in a substantially undifferentiated state is provided which includes a low osmotic pre... | 10/05/2004 |
| 6787133 | Using purified telomerase to identify telomerase activators and inhibitors This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, inter... | 09/07/2004 |
| 6777203 | Telomerase promoter driving expression of therapeutic gene sequences The present invention is related to novel nucleic acids comprising telomerase reverse transcriptase (TERT) cis-acting transcriptional control sequences, including TERT human and mouse promoter sequences. The present invention is further directed to methods of using ... | 08/17/2004 |
| 6767719 | Mouse telomerase reverse transcriptase This invention provides for murine telomerase reverse transcriptase (mTERT) enzyme proteins and nucleic acids, including methods for isolating and expressing these nucleic acids and proteins, which have application to the control of cell ... | 07/27/2004 |
