Quotables
"During my service in the United States Congress, I took the initiative in creating the Internet."
Al Gore ; The basis for the later misquote by US Republicans that Gore had "invented" the Internet. Gore was the leading political champion of the modern-day Internet.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7358253 | Indolylmaleimide derivatives Provided are compounds of formula (I) which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ or tissue allo- or xenografts... | 04/15/2008 |
| 7355043 | Preparation of purines A process for the preparation of a compound of formula (A) wherein: X is hydrogen or hydroxy, chloro, C1-6 alkoxy or pheny C1-6 alkoxy; and Ra and Rb are hydrogen, or acyl or phosphate derivatives thereof, which process co... | 04/08/2008 |
| 7297703 | Macrolides A mixture comprising a poly-ene macrolide and an antioxidant. Preferably, the poly-ene macrolide is rapamycin and the antioxidant is 2, 6-di-tert.-butyl-4-methylphenol. The presence of the antioxidant improves the stability of the poly-ene macrolide to oxidation. | 11/20/2007 |
| 7235555 | Indolylmaleimide derivatives Provided are compounds of formula (I) which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ or tissue allo- or... | 06/26/2007 |
| 7235248 | Pharmaceutical compositions comprising cyclosporins Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or [Nva]2-Ciclosporin, in “microemulsion pre-concentrate” and microemulsion form. The compositions typically comprise (1.1) a C1-5alkyl or tetrahydrofurfuryl di- or part... | 06/26/2007 |
| 7220774 | Indolylmaleimide derivatives Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute... | 05/22/2007 |
| 7205279 | Pharmaceutical compositions This invention provides a microemulsion pre-concentrate comprising a difficultly soluble active agent and a carrier medium comprising 1) a hydrophilic phase which comprises dimethylisosorbide and/or a lower alkyl alkanoic ester, 2) a lipophilic phase, and 3) a surfa... | 04/17/2007 |
| 7169389 | Human CD154 binding molecules and treatment methods A CD154 binding molecule, in particular an antibody to human CD154, especially a human antibody to human CD154 is provided, wherein the CDRs of the heavy chain and light chain have amino acid sequences as defined, for use in the treatment and/or prevention of diseas... | 01/30/2007 |
| 7148346 | Purification process This invention provides a process for purifying a cyclosporin, e.g. cyclosporin A, or a macrolide, to a high degree of purity on a large scale. In another aspect this invention provides a bulk quantity of cyclosporin A with an impurity level of less than about 0.7%,... | 12/12/2006 |
| 7081445 | Cyclosporin galenic forms Pharmaceutical compositions comprising a cyclosporin as active ingredient, a fatty acid triglyceride, a glycerol fatty acid partial ester or propylene glycol or sorbitol complete or partial ester, preferably, and a tenside having an HLB of at least 10. ... | 07/25/2006 |
| 7078054 | Soft gelatin capsule manufacture Soft gelatin capsules having a capsule shell comprising gelatin, plasticizers and, if desired or required, further auxiliary agents, and a capsule filling containing a solvent including a migrateable solvent such as 1,2-propyleneglycol as a solvent in the capsule fi... | 07/18/2006 |
| 7067084 | Package for a pharmaceutical product and method of manufacturing and sterilizing the package The invention relates to a plastic package for a pharmaceutical product, particularly a blister package to dispense liquids or strings, and a method of manufacturing and sterilizing said package. The blister package (1) consists of a lower base portion (2 | 06/27/2006 |
| 7025975 | Galenical formulations A pharmaceutical composition containing macrolide, e.g. a rapamycin compound in an emulsion preconcentrate or microemulsion preconcentrate for oral administration. The carrier medium for the rapamycin compound includes a hydrophilic phase, a lipophilic phase and a s... | 04/11/2006 |
| 6987104 | Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, salts or prodrugs thereof have interesting properties, e.g., in th... | 01/17/2006 |
| 6977141 | Direct adsorption scintillation assay for measuring enzyme activity and assaying biochemical processes Methods and materials for scintillation assays are disclosed. The scintillation assays rely on differences in general molecular property-based binding interactions, such as charge or hydrophobicity, to localize a radioactive substance near a scintillating material, ... | 12/20/2005 |
| 6897307 | Process for preparing 2,6-diaminopurine derivatives A one-pot process for preparing 2,6-diaminopurine derivatives or an acid addition salt thereof comprising: (i) reacting a purine compound with an amine compound in the presence of a tertiary amine at a pH of 7 to 14 to form a 6-substituted aminopurine derivative, an... | 05/24/2005 |
| 6852729 | Macrolides A mixture comprising a poly-ene macrolide and an antioxidant. Preferably, the poly-ene macrolide is rapamycin and the antioxidant is 2, 6-di-tert.-butyl-4-methylphenol. The presence of the antioxidant improves the stability of the poly-ene macrolide to oxidation. | 02/08/2005 |
| 6846927 | Preparation of purines A process for the preparation of a compound of formula (A) wherein: X is hydrogen, hydroxy, chloro, C1-6 alkoxy or phenyl C1-6 alkoxy; and Ra and Rb are hydrogen, or acyl or phosphate derivatives thereof, which process com... | 01/25/2005 |
| 6818638 | Melvinolin derivatives Mevinolin derivatives wherein the lactone ring is modified have interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1 interactions. ... | 11/16/2004 |
| 6806375 | Process for the production of purine derivatives and intermediates therefor Intermediates such as methyl 2,2-dimethyl-5-ethenyl-1,3-dioxane-5-carbonate useful to prepare antiviral compounds such as penciclovir and famciclovir are disclosed. ... | 10/19/2004 |
| 6767555 | Pharmaceutical compositions This invention provides composition comprising a cyclosporin and a carrier medium. ... | 07/27/2004 |
| 6765007 | High-content famciclovir tablets A pharmaceutical tablet wherein famciclovir is the active ingredient and wherein the percentage of famciclovir by weight in the tablet is 85% or greater. ... | 07/20/2004 |
| 6683084 | Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections The use of a compound of formula (A) or a bioprecursor, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the foregoing for use in the prophylactic treatment of HHV-6 infection. ##STR1##... | 01/27/2004 |
| 6638762 | Tissue-vectors specific replication and gene expression The invention generally relates to cell-specific expression vectors. It particularly relates to targeted gene therapy using recombinant expression vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional e... | 10/28/2003 |
| 6632978 | Transgenic animals for studying regulation of genes A transgenic non-human animal (e.g., a transgenic mouse) comprising a polynucleotide encoding a soluble marker protein functionally linked to a regulatory sequence of an endogenous gene encoding E-selectin. Also described are methods for detecting modulat... | 10/14/2003 |
| 6630492 | Lymphocyte function antigen-1 antagonists Mevinolin compounds for use in the treatment or prevention of autoimmune diseases, inflammation, ischemia/reperfusion injury and graft rejection. Such compounds bind to the LFA-1 I-domain and thereby inhibit LFA-1/ICAM-1 or LFA-1/ICAM-3 interactions.... | 10/07/2003 |
| 6579981 | Antiviral guanine derivatives A compound of formula (I) ##STR1## or a salt or acyl derivative thereof, in which X represents chlorine, C1-6 alkoxy, phenoxy, phenyl C1-6 alkoxy, NH2, --OH or --SH, is useful in treating viral infections.... | 06/17/2003 |
| 6573378 | Antiviral guanine derivatives A compound of formula (I) ##STR1## or a salt or acyl derivative thereof, in which X represents chlorine, C1-6 alkoxy, phenoxy, phenyl C1-6 alkoxy, NH2, --OH or --SH, is useful in treating viral infections.... | 06/03/2003 |
| 6555685 | Process for the production of purine derivatives and intermediates therefor A process for preparing purine derivatives, such as famiciclovir and penciclovir, by reacting, in the presence of a palladium (0) catalyst and a ligand, a compound of the formula ##STR1## with a compound of the formula ##STR2## wherein X is H, OH or ... | 04/29/2003 |
| 6514980 | Nucleoside analogs in combination therapy of herpes simplex infections A pharmaceutical product comprising a nucleoside analogue active against herpes simplex virus, such as acyclovir/valaciclovir or penciclorivir/famciclovir, and an immunosuppressant, as a combined preparation for simultaneous, separate or sequential use in... | 02/04/2003 |
| 6489330 | Use of penciclovir for the treatment of human herpes-virus-8 The present invention is directed to the use of a compound of Formula (A), ##STR1## or a bioprecursor, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the foregoing in the manufacture of a medicament for use in t... | 12/03/2002 |
| 6486209 | Use for 1,3-propanediol derivatives Use of a compound of formula I ##STR1## wherein R1 is an optionally substituted straight- or branched carbon chain having 12 to 22 carbon atoms which may be optionally interrupted by an optionally substituted phenylene, and each of R2 | 11/26/2002 |
| 6469015 | Pharmaceutical formulation An oil-in-water topical pharmaceutical formulation or an aqueous formulation for the treatment of virus infections of the skin or mucosa, comprising at least 30% of propylene glycol and solubilized penciclovir.... | 10/22/2002 |
| 6437125 | Process for the production of purine derivatives The invention provides a method of rearranging a compound of formula (I), wherein R and R' are selected independently from hydrogen and C1-12 alkyl; and R1 and R2 are selected independently from hydrogen, hydroxy, halo, C | 08/20/2002 |
| 6388074 | Process for the preparation of purine derivatives The present invention provides a process for the synthesis of penciclovir and famciclovir by 9-substituting 2-amino-6-chloropurine (ACP) with an appropriate side chain precursor, followed by conversion of the 6-chloro moiety to a hydroxy moiety (i.e. to f... | 05/14/2002 |
| 6228811 | Solid formulation The formation of undesirable sludge in the course of spraying a solution or dispersion of a water-soluble or water-dispersible solid or a structured gel formulation is reduced by the incorporation in the formulation of a low-density solid particulate mate... | 05/08/2001 |
| 6207840 | Process for preparing 3-isochromanone 3-Isochromanone is prepared by contacting an o-xylene-,'-dihalide with carbon monoxide in a two-phase liquid medium, in which one phase is aqueous and the other phase is water-immiscible, in the presence of a catalyst and a hindered amine ba... | 03/27/2001 |
| 6204223 | Packaged agrochemical composition An agrochemical composition packaged in a water soluble or water dispersible sachet is taught. The agrochemical composition is comprised of water-soluble, agrochemically active agent, water and an agent to minimize water loss through the walls of the sach... | 03/20/2001 |
| 6184392 | Process for preparing 3-isochromanone 3-Isochromanome is prepared by reacting an o-xylene-,'-dihalide with carbon monoxide and water in the presence of a metal catalyst such that the pH of the reaction is maintained between about 7 and 11.... | 02/06/2001 |
| 6169101 | Pyridine derivatives as fungicides A fungicidal compound having general formula (I) ##STR1## or a stereoisomer thereof, wherein A is CH or N, B is OCH3 or NHCH3, R1 is H, chloro or methyl and R2 is H, fluoro, chloro or methyl.... | 01/02/2001 |
